D:Hypoxia

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Disease Term
Synonyms Anoxia, ANOXIAS, Decreased Oxygen Supply, Deficiencies Oxygen, Deficiency Oxygen, HYPOXIAS, Hypoxic, Oxygen Decrease, Oxygen Deficiencies, Oxygen Deficiency
Documents 4358
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypoxia. They are ordered first by their relevance to Hypoxia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22 100.00
2 INT262710 Binding of Crem and Hif1a 1 0.00 1.85 0 100.00
3 INT149730 LOC500077 Regulation of Cebpz 1 0.34 1.23 0.77 100.00
4 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 100.00
5 INT280273 Tgfb1 Regulation of VEGFA 1 0.01 0.88 0 100.00
6 INT280269 Tgfb1 Regulation of Cxcr4 1 0.04 0.88 0 100.00
7 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1 100.00
8 INT262709 Binding of Crem and Gtf3a 1 0.00 0.92 0 100.00
9 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62 100.00
10 INT186187 LDLR Regulation of Gene_expression of SCARB1 1 0.17 1.71 0.04 100.00
11 INT281814 Negative_regulation of Akt1 Positive_regulation of Phgdh 1 0.00 1.7 0 100.00
12 INT323438 Binding of Hif1a and Vhl Positive_regulation of Positive_regulation of Hif1a 1 0.05 0.74 0.12 100.00
13 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 100.00
14 INT107031 Regulation of Binding of Tacr1 and Oprm1 1 0.29 0.5 0.21 100.00
15 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35 100.00
16 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 100.00
17 INT181899 TNF Regulation of ANGPT1 1 0.03 1.22 0.33 100.00
18 INT181893 TNF Regulation of ANGPT2 1 0.04 1.22 0.33 100.00
19 INT181896 TNF Regulation of TEK 1 0.03 1.21 0.33 100.00
20 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15 100.00
21 INT350984 Positive_regulation of VHL Positive_regulation of VEGFA 1 0.27 2.74 0 100.00
22 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0 100.00
23 INT219406 AHR Positive_regulation of CBL 1 0.03 0.65 0 100.00
24 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04 100.00
25 INT327339 Gtf3a Positive_regulation of VEGFA 1 0.00 2.34 0.58 100.00
26 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05 100.00
27 INT314011 VEGFA Regulation of IL19 1 0.04 1.11 0.08 100.00
28 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0 100.00
29 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13 100.00
30 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 100.00
31 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 100.00
32 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07 100.00
33 INT148818 IL1B Regulation of Gene_expression of TNC 1 0.29 0.57 0.47 100.00
34 INT191002 F2 Positive_regulation of Gene_expression of IL8 1 0.02 0.46 0.06 100.00
35 INT351098 MTOR Regulation of Binding of EPAS1 1 0.08 0.95 0 100.00
36 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48 100.00
37 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47 100.00
38 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 100.00
39 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 100.00
40 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 100.00
41 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28 100.00
42 INT305207 Pbrgcsf1 Positive_regulation of Gtf3a 1 0.00 0.36 0.13 100.00
43 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12 100.00
44 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11 100.00
45 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11 100.00
46 INT352751 Pkd2 Regulation of Localization of Vegfa 1 0.11 0.47 0.1 100.00
47 INT352750 Pkd2 Positive_regulation of Vegfa 1 0.20 0.47 0.1 100.00
48 INT304322 Hif1a Positive_regulation of Positive_regulation of VEGFA 1 0.11 0.39 0.05 100.00
49 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05 100.00
50 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 100.00
51 INT186186 LDLR Regulation of SCARB1 1 0.08 0.65 0.03 100.00
52 INT345163 Lpar1 Positive_regulation of Gtf3a 1 0.00 0.77 0 100.00
53 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0 100.00
54 INT240725 Esr1 Positive_regulation of Localization of Ca2 1 0.03 0.72 0 99.98
55 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0 99.98
56 INT294828 DPYD Positive_regulation of PIK3CB 1 0.00 0.51 0 99.98
57 INT294827 DPYD Positive_regulation of Gene_expression of REXO1 1 0.01 0.47 0 99.98
58 INT294831 DPYD Positive_regulation of Positive_regulation of RASGRP1 1 0.00 0.53 0 99.98
59 INT294880 DPYD Positive_regulation of Ephb1 1 0.00 0.53 0 99.98
60 INT107032 Binding of Tacr1 and Oprm1 1 0.31 0.5 0.21 99.96
61 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0 99.96
62 INT337092 Binding of HRES1 and Gtf3a 1 0.00 1.52 0 99.92
