D:Hypothyroidism

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Disease Term
Synonyms Goitrous Hypothyroidism, HYPOTHYROIDISMS, Lithium Induced Goiter, Lithium Induced Goitre, Myxedema, Myxedema Coma, Myxoedema, Myxoedema Coma, Primary Hypothyroidism, Seconary Hypothyroidism, Subclinical Hypothyroidism
Documents 170
Hot Single Events 89
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypothyroidism. They are ordered first by their relevance to Hypothyroidism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT92093 Lhb Positive_regulation of Localization of POMC 1 0.01 1.88 0.17 99.84
2 INT92088 ASNA1 Positive_regulation of Localization of POMC 1 0.00 0.97 0.13 98.08
3 INT92089 ASNA1 Positive_regulation of POMC 1 0.00 0.97 0.13 97.68
4 INT1390 Trh Positive_regulation of Prl 14 0.67 4.42 4.39 95.00
5 INT286228 Binding of Tpo and Ceat1 1 0.00 1.28 0.04 94.48
6 INT25036 TRH Regulation of Prl 4 0.27 1.75 1.09 93.60
7 INT311432 Binding of TSHR and TAOK1 1 0.12 1.05 0.07 85.08
8 INT17523 Ghsr Positive_regulation of Localization of Gh 2 0.02 0.24 0.13 84.44
9 INT286229 Psmb9 Regulation of Tpo 1 0.07 1.01 0 82.72
10 INT322733 CD40LG Positive_regulation of Gene_expression of CD40 1 0.08 0.62 0.18 73.52
11 INT322734 Binding of CD40LG and Positive_regulation of CD40 1 0.07 0.62 0.18 73.20
12 INT307054 RHCE Regulation of AKTIP 1 0.00 0.6 0 56.40
13 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0 36.88
14 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0 30.52
15 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 29.68
16 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0 25.96
17 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0 25.96
18 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 25.56
19 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0 24.68
20 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0 24.68
21 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 23.16
22 INT350119 Positive_regulation of GNRH1 Positive_regulation of PLOD1 1 0.04 0.86 0.03 21.80
23 INT350114 Positive_regulation of GNRH1 Positive_regulation of FSHR 1 0.05 0.86 0.03 21.80
24 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 21.40
25 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 20.96
26 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 20.96
27 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
28 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
29 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 5.00
30 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
31 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 5.00
32 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29 5.00
33 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 0.19 1.04 0.22 5.00
34 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 5.00
35 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15 5.00
36 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 5.00
37 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 5.00
38 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
39 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 5.00
40 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
41 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0 5.00
42 INT249664 Binding of CD81 and CHCHD2 1 0.00 2.51 0 5.00
43 INT290861 MNT Positive_regulation of INS 1 0.03 1.78 0 5.00
44 INT306764 Binding of Aes and ZMYND10 1 0.04 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypothyroidism. They are ordered first by their pain relevance and then by number of times they were reported in Hypothyroidism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT189088 Gene_expression of Psmb9 2 0.75 18.79 0.75 99.92
2 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.92
3 INT443 Localization of POMC 1020 0.81 284.52 443.17 99.84
4 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.84
5 INT5127 Localization of Lhb 488 0.80 50.48 162.66 99.84
6 INT7105 Gene_expression of pad 54 0.77 63.68 8.8 99.84
7 INT19009 Positive_regulation of Ghsr 17 0.64 5.71 2.78 99.66
8 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21 99.66
9 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.56
10 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 99.52
11 INT23366 Positive_regulation of Tshb 10 0.50 4.11 1.79 99.50
12 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.42
13 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.42
14 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.40
15 INT286206 Gene_expression of Ceat1 1 0.04 1.48 0.18 99.38
16 INT286198 Negative_regulation of Psmb9 1 0.42 2.95 0.03 99.32
17 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 99.32
18 INT286197 Positive_regulation of Gene_expression of Psmb9 1 0.49 2.44 0.21 99.32
19 INT921 Regulation of GH1 172 0.60 52.88 51.04 99.12
20 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 99.12
21 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78 99.12
22 INT132477 Negative_regulation of TSHB 5 0.45 3.24 0.05 99.10
23 INT286191 Negative_regulation of Tpo 1 0.06 1.57 0.05 98.80
24 INT253 Regulation of PRL 184 0.62 47.27 65.79 98.76
25 INT163259 Positive_regulation of Tpo 1 0.14 1.16 0.17 98.76
26 INT21067 Regulation of Regulation of PRL 11 0.60 2 5.31 98.76
27 INT27315 Positive_regulation of TPO 17 0.45 9.84 2.28 98.60
28 INT92090 Negative_regulation of Protein_catabolism of Crh 1 0.04 0.99 0.12 98.52
29 INT83897 Protein_catabolism of Crh 2 0.86 1.75 0.39 98.52
