D:Hypersomnia

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Disease Term
Synonyms CATEPLEXY, Disorders Of Excessive Somnolence, Does Disorders Of Excessive Somnolence, DOESS DISORDERS OF EXCESSIVE SOMNOLENCE, Excessive Sleep, EXCESSIVE SLEEPINESS, Excessive Somnolence Disorder, Excessive Somnolence Disorders, Hypersomnia Disorder, Hypersomnia Recurrent, HYPERSOMNIAS
Documents 97
Hot Single Events 38
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypersomnia. They are ordered first by their relevance to Hypersomnia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT336576 Binding of HCRTR1 and IGHG3 1 0.01 5.01 0 91.80
2 INT213608 Binding of PER2 and CLOCK 1 0.22 0.65 0.04 6.24
3 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91 5.00
4 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 5.00
5 INT250975 Binding of FMOD and CSAD 1 0.01 0.86 0.41 5.00
6 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
7 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 5.00
8 INT267685 Binding of CENPJ and ARID1B 1 0.09 0.58 0.04 5.00
9 INT213607 Binding of CSNK1D and CLOCK 1 0.27 0.65 0.04 5.00
10 INT267686 Binding of RYBP and CENPJ 1 0.01 0.12 0.03 5.00
11 INT213606 CLOCK Regulation of Gene_expression of PROK2 1 0.20 0.3 0 5.00
12 INT336574 Binding of CD40LG and HCRTR1 1 0.05 0.1 0 5.00
13 INT213609 CLOCK Regulation of PROK2 1 0.20 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypersomnia. They are ordered first by their pain relevance and then by number of times they were reported in Hypersomnia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234289 Binding of Swd1 1 0.03 5.79 0.23 99.98
2 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 99.92
3 INT130105 Positive_regulation of HCRTR1 3 0.27 6.47 0.38 99.84
4 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 99.84
5 INT27492 Gene_expression of Swd1 4 0.50 2.07 0.68 99.64
6 INT148885 Regulation of HCRTR1 2 0.29 3.41 0.14 99.56
7 INT336579 Regulation of Regulation of HCRTR1 1 0.15 1.94 0.05 99.56
8 INT106057 Negative_regulation of Hcrt 27 0.57 15.5 3.47 99.26
9 INT120210 Negative_regulation of Hcrtr1 3 0.58 1.17 0.34 99.26
10 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 98.88
11 INT336580 Binding of HCRTR1 1 0.20 3.67 0.13 98.68
12 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 98.10
13 INT148883 Gene_expression of HCRTR1 8 0.36 24.82 1.35 97.96
14 INT148886 Negative_regulation of Gene_expression of HCRTR1 2 0.23 3.42 0.05 97.96
15 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 95.80
16 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 95.00
17 INT258092 Regulation of Gene_expression of Hcrt 2 0.44 2.6 0.29 94.52
18 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 94.04
19 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16 93.88
20 INT2910 Regulation of Abat 169 0.62 36.95 153.53 92.64
21 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 92.36
22 INT336583 Positive_regulation of Gene_expression of HCRTR1 1 0.27 3.25 0.26 91.12
23 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 91.12
24 INT331017 Transcription of MAMLD1 1 0.67 0.4 0 89.24
25 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 87.84
26 INT81843 Binding of Olfr1097 1 0.06 0.44 0.63 87.40
27 INT695 Binding of POMC 304 0.48 56.66 126.85 86.96
28 INT81842 Binding of Olr1106 1 0.02 0.44 0.62 86.92
29 INT183556 Gene_expression of SNURF 1 0.47 1.83 0.25 85.52
30 INT183537 Gene_expression of SNRPN 16 0.64 5.07 0.28 85.28
31 INT183555 Gene_expression of SNORD108 1 0.44 1.61 0.25 84.32
32 INT183544 Gene_expression of SNORD64 1 0.11 1.61 0.25 83.80
33 INT183536 Gene_expression of SNORD109A 5 0.50 2.7 0.32 83.32
34 INT183551 Gene_expression of SNORD116-1 1 0.56 1.77 0.24 83.32
35 INT183539 Gene_expression of SNORD116@ 1 0.10 1.76 0.24 83.32
36 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 82.96
37 INT177643 Binding of CENPJ 12 0.36 8.59 0.22 82.56
38 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 82.56
39 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 79.36
40 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 79.36
41 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85 77.60
42 INT18088 Binding of Tspo 26 0.48 9.12 10.2 77.36
43 INT81841 Binding of Cbr1 2 0.47 0.17 0.57 77.36
44 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 75.00
45 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 75.00
46 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 75.00
47 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 75.00
48 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 75.00
49 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35 75.00
50 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 74.64