63 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1 99.92
64 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1 99.92
65 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1 99.92
66 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1 99.92
67 INT327336 Binding of VEGFA and Elavl1 1 0.06 0.94 0.04 99.92
68 INT142932 Binding of Arid1a and Samsn1 1 0.01 1.55 0 99.88
69 INT280272 VEGFA Regulation of Cxcr4 1 0.05 0.87 0 99.84
70 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48 99.84
71 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14 99.84
72 INT153720 Binding of VEGFA and Pscs 1 0.32 3.12 0.41 99.82
73 INT260728 Binding of Samsn1 and NAFLD2 1 0.00 1.15 0.05 99.82
74 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15 99.80
75 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 99.78
76 INT329225 Prkag1 Positive_regulation of Akt1 1 0.09 1.27 0.07 99.78
77 INT160225 Acot1 Negative_regulation of Ache 1 0.28 2.18 0.25 99.76
78 INT160226 Acot1 Negative_regulation of Ache Positive_regulation of Acot1 1 0.23 1.18 0.13 99.76
79 INT297159 Gsta3 Negative_regulation of Hif1a 1 0.00 0.54 0.03 99.74
80 INT323431 Binding of Hif1a and Vhl 1 0.07 0.68 0.12 99.72
81 INT294825 Phosphorylation of GRAP2 Regulation of Gene_expression of REXO1 1 0.03 0.48 0 99.70
82 INT294830 Phosphorylation of STAT3 Regulation of Gene_expression of REXO1 1 0.08 0.48 0 99.70
83 INT294881 Phosphorylation of Mdk Regulation of Gene_expression of REXO1 1 0.02 0.48 0 99.70
84 INT294829 STAT3 Regulation of Gene_expression of REXO1 1 0.10 0.48 0 99.70
85 INT262826 Serpinf1 Negative_regulation of Gene_expression of TNF 1 0.29 1.83 0.28 99.68
86 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54 99.60
87 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 99.60
88 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11 99.56
89 INT279144 RNF139 Regulation of TSN 1 0.24 3.47 0 99.52
90 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 99.46
91 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29 99.46
92 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19 99.44
93 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19 99.44
94 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19 99.44
95 INT280265 Binding of Cxcr4 and Tgfb1 1 0.06 0.89 0 99.44
96 INT280264 Negative_regulation of Binding of Cxcr4 and Tgfb1 1 0.07 0.89 0 99.44
97 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 99.44
98 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19 99.44
99 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19 99.44
100 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19 99.44
101 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19 99.44
102 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19 99.44
103 INT189558 Binding of VHL and LILRA3 1 0.05 0.94 0 99.36
104 INT180849 TGFB1 Positive_regulation of COL4A2 1 0.10 1.28 0 99.36
105 INT180865 TGFB1 Positive_regulation of S100A10 1 0.24 1.22 0 99.36
106 INT180861 TGFB1 Positive_regulation of MT1E 1 0.17 1.22 0 99.36
107 INT280276 Binding of Tgfb1 and Positive_regulation of VEGFA 1 0.02 1.27 0 99.28
108 INT240723 Atp2b2 Positive_regulation of Localization of Ca2 1 0.11 0.43 0 99.26
109 INT336339 Glp2r Positive_regulation of Timp1 1 0.16 1.82 0.36 99.20
110 INT350982 TSHB Regulation of VEGFA 1 0.01 0.64 0 99.20
111 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17 99.20
112 INT241400 Epas1 Positive_regulation of Gene_expression of VEGFA 1 0.03 1.09 0.07 99.18
113 INT249989 Agt Positive_regulation of Ca2 1 0.20 1.6 0.04 99.16
114 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0 99.16
115 INT261603 Il6 Regulation of Gene_expression of Vcam1 1 0.16 1.74 0.46 99.16
116 INT245835 Plg Negative_regulation of Gene_expression of VEGFA 1 0.05 3.51 0 99.16
117 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13 99.16
118 INT326726 Twist1 Regulation of Itk 1 0.02 0.84 0 99.14
119 INT216283 Bdnf Negative_regulation of Positive_regulation of Ephb1 1 0.04 0.99 0 99.12
120 INT247576 Binding of Hif1a and Vbp1 1 0.01 0.6 0 99.04
121 INT188318 MCPH1 Positive_regulation of Pah 3 0.02 3 0.85 99.04
122 INT166732 BATF Negative_regulation of PPIA 1 0.05 1.45 0.06 99.04
123 INT166734 BATF Negative_regulation of PPIL1 1 0.04 1.45 0.06 99.04
124 INT261607 Il6 Positive_regulation of smc 1 0.03 0.3 0.05 98.96
125 INT261604 Positive_regulation of Il6 Positive_regulation of smc 1 0.03 0.3 0.05 98.96
126 INT125153 IL1B Regulation of ITGB2 1 0.22 0.1 0.2 98.92
127 INT125154 IL1B Regulation of Gene_expression of ITGB2 1 0.50 0.1 0.2 98.92
128 INT125155 IL1B Regulation of ITGAM 1 0.49 0.1 0.2 98.92
