D:Ichthyosis

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Disease Term
Synonyms FISH SCALE DISEASE, ICHTHYOSES, Lamellar Ichthyosis, Skin Change Ichthyosiform, XERODERMA, Xerodermas
Documents 42
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ichthyosis. They are ordered first by their relevance to Ichthyosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 57.40
2 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 53.12
3 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 27.68
4 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13 22.28
5 INT311083 DST Regulation of FOS 1 0.03 0.15 0.08 5.00
6 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
7 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07 5.00
8 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07 5.00
9 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07 5.00
10 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
11 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
12 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
13 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
14 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
15 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04 5.00
16 INT303557 Binding of Dysf and Fgf22 1 0.01 0.45 0.03 5.00
17 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03 5.00
18 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03 5.00
19 INT303559 Binding of Fgf7 and Dysf 1 0.01 0.44 0.03 5.00
20 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
21 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
22 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
23 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
24 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
25 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
26 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ichthyosis. They are ordered first by their pain relevance and then by number of times they were reported in Ichthyosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT35558 Binding of Sts 4 0.32 3.76 0.48 100.00
2 INT232953 Binding of RBPJP3 1 0.03 0.26 0 99.76
3 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 99.74
4 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 95.00
5 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 95.00
6 INT163253 Binding of Flg 3 0.31 3.6 0.32 91.12
7 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 88.92
8 INT225958 Gene_expression of KRT12 13 0.68 1.57 0 88.84
9 INT176180 Negative_regulation of Nr1h2 6 0.16 7.47 0.69 87.52
10 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 87.52
11 INT232979 Gene_expression of RBPJP3 1 0.06 0.24 0 87.52
12 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 85.52
13 INT152045 Negative_regulation of Trav6-3 10 0.57 6.42 1.16 85.52
14 INT200136 Negative_regulation of ERCC2 1 0.37 1.91 0.07 84.96
15 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 81.12
16 INT116727 Gene_expression of Flg 3 0.53 3.13 0.34 80.88
17 INT116726 Negative_regulation of Gene_expression of Flg 1 0.01 0.45 0 80.88
18 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 80.72
19 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 75.80
20 INT200133 Negative_regulation of Xpa 5 0.58 9.85 0.09 74.52
21 INT94347 Gene_expression of DYSF 4 0.75 3.25 0.41 73.92
22 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24 72.32
23 INT180265 Localization of BCC1 7 0.65 9.48 0.15 66.36
24 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66 64.20
25 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42 64.20
26 INT285474 Negative_regulation of Gene_expression of Fgfr1 2 0.40 2.15 0.24 64.20
27 INT150949 Gene_expression of Fgfr1 6 0.63 5.71 0.57 63.88
28 INT126714 Binding of Xpc 1 0.34 1.69 0.1 59.08
29 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42 58.24
30 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2 58.24
31 INT145490 Binding of KRT76 2 0.36 0.29 0.09 55.64
32 INT232980 Binding of KRT3 2 0.29 0.43 0 55.64
33 INT73675 Gene_expression of Il1f6 2 0.09 3.3 0.37 52.80
34 INT303549 Positive_regulation of Gene_expression of Il1f6 1 0.08 0.96 0.22 52.80
35 INT232943 Binding of KRT12 3 0.47 0.88 0 51.28
36 INT232978 Localization of KRT4 1 0.35 0.2 0 49.08
37 INT187627 Gene_expression of KRT4 5 0.37 4.54 0 49.08
38 INT225960 Gene_expression of KRT13 4 0.39 2.47 0 49.00
39 INT232961 Localization of KRT13 1 0.38 0.2 0 48.96
40 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91 35.12
41 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01 35.12
42 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 29.16
43 INT303529 Positive_regulation of Gene_expression of Il1f8 1 0.27 0.89 0.25 25.36
44 INT303543 Gene_expression of Il1f8 1 0.42 3.28 1.43 24.72
45 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09 22.28
46 INT164348 Positive_regulation of KRT14 5 0.49 2 0.08 22.28
47 INT232969 Positive_regulation of KRT5 1 0.27 1.24 0 22.28
48 INT232992 Localization of KRT9 1 0.29 0.47 0 19.36
49 INT345344 Regulation of SMO 1 0.23 1.07 0.06 19.20
50 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27 17.80
51 INT232968 Negative_regulation of Gene_expression of KRT13 1 0.22 0.11 0 17.76
52 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24 17.32
53 INT99718 Positive_regulation of Gene_expression of FGFR2 9 0.49 4.47 0.12 16.36
54 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 15.96
55 INT303555 Negative_regulation of Gene_expression of FGFR2 2 0.41 0.31 0 15.96
56 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 11.52
57 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 11.52
58 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 11.12
59 INT238985 Positive_regulation of FGFR2 3 0.49 1.19 0 6.72
60 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
61 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
62 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
63 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
64 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
65 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
66 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
67 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
68 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
69 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
70 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
71 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
72 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
73 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
74 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
75 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
76 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
77 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
78 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 5.00
79 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
80 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
81 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
82 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
83 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
