D:Hypertelorism

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pChart

Disease Term
Synonyms Hypertelorisms
Documents 42
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypertelorism. They are ordered first by their relevance to Hypertelorism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT317900 Binding of NCAPH2 and MCPH1 1 0.02 0.53 0 43.52
2 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 23.00
3 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 5.00
4 INT207783 Binding of MRC1 and Ap3d1 1 0.00 2.54 0.22 5.00
5 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
6 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16 5.00
7 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13 5.00
8 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
9 INT265964 TNNI2 Regulation of CA2 1 0.22 0.09 0 5.00
10 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
11 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypertelorism. They are ordered first by their pain relevance and then by number of times they were reported in Hypertelorism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT135337 Gene_expression of PTPRN2 2 0.72 0.82 0 93.72
2 INT317903 Gene_expression of NCAPG2 1 0.64 1.56 0 91.48
3 INT139281 Gene_expression of VIPR2 3 0.74 0.88 0.2 90.08
4 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 88.08
5 INT317905 Gene_expression of ESYT2 1 0.64 0.76 0 88.08
6 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 88.04
7 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 87.28
8 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 87.08
9 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 86.24
10 INT317906 Gene_expression of WDR60 1 0.71 0.74 0 86.16
11 INT207777 Binding of Ap3d1 1 0.07 14.51 1.91 79.28
12 INT21855 Gene_expression of Ap3d1 4 0.32 12.21 4.66 77.28
13 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 75.52
14 INT317912 Gene_expression of NCAPH2 1 0.06 0.74 0 69.32
15 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 69.28
16 INT114499 Gene_expression of MCPH1 38 0.67 26.68 4.55 63.20
17 INT210272 Binding of Ccrs1 1 0.01 1.13 0 62.80
18 INT81155 Localization of CDCP1 5 0.08 4.49 1.4 62.16
19 INT317907 Gene_expression of DLGAP2 1 0.63 0.85 0 57.92
20 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 56.96
21 INT251821 Negative_regulation of COL11A1 3 0.42 3.45 0.16 51.52
22 INT172370 Binding of MCPH1 6 0.34 4.75 0.13 43.52
23 INT317916 Binding of NCAPH2 1 0.04 0.53 0 43.12
24 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 32.20
25 INT961 Positive_regulation of ATRX 3 0.53 1.99 0.36 28.32
26 INT256627 Regulation of Negative_regulation of Ptch2 1 0.32 1.33 0 28.16
27 INT256625 Negative_regulation of Ptch2 1 0.42 1.27 0 26.72
28 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0 25.04
29 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 22.48
30 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 12.12
31 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 11.76
32 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 10.40
33 INT256626 Regulation of Ptch2 1 0.28 1.11 0 5.60
34 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
35 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
36 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
37 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
38 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
39 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
40 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 5.00
41 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
42 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
43 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
44 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
45 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
46 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
47 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
48 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
49 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 5.00
50 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
