D:Hypopituitarism

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Disease Term
Synonyms Acth Deficiency, Adenohypophyseal Hyposecretion, Anterior Lobe Disorder, Anterior Lobe Disorders, Anterior Pituitary Hyposecretion Syndrome, Disease Simmonds, GENERALISED HYPOPITUITARISM, Generalized Hypopituitarism, Hypopituitarism Postpartum, HYPOSECRETION ADENOHYPOPHYSEAL, Hyposecretion Syndrome Anterior Pituitary
Documents 451
Hot Single Events 200
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypopituitarism. They are ordered first by their relevance to Hypopituitarism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 99.76
2 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 99.76
3 INT277308 Upf1 Regulation of Regulation of Celf1 1 0.00 1.05 0 96.00
4 INT311295 Gopc Positive_regulation of Gene_expression of Clcn1 1 0.07 0.29 0 94.16
5 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13 86.48
6 INT73167 Regulation of Lhb Positive_regulation of Gh 1 0.00 0.48 0.1 86.44
7 INT73168 Lhb Positive_regulation of Gh 2 0.00 0.95 0.2 85.88
8 INT73165 Gh Positive_regulation of Prl 2 0.00 0.95 0.2 85.88
9 INT52562 Lhb Positive_regulation of Prl 3 0.00 1.09 1.02 85.72
10 INT25156 TRH Regulation of PRL 2 0.27 0.81 0.56 83.52
11 INT98410 Binding of AMBP and Rf 1 0.02 0.95 0.22 81.84
12 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14 78.08
13 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35 74.20
14 INT272522 Celf1 Positive_regulation of Phosphorylation of CEBPD 1 0.03 0.52 0 73.24
15 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51 71.52
16 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36 69.52
17 INT272523 Binding of DMPK and Gtf3a 1 0.00 0.81 0 68.84
18 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0 68.84
19 INT311298 Binding of DMPK and Mbnl1 1 0.43 0.54 0 68.44
20 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 58.92
21 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 58.80
22 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0 56.36
23 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0 55.72
24 INT277310 Binding of Tnnt2 and Mbnl1 1 0.18 1.1 0 55.72
25 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 54.40
26 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29 53.84
27 INT222502 Binding of Crhr1 and Ucn2 1 0.01 0.05 0 53.84
28 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09 50.00
29 INT222544 Binding of Ucn and Crh 1 0.02 0 0.05 49.92
30 INT222469 Binding of Ucn and Crhr2 1 0.00 0 0.03 47.36
31 INT272524 DICER1 Negative_regulation of Dmpk 1 0.04 0.07 0 38.88
32 INT311296 Akt1 Positive_regulation of Gene_expression of Clcn1 1 0.11 0 0.05 33.60
33 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88 21.92
34 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15 14.84
35 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34 5.00
36 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2 5.00
37 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18 5.00
38 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44 5.00
39 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29 5.00
40 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79 5.00
41 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27 5.00
42 INT9786 Gnrh1 Regulation of LH 7 0.40 0.58 1.82 5.00
43 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25 5.00
44 INT62368 Gal Positive_regulation of Localization of LH 3 0.36 0 1.2 5.00
45 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12 5.00
46 INT36186 Npy Positive_regulation of Localization of Gnrh1 4 0.75 0.09 0.96 5.00
47 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95 5.00
48 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9 5.00
49 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
50 INT222528 Abat Positive_regulation of Gene_expression of Gh1 1 0.01 0 0.75 5.00
51 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
52 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71 5.00
