D:Hypoalphalipoproteinemias

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Disease Term
Synonyms Alpha Lipoprotein Deficiency Disease Familial, Familial Alpha Lipoprotein Deficiency Disease, Familial High Density Lipoprotein Deficiency Disease, Familial Hypoalphalipoproteinemia, Familial Hypoalphalipoproteinemias, Hdl Lipoprotein Deficiency Disease, High Density Lipoprotein Deficiency Disease Familial, HYPO ALPHA LIPOPROTEINEMIA, HYPO ALPHA LIPOPROTEINEMIAS, Hypoalphalipoproteinemia, Hypoalphalipoproteinemia Familial
Documents 4
Hot Single Events 20
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypoalphalipoproteinemias. They are ordered first by their relevance to Hypoalphalipoproteinemias and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT300199 PCSK9 Regulation of Gene_expression of LDLR 1 0.13 0.88 0 80.32
2 INT269783 Crp Positive_regulation of Sele 1 0.00 1.69 0.11 44.40
3 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11 43.12
4 INT269784 Crp Positive_regulation of Vcam1 1 0.00 1.6 0.11 40.32
5 INT344708 Hdl1 Positive_regulation of Gene_expression of Plat 1 0.08 1.26 0 40.08
6 INT344709 Niacr1 Positive_regulation of Hdl1 1 0.32 2.74 0.46 5.00
7 INT344704 Positive_regulation of Ppara Positive_regulation of Binding of Hdl1 1 0.13 0.83 0.28 5.00
8 INT344715 Positive_regulation of Ppara Positive_regulation of Gene_expression of Pltp 1 0.02 0.83 0.28 5.00
9 INT344714 Nr1h4 Negative_regulation of Gene_expression of Lipg 1 0.02 0.77 0.23 5.00
10 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18 5.00
11 INT344721 Binding of AHA and Hdl1 1 0.02 1.16 0.15 5.00
12 INT344707 Scarb1 Positive_regulation of Positive_regulation of Hdl1 1 0.14 0.88 0.14 5.00
13 INT344710 Lipc Positive_regulation of Positive_regulation of Hdl1 1 0.04 0.87 0.14 5.00
14 INT239317 Egfl7 Positive_regulation of Hdl1 2 0.01 2.3 0.14 5.00
15 INT344705 Nr1h2 Regulation of Scarb1 1 0.04 1.53 0.12 5.00
16 INT344706 Nr1h2 Regulation of Abca1 1 0.03 2.39 0.12 5.00
17 INT344713 Nr1h2 Regulation of Abcg1 1 0.03 2.39 0.12 5.00
18 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08 5.00
19 INT344719 Hdl1 Positive_regulation of Plat 1 0.10 1.23 0.05 5.00
20 INT344703 Hdl1 Negative_regulation of Gene_expression of Serpine1 1 0.07 1.26 0.05 5.00
21 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 5.00
22 INT300191 Binding of C1S and HSD11B1 1 0.13 1.75 0 5.00
23 INT300195 Binding of C1S and CHDH 1 0.23 2.51 0 5.00
24 INT344720 Niacr1 Negative_regulation of Binding of Hdl1 1 0.17 1.13 0 5.00
25 INT344722 Binding of Lig3 and Chdh 1 0.00 1.48 0 5.00
26 INT344711 Nr1h3 Regulation of Abcg1 1 0.03 1.67 0 5.00
27 INT344717 Binding of Niacr1 and Hdl1 1 0.17 1.51 0 5.00
28 INT300194 HSD11B1 Negative_regulation of CHDH 1 0.08 2.19 0 5.00
29 INT344723 Niacr1 Positive_regulation of Binding of APOB 1 0.31 1.05 0 5.00
30 INT344712 Nr1h3 Regulation of Abca1 1 0.03 1.68 0 5.00
31 INT344716 Binding of Hdl1 and Chdh 1 0.03 3.24 0 5.00
32 INT300197 Binding of APOA1 and C1S 1 0.39 3.56 0 5.00
33 INT300196 Binding of HSD11B1 and CHDH 1 0.07 4.01 0 5.00
34 INT300198 Positive_regulation of Binding of C1S and CHDH 1 0.31 1.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypoalphalipoproteinemias. They are ordered first by their pain relevance and then by number of times they were reported in Hypoalphalipoproteinemias. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT187415 Gene_expression of LCAT 3 0.39 1.26 0 99.80
2 INT300233 Positive_regulation of Gene_expression of LCAT 1 0.29 0.98 0 99.80
3 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.56
4 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 99.48
5 INT41986 Positive_regulation of Gene_expression of HSD11B1 26 0.49 32.84 1.52 99.48
6 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 98.88
7 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 98.12
8 INT344694 Positive_regulation of Binding of Niacr1 1 0.28 1.91 0 98.00