30 INT307060 Negative_regulation of AKTIP 6 0.01 2.79 0.08 98.32
31 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 98.24
32 INT2004 Localization of ASNA1 3 0.08 0.97 0.92 98.08
33 INT286208 Negative_regulation of Localization of Psmb9 1 0.41 0.74 0 98.08
34 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 97.92
35 INT286201 Localization of Psmb9 1 0.73 0.74 0 97.68
36 INT403 Localization of Trh 241 0.81 28.55 81.45 97.64
37 INT1327 Regulation of Localization of Trh 45 0.62 6.05 22.09 97.64
38 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 97.56
39 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.56
40 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 97.56
41 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 97.56
42 INT13716 Positive_regulation of TH 33 0.68 19.11 16 97.52
43 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 97.24
44 INT42210 Positive_regulation of TSHB 6 0.49 3.48 1.01 96.98
45 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53 96.08
46 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 96.08
47 INT34777 Localization of IGF1 82 0.80 42.68 8.62 95.68
48 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 95.68
49 INT1530 Regulation of Gh 382 0.61 115.96 112.47 94.92
50 INT16220 Negative_regulation of Regulation of Gh 13 0.42 3.59 4.33 94.92
51 INT18661 Localization of Ghsr 32 0.78 3.19 5.2 94.88
52 INT1512 Binding of Prl 73 0.48 26.22 20.63 94.80
53 INT16898 Localization of GHSR 8 0.74 1.76 0.91 94.56
54 INT5095 Localization of Ghrh 185 0.81 28.09 62.08 94.16
55 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 93.96
56 INT286207 Positive_regulation of Tpo 1 0.07 0.78 0 93.32
57 INT5454 Localization of CRH 124 0.79 79.18 41.53 92.44
58 INT33517 Gene_expression of TSHR 20 0.71 14.65 1.45 92.12
59 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 90.88
60 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 90.72
61 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 90.04
62 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 89.80
63 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 89.44
64 INT286193 Negative_regulation of Binding of Ceat1 1 0.03 1.79 0.07 89.04
65 INT286202 Binding of Ceat1 1 0.03 1.78 0.07 89.04
66 INT286196 Binding of Psmb9 3 0.36 1.95 0.33 88.92
67 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 88.16
68 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03 88.16
69 INT286190 Regulation of Localization of Psmb8 1 0.27 1.03 0 88.00
70 INT33516 Positive_regulation of TSHR 4 0.49 2.5 0.93 87.24
71 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 87.04
72 INT217952 Negative_regulation of MYH7 2 0.01 1.85 0.09 86.80
73 INT286192 Localization of Psmb8 1 0.45 1.02 0 86.72
74 INT286199 Regulation of Gene_expression of Psmb9 1 0.44 2.29 0.03 86.20
75 INT7035 Regulation of CGA 87 0.45 29.04 28.45 85.60
76 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 85.36
77 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 85.28
78 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 84.68
79 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 84.44
80 INT252 Localization of GH1 529 0.80 227.4 122.05 84.16
81 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 84.16
82 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 83.92
83 INT93350 Binding of Lepr 17 0.05 27.21 1.5 83.52
84 INT85963 Gene_expression of LIFR 23 0.75 9 0.98 83.08
85 INT49370 Localization of IGFBP3 21 0.81 9.85 0.71 82.72
86 INT307056 Positive_regulation of Localization of IGFBP3 1 0.39 0.99 0 82.72
87 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5 82.64
88 INT39265 Positive_regulation of Tapbp 2 0.17 2.28 0.08 80.84
89 INT56180 Negative_regulation of sch 8 0.43 2.99 0.36 80.56
90 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 79.96
91 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 79.76
92 INT286209 Positive_regulation of Psmb9 1 0.67 5.66 0.54 79.08
93 INT219980 Positive_regulation of THRA 4 0.49 1.17 0.96 78.60
94 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0 78.12
95 INT100861 Binding of CRP 179 0.48 175.2 26.45 76.24
96 INT178455 Localization of LIFR 6 0.61 2.24 0.83 75.76
97 INT294699 Negative_regulation of Localization of LIFR 2 0.04 1.52 0.67 75.76
98 INT20936 Binding of MGP 13 0.40 3.55 3.59 75.28
99 INT268701 Negative_regulation of SLC25A5 2 0.31 2.61 0.08 75.04
100 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 75.00
101 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 74.72
102 INT208225 Positive_regulation of Gene_expression of TSHR 2 0.46 2.84 0.22 74.04
103 INT311447 Negative_regulation of Gene_expression of TSHR 1 0.39 2.24 0.08 74.04
104 INT311450 Regulation of Gene_expression of TSHR 1 0.25 1.16 0.06 74.04
105 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 73.92
106 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 73.52
107 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 73.08
108 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 72.48
109 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 72.32
110 INT36686 Regulation of Tg 7 0.19 3.12 0.45 71.16
111 INT425 Localization of PRL 455 0.81 189.64 144.8 71.08
112 INT3505 Binding of TH 5 0.39 2.6 1.8 70.40
113 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38 70.40
114 INT10019 Binding of CD8A 57 0.36 31.49 10.08 70.36
115 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 69.68
