D:Hypospadias

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Disease Term
Synonyms HYPOSPADIA
Documents 139
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypospadias. They are ordered first by their relevance to Hypospadias and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT261355 Gh1 Regulation of Oxt 1 0.00 1.38 0 31.76
2 INT261356 Gh1 Regulation of Avp 1 0.00 1.38 0 30.72
3 INT276438 Binding of OPN1SW and MYP1 1 0.12 1.21 0.09 25.84
4 INT36684 Gh1 Regulation of Prl 2 0.18 1.25 0.48 18.96
5 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95 18.08
6 INT261357 Negative_regulation of Gh1 Regulation of Gnrhr 1 0.00 1.26 0 18.08
7 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7 5.00
8 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58 5.00
9 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41 5.00
10 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41 5.00
11 INT194358 Binding of Ddt and Scgb1d2 1 0.01 0 0.31 5.00
12 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25 5.00
13 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24 5.00
14 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23 5.00
15 INT261373 Nsdhl Positive_regulation of Gene_expression of Gfap 1 0.10 2.05 0.19 5.00
16 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19 5.00
17 INT261400 Binding of nt and ADHD1 1 0.00 1.69 0.18 5.00
18 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18 5.00
19 INT261384 Nsdhl Negative_regulation of Gene_expression of Mbp 1 0.01 1.43 0.14 5.00
20 INT194360 SNRPD1 Negative_regulation of Dbh 1 0.00 0 0.14 5.00
21 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13 5.00
22 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12 5.00
23 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11 5.00
24 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11 5.00
25 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1 5.00
26 INT261398 Nsdhl Positive_regulation of Binding of Nsdhl and Med1 1 0.01 2.14 0.09 5.00
27 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09 5.00
28 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09 5.00
29 INT261376 Nsdhl Positive_regulation of Gene_expression of Nrgn 1 0.06 0.86 0.08 5.00
30 INT261399 Nsdhl Positive_regulation of Binding of Nsdhl and Syn1 1 0.00 0.65 0.07 5.00
31 INT261386 Nsdhl Positive_regulation of Map2 1 0.08 0.59 0.07 5.00
32 INT261395 Nsdhl Positive_regulation of Syn1 1 0.00 0.59 0.07 5.00
33 INT261392 Binding of Nsdhl and Syn1 1 0.00 0.65 0.07 5.00
34 INT261385 LH Regulation of Localization of Nsdhl 1 0.02 0.65 0.05 5.00
35 INT261382 Nsdhl Regulation of Il6 1 0.03 0.66 0.04 5.00
36 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04 5.00
37 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04 5.00
38 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03 5.00
39 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03 5.00
40 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0 5.00
41 INT313384 Binding of PDLIM5 and ZMYND10 1 0.04 0.82 0 5.00
42 INT331883 Binding of MAGEA4 and GOPC 1 0.03 0 0 5.00
43 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypospadias. They are ordered first by their pain relevance and then by number of times they were reported in Hypospadias. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9 98.16
2 INT187017 Positive_regulation of Bcar1 2 0.44 2.02 0.27 89.44
3 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 84.52
4 INT116879 Gene_expression of MAGEA4 3 0.41 5.82 0.47 83.04
5 INT331886 Gene_expression of DDX4 1 0.12 2.38 0 82.08
6 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 81.92
7 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 80.52
8 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 79.40
9 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 78.24
10 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 78.24
11 INT282576 Negative_regulation of Gene_expression of POU5F1 12 0.43 2.79 0.16 76.16
12 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 74.24
13 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05 73.00
14 INT187016 Binding of Bcar1 1 0.31 1.36 0 71.92
15 INT52072 Negative_regulation of Ces1c 6 0.31 1.37 2.13 67.12
16 INT276439 Positive_regulation of Positive_regulation of MYP1 1 0.31 1.36 0 64.84
17 INT141924 Positive_regulation of MYP1 3 0.45 2.03 0.64 64.52
18 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 57.28
19 INT288836 Positive_regulation of tip 1 0.35 0.22 0 50.00
20 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12 47.76
21 INT163290 Binding of MIF 9 0.31 7.57 2.8 47.76
22 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 45.20
23 INT120011 Localization of MIF 6 0.58 5.72 2.6 42.96
24 INT451 Regulation of Oxt 142 0.62 22.07 69.42 31.76
25 INT4207 Regulation of Avp 267 0.62 63.72 115.33 30.72
26 INT117731 Binding of MYP1 7 0.30 10.61 0.67 25.84
27 INT17081 Binding of Ttpa 7 0.27 2.12 0.34 24.88
28 INT179300 Negative_regulation of TGFB1I1 1 0.06 1.92 0 23.16
29 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38 22.40
30 INT6481 Binding of TNF 624 0.48 510.2 214.82 21.92
31 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 15.24
32 INT1045 Localization of LH 1211 0.81 87.04 456.25 5.00
