D:Hypokalemic Periodic Paralysis

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pChart

Disease Term
Synonyms Familial Hypokalemic Periodic Paralysis, Hypokalemic Periodic Paralysis Familial, Paralysis Hypokalemic Periodic, Periodic Paralysis Hypokalemic, Primary Hypokalemic Periodic Paralysis
Documents 30
Hot Single Events 28
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypokalemic Periodic Paralysis. They are ordered first by their relevance to Hypokalemic Periodic Paralysis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0 100.00
2 INT314986 Ins1 Negative_regulation of CACNA1S 1 0.00 0.08 0 76.44
3 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14 35.76
4 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14 34.08
5 INT207783 Binding of MRC1 and Ap3d1 1 0.00 2.54 0.22 5.00
6 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16 5.00
7 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13 5.00
8 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 5.00
9 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03 5.00
10 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 5.00
11 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 5.00
12 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypokalemic Periodic Paralysis. They are ordered first by their pain relevance and then by number of times they were reported in Hypokalemic Periodic Paralysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT70104 Positive_regulation of CACNA1S 6 0.47 5.92 0.68 100.00
2 INT253029 Phosphorylation of HPP1 1 0.03 1.48 0.08 100.00
3 INT253030 Binding of HPP1 1 0.03 1.43 0.04 100.00
4 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 99.76
5 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43 99.70
6 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 99.36
7 INT315017 Regulation of Psmc1 1 0.06 0.49 0 98.56
8 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19 98.44
9 INT314985 Positive_regulation of Negative_regulation of Pam 1 0.05 2.1 0.15 98.44
10 INT315005 Binding of Hmgcs2 1 0.11 0.73 0.11 96.76
11 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 96.16
12 INT271733 Gene_expression of Psmc1 2 0.65 1.91 0.03 95.36
13 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 94.88
14 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 93.88
15 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78 93.44
16 INT220506 Binding of Cav1 13 0.45 5.46 0.38 93.44
17 INT314978 Binding of Lp1 1 0.09 0.25 0 90.00
18 INT315004 Positive_regulation of Psmc1 1 0.10 0.85 0 89.76
19 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 89.76
20 INT108117 Regulation of CACNA1S 1 0.39 0.25 0.05 88.16
21 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 83.96
22 INT170503 Positive_regulation of Localization of Tmie 11 0.29 3.27 0.61 83.96
23 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 83.96
24 INT315028 Regulation of Cav2 2 0.43 0.86 0.54 82.08
25 INT17561 Localization of Car2 303 0.79 60.95 44.52 82.00
26 INT170507 Localization of Tmie 27 0.43 6.25 1.31 81.80
27 INT315010 Negative_regulation of Transcription of Cav1 1 0.34 0.21 0 81.68
28 INT220491 Transcription of Cav1 2 0.54 1.1 0.07 80.52
29 INT300713 Regulation of Localization of Cav1 2 0.42 1.37 0.04 78.92
30 INT68500 Regulation of Ar 6 0.27 4.16 1.32 78.56
31 INT214975 Localization of Cav1 7 0.75 2.7 0.13 78.48
32 INT207777 Binding of Ap3d1 1 0.07 14.51 1.91 77.12
33 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 75.20
34 INT207779 Localization of Ap3d1 1 0.11 3.16 0.14 75.20
35 INT207778 Positive_regulation of Binding of Ap3d1 1 0.06 1.26 0.52 74.92
36 INT315009 Regulation of Phosphorylation of Cav1 1 0.36 0.2 0.05 73.80
37 INT135954 Positive_regulation of Phosphorylation of Cav1 2 0.40 0.64 0.22 73.20
38 INT135956 Phosphorylation of Cav1 5 0.64 2.24 0.22 72.28
39 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38 68.24
40 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09 67.52
41 INT315006 Regulation of Localization of Tmie 2 0.04 0.26 0.37 67.52
42 INT207781 Gene_expression of CACNA1S 3 0.63 0.9 0.03 63.60
43 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1 62.12
44 INT273279 Negative_regulation of Localization of Tmie 2 0.07 1.72 0.2 62.12
45 INT116831 Binding of Ryr1 11 0.47 0.12 0.9 61.04
46 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61 59.76
47 INT220497 Regulation of Gene_expression of Cav1 4 0.36 1.84 0.18 51.60