53 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71 5.00
54 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
55 INT32715 Prl Regulation of Localization of LH 2 0.34 0.09 0.68 5.00
56 INT60283 Positive_regulation of Gnrh1 Regulation of LH 2 0.31 0 0.68 5.00
57 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 5.00
58 INT222552 Abat Regulation of Gene_expression of Gh1 1 0.00 0 0.67 5.00
59 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
60 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
61 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 5.00
62 INT222492 Ngf Positive_regulation of Gene_expression of Prl 1 0.24 0 0.62 5.00
63 INT3617 Trh Regulation of Localization of Gh1 3 0.65 0.55 0.62 5.00
64 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61 5.00
65 INT32747 Avp Positive_regulation of Localization of Pomc 4 0.16 1.92 0.61 5.00
66 INT222521 Vip Positive_regulation of Localization of Ngf 1 0.14 0.08 0.6 5.00
67 INT60536 Gnrh1 Positive_regulation of Localization of Prl 2 0.22 1.12 0.6 5.00
68 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6 5.00
69 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 5.00
70 INT222524 Abat Negative_regulation of Localization of Trh 1 0.02 0.16 0.51 5.00
71 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43 5.00
72 INT222490 Npy Positive_regulation of Localization of Gh1 1 0.02 0.06 0.41 5.00
73 INT323491 Olfr781 Positive_regulation of Localization of Ins1 1 0.01 0.87 0.4 5.00
74 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39 5.00
75 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
76 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36 5.00
77 INT3616 Trh Positive_regulation of Localization of Gh1 4 0.73 0.49 0.36 5.00
78 INT331966 Binding of DES and SACM1L 1 0.01 1.86 0.36 5.00
79 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33 5.00
80 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32 5.00
81 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
82 INT222464 Col4a2 Regulation of Localization of Prl 1 0.03 0.32 0.3 5.00
83 INT222529 Binding of Trh and Vip 1 0.07 0.09 0.29 5.00
84 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 5.00
85 INT222428 Negative_regulation of Tlr4 Positive_regulation of Il6 1 0.01 0.26 0.27 5.00
86 INT222412 Cd14 Negative_regulation of Binding of Tlr4 1 0.02 0.26 0.27 5.00
87 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 5.00
88 INT222440 Tlr4 Positive_regulation of Localization of Pomc 1 0.01 0.35 0.27 5.00
89 INT222427 Il6 Positive_regulation of Localization of Pomc 1 0.02 0.27 0.26 5.00
90 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 5.00
91 INT222422 Tlr4 Positive_regulation of Il6 1 0.01 0.25 0.26 5.00
92 INT277317 Binding of Celf1 and Slc6a11 1 0.19 0.06 0.26 5.00
93 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 5.00
94 INT222467 Gh1 Positive_regulation of Prl 1 0.04 0.52 0.26 5.00
95 INT222557 Gal Positive_regulation of Gene_expression of Vip 1 0.06 0.07 0.25 5.00
96 INT222421 Tlr4 Negative_regulation of Localization of Prl 1 0.02 0.45 0.25 5.00
97 INT222563 Vip Positive_regulation of Gene_expression of Il6 1 0.05 0.38 0.25 5.00
98 INT222560 Calca Positive_regulation of Gene_expression of Il6 1 0.06 0.39 0.25 5.00
99 INT222540 Mzb1 Positive_regulation of Gene_expression of Il6 1 0.03 0.38 0.25 5.00
100 INT222561 Gnrh1 Positive_regulation of Prl 1 0.15 0.38 0.22 5.00
101 INT207783 Binding of MRC1 and Ap3d1 1 0.00 2.54 0.22 5.00
102 INT222527 Gal Regulation of Vip 1 0.03 0.05 0.22 5.00
103 INT277318 Upf1 Positive_regulation of Atxn8os 1 0.01 0.77 0.21 5.00
104 INT222566 Agt Positive_regulation of Localization of Prl 1 0.08 0.23 0.21 5.00
105 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2 5.00
106 INT222568 Vip Negative_regulation of Transcription of Nos2 1 0.06 0.3 0.19 5.00
107 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19 5.00
108 INT246468 GHS Regulation of Gh 1 0.05 1.12 0.19 5.00
