D:Hypophysis Disease

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Disease Term
Synonyms ADENOHYPOPHYSEAL DISEASE, Adenohypophyseal Diseases, Anterior Pituitary Disease, Anterior Pituitary Diseases, DISEASE ADENOHYPOPHYSEAL, Disease Anterior Pituitary, Disease Neurohypophyseal, Disease Of Pituitary Gland, DISEASE PITUITARY, Disease Pituitary Gland, Disease Posterior Pituitary
Documents 46
Hot Single Events 37
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypophysis Disease. They are ordered first by their relevance to Hypophysis Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT47639 GH1 Positive_regulation of Prl 1 0.09 0.64 0.25 94.00
2 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05 81.28
3 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0 81.28
4 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 30.16
5 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 22.64
6 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
7 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
8 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
9 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
10 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
11 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
12 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
13 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41 5.00
14 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
15 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
16 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
17 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
18 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
19 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
20 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
21 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
22 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
23 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 0.19 1.04 0.22 5.00
24 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19 5.00
25 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1 5.00
26 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04 5.00
27 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 5.00
28 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 5.00
29 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0 5.00
30 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0 5.00
31 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 0.03 0.52 0 5.00
32 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0 5.00
33 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0 5.00
34 INT334920 GNRH1 Positive_regulation of Gene_expression of PLOD1 1 0.16 0.52 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypophysis Disease. They are ordered first by their pain relevance and then by number of times they were reported in Hypophysis Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT425 Localization of PRL 455 0.81 189.64 144.8 99.76
2 INT252 Localization of GH1 529 0.80 227.4 122.05 98.98
3 INT1893 Localization of Gh 1041 0.79 340.23 256.58 98.90
4 INT1530 Regulation of Gh 382 0.61 115.96 112.47 98.88
5 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 98.84
6 INT249 Localization of GHRH 215 0.80 78.02 51.87 98.84
7 INT9683 Binding of GH1 57 0.47 21.14 5.99 98.52
8 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.08
9 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 97.56
10 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 97.56
11 INT334926 Positive_regulation of MEHMO 1 0.02 10.11 2.37 97.44
12 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 95.64
13 INT13063 Binding of RHCE 16 0.38 6.54 1.22 95.64
14 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 94.68
15 INT162 Regulation of Prl 794 0.62 165.01 322.24 94.00
16 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 93.88
17 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 92.84
18 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97 92.84
19 INT443 Localization of POMC 1020 0.81 284.52 443.17 90.88
20 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 90.16
21 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 89.92
22 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 89.68
23 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 88.92
24 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03 85.88
25 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 85.76
26 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 85.48
27 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 85.48
28 INT61067 Positive_regulation of Igfbp3 3 0.41 1.21 0.5 85.48
29 INT61065 Positive_regulation of Igfbp2 9 0.69 1.13 0.3 85.48
30 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 84.72
31 INT135234 Regulation of ETFDH 13 0.29 10.8 3.4 83.96
32 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 83.16
33 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 83.16
34 INT61066 Gene_expression of Igfbp2 55 0.77 2.01 1.35 83.16
35 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 82.48
36 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 81.92
37 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 81.92
38 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 78.52
39 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 76.88
40 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 76.88
41 INT54836 Regulation of RHCE 9 0.30 6.68 0.47 76.84
42 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 76.32
43 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 75.92
44 INT7033 Binding of FSHR 19 0.37 6.66 1.52 75.76
45 INT20179 Positive_regulation of Regulation of Gh 12 0.54 3.99 3.42 75.64
46 INT921 Regulation of GH1 172 0.60 52.88 51.04 75.00
47 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 75.00
48 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 73.24
49 INT126225 Gene_expression of MCM3AP-AS1 1 0.47 0.64 0.12 70.84
50 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 70.72
51 INT35295 Positive_regulation of RHCE 5 0.30 2.22 0.39 70.20
52 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 69.56
53 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 66.80
54 INT1512 Binding of Prl 73 0.48 26.22 20.63 64.00
55 INT68708 Negative_regulation of RHCE 4 0.26 2.53 0.48 63.04
56 INT158 Localization of Prl 2431 0.81 378.96 952.2 62.84
57 INT334927 Negative_regulation of MEHMO 1 0.01 3.46 0.1 61.92
58 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 59.04
59 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 55.96
60 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 53.76
61 INT308431 Gene_expression of CNC 1 0.01 2.84 0.18 52.88
62 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 50.60
63 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 47.92
64 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 47.76
65 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 47.76
66 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 47.76
67 INT70021 Localization of BCL2 23 0.74 21.6 1.09 47.44
68 INT161382 Localization of KRT20 25 0.61 12.97 2.13 46.92
69 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 39.28
70 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 38.08
71 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 38.08
72 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 38.08
73 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 38.08
74 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 38.08
75 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 38.00
