D:Hypersplenism

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Disease Term
Synonyms Anemia Splenic, ANEMIAS SPLENIC, Splenic Anemia, Splenic Anemias
Documents 117
Hot Single Events 21
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypersplenism. They are ordered first by their relevance to Hypersplenism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
2 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
3 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
4 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
5 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
6 INT258861 Binding of HLA-DOA and HLA-DRB1 2 0.14 1.88 0.28 5.00
7 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16 5.00
8 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16 5.00
9 INT258906 Binding of HLA-B and HLA-DRB1 1 0.31 1.36 0.15 5.00
10 INT258909 Binding of HLA-DOA and NDUFA2 1 0.03 1.44 0.15 5.00
11 INT293312 CTLA4 Negative_regulation of Binding of CD28 and CD80 1 0.01 0.29 0.12 5.00
12 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05 5.00
13 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04 5.00
14 INT293367 Binding of CABIN1 and Ppia 1 0.00 0.19 0.03 5.00
15 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03 5.00
16 INT293368 Binding of CSH1 and Ppia 1 0.00 0.19 0.03 5.00
17 INT258908 Binding of BSG and HLA-DQA1 1 0.00 0.1 0 5.00
18 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0 5.00
19 INT258923 Binding of CD8A and Atp8a1 1 0.23 0.07 0 5.00
20 INT258910 Binding of HLA-DQA1 and HLA-DQB1 1 0.17 0.22 0 5.00
21 INT322931 Binding of MOCS1 and Litaf 1 0.00 0.82 0 5.00
22 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0 5.00
23 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
24 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0 5.00
25 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
26 INT293366 Binding of CABIN1 and Fkbp1a 1 0.00 0.05 0 5.00
27 INT293362 CSH1 Negative_regulation of Gene_expression of IL2 1 0.01 0.12 0 5.00
28 INT258911 Binding of CD4 and HLA-G 1 0.04 0.06 0 5.00
29 INT258907 Binding of CD8A and HLA-G 1 0.05 0.07 0 5.00
30 INT333978 Binding of ELF3 and TRAP 1 0.15 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypersplenism. They are ordered first by their pain relevance and then by number of times they were reported in Hypersplenism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6996 Positive_regulation of Tfrc 6 0.70 2.22 1.2 99.84
2 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 99.52
3 INT80033 Binding of FAS 37 0.48 41.19 5.67 98.44
4 INT147464 Binding of Ptprc 13 0.36 15.18 0.98 98.24
5 INT59795 Regulation of Tfrc 5 0.43 4.43 1.48 97.44
6 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 96.88
7 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 95.96
8 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 95.32
9 INT320841 Positive_regulation of Chit1 1 0.02 0.82 0.07 93.60
10 INT173693 Localization of Gopc 249 0.65 70.49 38.81 92.40
11 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 91.36
12 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54 91.36
13 INT196191 Binding of Mrgpre 7 0.14 5.84 0.25 88.56
14 INT187286 Binding of HEY1 17 0.32 31.21 4.52 88.48
15 INT55529 Negative_regulation of Gba 13 0.59 7.91 2.1 85.76
16 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 84.20
17 INT174100 Gene_expression of YWHAE 14 0.31 12.42 0.08 84.00
18 INT10059 Binding of CSH1 17 0.35 5.28 3.37 82.96
19 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 81.84
20 INT4422 Positive_regulation of Gene_expression of Alb 30 0.50 18.56 6.12 81.84
21 INT308962 Regulation of SLC7A7 3 0.16 1.2 0.18 81.40
22 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 73.80
23 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 73.80
24 INT69478 Negative_regulation of GBA 16 0.55 7.9 0.59 73.80
25 INT310529 Positive_regulation of MDFIC 1 0.05 6.21 0.52 59.40
26 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 58.96
27 INT165213 Regulation of Gene_expression of Cd4 12 0.40 9.14 1.57 55.76
28 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 55.24
29 INT134945 Binding of GBA 3 0.37 3.69 0.24 54.56
30 INT191162 Negative_regulation of HLA-DOA 3 0.12 1.24 0 50.40
31 INT258921 Negative_regulation of Negative_regulation of HLA-DOA 1 0.12 0.38 0 50.40
32 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 49.96
33 INT134946 Localization of GBA 3 0.75 2.49 0.24 44.60
34 INT222906 Localization of HLA-DOA 5 0.25 2.41 0.08 44.36
35 INT22383 Binding of IL2 59 0.48 39.06 8.56 44.16
36 INT21726 Gene_expression of Tfrc 10 0.74 7.38 2.36 42.80
37 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 38.80
38 INT322930 Regulation of Gene_expression of GBA 1 0.39 0.26 0 38.40
39 INT310259 Localization of ST11 1 0.08 4.06 0 38.08
40 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 37.76
41 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39 37.12