109 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19 5.00
110 INT222525 Il1a Regulation of Localization of Gh1 1 0.00 0.64 0.19 5.00
111 INT222499 Il10 Regulation of Positive_regulation of Hpse 1 0.00 0.8 0.19 5.00
112 INT222473 Mzb1 Negative_regulation of Transcription of Nos2 1 0.04 0.29 0.19 5.00
113 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19 5.00
114 INT222531 Il6 Positive_regulation of Hpse 1 0.00 0.61 0.18 5.00
115 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18 5.00
116 INT222414 Tlr4 Positive_regulation of Hpse 1 0.00 0.61 0.18 5.00
117 INT222470 Prl Regulation of Gnrh1 1 0.14 0.09 0.18 5.00
118 INT323494 Ghrl Regulation of Ins1 1 0.16 2.12 0.17 5.00
119 INT1394 Binding of Prl and LH 3 0.36 0 0.17 5.00
120 INT222443 INCENP Positive_regulation of Localization of Pomc 1 0.00 0.75 0.17 5.00
121 INT222426 Lif Positive_regulation of Localization of Pomc 1 0.02 0.75 0.17 5.00
122 INT222505 Gene_expression of Crh Negative_regulation of Gene_expression of Hpse 1 0.02 0.55 0.17 5.00
123 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16 5.00
124 INT222509 Ghrh Positive_regulation of Localization of Prl 1 0.28 0.23 0.16 5.00
125 INT222430 Il11 Positive_regulation of Localization of Pomc 1 0.01 0.69 0.16 5.00
126 INT222548 Il11 Positive_regulation of Transcription of Pomc 1 0.03 0.7 0.16 5.00
127 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15 5.00
128 INT222420 Tlr4 Positive_regulation of Positive_regulation of Hpse 1 0.00 0.67 0.15 5.00
129 INT39154 Crh Positive_regulation of Avp 2 0.11 0.15 0.14 5.00
130 INT222673 Gnrh1 Negative_regulation of Gnrh1 Positive_regulation of Prl 1 0.08 0.21 0.14 5.00
131 INT222551 Il6 Positive_regulation of Positive_regulation of Hpse 1 0.01 0.5 0.13 5.00
132 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13 5.00
133 INT222465 Binding of Calcrl and Rxfp2 1 0.02 0 0.12 5.00
134 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 5.00
135 INT222546 Mzb1 Positive_regulation of Localization of Prl 1 0.10 0.17 0.12 5.00
136 INT222549 Pomc Positive_regulation of Gnrh1 1 0.13 0 0.12 5.00
137 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11 5.00
138 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11 5.00
139 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11 5.00
140 INT222503 Agt Positive_regulation of Localization of Gh1 1 0.02 0.23 0.11 5.00
141 INT246466 GHS Positive_regulation of GHS Regulation of Gh 1 0.01 0.6 0.1 5.00
142 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1 5.00
143 INT222558 Mzb1 Regulation of Localization of Prl 1 0.13 0.14 0.1 5.00
144 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
145 INT222501 Cartpt Negative_regulation of Localization of Prl 1 0.08 0 0.1 5.00
146 INT222553 Binding of Sdc1 and Egf 1 0.02 0 0.1 5.00
147 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 5.00
148 INT222517 Calca Positive_regulation of Localization of Gh1 1 0.03 0 0.09 5.00
149 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 5.00
150 INT246467 GHS Regulation of Localization of Gh 1 0.03 0.52 0.09 5.00
151 INT222442 Tlr4 Positive_regulation of Gene_expression of INCENP 1 0.00 0.34 0.09 5.00
152 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 5.00
153 INT277316 Upf1 Positive_regulation of Slc6a11 1 0.01 0.47 0.09 5.00
154 INT222425 Mif Regulation of Tlr4 1 0.01 0.24 0.09 5.00
155 INT222483 Trh Regulation of Gene_expression of Gh1 1 0.03 0 0.09 5.00
156 INT222484 Pomc Positive_regulation of Transcription of Prl 1 0.14 0 0.09 5.00
157 INT277320 Upf1 Positive_regulation of Upf1 Positive_regulation of Slc6a11 1 0.00 0.47 0.09 5.00
158 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
159 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08 5.00
160 INT1388 Binding of Prl and Gnrh1 3 0.35 0.17 0.08 5.00
161 INT277319 Gene_expression of Celf1 Positive_regulation of Positive_regulation of Slc6a11 1 0.24 0.08 0.08 5.00
162 INT222545 Lep Negative_regulation of Nmb 1 0.04 0.52 0.08 5.00