33 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 5.00
34 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
35 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
36 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
37 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
38 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
39 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
40 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 5.00
41 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
42 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
43 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
44 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
45 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 5.00
46 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
47 INT1898 Regulation of Crh 220 0.62 61.33 102.64 5.00
48 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 5.00
49 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 5.00
50 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
51 INT2155 Negative_regulation of Sst 111 0.59 16.58 77.74 5.00
52 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
53 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
54 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14 5.00
55 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
56 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 5.00
57 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 5.00
58 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
59 INT1782 Regulation of Gh1 125 0.62 22 55.74 5.00
60 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
61 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 5.00
62 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
63 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 5.00
64 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
65 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
66 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 5.00
67 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
68 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 5.00
69 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
70 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
71 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08 5.00
72 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
73 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
74 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 5.00
75 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
76 INT5533 Binding of Oxt 43 0.48 8.69 18.35 5.00
77 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1 5.00
78 INT14887 Gene_expression of Mbp 55 0.75 36.13 16.11 5.00
79 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
80 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86 5.00
81 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
82 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
83 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
84 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
85 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 5.00
86 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 5.00
87 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
88 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
89 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
90 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
91 INT5011 Negative_regulation of Gal 30 0.57 9.88 11.49 5.00
92 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08 5.00
93 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
94 INT26248 Positive_regulation of Ptprg 12 0.40 1.42 9.48 5.00
95 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29 5.00
96 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21 5.00
97 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
98 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
99 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54 5.00
100 INT93673 Transcription of Creb1 19 0.66 9.27 8.26 5.00
101 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
102 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 5.00
103 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 5.00
104 INT3500 Positive_regulation of Gene_expression of Gnrh1 25 0.69 4.59 6.69 5.00
105 INT7873 Positive_regulation of Ugt2b 36 0.70 0.72 6.59 5.00
106 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
107 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28 5.00
108 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 5.00
109 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05 5.00
110 INT3276 Binding of LH 16 0.37 4.76 5.94 5.00
111 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
112 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 5.00
113 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 5.00
114 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02 5.00
115 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84 5.00
116 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 5.00
117 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 5.00
118 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
119 INT94863 Gene_expression of Litaf 27 0.65 10.21 4.35 5.00