51 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
52 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
53 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
54 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
55 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
56 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
57 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
58 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
59 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
60 INT28088 Binding of Alb 34 0.47 11.06 5.48 5.00
61 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 5.00
62 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
63 INT59555 Binding of RYR1 39 0.42 8.65 4.92 5.00
64 INT5408 Localization of Alb 30 0.73 12.1 3.84 5.00
65 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 5.00
66 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
67 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 5.00
68 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14 5.00
69 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 5.00
70 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
71 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96 5.00
72 INT21853 Regulation of Ap3d1 3 0.10 1.4 2.95 5.00
73 INT24712 Positive_regulation of Ap3d1 18 0.54 8.58 2.71 5.00
74 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 5.00
75 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
76 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 5.00
77 INT17688 Positive_regulation of IKZF1 5 0.50 0.48 2.11 5.00
78 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
79 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
80 INT11713 Localization of RYR1 22 0.76 10.42 1.64 5.00
81 INT21852 Regulation of Gene_expression of Ap3d1 2 0.18 1.34 1.54 5.00
82 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 5.00
83 INT55305 Regulation of RYR1 14 0.45 5.27 1.33 5.00
84 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
85 INT11367 Localization of MB 9 0.78 9.34 1.24 5.00
86 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2 5.00
87 INT51897 Binding of OPCML 8 0.43 5.59 1.11 5.00
88 INT88948 Localization of Ace 9 0.69 9.18 1.11 5.00
89 INT198406 Localization of C2 5 0.65 1.42 1.01 5.00
90 INT210571 Gene_expression of KCNE2 7 0.61 2.7 0.97 5.00
91 INT43484 Binding of Runx2 7 0.37 3.22 0.95 5.00
92 INT21660 Regulation of CHM 14 0.61 8.51 0.93 5.00
93 INT959 Regulation of ATRX 5 0.47 5.04 0.89 5.00
94 INT210276 Positive_regulation of Gene_expression of PMP22 3 0.46 1.58 0.88 5.00
95 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 5.00
96 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8 5.00
97 INT182293 Binding of MAPK8 11 0.34 4.6 0.77 5.00
98 INT69744 Gene_expression of CDT1 3 0.65 1.6 0.75 5.00
99 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
100 INT132662 Binding of Hcm 11 0.31 14.41 0.73 5.00
101 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
102 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 5.00
103 INT52590 Transcription of SCN5A 4 0.55 0.91 0.65 5.00
104 INT207780 Positive_regulation of NMS 2 0.28 3.2 0.61 5.00
105 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 5.00
106 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 5.00
107 INT51895 Localization of OPCML 6 0.68 3.43 0.54 5.00
108 INT207778 Positive_regulation of Binding of Ap3d1 1 0.06 1.26 0.52 5.00
109 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 5.00
110 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 5.00
111 INT200401 Gene_expression of KCNE1 14 0.57 6.42 0.45 5.00
112 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44 5.00
113 INT192006 Gene_expression of RYR2 5 0.23 7.69 0.44 5.00
114 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 5.00
115 INT235457 Negative_regulation of Regulation of Nos2 3 0.42 1.55 0.39 5.00
116 INT120165 Binding of NTM 2 0.47 2.23 0.29 5.00
117 INT136267 Binding of KCNQ1 3 0.36 3.28 0.28 5.00
118 INT962 Gene_expression of ATRX 2 0.59 1.72 0.27 5.00