42 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 36.48
43 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 34.96
44 INT26477 Regulation of ACE 26 0.45 16.31 4.33 18.24
45 INT82648 Positive_regulation of Gene_expression of GBA 1 0.50 2.77 0.08 14.28
46 INT50530 Binding of MDFIC 2 0.17 1.88 0.38 14.04
47 INT258912 Positive_regulation of Binding of HLA-DOA 1 0.17 0.41 0 11.36
48 INT293341 Binding of FCGRT 1 0.01 0 0.04 10.56
49 INT234410 Binding of ISG20 4 0.22 1.66 0.26 8.00
50 INT258922 Negative_regulation of Binding of HLA-DOA 1 0.14 0.41 0 7.12
51 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
52 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
53 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
54 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
55 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
56 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
57 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
58 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
59 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
60 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
61 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
62 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 5.00
63 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
64 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
65 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
66 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
67 INT139664 Gene_expression of CCL18 83 0.76 37.05 21.95 5.00
68 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
69 INT15796 Regulation of IL2 66 0.61 25.43 20.62 5.00
70 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
71 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
72 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 5.00
73 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
74 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
75 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
76 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 5.00
77 INT5057 Negative_regulation of Gene_expression of IFNG 23 0.58 8.33 12.3 5.00
78 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
79 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
80 INT15305 Positive_regulation of Mtor 51 0.67 8.28 11 5.00
81 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
82 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
83 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
84 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
85 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
86 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
87 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 5.00
88 INT30777 Negative_regulation of SELL 20 0.56 18.05 7.32 5.00
89 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 5.00
90 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
91 INT3915 Gene_expression of SCD 25 0.57 13.94 6 5.00
92 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 5.00
93 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 5.00
94 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 5.00
95 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 5.00
96 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 5.00
97 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 5.00
98 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
99 INT113186 Gene_expression of Prf1 46 0.53 21.06 5.32 5.00
100 INT39512 Negative_regulation of TRAP 22 0.56 8.18 4.76 5.00
101 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 5.00
102 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
103 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 5.00
104 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46 5.00
105 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
106 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 5.00
107 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 5.00
108 INT1645 Negative_regulation of CSH1 20 0.42 1.71 3.7 5.00
109 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 5.00
110 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 5.00
111 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 5.00
112 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 5.00
113 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 5.00
114 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29 5.00
115 INT125237 Negative_regulation of Gene_expression of CD40LG 16 0.54 9.9 3.27 5.00
116 INT36286 Binding of Cd3e 33 0.36 10.11 3.21 5.00
117 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 5.00
118 INT9055 Positive_regulation of Cog1 22 0.68 14.08 2.95 5.00
119 INT77226 Phosphorylation of Eif4ebp1 36 0.09 6.39 2.91 5.00
120 INT156522 Gene_expression of NAPEPLD 11 0.75 4.25 2.87 5.00
121 INT81578 Gene_expression of TRAP 25 0.72 9.75 2.82 5.00
122 INT22831 Negative_regulation of Positive_regulation of IL2 7 0.55 1.7 2.62 5.00