129 INT125156 IL1B Regulation of Gene_expression of ITGAM 1 0.49 0.1 0.2 98.92
130 INT125152 IL1B Regulation of Gene_expression of ICAM1 1 0.50 0.1 0.2 98.92
131 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21 98.84
132 INT180860 TGFB1 Regulation of Transcription of NID2 1 0.23 0.77 0 98.80
133 INT180852 TGFB1 Regulation of Transcription of TM4SF1 1 0.24 0.77 0 98.80
134 INT180858 TGFB1 Regulation of Transcription of IGFBP3 1 0.24 0.77 0 98.80
135 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13 98.76
136 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14 98.76
137 INT338827 Binding of Slc40a1 and HAMP 1 0.00 0.27 0.05 98.76
138 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0 98.72
139 INT279145 Binding of VHL and RNF139 1 0.30 1.87 0 98.64
140 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29 98.64
141 INT47352 Positive_regulation of Binding of Ralbp1 and Ccl4 1 0.14 0.17 0.14 98.62
142 INT249988 Agt Regulation of Ca2 1 0.18 0.9 0.04 98.60
143 INT260495 VEGFA Positive_regulation of Grin1 1 0.08 1.08 0.12 98.28
144 INT260497 VEGFA Positive_regulation of Gria2 1 0.03 1.08 0.12 98.28
145 INT303010 Ptgis Positive_regulation of Rock2 1 0.05 1.23 0.03 98.28
146 INT47351 Binding of Ralbp1 and Ccl4 1 0.11 0.17 0.14 98.28
147 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0 98.28
148 INT351976 Binding of Tp53 and Stk11 1 0.13 2.3 0 98.28
149 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42 98.24
150 INT191001 F3 Positive_regulation of F2 1 0.00 0.62 0.14 98.22
151 INT249924 Cpox Positive_regulation of Hif1a 1 0.01 0.68 0 98.16
152 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29 98.16
153 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37 98.12
154 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06 98.12
155 INT337303 Positive_regulation of PTAFR Positive_regulation of EDNRA 1 0.04 1.21 0.06 98.12
156 INT245822 Plg Negative_regulation of Phosphorylation of Mapk3 1 0.10 2.09 0 98.08
157 INT314054 Gtf3a Positive_regulation of Gene_expression of VEGFA 1 0.00 1.7 0.16 98.08
158 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 98.04
159 INT327182 Binding of Mpl and Thpo 1 0.41 0.54 0.37 98.00
160 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15 97.92
161 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 97.92
162 INT336335 Glp2r Regulation of Mmp13 1 0.06 0.68 0.28 97.80
163 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3 97.80
164 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22 97.68
165 INT243214 Myst2 Negative_regulation of Gene_expression of Ptgs2 1 0.01 1.4 0.28 97.64
166 INT339260 EPAS1 Positive_regulation of VEGFA 1 0.19 3.67 0 97.60
167 INT240722 Cd38 Positive_regulation of Localization of Ca2 1 0.04 0.79 0 97.60
168 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13 97.60
169 INT350980 ESR1 Regulation of VEGFA 1 0.01 0.62 0 97.60
170 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08 97.56
171 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24 97.28
172 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29 97.28
173 INT304321 Ptger4 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.59 0.23 97.28
174 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26 97.20
175 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26 97.20
176 INT272161 Gh1 Negative_regulation of Gh1 Regulation of Bcl2 1 0.24 1.2 0.26 97.20
177 INT158399 Binding of Preb and Frg1 1 0.01 0.3 0.62 97.20
178 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08 97.12
179 INT185516 Binding of Igfbp2 and Csf2 1 0.14 0.29 0.17 97.10
180 INT178060 EDN1 Positive_regulation of EDN1 Positive_regulation of HIF1A 1 0.03 1.13 0.08 97.08
181 INT247849 Edn1 Regulation of Gene_expression of Aqp4 1 0.12 1.05 0 97.08
182 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0 97.04
183 INT216284 Bdnf Negative_regulation of Phosphorylation of Mapk14 1 0.04 0.97 0 97.00
184 INT343719 Nlrp1a Positive_regulation of PAH 1 0.00 1.9 0.04 96.88
185 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27 96.76
186 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2 96.76
187 INT314055 THL Negative_regulation of Localization of VEGFA 1 0.04 3.73 0.11 96.72
188 INT314056 THL Negative_regulation of VEGFA 1 0.03 0.85 0.06 96.72
189 INT345287 Binding of SCN10A and RAPGEF5 1 0.01 0.67 0 96.68
190 INT245074 Gene_expression of VHL Negative_regulation of Gene_expression of CXCR4 1 0.31 1.84 0 96.64
191 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6 96.64
192 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04 96.56
193 INT350983 TP53 Regulation of VEGFA 1 0.03 0.61 0 96.48