9 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 96.16
10 INT300226 Regulation of DGAT1 1 0.01 1.67 0.06 95.40
11 INT294370 Negative_regulation of Niacr1 3 0.24 2.54 0.42 94.32
12 INT344683 Positive_regulation of Negative_regulation of Niacr1 1 0.28 1.77 0 94.32
13 INT116848 Negative_regulation of Chdh 10 0.42 19.68 1.95 93.36
14 INT344693 Positive_regulation of Negative_regulation of Chdh 1 0.05 1.76 0 93.36
15 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 91.92
16 INT226768 Positive_regulation of Negative_regulation of Hdl1 3 0.29 6.34 0.2 91.92
17 INT261193 Binding of Niacr1 7 0.42 3.6 0.03 84.72
18 INT344689 Negative_regulation of Binding of Niacr1 1 0.24 1.75 0 84.72
19 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 81.28
20 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 80.32
21 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 75.84
22 INT23191 Gene_expression of HDLCQ1 13 0.60 14.39 1.58 75.00
23 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 74.36
24 INT344691 Negative_regulation of Binding of Hdl1 2 0.31 2.95 0.19 74.36
25 INT300232 Gene_expression of PCSK9 1 0.57 0.8 0 73.20
26 INT24332 Regulation of Hdl1 28 0.45 45.45 4.26 68.40
27 INT66646 Regulation of Chdh 13 0.44 16.24 8.84 68.08
28 INT239296 Negative_regulation of Abca1 3 0.26 3.83 0.04 66.72
29 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 60.28
30 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56 60.24
31 INT27363 Negative_regulation of Gene_expression of Serpinc1 5 0.29 3.2 0.3 52.40
32 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32 51.52
33 INT344695 Positive_regulation of Tgs1 1 0.02 1.86 0 48.72
34 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 48.24
35 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 48.24
36 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 41.28
37 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85 37.12
38 INT208334 Localization of Hdl1 22 0.54 18.94 0.74 36.48
39 INT344701 Localization of CD1A 1 0.01 1.06 0.04 35.76
40 INT344679 Gene_expression of Csl 1 0.01 0.91 0 31.28
41 INT122047 Positive_regulation of Lcat 3 0.35 1.94 0.4 29.04
42 INT65698 Localization of CCL2 118 0.81 77.54 32.69 27.76
43 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 27.76
44 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 19.32
45 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17 18.32
46 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
47 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
48 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
49 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
50 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
51 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
52 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
53 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
54 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
55 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
56 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
57 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 5.00
58 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
59 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
60 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
61 INT13501 Binding of Drd2 65 0.48 23.76 35.6 5.00
62 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
63 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
64 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
65 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 5.00
66 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 5.00
67 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
68 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
69 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 5.00
70 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
71 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
72 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