116 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 69.36
117 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 68.16
118 INT23257 Regulation of CRP 127 0.62 100.05 21.87 68.16
119 INT211806 Gene_expression of PLXNC1 4 0.63 2.95 0.07 67.12
120 INT35295 Positive_regulation of RHCE 5 0.30 2.22 0.39 66.92
121 INT1793 Localization of CGA 379 0.81 67.38 114.69 65.52
122 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 65.28
123 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 65.28
124 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 64.68
125 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 64.40
126 INT286210 Regulation of Psmb9 1 0.44 2.03 0.19 64.04
127 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 60.44
128 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 60.12
129 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 60.00
130 INT189096 Gene_expression of Psmb8 3 0.47 5.92 0.6 59.20
131 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 58.00
132 INT249 Localization of GHRH 215 0.80 78.02 51.87 56.92
133 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 56.24
134 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 55.96
135 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 55.96
136 INT954 Positive_regulation of Gene_expression of GHRH 18 0.50 7.6 1.63 55.96
137 INT318136 Positive_regulation of Gene_expression of HBB 1 0.04 2.65 0 55.80
138 INT128794 Negative_regulation of Gene_expression of HBB 1 0.59 5.98 0.06 55.40
139 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 55.08
140 INT286205 Gene_expression of Tpo 1 0.09 2.32 0.18 55.04
141 INT286194 Positive_regulation of Gene_expression of Tpo 1 0.07 1.16 0.15 55.04
142 INT286204 Positive_regulation of Gene_expression of Psmb8 1 0.30 1.16 0.15 54.44
143 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 54.04
144 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 54.04
145 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 54.00
146 INT274104 Regulation of PLXNA2 2 0.33 2.66 0.25 53.92
147 INT202499 Positive_regulation of Psmb8 2 0.42 2.98 0.51 53.32
148 INT1650 Regulation of TSHR 3 0.28 0.88 1.99 53.04
149 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 52.40
150 INT142735 Regulation of RLS 33 0.53 45.83 11.35 51.04
151 INT286203 Protein_catabolism of Dag1 2 0.26 1.56 0.22 50.00
152 INT346713 Positive_regulation of AKTIP 1 0.01 0.31 0.05 50.00
153 INT286211 Positive_regulation of Binding of Psmb9 1 0.49 0 0.04 50.00
154 INT286200 Gene_expression of Psmb6 1 0.01 0.35 0 50.00
155 INT286195 Regulation of Tpo 1 0.08 0.34 0 50.00
156 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 49.76
157 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 49.24
158 INT9683 Binding of GH1 57 0.47 21.14 5.99 44.68
159 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 44.08
160 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 40.24
161 INT397 Localization of SST 232 0.81 58.05 101.19 38.84
162 INT30317 Regulation of TH 14 0.43 7.27 5.38 37.28
163 INT311440 Binding of G0S2 1 0.00 0.55 0 37.24
164 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 37.12
165 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21 33.20
166 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 31.08
167 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 31.08
168 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 31.08
169 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 31.08
170 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 30.92
171 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 30.92
172 INT12082 Localization of IL6 365 0.81 241.78 105.78 30.48
173 INT6849 Localization of IL1B 229 0.81 112.56 69.63 30.48
174 INT74423 Localization of IL10 91 0.80 61.6 22.95 30.48
175 INT69158 Localization of IL4 48 0.71 31.3 11.98 30.48
176 INT69156 Localization of IL5 21 0.68 14.95 5.37 30.48
177 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 29.68
178 INT256822 Binding of Gm3813 2 0.36 1.81 0.08 28.92
179 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 27.24
180 INT184418 Negative_regulation of Positive_regulation of GOPC 15 0.26 5.47 0.87 27.24
181 INT180534 Gene_expression of SARS 40 0.59 35.47 0.81 26.32
182 INT207239 Binding of HBE1 2 0.20 1.53 0 25.56
183 INT39463 Positive_regulation of Tg 15 0.69 11.49 2.46 25.00
184 INT87963 Regulation of Tg 3 0.45 2.7 0.32 25.00
185 INT99619 Regulation of ASNA1 1 0.00 0.53 0.19 25.00
186 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 24.68
187 INT920 Localization of PLOD1 223 0.81 42.25 78.7 24.04
188 INT912 Localization of FSHR 91 0.79 23.61 15.58 23.92
189 INT276148 Negative_regulation of Positive_regulation of SLC25A5 1 0.08 0.68 0.03 23.76
190 INT276150 Positive_regulation of SLC25A5 1 0.13 0.68 0.03 22.60
191 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 22.44
192 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 22.44
193 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 21.12
194 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 20.36
195 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 18.92
196 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 18.92
197 INT177467 Negative_regulation of MTRF1 22 0.05 11.84 5.57 18.64
198 INT18825 Gene_expression of PRLR 8 0.40 2 3.47 18.16
199 INT307059 Localization of AKTIP 1 0.01 0.48 0.14 13.80
200 INT352185 Negative_regulation of PCDH11X 1 0.01 0.83 0 11.60
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