D:Idiopathic Pulmonary Fibrosis

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Disease Term
Synonyms Cryptogenic Fibrosing Alveolitides, Cryptogenic Fibrosing Alveolitis, Fibrosing Alveolitides Cryptogenic, Fibrosing Alveolitis Cryptogenic, IDIOPATHIC PULMONARY FIBROSES, Interstitial Pneumonia Usual, Interstitial Pneumonias Usual, PULMONARY FIBROSES IDIOPATHIC, Pulmonary Fibrosis Idiopathic, Usual Interstitial Pneumonia, USUAL INTERSTITIAL PNEUMONIAS
Documents 20
Hot Single Events 64
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Idiopathic Pulmonary Fibrosis. They are ordered first by their relevance to Idiopathic Pulmonary Fibrosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT335456 Binding of PDX1 and hb 1 0.02 2.59 0.66 100.00
2 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 100.00
3 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 100.00
4 INT335455 Negative_regulation of Binding of PDX1 and hb 1 0.02 1.3 0.33 100.00
5 INT335447 PDX1 Regulation of Gene_expression of COPD 1 0.02 1.03 0.24 100.00
6 INT335446 Binding of PDX1 and COPD 1 0.02 1.99 0.3 100.00
7 INT335457 Binding of SRA1 and hb 1 0.00 1.83 0.37 95.80
8 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 89.52
9 INT335458 hb Positive_regulation of SRA1 1 0.00 0.87 0.25 88.36
10 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24 80.92
11 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68 5.00
12 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57 5.00
13 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49 5.00
14 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38 5.00
15 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38 5.00
16 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37 5.00
17 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37 5.00
18 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37 5.00
19 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36 5.00
20 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35 5.00
21 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29 5.00
22 INT185806 Binding of PDX1 and MMP7 1 0.02 0.84 0.28 5.00
23 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28 5.00
24 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28 5.00
25 INT171050 Negative_regulation of F13A1 Regulation of PLG 1 0.02 0.55 0.28 5.00
26 INT171048 F13A1 Regulation of PLG 1 0.02 0.55 0.27 5.00
27 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21 5.00
28 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21 5.00
29 INT185805 SPP1 Regulation of MMP7 1 0.25 0.38 0.19 5.00
30 INT185816 SPP1 Positive_regulation of Positive_regulation of MMP7 1 0.46 0.36 0.18 5.00
31 INT185803 Binding of MMP11 and SPP1 1 0.06 0.34 0.17 5.00
32 INT185815 Binding of MMP1 and SPP1 1 0.21 0.34 0.17 5.00
33 INT185810 Binding of MMP2 and SPP1 1 0.14 0.34 0.17 5.00
34 INT185808 SPP1 Positive_regulation of TIMP1 1 0.64 0.33 0.16 5.00
35 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16 5.00
36 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
37 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
38 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
39 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
40 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 5.00
41 INT185796 SPP1 Regulation of Gene_expression of COL7A1 1 0.06 0 0 5.00
42 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
43 INT185817 SPP1 Positive_regulation of Gene_expression of TIMP1 1 0.64 0 0 5.00
44 INT185801 SPP1 Regulation of Gene_expression of TIMP1 1 0.25 0 0 5.00
45 INT185794 SPP1 Regulation of Gene_expression of MMP1 1 0.16 0 0 5.00
46 INT185812 SPP1 Negative_regulation of MMP1 1 0.26 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Idiopathic Pulmonary Fibrosis. They are ordered first by their pain relevance and then by number of times they were reported in Idiopathic Pulmonary Fibrosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 100.00
2 INT149138 Binding of PDX1 27 0.37 32.62 9.33 100.00
3 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 100.00
4 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
5 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 100.00
6 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29 100.00
7 INT230440 Gene_expression of HAUS7 1 0.04 4.13 1.02 100.00
8 INT335454 Negative_regulation of Localization of TFPI 1 0.25 3.24 0.93 100.00
9 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 100.00
10 INT335451 Positive_regulation of Localization of TFPI 1 0.29 1.65 0.48 100.00
11 INT230442 Binding of HAUS7 1 0.02 2.2 0.3 100.00
12 INT335453 Negative_regulation of Localization of INTU 1 0.13 1.62 0.47 100.00
13 INT335452 Regulation of Gene_expression of PDX1 1 0.05 2.56 0.5 100.00
14 INT335450 Positive_regulation of Localization of INTU 1 0.16 0.82 0.24 100.00
15 INT179686 Regulation of Gene_expression of COPD 10 0.34 14.1 1.52 100.00
16 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 100.00
17 INT202424 Gene_expression of HRCT1 3 0.07 3.47 0.36 100.00
18 INT171059 Localization of PDX1 8 0.56 6.7 1.9 100.00
19 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 99.92
20 INT147793 Localization of COPD 70 0.64 89.01 7.3 99.80
21 INT268264 Negative_regulation of Gene_expression of hb 9 0.44 6.1 1.09 99.64
22 INT117935 Negative_regulation of SRA1 6 0.11 2.63 0.66 99.64
23 INT328893 Negative_regulation of Binding of hb 2 0.17 0.62 0.15 99.64
24 INT199809 Negative_regulation of hb 20 0.36 13.26 1.86 99.56
25 INT145281 Gene_expression of hb 89 0.59 63.22 11.96 99.52
26 INT176594 Gene_expression of SRA1 20 0.35 9.65 1.15 99.52
27 INT96136 Binding of hb 12 0.34 10.21 1.68 99.28
28 INT181631 Positive_regulation of Gene_expression of hb 5 0.38 8.88 2.12 99.04
29 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.00
30 INT12039 Localization of TFPI 22 0.68 9.88 5.35 98.72
31 INT118361 Localization of INTU 3 0.33 0.8 0.35 98.40
32 INT335448 Protein_catabolism of hb 1 0.26 1.55 0.48 98.00
33 INT146139 Gene_expression of ETV4 11 0.12 8.43 0.11 97.32
34 INT145280 Regulation of Gene_expression of hb 6 0.34 5.89 0.98 97.28
35 INT180149 Positive_regulation of SRA1 7 0.40 2.65 0.65 96.84
36 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 96.68
37 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 96.68
38 INT241854 Localization of hb 4 0.57 8.58 1.49 96.40
39 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 96.20
40 INT230441 Positive_regulation of HRCT1 1 0.05 0.74 0.12 95.20
41 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 94.80
42 INT170755 Positive_regulation of Positive_regulation of IFN1@ 17 0.67 8.72 3.65 94.80
43 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 94.32
44 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 94.08
45 INT145279 Regulation of hb 19 0.34 16.58 2.41 93.04
46 INT265794 Regulation of SRA1 3 0.23 3.05 0.35 92.96
47 INT310726 Localization of Terc 1 0.24 0.27 0 92.88
48 INT274377 Localization of TERT 3 0.70 0.78 0 92.88
49 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 92.64
50 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 88.64
51 INT111461 Positive_regulation of hb 30 0.38 21.08 2.1 88.36
52 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 88.20
53 INT335449 Negative_regulation of Localization of hb 1 0.15 0.9 0.22 88.16
54 INT147607 Binding of TERT 16 0.48 12.36 1.31 88.16
55 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 88.12
56 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 87.52
57 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 86.16