123 INT102729 Gene_expression of APCS 20 0.65 8.86 2.52 5.00
124 INT210058 Regulation of ELF3 11 0.29 7.93 2.51 5.00
125 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
126 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
127 INT258404 Positive_regulation of Gene_expression of ACR 4 0.28 1.08 2.24 5.00
128 INT134944 Gene_expression of MOCS1 37 0.06 10.76 2.17 5.00
129 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 5.00
130 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
131 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97 5.00
132 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93 5.00
133 INT78960 Binding of SOAT1 9 0.36 2.56 1.92 5.00
134 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92 5.00
135 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87 5.00
136 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84 5.00
137 INT181720 Regulation of IL15 9 0.20 3.65 1.79 5.00
138 INT183753 Regulation of HBM 24 0.39 13.13 1.79 5.00
139 INT278981 Negative_regulation of JAK3 5 0.46 2.12 1.69 5.00
140 INT102582 Positive_regulation of Gene_expression of Gdf15 11 0.69 7.66 1.68 5.00
141 INT39513 Positive_regulation of TRAP 14 0.48 5.11 1.67 5.00
142 INT58456 Gene_expression of HFE 10 0.58 7.68 1.65 5.00
143 INT85411 Regulation of IL9 4 0.10 0.85 1.65 5.00
144 INT181963 Regulation of IL7 7 0.49 3.56 1.61 5.00
145 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
146 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 5.00
147 INT57959 Positive_regulation of Prf1 12 0.41 5.29 1.47 5.00
148 INT148026 Positive_regulation of Pik3cg 4 0.45 0.54 1.46 5.00
149 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
150 INT5147 Binding of BTNL2 4 0.36 4.77 1.43 5.00
151 INT65153 Binding of HLA-DPB1 5 0.34 3.29 1.4 5.00
152 INT132453 Binding of TF 31 0.36 12.98 1.22 5.00
153 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 5.00
154 INT58042 Binding of HLA-DQA1 8 0.24 5.03 1.14 5.00
155 INT103699 Negative_regulation of IL15 5 0.24 2.42 1.12 5.00
156 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1 5.00
157 INT142777 Phosphorylation of PPP2R4 2 0.61 1.03 1.07 5.00
158 INT188398 Positive_regulation of IL15 8 0.19 4.64 1.06 5.00
159 INT231266 Gene_expression of Prh1 13 0.08 3.95 1.02 5.00
160 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 5.00
161 INT159446 Negative_regulation of Gdf15 5 0.58 3.36 1 5.00
162 INT56098 Gene_expression of HLA-DRB3 5 0.59 2.89 0.99 5.00
163 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 5.00
164 INT278975 Gene_expression of JAK3 3 0.52 1.03 0.97 5.00
165 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96 5.00
166 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 5.00
167 INT226480 Positive_regulation of JAK3 4 0.45 0.96 0.95 5.00
168 INT174029 Protein_catabolism of BSG 5 0.01 2.5 0.95 5.00
169 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94 5.00
170 INT204156 Gene_expression of HAMP 7 0.75 8.1 0.94 5.00
171 INT209387 Negative_regulation of Ugcg 9 0.25 7.61 0.9 5.00
172 INT181969 Regulation of Gene_expression of Prf1 7 0.23 3.62 0.85 5.00
173 INT322929 Positive_regulation of Gene_expression of CHIT1 1 0.07 6.12 0.83 5.00
174 INT79941 Negative_regulation of Npc1 9 0.59 3.97 0.82 5.00
175 INT100458 Positive_regulation of LTA 11 0.49 6.55 0.8 5.00
176 INT199433 Negative_regulation of LTA 5 0.17 3.84 0.74 5.00
177 INT77223 Regulation of Eif4ebp1 6 0.03 1.32 0.7 5.00
178 INT28308 Localization of SLC17A5 10 0.73 6.77 0.7 5.00
179 INT241797 Gene_expression of CHIT1 10 0.24 9.75 0.69 5.00
180 INT65089 Positive_regulation of ACP5 4 0.50 1.67 0.57 5.00
181 INT42410 Positive_regulation of Cyb5d2 13 0.31 6.75 0.54 5.00
182 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
183 INT297528 Transcription of HAMP 3 0.69 3.64 0.5 5.00
184 INT226429 Regulation of IL21 2 0.04 0.74 0.49 5.00
185 INT170346 Gene_expression of Npc1 18 0.78 7.69 0.48 5.00
186 INT81965 Gene_expression of F5 16 0.65 13.29 0.48 5.00
187 INT3477 Regulation of Npc1 6 0.45 1.87 0.47 5.00
188 INT161692 Regulation of NAPEPLD 2 0.17 0.9 0.45 5.00
189 INT264192 Positive_regulation of Gene_expression of CTLA4 6 0.43 2.06 0.45 5.00
190 INT201091 Regulation of HLA-DOA 5 0.20 3.6 0.44 5.00
191 INT241799 Negative_regulation of CHIT1 13 0.42 4.37 0.44 5.00
192 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 5.00
193 INT242445 Positive_regulation of Gene_expression of Prf1 4 0.40 1.31 0.41 5.00
194 INT187182 Binding of BSG 7 0.32 2.83 0.37 5.00
195 INT306940 Positive_regulation of HAMP 3 0.49 5.06 0.36 5.00
196 INT206440 Binding of MOCS1 13 0.01 3.76 0.35 5.00
197 INT97859 Localization of Npc1 12 0.75 6.66 0.35 5.00
198 INT196189 Positive_regulation of Mrgpre 3 0.46 3.34 0.34 5.00
199 INT86946 Localization of TRAP 5 0.74 2.87 0.34 5.00
200 INT181781 Positive_regulation of FOSB 6 0.39 4.77 0.34 5.00
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