D:Hypokalemia

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Disease Term
Synonyms Bartter S Syndrome, Hypokaelemia, Hypokaelemic, Hypokalemias, Hypokalemic, Hypopotassemia, HYPOPOTASSEMIAS, Liddle S Syndrome
Documents 67
Hot Single Events 38
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypokalemia. They are ordered first by their relevance to Hypokalemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 85.12
2 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 84.76
3 INT205955 Gopc Regulation of Tdrd6 1 0.06 0.27 0.13 72.56
4 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
5 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
6 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
7 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
8 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
9 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
10 INT241780 Binding of AVP and TRGV9 1 0.12 2.41 0.35 5.00
11 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32 5.00
12 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25 5.00
13 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15 5.00
14 INT241777 Negative_regulation of Binding of AVP and TRGV9 1 0.10 0.75 0.13 5.00
15 INT241774 Binding of AVPR1A and TRGV9 1 0.02 0.48 0.09 5.00
16 INT241775 AVP Positive_regulation of Gene_expression of AQP2 1 0.08 0.17 0 5.00
17 INT241779 AVP Positive_regulation of TRGV9 1 0.17 0.48 0 5.00
18 INT241769 AVP Regulation of Binding of AVPR1A 1 0.11 0.49 0 5.00
19 INT241771 Binding of AVP and AVPR1B 1 0.04 0.49 0 5.00
20 INT241778 AVP Positive_regulation of AVPR1A 1 0.10 1.32 0 5.00
21 INT241768 Binding of AVP and AVPR1A 1 0.08 0.49 0 5.00
22 INT241770 AVP Regulation of Binding of TRGV9 1 0.11 0.49 0 5.00
23 INT241773 AVP Regulation of Binding of AVPR1B 1 0.05 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypokalemia. They are ordered first by their pain relevance and then by number of times they were reported in Hypokalemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 99.90
2 INT104083 Negative_regulation of Gene_expression of Plxna3 1 0.42 0.19 0.32 99.84
3 INT104079 Gene_expression of Plxna3 4 0.65 0.86 0.94 99.84
4 INT205949 Positive_regulation of Shbdp1 7 0.15 1.58 0.85 99.74
5 INT205950 Negative_regulation of Positive_regulation of Shbdp1 1 0.13 0.38 0.25 99.74
6 INT104078 Localization of Plxna3 1 0.78 0.36 0.64 99.48
7 INT104084 Negative_regulation of Localization of Plxna3 1 0.57 0.19 0.32 99.48
8 INT34306 Localization of Gnrh1 43 0.81 4.86 6 99.28
9 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 99.12
10 INT64621 Negative_regulation of LGALS3BP 2 0.30 1.96 0.17 99.08
11 INT104082 Negative_regulation of Plxna3 1 0.41 0.19 0.32 98.72
12 INT173693 Localization of Gopc 249 0.65 70.49 38.81 98.70
13 INT58060 Negative_regulation of HMI 30 0.44 11.9 5.06 98.40
14 INT108713 Negative_regulation of Kcnn4 4 0.31 1.57 0.66 98.40
15 INT34302 Regulation of Localization of Gnrh1 12 0.62 0.85 1.79 97.56
16 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 97.24
17 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 97.24
18 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 97.24
19 INT205954 Regulation of Psmd1 8 0.33 3.72 4.52 96.16
20 INT205953 Regulation of Shbdp1 2 0.14 0.61 0.21 94.08
21 INT104080 Regulation of Localization of Plxna3 1 0.60 0.17 0.32 93.20
22 INT170444 Binding of Gopc 172 0.39 45.05 20.71 92.72
23 INT277 Negative_regulation of Adra2c 8 0.43 1.89 3.42 90.60
24 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 89.16
25 INT812 Localization of INS 1026 0.81 515.6 145.31 88.76
26 INT258890 Positive_regulation of Positive_regulation of Shbdp1 1 0.13 0.71 0.23 88.40
27 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 87.32
28 INT205952 Gene_expression of Shbdp1 14 0.24 2.46 1.27 87.28
29 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 86.72
30 INT10783 Negative_regulation of Gnrh1 24 0.59 7.9 6.2 86.68
31 INT95420 Negative_regulation of Localization of Gnrh1 4 0.43 0.21 0.8 86.68
32 INT104081 Positive_regulation of Negative_regulation of Gnrh1 1 0.50 0.16 0.31 86.68
33 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 85.64
34 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 85.64
35 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 85.64
36 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 84.76
37 INT205951 Regulation of Tdrd6 1 0.11 0.15 0.21 82.28
38 INT57293 Regulation of Gnrh1 21 0.62 7.29 5.41 81.52
39 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 80.00
40 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 75.80
41 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4 75.00
42 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 74.92
43 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19 74.92
44 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 73.88
45 INT17561 Localization of Car2 303 0.79 60.95 44.52 71.48
46 INT14954 Gene_expression of COLQ 7 0.52 2.59 1.39 66.08
47 INT112424 Gene_expression of AVPR1B 6 0.65 1.35 0.16 62.40
48 INT685 Regulation of AVP 124 0.62 34.9 39.91 57.20
49 INT45427 Positive_regulation of Cacna2d2 20 0.49 11.89 4.85 52.16
50 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 41.56
51 INT1562 Localization of Crh 499 0.81 126.74 236.68 27.92
52 INT9660 Regulation of TNF 363 0.62 312.94 139.99 25.48
53 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 24.56
54 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 22.00
55 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 20.08
56 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 14.56
57 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 14.56
58 INT661 Gene_expression of REN 100 0.78 48.21 11.36 11.52
59 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 7.48
60 INT443 Localization of POMC 1020 0.81 284.52 443.17 7.32
61 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
62 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
63 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
64 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
65 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
66 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
67 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
68 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
69 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
70 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
71 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
72 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
73 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
74 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
75 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
76 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