163 INT8092 Npy Regulation of Localization of Gnrh1 2 0.30 0.08 0.08 5.00
164 INT277313 Negative_regulation of Mbnl1 Positive_regulation of Positive_regulation of Slc6a11 1 0.52 0.08 0.08 5.00
165 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
166 INT222514 Mif Regulation of Localization of Il6 1 0.04 0.23 0.08 5.00
167 INT222506 Gnrh1 Regulation of Localization of Prl 1 0.20 0.16 0.08 5.00
168 INT222662 Il1a Positive_regulation of Gene_expression of INCENP 1 0.00 0.32 0.08 5.00
169 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07 5.00
170 INT222466 Gnrh1 Regulation of Prl 1 0.14 1.16 0.07 5.00
171 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07 5.00
172 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07 5.00
173 INT323490 Ghsr Regulation of Ins1 1 0.26 0.54 0.07 5.00
174 INT226787 Trglyd Positive_regulation of Lbp 1 0.04 1.67 0.07 5.00
175 INT32745 Crh Positive_regulation of Localization of Pomc 2 0.16 0.49 0.07 5.00
176 INT226786 Scl1 Positive_regulation of Lbp 1 0.04 1.68 0.07 5.00
177 INT222416 Tlr4 Positive_regulation of Gene_expression of Inhba 1 0.00 0.29 0.06 5.00
178 INT222488 Gal Positive_regulation of Gene_expression of Prl 1 0.05 0.05 0.06 5.00
179 INT222479 Binding of Ramp1 and Rxfp2 1 0.01 0 0.06 5.00
180 INT222431 Tlr4 Positive_regulation of Gene_expression of Fst 1 0.01 0.29 0.06 5.00
181 INT222533 Mzb1 Positive_regulation of Gene_expression of Gh1 1 0.03 0 0.06 5.00
182 INT222478 Binding of Calca and Rxfp2 1 0.02 0 0.06 5.00
183 INT222513 Mzb1 Positive_regulation of Localization of Gh1 1 0.03 0 0.06 5.00
184 INT222570 Cnp Positive_regulation of Localization of Gh1 1 0.03 0 0.06 5.00
185 INT222663 Mzb1 Positive_regulation of Localization of VEGFA 1 0.02 0 0.05 5.00
186 INT222463 Inhba Positive_regulation of Gene_expression of Fst 1 0.01 0 0.05 5.00
187 INT222520 Mzb1 Positive_regulation of Gene_expression of Fst 1 0.04 0 0.05 5.00
188 INT222476 Gnrh1 Negative_regulation of Gene_expression of Fst 1 0.04 0 0.05 5.00
189 INT323498 Ghsr Positive_regulation of Ins1 1 0.24 0.23 0.05 5.00
190 INT222508 Ghrh Regulation of Localization of LH 1 0.07 0 0.05 5.00
191 INT222487 Trh Negative_regulation of Nmb 1 0.05 0.26 0.05 5.00
192 INT222512 Nppa Positive_regulation of Localization of LH 1 0.02 0 0.05 5.00
193 INT323482 Ghrl Negative_regulation of Ins1 1 0.13 0.24 0.05 5.00
194 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 5.00
195 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05 5.00
196 INT222664 Il6 Positive_regulation of Localization of VEGFA 1 0.01 0 0.05 5.00
197 INT222559 Binding of Ramp3 and Ramp1 1 0.02 0 0.05 5.00
198 INT222485 Binding of Iapp and Ramp1 1 0.09 0 0.05 5.00
199 INT323485 Ghrl Negative_regulation of Localization of Ins1 1 0.15 1.99 0.05 5.00
200 INT222567 Negative_regulation of Gh1 Negative_regulation of Ghrh 1 0.03 0.19 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypopituitarism. They are ordered first by their pain relevance and then by number of times they were reported in Hypopituitarism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 100.00
2 INT314985 Positive_regulation of Negative_regulation of Pam 1 0.05 2.1 0.15 100.00
3 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19 100.00
4 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 100.00
5 INT44426 Localization of BRD2 6 0.78 4.02 2.59 100.00
6 INT1308 Localization of Pomc 457 0.81 66.83 217.5 100.00
7 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3 100.00
8 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 100.00
9 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.96
10 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62 99.96
11 INT23645 Regulation of Scnn1a 2 0.23 1.18 0.44 99.92
12 INT65352 Negative_regulation of CNBP 6 0.37 4.59 0.35 99.92
13 INT41928 Binding of AFP 9 0.36 7.85 0.7 99.90
14 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 99.82
15 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 99.76