51 INT106055 Negative_regulation of Gene_expression of Hcrt 15 0.46 5.64 2.09 71.92
52 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 71.20
53 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 71.04
54 INT263095 Transcription of COPD 3 0.53 2.78 0.33 68.56
55 INT284125 Regulation of Cenpj 1 0.07 0.6 0 67.96
56 INT249049 Positive_regulation of ARID1B 14 0.56 24.77 0.71 67.88
57 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 66.72
58 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 65.56
59 INT64834 Negative_regulation of Cenpj 3 0.42 0.58 0.19 65.52
60 INT184825 Regulation of Thy1 7 0.42 4.14 0.28 63.72
61 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 62.56
62 INT326713 Negative_regulation of Thy1 2 0.47 1.08 0.09 61.36
63 INT219535 Negative_regulation of Localization of CENPJ 2 0.41 1.01 0.05 60.32
64 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 59.84
65 INT161574 Localization of CENPJ 7 0.73 6.11 1.54 58.16
66 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 57.52
67 INT36499 Negative_regulation of Tf 6 0.38 3.02 1.85 53.36
68 INT259697 Regulation of MSSE 6 0.14 3 0.23 52.40
69 INT89368 Positive_regulation of Tf 7 0.34 3.62 0.83 49.76
70 INT16153 Gene_expression of Cenpj 7 0.77 2.56 1.42 48.24
71 INT336581 Regulation of Gene_expression of HCRTR1 1 0.24 0.71 0 48.20
72 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 47.52
73 INT336582 Positive_regulation of Binding of HCRTR1 1 0.27 0.84 0 47.28
74 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 46.16
75 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 46.16
76 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 46.16
77 INT3439 Localization of Abat 1017 0.78 112.39 727.06 38.00
78 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 38.00
79 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 36.40
80 INT274343 Localization of Mt1 1 0.11 0.84 0.48 35.36
81 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79 34.32
82 INT654 Localization of REN 250 0.81 75.12 47.86 25.00
83 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41 25.00
84 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 25.00
85 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79 24.68
86 INT75014 Regulation of Cyp2a1 3 0.06 1.22 0.09 24.68
87 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 24.08
88 INT142735 Regulation of RLS 33 0.53 45.83 11.35 23.60
89 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 19.04
90 INT267698 Gene_expression of ARID1B 18 0.63 20.47 0.47 15.12
91 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 13.52
92 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 10.16
93 INT183549 Localization of DFNB31 1 0.01 0.24 0 7.12
94 INT183548 Localization of SLC9A1 1 0.01 0.24 0 7.12
95 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 7.04
96 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
97 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
98 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
99 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
100 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
101 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 5.00
102 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 5.00
103 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
104 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
105 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
106 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
107 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
108 INT3441 Regulation of Localization of Abat 117 0.38 8.67 87.59 5.00
109 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
110 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
111 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 5.00
112 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
113 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
114 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
115 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
116 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
117 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
118 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 5.00
119 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
120 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
121 INT1703 Regulation of PCa 52 0.52 23.65 20.6 5.00
122 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
123 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
124 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
125 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
126 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
127 INT65214 Binding of Slc6a3 54 0.48 4.77 16.79 5.00