194 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 96.40
195 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4 96.40
196 INT92196 Binding of EDNRB and Edn3 1 0.03 0.91 0 96.40
197 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 96.40
198 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 96.40
199 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 96.24
200 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07 96.24

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypoxia. They are ordered first by their pain relevance and then by number of times they were reported in Hypoxia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
2 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 100.00
3 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 100.00
4 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 100.00
5 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 100.00
6 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 100.00
7 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07 100.00
8 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23 100.00
9 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 100.00
10 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 100.00
11 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 100.00
12 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 100.00
13 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45 100.00
14 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 100.00
15 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 100.00
16 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17 100.00
17 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 100.00
18 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27 100.00
19 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 100.00
20 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 100.00
21 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 100.00
22 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 100.00
23 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 100.00
24 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 100.00
25 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 100.00
26 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44 100.00
27 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 100.00
28 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 100.00
29 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96 100.00
30 INT249976 Gene_expression of Igkv4-55 1 0.04 5.98 0.31 100.00
31 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
32 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 100.00
33 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 100.00
34 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 100.00
35 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68 100.00
36 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 100.00
37 INT135169 Binding of Hif1a 22 0.47 12.48 0.79 100.00
38 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 100.00
39 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 100.00
40 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51 100.00
41 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 100.00
42 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 100.00
43 INT133112 Regulation of Baat 2 0.61 11.99 1.2 100.00
44 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 100.00
45 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17 100.00
46 INT38111 Negative_regulation of VIPR1 3 0.12 3.79 1.45 100.00
47 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 100.00
48 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 100.00
49 INT341637 Negative_regulation of Atp11a 1 0.13 6.97 0 100.00
50 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 100.00
51 INT143443 Localization of HIF1A 14 0.78 10.93 1.49 100.00
52 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 100.00
53 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 100.00
54 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 100.00
55 INT249978 Positive_regulation of Gene_expression of Igkv4-55 1 0.04 2.94 0.16 100.00
56 INT119753 Regulation of Pscs 7 0.45 12.88 4 100.00
57 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 100.00
58 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 100.00
59 INT22083 Regulation of Pth 55 0.62 22.32 8.9 100.00
60 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 100.00
61 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 100.00
62 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 100.00
63 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 100.00