76 INT12082 Localization of IL6 365 0.81 241.78 105.78 37.48
77 INT6849 Localization of IL1B 229 0.81 112.56 69.63 37.48
78 INT74423 Localization of IL10 91 0.80 61.6 22.95 37.48
79 INT69158 Localization of IL4 48 0.71 31.3 11.98 37.48
80 INT69156 Localization of IL5 21 0.68 14.95 5.37 37.48
81 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 36.20
82 INT284796 Positive_regulation of Binding of RHCE 1 0.30 0.54 0 34.40
83 INT11157 Binding of EGF 88 0.48 53.73 21.25 34.32
84 INT2036 Localization of EGF 42 0.77 21.5 9.74 34.32
85 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16 34.32
86 INT626 Localization of CALCA 289 0.81 125.39 221.15 33.92
87 INT6761 Binding of CALCA 100 0.48 26.71 62.05 33.92
88 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 33.92
89 INT691 Binding of SST 67 0.48 24.66 32.67 32.96
90 INT10237 Binding of EDN1 40 0.48 16 8.48 32.96
91 INT58750 Binding of GAL 16 0.47 5.48 4.92 32.96
92 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 32.32
93 INT397 Localization of SST 232 0.81 58.05 101.19 30.88
94 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 30.88
95 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 28.72
96 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 28.12
97 INT9191 Localization of EDN1 94 0.81 57.01 14.78 27.92
98 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 27.92
99 INT7587 Localization of GAL 27 0.78 4.79 14.29 26.96
100 INT232444 Regulation of Localization of GAL 1 0.44 0.28 0.27 26.96
101 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32 23.36
102 INT232442 Negative_regulation of Gene_expression of DDC 1 0.05 1.44 0.58 23.36
103 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 22.80
104 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 22.64
105 INT18825 Gene_expression of PRLR 8 0.40 2 3.47 22.32
106 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 22.16
107 INT28861 Binding of Gh 61 0.46 25.61 6.38 22.12
108 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 21.24
109 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6 14.08
110 INT224959 Positive_regulation of Gene_expression of Ghsr 5 0.45 1.09 0.5 14.08
111 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
112 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
113 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 5.00
114 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
115 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
116 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
117 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
118 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
119 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
120 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
121 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
122 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
123 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
124 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
125 INT462 Regulation of Pomc 157 0.62 41.67 67.27 5.00
126 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
127 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
128 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
129 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
130 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
131 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
132 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
133 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
134 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 5.00
135 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
136 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
137 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
138 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
139 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
140 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
141 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 5.00
142 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
143 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 5.00
144 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
145 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 5.00
146 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 5.00
147 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 5.00
148 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
149 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
150 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 5.00
151 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 5.00
152 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
153 INT14506 Regulation of Sst 46 0.62 15.02 22.66 5.00
154 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
155 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
156 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
157 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 5.00
158 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
159 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
160 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
161 INT2165 Localization of Cga 41 0.80 4.02 19.53 5.00
162 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
163 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66 5.00
164 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49 5.00
165 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
166 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
167 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 5.00
168 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
169 INT912 Localization of FSHR 91 0.79 23.61 15.58 5.00
170 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 5.00
171 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
172 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
173 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 5.00
174 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
175 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 5.00
176 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 5.00
177 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
178 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
179 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 5.00
180 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
181 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
182 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
183 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
184 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
185 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
186 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 5.00
187 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 5.00
188 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
189 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
190 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
191 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7 5.00
192 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
193 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
194 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
195 INT8740 Localization of Gcg 65 0.78 19 9.81 5.00
196 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
197 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
198 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
199 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
200 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
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