73 INT113603 Negative_regulation of Gene_expression of Mcpt1 26 0.41 22.82 9.91 5.00
74 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
75 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
76 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 5.00
77 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
78 INT127023 Negative_regulation of Gene_expression of Vcam1 24 0.59 20.39 6.28 5.00
79 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 5.00
80 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
81 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 5.00
82 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 5.00
83 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
84 INT47662 Localization of CHKB 34 0.81 22.63 5.14 5.00
85 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 5.00
86 INT156416 Gene_expression of Lipg 38 0.67 18.35 4.07 5.00
87 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 5.00
88 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 5.00
89 INT57728 Regulation of LDLR 25 0.41 13.18 3.46 5.00
90 INT28130 Positive_regulation of ABCA1 18 0.61 7.08 3.22 5.00
91 INT224413 Positive_regulation of CIMT 25 0.68 23.61 3.14 5.00
92 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
93 INT194465 Gene_expression of Ldlr 27 0.76 31.36 2.73 5.00
94 INT49759 Negative_regulation of CETP 43 0.58 52 2.68 5.00
95 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 5.00
96 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 5.00
97 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 5.00
98 INT34585 Negative_regulation of Positive_regulation of HSD11B1 31 0.57 43.54 2.47 5.00
99 INT169073 Positive_regulation of Nr1h4 8 0.47 2.44 2.45 5.00
100 INT45202 Regulation of Cys1 8 0.08 5.62 2.23 5.00
101 INT169072 Gene_expression of Nr1h4 7 0.60 6.23 2.18 5.00
102 INT197681 Binding of CHDH 40 0.48 33.72 2.13 5.00
103 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94 5.00
104 INT261192 Gene_expression of Niacr1 57 0.67 24.37 1.89 5.00
105 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 5.00
106 INT154816 Negative_regulation of Sphk1 19 0.41 11.38 1.84 5.00
107 INT261186 Positive_regulation of Niacr1 6 0.49 5.28 1.81 5.00
108 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67 5.00
109 INT162726 Localization of RCT 12 0.58 4.53 1.66 5.00
110 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
111 INT178889 Negative_regulation of CHDH 38 0.48 36.69 1.53 5.00
112 INT178890 Localization of CHDH 12 0.62 15.76 1.49 5.00
113 INT224414 Regulation of CIMT 15 0.39 11.75 1.42 5.00
114 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 5.00
115 INT181882 Localization of Apoa1 8 0.71 7.94 1.37 5.00
116 INT128061 Negative_regulation of Gene_expression of Serpine1 16 0.43 13.13 1.29 5.00
117 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 5.00
118 INT224415 Gene_expression of CIMT 28 0.57 12.35 1.15 5.00
119 INT239302 Positive_regulation of Gene_expression of Abca1 9 0.32 9.1 1.06 5.00
120 INT52113 Gene_expression of CETP 25 0.69 25.71 0.99 5.00
121 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 5.00
122 INT72672 Positive_regulation of Gene_expression of APOA1 4 0.67 3.81 0.89 5.00
123 INT261188 Localization of Niacr1 10 0.73 6.58 0.85 5.00
124 INT190089 Binding of Abca1 5 0.36 2.21 0.83 5.00
125 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 5.00
126 INT176180 Negative_regulation of Nr1h2 6 0.16 7.47 0.69 5.00
127 INT277205 Localization of Ptgdr 2 0.22 1.74 0.65 5.00
128 INT176181 Positive_regulation of Srebf1 10 0.42 3.69 0.62 5.00
129 INT46134 Positive_regulation of Gene_expression of Cys1 4 0.50 11.52 0.61 5.00
130 INT212959 Binding of Scarb1 12 0.35 7.7 0.61 5.00
131 INT212994 Positive_regulation of Positive_regulation of Hdl1 8 0.36 7.21 0.55 5.00
132 INT3557 Positive_regulation of C1S 10 0.67 8.73 0.54 5.00
133 INT227457 Positive_regulation of Gene_expression of CIMT 9 0.15 3.19 0.54 5.00