84 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
85 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
86 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
87 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
88 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
89 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 5.00
90 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
91 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
92 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
93 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
94 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 5.00
95 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 5.00
96 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
97 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
98 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
99 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
100 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
101 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
102 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
103 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 5.00
104 INT132246 Negative_regulation of S100a8 19 0.43 22 7.25 5.00
105 INT53189 Gene_expression of VSX1 32 0.69 10.59 7.21 5.00
106 INT5864 Localization of IL36RN 19 0.44 14.5 6.87 5.00
107 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
108 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
109 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
110 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
111 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
112 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
113 INT181054 Positive_regulation of S100a9 14 0.56 9.83 4.6 5.00
114 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6 5.00
115 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
116 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
117 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
118 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 5.00
119 INT148085 Binding of CXCL10 14 0.32 10.22 3.81 5.00
120 INT52678 Positive_regulation of VSX1 15 0.42 3.94 3.64 5.00
121 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52 5.00
122 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 5.00
123 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3 5.00
124 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
125 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 5.00
126 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 5.00
127 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97 5.00
128 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
129 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91 5.00
130 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
131 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
132 INT34830 Regulation of PGR 14 0.45 6.99 2.32 5.00
133 INT108250 Regulation of Prdx2 5 0.25 2.02 2.08 5.00
134 INT2116 Negative_regulation of VSX1 29 0.36 10.67 1.89 5.00
135 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
136 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74 5.00
137 INT233010 Gene_expression of PERP 5 0.26 6.04 1.66 5.00
138 INT69125 Gene_expression of Prlr 6 0.78 2 1.58 5.00
139 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
140 INT121335 Localization of SCD 10 0.68 6.81 1.51 5.00
141 INT28647 Binding of CTD 13 0.31 14.2 1.5 5.00
142 INT36777 Gene_expression of CTD 12 0.41 11.47 1.42 5.00
143 INT181032 Gene_expression of Fgf7 8 0.61 5.96 1.41 5.00
144 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
145 INT139725 Binding of CDCP1 3 0.01 2.1 1.4 5.00
146 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
147 INT126370 Localization of VSX1 6 0.56 1.7 1.28 5.00
148 INT101027 Binding of DST 20 0.41 10.9 1.17 5.00
149 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
150 INT127064 Gene_expression of KRT76 7 0.75 1.71 1.1 5.00
151 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 5.00
152 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 5.00
153 INT5006 Transcription of KRT20 9 0.46 7.11 1.03 5.00
154 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 5.00
155 INT58755 Binding of PAM 6 0.34 3.09 0.97 5.00
156 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 5.00
157 INT294726 Positive_regulation of Lts1 5 0.49 4.06 0.87 5.00
158 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87 5.00
159 INT29636 Localization of PAM 5 0.73 2.1 0.87 5.00
160 INT117120 Gene_expression of Krt14 20 0.75 6.53 0.77 5.00
161 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75 5.00
162 INT127633 Localization of KRT18 5 0.52 5.93 0.75 5.00
163 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75 5.00
164 INT129630 Regulation of Sod1 6 0.44 4.94 0.73 5.00
165 INT59175 Localization of TNMD 4 0.70 4.14 0.71 5.00
166 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 5.00
167 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
168 INT47553 Gene_expression of ARSH 11 0.42 4.93 0.65 5.00
169 INT195206 Binding of BCC1 15 0.41 21.3 0.62 5.00
170 INT117437 Protein_catabolism of KRT18 3 0.46 4.64 0.61 5.00
171 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 5.00
172 INT159143 Gene_expression of Ocln 14 0.42 5.25 0.57 5.00
173 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57 5.00
174 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 5.00
175 INT297421 Positive_regulation of Flg 1 0.40 1.6 0.53 5.00
176 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 5.00
177 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51 5.00
178 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
179 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
180 INT189634 Regulation of DCN 3 0.25 1.69 0.49 5.00
181 INT70445 Binding of KRT1 10 0.35 5.38 0.47 5.00
182 INT47805 Positive_regulation of Gspt1 5 0.11 1.02 0.47 5.00
183 INT61822 Negative_regulation of Ocln 8 0.41 5.33 0.45 5.00
184 INT303541 Gene_expression of Fgfr4 2 0.62 0.72 0.43 5.00
185 INT110777 Regulation of CTD 4 0.23 3.17 0.42 5.00
186 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 5.00
187 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 5.00
188 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 5.00
189 INT273630 Positive_regulation of Gene_expression of Lor 2 0.39 1.91 0.38 5.00
190 INT273628 Gene_expression of Lor 3 0.52 3.07 0.38 5.00
191 INT153705 Gene_expression of CLDN3 5 0.58 4.07 0.37 5.00
192 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
193 INT159145 Negative_regulation of Gene_expression of Ocln 4 0.32 3.07 0.34 5.00
194 INT33009 Gene_expression of Cdk2ap1 6 0.31 6.69 0.33 5.00
195 INT303531 Negative_regulation of Gene_expression of Il1f8 1 0.23 0.75 0.32 5.00
196 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 5.00
197 INT137153 Positive_regulation of VIS1 2 0.04 1.52 0.31 5.00
198 INT285472 Positive_regulation of Fgfrl1 2 0.28 1.39 0.3 5.00
199 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 5.00
200 INT103446 Gene_expression of Krt10 4 0.39 2.21 0.29 5.00
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