D:Hypoactive Sexual Desire Disorder

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Disease Term
Synonyms Abnormal Sexual Function, APHRODISIAC, Arousal Disorders Sexual, AVERSION DISORDERS SEXUAL, Disorder Psychosexual, Disorders Orgasmic, Disorders Psychosexual, DISORDERS SEXUAL AROUSAL, Disorders Sexual Aversion, DYSFUNCTION PSYCHOLOGICAL SEXUAL, DYSFUNCTION PSYCHOSEXUAL
Documents 306
Hot Single Events 52
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypoactive Sexual Desire Disorder. They are ordered first by their relevance to Hypoactive Sexual Desire Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT126791 RASL12 Positive_regulation of ADRA1D 1 0.24 2.62 0.22 100.00
2 INT126795 RASL12 Positive_regulation of Hal 1 0.01 2.62 0.22 100.00
3 INT293625 Binding of BGLAP and SHBG 1 0.03 0.1 0 100.00
4 INT264662 ESR1 Regulation of Gene_expression of PRL 1 0.43 0.21 0 41.84
5 INT264663 Binding of ESR1 and PRL 1 0.22 0.18 0 30.36
6 INT264664 Binding of AES and ESR1 1 0.15 0.18 0 29.64
7 INT317597 Binding of Gnrh1 and Hpse 1 0.08 0 0 29.48
8 INT264661 ESR1 Positive_regulation of PRL 1 0.43 0.68 0 23.60
9 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0 10.88
10 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26 9.60
11 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
12 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27 5.00
13 INT270680 Fos Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.03 0.39 1.05 5.00
14 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
15 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
16 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
17 INT241844 Positive_regulation of GNRH1 Positive_regulation of Localization of PLOD1 1 0.13 0.08 0.15 5.00
18 INT270355 Vcsa1 Positive_regulation of Negative_regulation of Mme 1 0.13 0.52 0.12 5.00
19 INT231134 Itbq1 Regulation of HAND1 1 0.00 0.18 0.1 5.00
20 INT231120 GYPA Positive_regulation of Gene_expression of GSTM1 1 0.05 0.15 0.07 5.00
21 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03 5.00
22 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 5.00
23 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0 5.00
24 INT327198 DBT Positive_regulation of Gene_expression of ESRRA 1 0.00 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypoactive Sexual Desire Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Hypoactive Sexual Desire Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT194022 Negative_regulation of RQCD1 4 0.33 3.18 0.13 100.00
2 INT194023 Gene_expression of RQCD1 3 0.52 3.99 0.12 100.00
3 INT1512 Binding of Prl 73 0.48 26.22 20.63 99.76
4 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 99.48
5 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 99.20
6 INT96557 Binding of Bdnf 46 0.47 21.74 24.26 99.16
7 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.04
8 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 98.72
9 INT4146 Binding of SHBG 49 0.47 31 4.71 98.72
10 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 98.60
11 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 98.28
12 INT154027 Binding of FSD1 1 0.31 0.66 0 97.68
13 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 97.56
14 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 96.36
15 INT341767 Gene_expression of FSD1 1 0.09 1.57 0.03 96.22
16 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 95.72
17 INT170770 Positive_regulation of UGCG 4 0.24 1.34 0.03 95.44
18 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 95.44
19 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 95.00
20 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 94.76
21 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 94.56
22 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 93.64
23 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 93.64
24 INT17276 Negative_regulation of Gene_expression of HIVEP1 27 0.42 26.85 2.61 93.52
25 INT270350 Positive_regulation of S1pr1 1 0.32 0.98 0 92.40
26 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 91.44
27 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 91.44
28 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 91.44
29 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 91.04
30 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 91.04
31 INT233322 Negative_regulation of Localization of HIVEP1 4 0.10 6.1 0.57 90.94
32 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22 90.80
33 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 90.52
34 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 89.86
35 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 89.48
36 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 89.36
37 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 88.72
38 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 88.48
39 INT335 Binding of Adra1a 16 0.36 6.16 6 88.00
40 INT197662 Negative_regulation of Positive_regulation of SHBG 5 0.39 3.54 0.52 88.00
41 INT98445 Negative_regulation of BPHL 7 0.32 7.24 1.08 87.12