16 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 99.70
17 INT23598 Binding of SCN5A 32 0.40 16 5.35 99.68
18 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 99.62
19 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 99.58
20 INT272461 Negative_regulation of Gene_expression of Clcn1 2 0.52 0.82 0 99.52
21 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 99.44
22 INT45901 Localization of LGR6 5 0.80 2.48 1.64 99.40
23 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 99.36
24 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46 99.36
25 INT1530 Regulation of Gh 382 0.61 115.96 112.47 99.28
26 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 99.20
27 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 99.20
28 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 99.12
29 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 99.08
30 INT5793 Binding of CTS 110 0.48 63.91 40.62 99.08
31 INT300712 Negative_regulation of Gene_expression of Elpt 1 0.07 1.02 0.09 99.08
32 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51 99.06
33 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 99.04
34 INT45900 Regulation of LGR6 1 0.16 0.48 0.57 99.00
35 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 98.96
36 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 98.92
37 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 98.88
38 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 98.88
39 INT249 Localization of GHRH 215 0.80 78.02 51.87 98.86
40 INT272476 Negative_regulation of Transcription of Clcn1 3 0.43 1.05 0 98.84
41 INT158 Localization of Prl 2431 0.81 378.96 952.2 98.82
42 INT443 Localization of POMC 1020 0.81 284.52 443.17 98.76
43 INT211586 Regulation of DMPK 6 0.31 2.11 0.33 98.76
44 INT19342 Regulation of Insr 12 0.24 6.11 1.54 98.76
45 INT235683 Regulation of Clcn1 4 0.21 1.49 0.03 98.76
46 INT300716 Gene_expression of Elpt 1 0.11 1.02 0.09 98.72
47 INT272462 Transcription of Clcn1 4 0.63 1.21 0 98.68
48 INT1438 Localization of Pomc 360 0.81 101.26 116.47 98.66
49 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 98.62
50 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 98.60
51 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 98.56
52 INT18660 Binding of Gnrhr 45 0.41 10.6 16.85 98.56
53 INT166820 Gene_expression of CLCN1 3 0.38 2.38 2.04 98.52
54 INT272505 Negative_regulation of Gene_expression of CLCN1 1 0.27 0.1 0 98.52
55 INT20630 Positive_regulation of Gene_expression of CHKB 19 0.47 15.79 1.85 98.40
56 INT425 Localization of PRL 455 0.81 189.64 144.8 98.36
57 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 98.36
58 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.32
59 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 98.28
60 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 98.24
61 INT311280 Positive_regulation of Transcription of Clcn1 1 0.44 0.24 0 98.24
62 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 98.20
63 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 98.20
64 INT987 Localization of TRH 37 0.78 10.53 11.1 98.20
65 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22 98.12
66 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 98.08
67 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 98.08
68 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 98.04
69 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 97.96
70 INT255112 Negative_regulation of Mbnl1 22 0.58 8.5 0.45 97.64
71 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 97.64
72 INT138592 Gene_expression of INHBB 2 0.58 0.74 0.19 97.64
73 INT11770 Binding of Lhb 14 0.48 3.57 1.91 97.56
74 INT272465 Negative_regulation of Mbnl2 1 0.16 0.57 0 97.50
75 INT255132 Positive_regulation of Mbnl1 15 0.54 2.58 0.27 97.48
76 INT255111 Positive_regulation of Positive_regulation of Mbnl1 1 0.47 0.54 0.05 97.48
77 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 97.44
78 INT1893 Localization of Gh 1041 0.79 340.23 256.58 97.32
