D:Hypoaldosteronism

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pChart

Disease Term
Synonyms Acidosis Renal Tubular Type Iv, HYPOALDERSTERONISM, Hypoaldosteronism Hyporeninemic, Hyporeninemic Hypoaldosteronism, Pseudohypoaldosteronism, Renal Tubular Acidosis Type Iv, Type Iv Renal Tubular Acidosis
Documents 22
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypoaldosteronism. They are ordered first by their relevance to Hypoaldosteronism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT196627 IL1B Regulation of DNAH8 1 0.00 0.63 0.09 73.92
2 INT196643 IL1B Regulation of NA 1 0.00 0.63 0.09 73.92
3 INT196619 KNG1 Regulation of DNAH8 1 0.00 0.62 0.09 73.56
4 INT196645 KNG1 Regulation of NA 1 0.00 0.62 0.09 73.56
5 INT196640 PTGER2 Negative_regulation of DNAH8 1 0.00 0.46 0.08 63.40
6 INT196611 PTGER2 Negative_regulation of NA 1 0.00 0.46 0.08 63.40
7 INT196648 PTGER2 Regulation of DNAH8 1 0.00 0.14 0.12 40.48
8 INT196636 PTGER2 Regulation of NA 1 0.00 0.14 0.12 40.48
9 INT196628 IFNG Negative_regulation of Gene_expression of DNAH8 1 0.02 0.31 0.05 26.08
10 INT196634 IFNG Negative_regulation of DNAH8 1 0.03 1.49 0.47 22.08
11 INT196647 IFNG Negative_regulation of NA 1 0.04 0.79 0.24 21.36
12 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84 5.00
13 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84 5.00
14 INT196644 PTGER2 Positive_regulation of Gene_expression of NA 1 0.00 0.93 0.35 5.00
15 INT196618 Binding of KNG1 and Positive_regulation of NA 1 0.01 0.19 0.32 5.00
16 INT196623 Binding of KNG1 and Positive_regulation of DNAH8 1 0.01 0.19 0.32 5.00
17 INT196605 Binding of DNAH8 and SPANXB1 Positive_regulation of DNAH8 1 0.00 0.08 0.3 5.00
18 INT196604 Binding of DNAH8 and SPANXB1 Positive_regulation of NA 1 0.00 0.08 0.3 5.00
19 INT196641 Binding of KNG1 and Negative_regulation of DNAH8 1 0.01 0.19 0.29 5.00
20 INT196612 Binding of KNG1 and Negative_regulation of NA 1 0.01 0.19 0.29 5.00
21 INT196621 PTGER2 Negative_regulation of Gene_expression of DNAH8 1 0.00 0.33 0.28 5.00
22 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28 5.00
23 INT196626 Binding of DNAH8 and KNG1 1 0.00 0.08 0.27 5.00
24 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27 5.00
25 INT196637 Binding of DNAH8 and SPANXB1 1 0.00 0.08 0.27 5.00
26 INT196613 Binding of KNG1 and NA 1 0.01 0.08 0.27 5.00
27 INT196616 Binding of NA and SPANXB1 1 0.00 0.08 0.27 5.00
28 INT196614 TNF Positive_regulation of Positive_regulation of NA 1 0.03 0.88 0.24 5.00
29 INT196615 TNF Positive_regulation of Negative_regulation of DNAH8 1 0.02 0.88 0.24 5.00
30 INT196609 IFNG Positive_regulation of Positive_regulation of NA 1 0.03 0.87 0.24 5.00
31 INT196622 IFNG Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.87 0.24 5.00
32 INT196620 TNF Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.88 0.24 5.00
33 INT196646 IFNG Positive_regulation of Negative_regulation of DNAH8 1 0.03 0.87 0.24 5.00
34 INT196629 PTGER2 Negative_regulation of Gene_expression of NA 1 0.00 0.24 0.22 5.00
35 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21 5.00
36 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19 5.00
37 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16 5.00
38 INT196608 TNF Negative_regulation of CFTR 1 0.16 0.11 0.14 5.00
39 INT196642 IL1B Positive_regulation of Gene_expression of DNAH8 1 0.00 0 0.08 5.00
40 INT196630 TNF Regulation of Gene_expression of NA 1 0.04 0.16 0.08 5.00
41 INT196624 TNF Negative_regulation of Transcription of SCNN1G 1 0.02 0.07 0.07 5.00
42 INT196617 TNF Negative_regulation of Gene_expression of SCNN1G 1 0.02 0.08 0.03 5.00
43 INT196639 Negative_regulation of NA Negative_regulation of Transcription of CFTR 1 0.02 0.63 0.03 5.00
44 INT196625 TNF Negative_regulation of Positive_regulation of SCNN1G 1 0.02 0.14 0.03 5.00
45 INT196607 IFNG Regulation of Gene_expression of SCNN1G 1 0.03 0.08 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypoaldosteronism. They are ordered first by their pain relevance and then by number of times they were reported in Hypoaldosteronism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT46 Localization of Ren 233 0.81 46.15 62.44 100.00