48 INT314979 Negative_regulation of Localization of Lp1 1 0.10 0.1 0 51.44
49 INT314980 Localization of Lp1 1 0.18 0 0 47.76
50 INT314984 Positive_regulation of Cd2ap 1 0.01 0.75 0.11 43.72
51 INT21855 Gene_expression of Ap3d1 4 0.32 12.21 4.66 41.16
52 INT315011 Gene_expression of Cacna1d 1 0.57 4.47 0.29 41.04
53 INT315023 Transcription of Cacna1d 1 0.50 0.26 0.13 41.04
54 INT11713 Localization of RYR1 22 0.76 10.42 1.64 38.16
55 INT17962 Regulation of Car2 124 0.41 33.98 22.71 30.96
56 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 25.84
57 INT170514 Gene_expression of Ryr1 4 0.49 0.56 0.12 11.52
58 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 5.00
59 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
60 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 5.00
61 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 5.00
62 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
63 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
64 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 5.00
65 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
66 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
67 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
68 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
69 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 5.00
70 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
71 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
72 INT145971 Localization of Nav1 20 0.81 10.3 18.11 5.00
73 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
74 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
75 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
76 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
77 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45 5.00
78 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91 5.00
79 INT25585 Positive_regulation of DNAH8 39 0.70 17.96 7.85 5.00
80 INT134864 Binding of Calm3 20 0.27 1.86 6.86 5.00
81 INT59555 Binding of RYR1 39 0.42 8.65 4.92 5.00
82 INT14091 Binding of Vsig2 8 0.42 3.21 3.91 5.00
83 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 5.00
84 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 5.00
85 INT92632 Gene_expression of Vsig2 48 0.50 19.93 3.04 5.00
86 INT30171 Gene_expression of Calm3 13 0.73 0.58 2.96 5.00
87 INT21853 Regulation of Ap3d1 3 0.10 1.4 2.95 5.00
88 INT24712 Positive_regulation of Ap3d1 18 0.54 8.58 2.71 5.00
89 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 5.00
90 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
91 INT21852 Regulation of Gene_expression of Ap3d1 2 0.18 1.34 1.54 5.00
92 INT55305 Regulation of RYR1 14 0.45 5.27 1.33 5.00
93 INT11367 Localization of MB 9 0.78 9.34 1.24 5.00
94 INT236517 Gene_expression of Cacna1f 8 0.65 5.18 0.77 5.00
95 INT248968 Regulation of Csn2 2 0.20 0.09 0.68 5.00
96 INT207780 Positive_regulation of NMS 2 0.28 3.2 0.61 5.00
97 INT262546 Positive_regulation of Binding of Calm3 2 0.11 0.3 0.39 5.00
98 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19 5.00
99 INT315024 Positive_regulation of Cacna1f 1 0.41 0.5 0.17 5.00
100 INT315022 Regulation of Cacna1d 1 0.20 0.32 0.16 5.00
101 INT145253 Negative_regulation of Cav1 9 0.46 3.02 0.15 5.00
102 INT315026 Gene_expression of Csn2 1 0.30 0.24 0.12 5.00
103 INT315027 Positive_regulation of Gene_expression of Cacna1f 1 0.41 0.27 0.12 5.00
104 INT315018 Positive_regulation of Gene_expression of Csn2 1 0.22 0 0.12 5.00
105 INT315016 Negative_regulation of Csn2 1 0.19 0 0.12 5.00
106 INT236521 Negative_regulation of Cacna1f 2 0.36 0.07 0.09 5.00
107 INT315020 Positive_regulation of Gene_expression of Cacna1d 1 0.51 2.24 0.08 5.00
108 INT315015 Regulation of Gene_expression of Cacna1d 1 0.20 0.67 0.07 5.00
109 INT315008 Negative_regulation of Gene_expression of Cacna1d 1 0.31 0.73 0.04 5.00
110 INT315012 Positive_regulation of Binding of Vsig2 1 0.04 0.09 0.04 5.00
111 INT247175 Gene_expression of SPDYA 1 0.01 0 0.04 5.00
112 INT207782 Binding of CACNA1S 1 0.30 0.53 0.03 5.00
113 INT236516 Regulation of Cacna1f 3 0.44 0.23 0 5.00
114 INT315013 Negative_regulation of Binding of Vsig2 1 0.04 0 0 5.00
115 INT315019 Regulation of Binding of Cacna1f 1 0.37 0.07 0 5.00
116 INT236525 Binding of Cacna1f 5 0.39 0.07 0 5.00
117 INT315007 Positive_regulation of Cacna1d 1 0.42 0.55 0 5.00
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