128 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
129 INT49768 Positive_regulation of Kcnj5 58 0.41 11.89 16.02 5.00
130 INT54356 Regulation of Slc6a3 48 0.58 5.86 15.24 5.00
131 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01 5.00
132 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
133 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72 5.00
134 INT8223 Transcription of PENK 53 0.69 6.84 14.7 5.00
135 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 5.00
136 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
137 INT57882 Negative_regulation of Kcnj5 33 0.35 13.06 12.27 5.00
138 INT9945 Negative_regulation of Csf2 35 0.51 17.85 11.22 5.00
139 INT19575 Negative_regulation of Positive_regulation of Abat 14 0.43 2.07 11.05 5.00
140 INT28843 Positive_regulation of Scn2a1 31 0.68 5.35 10.7 5.00
141 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04 5.00
142 INT67101 Gene_expression of DST 47 0.54 25.92 9.59 5.00
143 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
144 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
145 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
146 INT250978 Binding of FMOD 4 0.16 12.32 8.75 5.00
147 INT11732 Negative_regulation of Gtf3a 25 0.30 15.73 8.5 5.00
148 INT81153 Gene_expression of Hcrt 31 0.77 6.04 8.16 5.00
149 INT130117 Regulation of Per1 26 0.53 3.25 7.63 5.00
150 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
151 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57 5.00
152 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48 5.00
153 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
154 INT170385 Regulation of Clock 29 0.49 4.95 6.39 5.00
155 INT250982 Positive_regulation of FMOD 7 0.24 8.65 6.09 5.00
156 INT32793 Negative_regulation of Slc6a2 12 0.44 1.8 5.78 5.00
157 INT128045 Positive_regulation of Per1 29 0.69 5.32 5.5 5.00
158 INT12183 Negative_regulation of Cyp2d1 11 0.58 3.11 5.49 5.00
159 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 5.00
160 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 5.00
161 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
162 INT250981 Gene_expression of FMOD 2 0.20 7.3 4.47 5.00
163 INT56159 Regulation of Scn2a1 17 0.51 3.23 4.27 5.00
164 INT144 Positive_regulation of H1 10 0.64 2.77 4.13 5.00
165 INT190722 Positive_regulation of Gene_expression of Scn2a1 15 0.36 0.5 3.78 5.00
166 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 5.00
167 INT90823 Positive_regulation of Ptpn2 25 0.59 22.97 3.59 5.00
168 INT55516 Gene_expression of Cyp2d1 5 0.60 0.83 3.58 5.00
169 INT4562 Regulation of Slc6a2 8 0.53 1.45 3.43 5.00
170 INT118761 Positive_regulation of Per2 9 0.42 0.68 3.33 5.00
171 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
172 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 5.00
173 INT54370 Negative_regulation of VTA1 5 0.50 2.06 2.77 5.00
174 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 5.00
175 INT128328 Gene_expression of Arntl 44 0.74 3.77 2.63 5.00
176 INT113638 Negative_regulation of Hcrt 5 0.57 0.9 2.63 5.00
177 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 5.00
178 INT250980 Negative_regulation of FMOD 2 0.14 2.67 2.31 5.00
179 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3 5.00
180 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 5.00
181 INT250983 Regulation of Gene_expression of FMOD 2 0.09 2.62 2.18 5.00
182 INT12835 Negative_regulation of Positive_regulation of CRH 6 0.42 3.15 1.76 5.00
183 INT80032 Gene_expression of NPSR1 3 0.75 5.06 1.75 5.00
184 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 5.00
185 INT70860 Binding of SNRPB 17 0.35 7 1.46 5.00
186 INT128316 Regulation of Gene_expression of Arntl 6 0.43 0.68 1.43 5.00
187 INT290803 Binding of Arntl 10 0.37 1.82 1.34 5.00
188 INT183557 Localization of GABRB3 3 0.46 1.01 1.34 5.00
189 INT118758 Negative_regulation of Positive_regulation of Per2 3 0.09 0.07 1.23 5.00
190 INT78050 Positive_regulation of Positive_regulation of Selp 3 0.43 3.63 1.02 5.00
191 INT190964 Regulation of Gene_expression of Scn2a1 7 0.29 1.29 1.02 5.00
192 INT131488 Binding of MAS1 9 0.36 8.49 1.01 5.00
193 INT27813 Regulation of CENPJ 12 0.29 14.26 0.99 5.00
194 INT179688 Negative_regulation of Gene_expression of COPD 13 0.35 16.06 0.97 5.00
195 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 5.00
196 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68 5.00
197 INT190961 Negative_regulation of Positive_regulation of Scn2a1 2 0.27 0.15 0.64 5.00
198 INT213617 Gene_expression of PDE4D 3 0.53 1.98 0.62 5.00
199 INT212293 Gene_expression of Vsnl1 14 0.29 8.1 0.61 5.00
200 INT146563 Gene_expression of PROK2 15 0.75 4.12 0.61 5.00
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