79 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 97.16
80 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 97.12
81 INT341481 Binding of SCN8A 1 0.28 1.47 1.23 97.12
82 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 97.08
83 INT98409 Binding of Rf 4 0.08 3.97 0.94 97.04
84 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 96.92
85 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 96.88
86 INT116314 Gene_expression of Myod1 38 0.70 16.6 0.89 96.84
87 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 96.84
88 INT272469 Negative_regulation of Gene_expression of Myod1 5 0.39 2.82 0.07 96.84
89 INT341484 Negative_regulation of SCN1A 1 0.53 1.27 0.94 96.72
90 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 96.56
91 INT211584 Gene_expression of Dmpk 32 0.73 12.28 0.46 96.52
92 INT255100 Positive_regulation of Gene_expression of Dmpk 8 0.56 3.3 0.13 96.52
93 INT255139 Positive_regulation of Positive_regulation of IGHD1-7 1 0.05 0.33 0 96.48
94 INT272484 Negative_regulation of Myod1 8 0.39 6.77 0.2 96.44
95 INT255131 Gene_expression of Mbnl1 34 0.77 10.44 0.55 96.36
96 INT255113 Positive_regulation of Gene_expression of Mbnl1 15 0.69 3.28 0.47 96.28
97 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 96.20
98 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 96.12
99 INT5033 Negative_regulation of tf 39 0.54 13.37 48.62 96.12
100 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 95.92
101 INT214730 Positive_regulation of IGHD1-7 2 0.39 1.08 0.08 95.92
102 INT214735 Gene_expression of IGHD1-7 5 0.57 3.28 0.14 95.92
103 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 95.92
104 INT34777 Localization of IGF1 82 0.80 42.68 8.62 95.80
105 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95 95.72
106 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 95.64
107 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 95.48
108 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 95.48
109 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 95.24
110 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 95.24
111 INT106037 Gene_expression of PEPD 10 0.75 4.18 3.11 95.20
112 INT253 Regulation of PRL 184 0.62 47.27 65.79 95.16
113 INT26678 Negative_regulation of Dmpk 11 0.47 3.45 0.26 95.04
114 INT287307 Binding of ENO1 9 0.48 11.24 2.51 94.88
115 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 94.84
116 INT45898 Positive_regulation of Localization of LGR6 1 0.25 0.32 0.63 94.84
117 INT462 Regulation of Pomc 157 0.62 41.67 67.27 94.76
118 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 94.44
119 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 93.92
120 INT46305 Negative_regulation of GAA 2 0.57 1.17 0.07 93.72
121 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 93.44
122 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 93.28
123 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 93.12
124 INT184678 Regulation of Uts2r 7 0.14 2.57 0.85 92.92
125 INT9179 Positive_regulation of Localization of Ghrh 42 0.70 7.05 18.1 92.72
126 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 92.68
127 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 92.68
128 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 92.68
129 INT5757 Gene_expression of SCN4A 6 0.75 1.73 2.73 92.44
130 INT921 Regulation of GH1 172 0.60 52.88 51.04 92.40
131 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 92.40
132 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 92.24
133 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 91.96
134 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 91.84
135 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 91.76
136 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 91.76
137 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 91.76
138 INT255125 Localization of Celf1 7 0.60 2.84 0.11 91.56
139 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 91.56
140 INT255123 Localization of Mbnl1 7 0.80 3.76 0.24 91.56