64 INT136752 Positive_regulation of Gene_expression of SCARB1 5 0.69 10.63 1.76 100.00
65 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 100.00
66 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8 100.00
67 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64 100.00
68 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47 100.00
69 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51 100.00
70 INT126479 Regulation of Cxcr4 11 0.58 10.75 0.34 100.00
71 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 100.00
72 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 100.00
73 INT2541 Binding of Calca 200 0.48 67.14 134.62 100.00
74 INT260480 Transcription of Gsk3b 1 0.02 3.08 0 100.00
75 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 100.00
76 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 100.00
77 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 100.00
78 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83 100.00
79 INT136753 Regulation of Gene_expression of SCARB1 2 0.60 7.79 0.77 100.00
80 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5 100.00
81 INT12031 Negative_regulation of Car1 44 0.59 20.46 19.36 100.00
82 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63 100.00
83 INT49536 Regulation of Regulation of Ca2 6 0.38 3.89 1.13 100.00
84 INT213447 Gene_expression of APOLD1 1 0.09 2.98 0.22 100.00
85 INT232785 Localization of Hif1a 8 0.46 10.37 1.33 100.00
86 INT83799 Phosphorylation of Bcl2l1 8 0.82 7.86 2.23 100.00
87 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51 100.00
88 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 100.00
89 INT94784 Binding of ROS1 113 0.40 71.57 10.26 100.00
90 INT121964 Positive_regulation of Positive_regulation of Casp9 8 0.32 5.52 1.73 100.00
91 INT106757 Gene_expression of Dusp1 9 0.66 10.45 7.26 100.00
92 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 100.00
93 INT19775 Localization of Il1 183 0.78 145.5 50.91 100.00
94 INT249914 Positive_regulation of Epas1 2 0.19 2.42 0.05 100.00
95 INT24122 Positive_regulation of Ltf 9 0.61 5.33 2.44 100.00
96 INT189614 Gene_expression of EGLN1 6 0.49 4.3 0.12 100.00
97 INT154437 Positive_regulation of Slc2a1 4 0.26 2.67 1.08 100.00
98 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36 100.00
99 INT92509 Regulation of Sh2b2 7 0.35 3.41 3.8 100.00
100 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 100.00
101 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2 100.00
102 INT193016 Regulation of EPAS1 9 0.15 7.38 0.06 100.00
103 INT54895 Binding of Epo 24 0.48 11.38 4.48 100.00
104 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 100.00
105 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27 100.00
106 INT11937 Localization of Il6 228 0.81 139.83 64.39 100.00
107 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03 100.00
108 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 100.00
109 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 100.00
110 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
111 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23 100.00
112 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 100.00
113 INT60684 Positive_regulation of Negative_regulation of VIPR1 1 0.13 1.3 0.4 100.00
114 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63 100.00
115 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 100.00
116 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 100.00
117 INT161778 Regulation of Gene_expression of Esr1 13 0.51 9.46 0.73 100.00
118 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 100.00
119 INT93947 Regulation of Gene_expression of Timp1 5 0.25 5.04 3.42 100.00
120 INT82079 Positive_regulation of Lep 79 0.70 40 11.07 100.00
121 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
122 INT6481 Binding of TNF 624 0.48 510.2 214.82 100.00
123 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53 100.00
124 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 100.00
125 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 100.00
126 INT203949 Regulation of Srebf1 8 0.38 3.19 0.48 100.00
127 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 100.00
128 INT162725 Binding of Kdr 13 0.42 8.86 1.79 100.00
129 INT260478 Negative_regulation of Positive_regulation of Hif1a 2 0.30 1.23 0.09 100.00
130 INT141968 Positive_regulation of ADM 12 0.65 11.19 2 100.00
131 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7 100.00
132 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75 100.00
133 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21 100.00
134 INT260479 Positive_regulation of Gene_expression of Epor 1 0.48 0.91 0 100.00