134 INT239303 Positive_regulation of Gene_expression of Hdl1 8 0.36 12.46 0.53 5.00
135 INT20239 Regulation of APOA1 10 0.60 10.98 0.51 5.00
136 INT239289 Gene_expression of Abcg1 3 0.31 2.27 0.5 5.00
137 INT212966 Negative_regulation of Gene_expression of Hdl1 8 0.27 10.98 0.49 5.00
138 INT84978 Positive_regulation of CHDH 21 0.50 21.97 0.48 5.00
139 INT217592 Positive_regulation of HCAR2 4 0.56 2.02 0.47 5.00
140 INT115600 Positive_regulation of Bas 5 0.49 1.89 0.46 5.00
141 INT165620 Negative_regulation of Gene_expression of HSD11B1 10 0.41 14.52 0.45 5.00
142 INT130015 Positive_regulation of Localization of CHKB 3 0.48 1.72 0.39 5.00
143 INT69865 Binding of Ptgdr 2 0.08 1.25 0.38 5.00
144 INT344684 Positive_regulation of Gene_expression of Abcg1 1 0.10 0.95 0.38 5.00
145 INT252223 Positive_regulation of Gene_expression of Ldlr 3 0.55 10.28 0.37 5.00
146 INT8668 Regulation of Positive_regulation of HSD11B1 6 0.44 6.36 0.35 5.00
147 INT344682 Positive_regulation of Localization of Niacr1 1 0.28 1.27 0.35 5.00
148 INT176192 Negative_regulation of Positive_regulation of Srebf1 2 0.26 0.95 0.35 5.00
149 INT254886 Positive_regulation of Fasn 2 0.06 0.94 0.31 5.00
150 INT187410 Localization of Cd320 14 0.78 9.03 0.31 5.00
151 INT189968 Binding of APOA1 12 0.47 10.1 0.3 5.00
152 INT211553 Gene_expression of Pltp 2 0.48 0.96 0.3 5.00
153 INT300223 Gene_expression of ABCG1 3 0.58 1.26 0.29 5.00
154 INT229971 Localization of C1S 3 0.68 2.91 0.28 5.00
155 INT344673 Positive_regulation of Binding of Scarb1 1 0.16 0.82 0.28 5.00
156 INT344676 Regulation of Binding of Hdl1 1 0.20 0.75 0.27 5.00
157 INT344685 Positive_regulation of Binding of Abca1 1 0.12 0.76 0.26 5.00
158 INT344678 Positive_regulation of Localization of RCT 1 0.10 0.66 0.25 5.00
159 INT175691 Gene_expression of Lcat 6 0.57 7.87 0.21 5.00
160 INT256251 Regulation of Gene_expression of Hdl1 4 0.33 7.35 0.21 5.00
161 INT300227 Positive_regulation of Binding of ABCA1 1 0.41 1.85 0.19 5.00
162 INT300220 Positive_regulation of Binding of ABCG1 1 0.34 1.96 0.19 5.00
163 INT187412 Negative_regulation of Cd320 5 0.42 3.09 0.18 5.00
164 INT288858 Gene_expression of HCAR2 2 0.66 2.41 0.17 5.00
165 INT212962 Phosphorylation of Hdl1 2 0.59 2.77 0.17 5.00
166 INT229968 Binding of C1S 6 0.36 5.87 0.16 5.00
167 INT269777 Regulation of Regulation of Esr1 2 0.02 1.17 0.16 5.00
168 INT217387 Regulation of Abca1 3 0.27 2.01 0.15 5.00
169 INT4173 Binding of Cys1 3 0.37 2.8 0.15 5.00
170 INT61422 Positive_regulation of Egfl7 10 0.12 7.87 0.15 5.00
171 INT159425 Positive_regulation of Cd320 11 0.67 9.35 0.11 5.00
172 INT187880 Binding of Abcg1 3 0.33 2.07 0.1 5.00
173 INT300231 Positive_regulation of Gene_expression of ABCG1 1 0.32 0.97 0.09 5.00
174 INT300228 Positive_regulation of ABCG1 1 0.32 0.97 0.09 5.00
175 INT300237 Binding of ABCG1 1 0.25 0.97 0.09 5.00
176 INT300215 Regulation of Positive_regulation of HCAR2 1 0.22 1.21 0.07 5.00
177 INT256249 Negative_regulation of Dgat2 3 0.18 3.22 0.03 5.00
178 INT300234 Localization of LIG3 1 0.02 1.46 0.03 5.00
179 INT187413 Positive_regulation of Localization of Cd320 3 0.49 1.98 0.03 5.00
180 INT344672 Positive_regulation of Negative_regulation of Cd320 1 0.49 1.05 0 5.00
181 INT265492 Negative_regulation of Positive_regulation of CASP9 4 0.57 3.61 0 5.00
182 INT300235 Regulation of Negative_regulation of CHDH 1 0.34 3.27 0 5.00
183 INT261195 Negative_regulation of Gene_expression of Niacr1 2 0.37 0.74 0 5.00
184 INT344687 Negative_regulation of Gene_expression of Chdh 1 0.04 1.73 0 5.00
185 INT300236 Regulation of Positive_regulation of LPAL1 1 0.00 1.82 0 5.00
186 INT344674 Negative_regulation of Bas 1 0.42 1.17 0 5.00
187 INT300219 Positive_regulation of LPAL1 1 0.01 1.81 0 5.00
188 INT187414 Negative_regulation of Localization of Cd320 3 0.57 1.99 0 5.00
189 INT312756 Protein_catabolism of Hdl1 2 0.56 2.43 0 5.00
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