141 INT16897 Gene_expression of GHSR 6 0.77 0.46 0.41 91.44
142 INT272482 Positive_regulation of Positive_regulation of Cnbp 1 0.32 0.63 0.05 91.36
143 INT255102 Transcription of Dmpk 8 0.60 2.47 0.03 91.28
144 INT144465 Gene_expression of DMPK 9 0.69 5.01 0.94 90.96
145 INT94303 Gene_expression of Upf1 44 0.04 11.62 3.87 90.96
146 INT272475 Regulation of Mbnl1 15 0.61 5.39 0.56 90.92
147 INT277278 Regulation of Celf1 4 0.49 4.63 0.48 90.92
148 INT252 Localization of GH1 529 0.80 227.4 122.05 90.76
149 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 90.68
150 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 90.68
151 INT17584 Regulation of tf 12 0.50 4.69 10.39 90.48
152 INT272488 Positive_regulation of Cnbp 1 0.32 0.62 0.05 90.16
153 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 90.12
154 INT180497 Binding of MRI1 45 0.42 28.35 14.77 90.08
155 INT5095 Localization of Ghrh 185 0.81 28.09 62.08 89.60
156 INT23376 Localization of NPL 7 0.47 2.59 3.29 89.60
157 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 89.44
158 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 89.28
159 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 89.16
160 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 89.16
161 INT255120 Gene_expression of Celf1 29 0.62 10.82 0.59 89.04
162 INT255101 Positive_regulation of Celf1 23 0.56 11.91 0.84 89.04
163 INT5454 Localization of CRH 124 0.79 79.18 41.53 89.04
164 INT45899 Regulation of Localization of LGR6 3 0.27 1.85 0.64 88.96
165 INT45902 Negative_regulation of Localization of LGR6 1 0.15 0.31 0.51 88.96
166 INT307060 Negative_regulation of AKTIP 6 0.01 2.79 0.08 88.84
167 INT211585 Negative_regulation of Gene_expression of Dmpk 5 0.47 1.63 0.03 88.72
168 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 88.56
169 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 88.28
170 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 88.24
171 INT21805 Negative_regulation of Hdlbp 7 0.30 9.66 1.43 88.08
172 INT232584 Transcription of DMPK 5 0.47 3.41 0.13 87.60
173 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 87.48
174 INT299511 Negative_regulation of Elpt 2 0.07 1.79 0.4 87.32
175 INT21502 Gene_expression of Scn4a 22 0.78 4.47 7.97 87.28
176 INT5127 Localization of Lhb 488 0.80 50.48 162.66 87.12
177 INT4029 Positive_regulation of HYAL1 10 0.69 2 1.39 87.04
178 INT277276 Positive_regulation of Gene_expression of Upf1 1 0.01 1.04 0 87.04
179 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79 86.88
180 INT112327 Positive_regulation of Gene_expression of FSHB 5 0.44 3.64 0.39 86.88
181 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 86.84
182 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 86.84
183 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 86.84
184 INT214 Localization of AVP 370 0.81 208.51 91.09 86.80
185 INT311289 Regulation of CELF1 1 0.15 1.78 0.03 86.68
186 INT311291 Regulation of MBNL1 1 0.02 0.69 0 86.68
187 INT1975 Regulation of Regulation of Prl 32 0.59 5.78 18.53 86.52
188 INT847 Regulation of Lhb 131 0.61 22.08 46.54 86.44
189 INT745 Gene_expression of Afp 65 0.78 52.89 4.24 86.20
190 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 86.16
191 INT260581 Binding of DMPK 7 0.43 5.09 0.28 86.16
192 INT311284 Negative_regulation of Gene_expression of DMPK 1 0.33 0.33 0 85.88
193 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 85.76
194 INT13735 Negative_regulation of Regulation of GH1 14 0.42 4.35 5.39 85.52
195 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 85.52
196 INT25031 Negative_regulation of Gene_expression of PLOD1 14 0.54 3.86 2.89 85.52
197 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49 85.48
198 INT54836 Regulation of RHCE 9 0.30 6.68 0.47 85.32
199 INT301729 Positive_regulation of Gene_expression of Myod1 2 0.24 1.53 0 85.28
200 INT167705 Positive_regulation of Clcn2 3 0.46 1.32 0.63 85.28
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