2 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03 100.00
3 INT3533 Binding of REN 24 0.37 10.84 2.16 99.98
4 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62 99.92
5 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8 97.52
6 INT196690 Regulation of SEC23B 1 0.01 2.88 0.43 97.40
7 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 95.28
8 INT91999 Transcription of Gfra1 10 0.67 4.67 2.45 84.40
9 INT16879 Binding of Crh 72 0.48 21.65 28.43 83.56
10 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 83.16
11 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 82.64
12 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 82.40
13 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 82.40
14 INT20585 Gene_expression of Gfra1 39 0.77 26.94 26.69 82.08
15 INT2140 Regulation of REN 104 0.62 28.24 24.49 76.40
16 INT37403 Negative_regulation of Regulation of REN 1 0.43 0.35 0.11 76.40
17 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 75.00
18 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 75.00
19 INT5536 Regulation of NA 74 0.59 16.61 15.36 70.76
20 INT21545 Regulation of DNAH8 22 0.59 8.67 6.48 70.76
21 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 67.60
22 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02 60.40
23 INT196673 Regulation of Gene_expression of CFTR 1 0.36 0.62 0.08 60.40
24 INT22083 Regulation of Pth 55 0.62 22.32 8.9 34.52
25 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 34.52
26 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 33.92
27 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 26.08
28 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 26.08
29 INT12924 Negative_regulation of Gene_expression of NA 25 0.30 6.59 6.71 26.08
30 INT81314 Regulation of Gene_expression of NA 10 0.27 4.53 2.45 26.08
31 INT120698 Negative_regulation of Gene_expression of DNAH8 10 0.11 3.2 1.29 26.08
32 INT50454 Regulation of Gene_expression of DNAH8 6 0.44 2.56 0.97 26.08
33 INT151101 Regulation of CFTR 4 0.62 3.69 1.89 12.64
34 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.60
35 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 5.60
36 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
37 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
38 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
39 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
40 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
41 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 5.00
42 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
43 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
44 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
45 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
46 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
47 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
48 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
49 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
50 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
51 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
52 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 5.00
53 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
54 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
55 INT3167 Binding of KNG1 48 0.48 23.26 26.77 5.00
56 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 5.00
57 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
58 INT78901 Localization of CCL5 67 0.78 40.79 20.59 5.00
59 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
60 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
61 INT35487 Localization of PTGER2 103 0.46 51.24 17.45 5.00
62 INT74449 Positive_regulation of B4GALNT1 53 0.30 34.49 14.96 5.00
63 INT4931 Localization of IFNG 53 0.78 33.25 13.65 5.00
64 INT2578 Binding of Ins1 74 0.48 33.57 12.92 5.00
65 INT1762 Negative_regulation of PTGER2 64 0.43 28.21 11.27 5.00
66 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