119 INT244343 Localization of NTM 16 0.73 14.26 0.26 5.00
120 INT230722 Regulation of Hcm 4 0.37 3 0.21 5.00
121 INT317920 Localization of SNX19 1 0.73 1.88 0.2 5.00
122 INT317915 Binding of SNX19 1 0.36 2.04 0.2 5.00
123 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19 5.00
124 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 5.00
125 INT317881 Transcription of Eef1a1 2 0.03 1.38 0.18 5.00
126 INT231220 Localization of ANK2 1 0.40 0.91 0.17 5.00
127 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16 5.00
128 INT207779 Localization of Ap3d1 1 0.11 3.16 0.14 5.00
129 INT317913 Gene_expression of SHANK3 1 0.64 2.19 0.13 5.00
130 INT196324 Localization of Cyp2b10 5 0.73 2.81 0.13 5.00
131 INT196691 Positive_regulation of Positive_regulation of DNAH8 2 0.10 1.23 0.13 5.00
132 INT166325 Negative_regulation of RAI1 2 0.36 2.74 0.13 5.00
133 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 5.00
134 INT231217 Positive_regulation of ANK2 1 0.26 0.67 0.12 5.00
135 INT195744 Gene_expression of XIST 3 0.65 1.61 0.12 5.00
136 INT193632 Positive_regulation of ARVD4 2 0.01 2.73 0.11 5.00
137 INT317910 Localization of THYN1 1 0.65 0.88 0.1 5.00
138 INT317919 Binding of VPS26B 1 0.23 0.93 0.1 5.00
139 INT317911 Localization of VPS26B 1 0.47 0.88 0.1 5.00
140 INT317908 Binding of NCAPD3 1 0.32 0.91 0.1 5.00
141 INT317904 Binding of THYN1 1 0.32 0.96 0.1 5.00
142 INT317914 Localization of NCAPD3 1 0.65 0.88 0.1 5.00
143 INT265969 Regulation of TNNI2 1 0.45 1.35 0.09 5.00
144 INT151522 Binding of NSD1 2 0.37 4.28 0.09 5.00
145 INT265966 Regulation of MYH3 1 0.44 1.35 0.09 5.00
146 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 5.00
147 INT317918 Gene_expression of MAPK8IP2 2 0.59 1.43 0.09 5.00
148 INT211942 Transcription of Runx2 3 0.69 2.46 0.08 5.00
149 INT329075 Transcription of MYT1 1 0.27 0.37 0.08 5.00
150 INT329073 Regulation of Myt1 1 0.42 0.34 0.08 5.00
151 INT213515 Binding of Shh 8 0.37 1.92 0.08 5.00
152 INT329074 Transcription of Pcmtd2 1 0.66 0.37 0.08 5.00
153 INT51444 Regulation of PMP22 2 0.44 1.39 0.07 5.00
154 INT205973 Binding of SHH 3 0.35 1.03 0.07 5.00
155 INT192016 Localization of RYR2 5 0.25 4.18 0.05 5.00
156 INT201155 Regulation of Jph2 2 0.37 1.13 0.05 5.00
157 INT221865 Positive_regulation of Localization of RYR2 2 0.15 4.56 0.05 5.00
158 INT231205 Negative_regulation of Binding of Hcm 1 0.03 0.87 0.04 5.00
159 INT207781 Gene_expression of CACNA1S 3 0.63 0.9 0.03 5.00
160 INT329071 Negative_regulation of Arfgap1 1 0.41 1.14 0.03 5.00
161 INT231221 Gene_expression of Prkag2 1 0.07 0.94 0.03 5.00
162 INT329072 Negative_regulation of Kcnq2 1 0.42 1.14 0.03 5.00
163 INT231222 Gene_expression of Lamp2 1 0.07 0.93 0.03 5.00
164 INT317917 Gene_expression of RABL2B 1 0.61 0.68 0.03 5.00
165 INT207782 Binding of CACNA1S 1 0.30 0.53 0.03 5.00
166 INT317909 Binding of MAPK8IP2 1 0.31 0.84 0.03 5.00
167 INT210275 Positive_regulation of PMP22 1 0.55 0.52 0 5.00
168 INT210279 Negative_regulation of Gene_expression of PMP22 1 0.34 0.3 0 5.00
169 INT214055 Gene_expression of NSD1 8 0.67 4.46 0 5.00
170 INT210280 Negative_regulation of Gene_expression of RAI1 1 0.35 1.01 0 5.00
171 INT265972 Positive_regulation of Gene_expression of ATRX 1 0.38 1.72 0 5.00
172 INT265970 Binding of TNNI2 1 0.37 0.2 0 5.00
173 INT265971 Gene_expression of MYH3 1 0.66 1.2 0 5.00
174 INT210278 Positive_regulation of RAI1 2 0.42 1.64 0 5.00
175 INT272228 Localization of TGFBR1 1 0.34 0.74 0 5.00
176 INT315136 Gene_expression of TSIX 1 0.19 0.52 0 5.00
177 INT265967 Gene_expression of TNNI2 1 0.67 1.39 0 5.00
178 INT265823 Binding of WHSC1 1 0.08 1.17 0 5.00
179 INT265814 Localization of Runx2 1 0.75 0.84 0 5.00
180 INT210277 Regulation of RAI1 3 0.37 1.49 0 5.00
181 INT272225 Localization of Tgfbr2 1 0.29 0.74 0 5.00
182 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0 5.00
183 INT265813 Regulation of Binding of Runx2 1 0.27 0.19 0 5.00
184 INT265968 Gene_expression of TNNT3 1 0.65 1.39 0 5.00
185 INT210271 Positive_regulation of Ccrs1 1 0.01 0.4 0 5.00
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