135 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 100.00
136 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3 100.00
137 INT106020 Transcription of EPO 8 0.71 9.34 0.6 100.00
138 INT57903 Gene_expression of Sh2b3 2 0.07 1.09 0.6 100.00
139 INT143244 Negative_regulation of Phosphorylation of Actvty1 1 0.00 0.86 0.44 100.00
140 INT193815 Regulation of Gene_expression of CXCR4 17 0.61 20.27 1.15 100.00
141 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 100.00
142 INT201196 Negative_regulation of Gene_expression of PAH 2 0.30 3.11 0.19 100.00
143 INT115309 Gene_expression of Slc2a1 6 0.75 2.85 1.64 100.00
144 INT155351 Negative_regulation of Positive_regulation of CREM 1 0.00 1.3 0.27 100.00
145 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61 100.00
146 INT106756 Positive_regulation of Gene_expression of Dusp1 7 0.59 7.65 5.24 100.00
147 INT178587 Positive_regulation of DPYD 4 0.50 4.7 0.74 100.00
148 INT15296 Regulation of Rbm39 45 0.29 10.66 29.27 100.00
149 INT9655 Regulation of Il6 98 0.62 70.92 31.95 100.00
150 INT127463 Negative_regulation of Positive_regulation of PAH 1 0.30 2.3 0.27 100.00
151 INT260484 Regulation of Positive_regulation of Epor 1 0.26 1 0.05 100.00
152 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52 100.00
153 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89 100.00
154 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 100.00
155 INT14081 Regulation of Cyp2a5 11 0.50 7.91 2.18 100.00
156 INT144969 Binding of EPAS1 3 0.06 4.12 0.44 100.00
157 INT127145 Gene_expression of SET 46 0.65 10.39 1.7 100.00
158 INT213445 Regulation of Gene_expression of APOLD1 1 0.03 1.12 0.05 100.00
159 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72 100.00
160 INT122602 Transcription of Hif3a 1 0.63 0.78 0.22 100.00
161 INT103825 Regulation of Binding of Pth 1 0.27 0.63 0.45 100.00
162 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 100.00
163 INT100374 Positive_regulation of Positive_regulation of Flt1 1 0.09 0.99 0.62 100.00
164 INT116823 Regulation of Rgc32 2 0.44 1.82 1.03 100.00
165 INT173096 Regulation of DEC1 1 0.25 1.67 0 100.00
166 INT173094 Regulation of HK2 1 0.07 1.67 0 100.00
167 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03 100.00
168 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 100.00
169 INT2649 Regulation of Calca 433 0.62 146.05 330.95 100.00
170 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69 100.00
171 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0 100.00
172 INT297157 Negative_regulation of Negative_regulation of Hif1a 1 0.03 0.54 0.07 100.00
173 INT108340 Negative_regulation of Phosphorylation of BAD 11 0.49 8.29 1.02 100.00
174 INT232494 Localization of RANGAP1 5 0.11 1.5 0.49 100.00
175 INT68340 Positive_regulation of DEC1 2 0.25 2.28 0.06 100.00
176 INT108555 Positive_regulation of HK2 5 0.29 4.91 2.62 100.00
177 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4 100.00
178 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73 100.00
179 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 100.00
180 INT88920 Negative_regulation of Positive_regulation of Casp9 7 0.59 5.27 1.57 100.00
181 INT339265 Negative_regulation of Gene_expression of EPAS1 2 0.15 2.67 0 100.00
182 INT255664 Regulation of Gene_expression of Flt1 2 0.44 1.67 0.04 100.00
183 INT3978 Regulation of Regulation of cerebral blood flow 2 0.00 0.57 1.16 100.00
184 INT178393 Positive_regulation of Hist1h1a 2 0.67 0.62 0.08 100.00
185 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83 100.00
186 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 100.00
187 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 100.00
188 INT318432 Negative_regulation of Negative_regulation of Rad23b 1 0.41 1.03 0.17 100.00
189 INT18158 Negative_regulation of Positive_regulation of NA 11 0.36 1.45 1.45 100.00
190 INT20624 Regulation of Gene_expression of TNC 5 0.60 2.49 0.87 100.00
191 INT118791 Binding of AKT1 32 0.48 15.51 2.25 100.00
192 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53 100.00
193 INT339266 Regulation of Gene_expression of EPAS1 3 0.11 2.92 0.14 100.00
194 INT307842 Positive_regulation of Localization of Car9 1 0.26 1.04 0 100.00
195 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 100.00
196 INT307843 Localization of Car9 1 0.39 1.04 0 100.00
197 INT12082 Localization of IL6 365 0.81 241.78 105.78 100.00
198 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54 100.00
199 INT141969 Positive_regulation of Gene_expression of ADM 4 0.57 4.07 1.2 100.00
200 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 100.00
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