42 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 86.44
43 INT236877 Negative_regulation of Gene_expression of BPHL 12 0.32 16.43 0.56 85.44
44 INT114746 Gene_expression of Sepp1 15 0.60 3.33 1.86 85.16
45 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 84.48
46 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 84.48
47 INT147412 Binding of DRD4 11 0.47 7.57 2.77 84.44
48 INT151835 Positive_regulation of UBE4B 1 0.48 0.68 0.08 82.96
49 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 82.56
50 INT53929 Positive_regulation of GNPTAB 12 0.32 6.66 1.4 81.76
51 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 81.12
52 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 80.08
53 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 79.84
54 INT201130 Localization of AES 31 0.63 25.45 5.12 79.76
55 INT231133 Gene_expression of SNF8 2 0.32 0.14 0.15 79.64
56 INT425 Localization of PRL 455 0.81 189.64 144.8 79.44
57 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 78.16
58 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 74.88
59 INT241849 Positive_regulation of Protein_catabolism of CNDP2 1 0.01 0.82 0 74.56
60 INT231128 Gene_expression of HAND1 4 0.40 1.32 0.25 74.24
61 INT241848 Protein_catabolism of CNDP2 1 0.02 0.81 0 73.60
62 INT185519 Binding of Vms1 5 0.12 4.58 1.37 71.16
63 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 70.72
64 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 70.44
65 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23 70.40
66 INT1045 Localization of LH 1211 0.81 87.04 456.25 69.92
67 INT331894 Localization of SEPT8 1 0.14 0.61 0 69.56
68 INT318710 Positive_regulation of Gene_expression of Sept3 2 0.25 3.24 0.71 66.40
69 INT318712 Gene_expression of Sept3 2 0.34 2.2 0.35 66.40
70 INT331893 Binding of Sept3 1 0.19 0.59 0 66.40
71 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 65.20
72 INT16165 Regulation of DMD 114 0.60 35.13 3.64 63.44
73 INT331895 Gene_expression of SEPT4 1 0.27 0.57 0 63.00
74 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 61.24
75 INT56118 Gene_expression of EDAR 27 0.35 6.33 0.82 61.20
76 INT158 Localization of Prl 2431 0.81 378.96 952.2 60.64
77 INT127372 Gene_expression of Ager 9 0.57 14.44 0.98 60.64
78 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 52.80
79 INT5533 Binding of Oxt 43 0.48 8.69 18.35 52.60
80 INT11796 Positive_regulation of Helt 52 0.31 11.7 29.22 52.16
81 INT231290 Positive_regulation of Positive_regulation of Helt 3 0.03 1.71 0.68 52.16
82 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 49.88
83 INT183429 Localization of Pde5a 5 0.56 1.61 0.25 49.20
84 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18 49.20
85 INT269743 Positive_regulation of Binding of BPHL 1 0.19 2.94 0.13 48.72
86 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 48.24
87 INT103942 Binding of BPHL 11 0.30 14.26 0.53 48.20
88 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 45.00
89 INT231129 Positive_regulation of HAND1 5 0.30 2.73 0.45 44.92
90 INT231130 Positive_regulation of Positive_regulation of HAND1 1 0.30 0 0.04 44.28
91 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 40.24
92 INT217950 Positive_regulation of Negative_regulation of CYP21A2 2 0.03 1.34 0.97 39.08
93 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 38.80
94 INT331007 Negative_regulation of Gene_expression of CYP21A2 1 0.02 1.34 0.97 38.80
95 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77 38.24
96 INT175796 Binding of Hpse 6 0.35 2.19 0.28 38.24
97 INT270348 Binding of Vcsa1 1 0.39 0.38 0.1 33.80
98 INT26863 Regulation of Vms1 7 0.09 2.67 2.23 32.16
99 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 31.52
100 INT6661 Positive_regulation of Positive_regulation of Jun 31 0.50 7.12 3.89 31.52
101 INT545 Binding of GC 15 0.45 10.74 3.47 31.04
102 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 30.88
103 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33 30.88
104 INT264669 Positive_regulation of Positive_regulation of AES 2 0.30 0.6 0.2 30.88
105 INT20462 Binding of ESR1 210 0.44 102.7 26.34 29.48
106 INT146130 Binding of Gnrh1 6 0.47 2.21 0.03 29.16
107 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 28.32
108 INT2415 Binding of MAOA 26 0.47 13.26 11.86 27.16
109 INT69485 Regulation of Bcl2a1c 14 0.34 9.99 0.13 26.64
110 INT151904 Binding of Ager 4 0.18 8.07 0.6 26.24
111 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 25.00
112 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 25.00
113 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 22.88
114 INT156671 Gene_expression of Vcsa1 22 0.75 23.32 1.69 22.40
115 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 22.24
116 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85 21.96
117 INT168658 Regulation of Gene_expression of HTR1B 2 0.44 2.11 2.44 19.52
118 INT331005 Regulation of Gene_expression of HTR1A 1 0.44 1.84 1.83 19.52
119 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 18.92