67 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
68 INT10924 Positive_regulation of Sysbp1 25 0.04 11.12 7.35 5.00
69 INT79062 Gene_expression of B4GALNT1 42 0.14 18.89 6.98 5.00
70 INT9321 Transcription of Igf1 25 0.69 10.2 6.08 5.00
71 INT58393 Positive_regulation of Localization of PTGER2 37 0.25 16.8 6 5.00
72 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12 5.00
73 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 5.00
74 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75 5.00
75 INT169756 Binding of CFTR 9 0.35 9.65 4.55 5.00
76 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 5.00
77 INT58390 Negative_regulation of Localization of PTGER2 25 0.21 14.4 4.25 5.00
78 INT95512 Transcription of Ghr 24 0.69 3.1 4.12 5.00
79 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79 5.00
80 INT23886 Positive_regulation of Gene_expression of NA 15 0.40 3.69 3.59 5.00
81 INT87027 Positive_regulation of Localization of IFNG 12 0.67 5.78 3.35 5.00
82 INT34425 Positive_regulation of Negative_regulation of NA 12 0.38 4.17 3.2 5.00
83 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 5.00
84 INT91669 Negative_regulation of Localization of IFNG 5 0.57 4.1 2.58 5.00
85 INT25706 Phosphorylation of NA 7 0.54 2.3 2.55 5.00
86 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 5.00
87 INT11787 Positive_regulation of Positive_regulation of NA 14 0.21 2.97 2.46 5.00
88 INT35643 Positive_regulation of BPIFA4P 7 0.67 4.87 2.39 5.00
89 INT104075 Positive_regulation of Gene_expression of B4GALNT1 8 0.09 7.36 2.21 5.00
90 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03 5.00
91 INT125820 Localization of TPSD1 13 0.70 2.19 1.7 5.00
92 INT196687 Positive_regulation of SCNN1G 6 0.06 3.85 1.32 5.00
93 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 5.00
94 INT196675 Localization of CFTR 4 0.64 1.95 1.19 5.00
95 INT186251 Negative_regulation of Gene_expression of B4GALNT1 5 0.07 1.84 1.07 5.00
96 INT120696 Gene_expression of SCNN1G 9 0.43 5.46 1.03 5.00
97 INT44972 Negative_regulation of Gfra1 16 0.58 10.17 0.93 5.00
98 INT120697 Negative_regulation of SCNN1G 6 0.32 3.53 0.92 5.00
99 INT196682 Negative_regulation of Gene_expression of CFTR 6 0.34 1.96 0.73 5.00
100 INT151098 Positive_regulation of Positive_regulation of CFTR 2 0.50 0.9 0.63 5.00
101 INT18008 Negative_regulation of IL3 4 0.40 1.5 0.62 5.00
102 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 5.00
103 INT196678 Regulation of Gene_expression of SEC23B 1 0.01 0.49 0.47 5.00
104 INT196668 Gene_expression of SEC23B 1 0.01 0.49 0.47 5.00
105 INT57643 Negative_regulation of Binding of Ins1 6 0.43 3.51 0.43 5.00
106 INT24154 Negative_regulation of Regulation of NA 2 0.04 0.98 0.39 5.00
107 INT196669 Phosphorylation of DNAH8 2 0.15 1.01 0.36 5.00
108 INT196684 Regulation of Negative_regulation of PTGER2 1 0.02 0.24 0.31 5.00
109 INT196688 Positive_regulation of Binding of CFTR 1 0.26 0.33 0.24 5.00
110 INT43545 Positive_regulation of Negative_regulation of DNAH8 2 0.14 0.9 0.18 5.00
111 INT196681 Negative_regulation of Localization of CFTR 1 0.34 0.18 0.15 5.00
112 INT196671 Positive_regulation of Positive_regulation of SCNN1G 2 0.04 1.04 0.13 5.00
113 INT196691 Positive_regulation of Positive_regulation of DNAH8 2 0.10 1.23 0.13 5.00
114 INT196672 Positive_regulation of Localization of CFTR 1 0.41 0 0.1 5.00
115 INT196674 Transcription of SCNN1G 1 0.04 0.22 0.1 5.00
116 INT196692 Positive_regulation of Gene_expression of SCNN1G 2 0.06 0.35 0.09 5.00
117 INT196680 Negative_regulation of Positive_regulation of SCNN1G 1 0.04 0.28 0.07 5.00
118 INT214037 Positive_regulation of Positive_regulation of BPIFA4P 2 0.11 1.36 0.05 5.00
119 INT346335 Positive_regulation of Negative_regulation of Gfra1 1 0.02 1.47 0.04 5.00
120 INT196683 Negative_regulation of Transcription of CFTR 1 0.22 0.61 0.03 5.00
121 INT196685 Transcription of CFTR 1 0.37 0.6 0.03 5.00
122 INT346340 Regulation of Gene_expression of BPIFA4P 1 0.06 0.68 0 5.00
123 INT179369 Regulation of SIT1 5 0.38 0.56 0 5.00
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