77 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
78 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
79 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
80 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
81 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
82 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
83 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
84 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
85 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
86 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
87 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
88 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
89 INT46 Localization of Ren 233 0.81 46.15 62.44 5.00
90 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
91 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
92 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
93 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
94 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
95 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
96 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
97 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
98 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
99 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
100 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
101 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
102 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
103 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
104 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
105 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
106 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
107 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
108 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 5.00
109 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
110 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74 5.00
111 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
112 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
113 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
114 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
115 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 5.00
116 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73 5.00
117 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
118 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
119 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
120 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 5.00
121 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 5.00
122 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
123 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
124 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
125 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 5.00
126 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61 5.00
127 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
128 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 5.00
129 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
130 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
131 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
132 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
133 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
134 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
135 INT684 Binding of AVP 38 0.48 13.9 8.85 5.00
136 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
137 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 5.00
138 INT11591 Gene_expression of IgG2a 53 0.65 23.14 6.73 5.00
139 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
140 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
141 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
142 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 5.00
143 INT94427 Positive_regulation of Positive_regulation of NOS2 14 0.47 11.15 4.3 5.00
144 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 5.00
145 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89 5.00
146 INT70919 Binding of Il4 19 0.36 6.58 3.59 5.00
147 INT2629 Localization of Shbg 27 0.72 15.12 3.2 5.00
148 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 5.00
149 INT112425 Gene_expression of TRGV9 15 0.58 7.34 2.49 5.00
150 INT46160 Regulation of Positive_regulation of AVP 4 0.53 0.99 2.14 5.00
151 INT80862 Negative_regulation of CYP3A5 5 0.57 1.66 2.13 5.00
152 INT35325 Regulation of Localization of CA2 10 0.32 1.13 1.69 5.00
153 INT22058 Positive_regulation of Igha 7 0.49 5.29 1.69 5.00
154 INT234761 Binding of IL13 6 0.35 4.18 1.55 5.00
155 INT650 Gene_expression of Afp 13 0.78 7.44 1.47 5.00
156 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44 5.00
157 INT118668 Negative_regulation of TRGV9 6 0.37 2.58 1.23 5.00
158 INT100328 Gene_expression of AQP2 6 0.75 2.41 1.21 5.00
159 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 5.00
160 INT25539 Regulation of Gene_expression of AVP 9 0.45 2.74 0.89 5.00
161 INT159531 Positive_regulation of Gene_expression of SLC17A5 8 0.49 9.3 0.77 5.00
162 INT27220 Binding of CYP3A5 4 0.47 0.53 0.73 5.00
163 INT241788 Positive_regulation of Gene_expression of AQP2 3 0.67 1.26 0.7 5.00
164 INT28118 Binding of Atm 13 0.38 12.24 0.68 5.00
165 INT173507 Positive_regulation of Gene_expression of IgG2a 12 0.26 5.97 0.65 5.00
166 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
167 INT15046 Positive_regulation of Gene_expression of Afp 6 0.46 5.95 0.52 5.00
168 INT300950 Positive_regulation of Transcription of Ts1 1 0.08 0 0.49 5.00
169 INT209189 Binding of AVPR1A 5 0.29 1.94 0.43 5.00
170 INT192806 Binding of SSRP1 11 0.27 9.12 0.37 5.00
171 INT241790 Negative_regulation of AVPR1A 6 0.57 4.62 0.35 5.00
172 INT177594 Binding of TRGV9 7 0.14 3.28 0.33 5.00
173 INT300949 Transcription of Ts1 1 0.12 0 0.25 5.00
174 INT300951 Negative_regulation of Transcription of Ts1 1 0.07 0 0.25 5.00
175 INT134512 Negative_regulation of Dct 4 0.22 2.31 0.22 5.00
176 INT258892 Gene_expression of Angle1 2 0.19 0.24 0.16 5.00
177 INT258891 Positive_regulation of Gene_expression of Angle1 1 0.14 0.1 0.16 5.00
178 INT258893 Positive_regulation of Angle1 1 0.20 0.1 0.16 5.00
179 INT115329 Gene_expression of HM13 1 0.38 0.67 0.16 5.00
180 INT200585 Negative_regulation of Binding of AVP 3 0.39 0.61 0.14 5.00
181 INT241783 Positive_regulation of AVPR1A 2 0.67 1.34 0.14 5.00
182 INT241292 Transcription of TRGV9 2 0.16 1.13 0.12 5.00
183 INT129933 Negative_regulation of SLC12A3 2 0.38 3.67 0.08 5.00
184 INT177599 Binding of AVPR1B 2 0.04 0.49 0.04 5.00
185 INT241787 Negative_regulation of AQP2 1 0.57 1.38 0.03 5.00
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