120 INT28484 Regulation of Cog1 6 0.43 4.96 0.71 18.64
121 INT261279 Localization of GNAQ 1 0.05 1.1 0 18.56
122 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94 18.48
123 INT200442 Positive_regulation of Gene_expression of AES 5 0.42 5.12 0.48 16.88
124 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 16.80
125 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 15.40
126 INT270341 Positive_regulation of Gene_expression of Vcsa1 3 0.57 1.12 0.29 14.64
127 INT32962 Positive_regulation of Localization of GNRHR 3 0.41 0.59 0.49 11.96
128 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 11.40
129 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 11.40
130 INT231131 Regulation of HAND1 5 0.27 1.81 0.63 10.28
131 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 10.00
132 INT106556 Negative_regulation of Gene_expression of Bdnf 42 0.59 34.71 17.64 8.28
133 INT1793 Localization of CGA 379 0.81 67.38 114.69 8.20
134 INT920 Localization of PLOD1 223 0.81 42.25 78.7 8.20
135 INT912 Localization of FSHR 91 0.79 23.61 15.58 8.20
136 INT11519 Negative_regulation of Coc 8 0.50 3.96 2.74 8.20
137 INT241817 Negative_regulation of Gene_expression of Coc 2 0.36 1 0.12 8.20
138 INT56053 Negative_regulation of Bdnf 77 0.58 64.4 26.83 7.88
139 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 7.20
140 INT11622 Gene_expression of Coc 26 0.57 10.56 5.52 7.20
141 INT185518 Gene_expression of Vms1 2 0.22 2.16 0.25 5.12
142 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
143 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
144 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
145 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
146 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 5.00
147 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
148 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
149 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
150 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
151 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
152 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
153 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 5.00
154 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 5.00
155 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
156 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 5.00
157 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
158 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
159 INT2379 Positive_regulation of Localization of LH 349 0.70 27.86 144.53 5.00
160 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 5.00
161 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
162 INT416 Regulation of LH 253 0.62 31.48 125.55 5.00
163 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
164 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 5.00
165 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
166 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
167 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
168 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
169 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
170 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
171 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
172 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
173 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 5.00
174 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
175 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
176 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
177 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
178 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
179 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
180 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
181 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 5.00
182 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 5.00
183 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12 5.00
184 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
185 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
186 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
187 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
188 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
189 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
190 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
191 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
192 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
193 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
194 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
195 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
196 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
197 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
198 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
199 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
200 INT28 Regulation of Gast 106 0.62 26.37 29.85 5.00
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