120 INT187346 Regulation of Dlat 12 0.29 1.82 4.28 5.00
121 INT117205 Transcription of Esr1 23 0.65 9.4 4.14 5.00
122 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 5.00
123 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92 5.00
124 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83 5.00
125 INT92017 Regulation of Gene_expression of Flvcr2 3 0.18 1.69 3.75 5.00
126 INT20422 Regulation of Gap43 10 0.61 5.24 3.73 5.00
127 INT20461 Binding of Esr1 34 0.48 9.58 3.66 5.00
128 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 5.00
129 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56 5.00
130 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 5.00
131 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
132 INT37532 Positive_regulation of Bst1 5 0.40 2.23 3.37 5.00
133 INT19211 Binding of Shbg 35 0.48 16.29 3.31 5.00
134 INT85260 Negative_regulation of ATF7IP 14 0.41 7.08 3.17 5.00
135 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 5.00
136 INT73918 Transcription of Esr1 21 0.66 8.74 3.12 5.00
137 INT82168 Positive_regulation of S100b 20 0.68 9.72 3.08 5.00
138 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 5.00
139 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01 5.00
140 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68 5.00
141 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 5.00
142 INT7978 Positive_regulation of Nsdhl 9 0.43 5.6 2.63 5.00
143 INT15606 Localization of FSHB 24 0.78 9.16 2.49 5.00
144 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
145 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
146 INT43880 Binding of Scgb1d2 10 0.48 0.33 2.39 5.00
147 INT63394 Gene_expression of Drd5 7 0.76 1.85 2.3 5.00
148 INT13267 Binding of Pgr 15 0.40 3.5 2.22 5.00
149 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17 5.00
150 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
151 INT84722 Regulation of Gene_expression of AR 20 0.61 7.73 1.69 5.00
152 INT19747 Regulation of Egf 14 0.46 4.67 1.68 5.00
153 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62 5.00
154 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6 5.00
155 INT139164 Gene_expression of Nrgn 6 0.72 1.31 1.59 5.00
156 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55 5.00
157 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
158 INT63185 Binding of Ddt 3 0.29 0.4 1.41 5.00
159 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39 5.00
160 INT48269 Negative_regulation of FANCB 16 0.56 5.34 1.38 5.00
161 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
162 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 5.00
163 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 5.00
164 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2 5.00
165 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
166 INT282572 Positive_regulation of POU5F1 24 0.70 5.8 1.13 5.00
167 INT33884 Gene_expression of Ptprg 3 0.59 0.83 1.07 5.00
168 INT63393 Positive_regulation of Gene_expression of Drd5 3 0.49 1.21 1.02 5.00
169 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 5.00
170 INT181587 Negative_regulation of OPN1SW 12 0.51 4.36 0.89 5.00
171 INT29762 Negative_regulation of P4hb 4 0.21 1.41 0.86 5.00
172 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84 5.00
173 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8 5.00
174 INT139165 Negative_regulation of Nrgn 1 0.54 1.08 0.76 5.00
175 INT28278 Positive_regulation of Binding of Oxt 2 0.43 0.75 0.76 5.00
176 INT186941 Localization of Nsdhl 2 0.46 2.7 0.74 5.00
177 INT199812 Localization of CTSL1 2 0.30 0.16 0.73 5.00
178 INT287087 Localization of EEC1 2 0.61 1.6 0.72 5.00
179 INT232465 Positive_regulation of ZMYND10 4 0.67 2.07 0.71 5.00
180 INT73917 Regulation of Transcription of Esr1 4 0.25 1.5 0.7 5.00
181 INT261350 Positive_regulation of Ifi205 1 0.02 0.13 0.66 5.00
182 INT204254 Localization of KIT 8 0.73 6.78 0.61 5.00
183 INT29619 Negative_regulation of Gene_expression of FSHB 5 0.05 0.59 0.57 5.00
184 INT261352 Gene_expression of Ifi205 2 0.19 0.39 0.54 5.00
185 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 5.00
186 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51 5.00
187 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49 5.00
188 INT150497 Regulation of Bst1 2 0.24 0.99 0.47 5.00
189 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 5.00
190 INT3129 Phosphorylation of LH 2 0.69 0.44 0.46 5.00
191 INT217265 Positive_regulation of Gene_expression of Litaf 3 0.06 1.42 0.46 5.00
192 INT261353 Negative_regulation of Gene_expression of Nsdhl 1 0.17 0.71 0.43 5.00
193 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 5.00
194 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41 5.00
195 INT7979 Binding of Nsdhl 6 0.30 3.71 0.4 5.00
196 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38 5.00
197 INT186535 Negative_regulation of Gene_expression of Esr2 2 0.25 1.07 0.38 5.00
198 INT186939 Positive_regulation of Positive_regulation of Nsdhl 2 0.31 0.86 0.34 5.00
199 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 5.00
200 INT199813 Negative_regulation of PTPRJ 2 0.41 2.09 0.32 5.00
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