58 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 85.60
59 INT93003 Binding of CD40 28 0.47 20.25 7.13 84.72
60 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 83.80
61 INT170986 Positive_regulation of BCO2 2 0.04 1.06 0.55 83.32
62 INT80033 Binding of FAS 37 0.48 41.19 5.67 80.92
63 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45 80.08
64 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 80.08
65 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 79.44
66 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 78.88
67 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 78.40
68 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 77.92
69 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 73.28
70 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 72.48
71 INT25634 Binding of Mpo 21 0.48 14.78 4.39 52.80
72 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 52.56
73 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 50.04
74 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 50.00
75 INT170985 Localization of IPCEF1 2 0.01 1.12 0.37 50.00
76 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 48.04
77 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 47.92
78 INT57875 Positive_regulation of Positive_regulation of Egr1 6 0.49 2.74 1.75 40.16
79 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 39.16
80 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 33.08
81 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02 31.84
82 INT171057 Gene_expression of PDGFC 7 0.15 5.84 1.22 29.68
83 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 21.96
84 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 20.64
85 INT310728 Binding of DKC1 1 0.25 2.36 0.38 19.28
86 INT6852 Localization of TNF 883 0.81 705.95 270.84 16.84
87 INT60974 Gene_expression of Scgb1a1 34 0.71 7.48 0.9 15.48
88 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 14.16
89 INT187045 Regulation of Scgb1a1 6 0.46 1.42 0.3 7.44
90 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 6.40
91 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
92 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
93 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
94 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
95 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
96 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
97 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
98 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
99 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
100 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
101 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
102 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
103 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
104 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
105 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
106 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
107 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
108 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
109 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
110 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
111 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
112 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
113 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
114 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
115 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
116 INT48081 Localization of Il1b 46 0.80 21.59 22.4 5.00
117 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
118 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
119 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
120 INT19509 Localization of Ifng 55 0.78 28.25 18.67 5.00
121 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
122 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
123 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
124 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
125 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
126 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
127 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
128 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
129 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
130 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
131 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
132 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
133 INT3962 Regulation of AGT 50 0.62 20.96 13.01 5.00
134 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
135 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31 5.00
136 INT150851 Positive_regulation of Cxcl1 45 0.57 20.83 11.88 5.00
137 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
138 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
139 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 5.00
140 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 5.00
141 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
142 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
143 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
144 INT12563 Localization of Mpo 33 0.81 20.99 9.58 5.00
145 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 5.00
146 INT140224 Localization of Ccl2 32 0.72 26.91 9.39 5.00
147 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
148 INT48233 Negative_regulation of Gene_expression of MMP1 34 0.58 12.94 9.08 5.00
149 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
150 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
151 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
152 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
153 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
154 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 5.00
155 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01 5.00
156 INT104388 Positive_regulation of Gene_expression of Cxcl2 31 0.66 25.68 7.49 5.00
157 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
158 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
159 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
160 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 5.00
161 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
162 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
163 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
164 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
165 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
166 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 5.00
167 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49 5.00
168 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
169 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 5.00
170 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
171 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
172 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
173 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 5.00
174 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
175 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
176 INT83955 Regulation of Cxcl2 14 0.58 9.77 4.45 5.00
177 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
178 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
179 INT97128 Localization of SPP1 32 0.80 21.75 4.02 5.00
180 INT10162 Positive_regulation of Gpx3 10 0.40 3.37 3.68 5.00
181 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
182 INT157805 Negative_regulation of Gene_expression of Col7a1 22 0.34 12.85 3.51 5.00
183 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
184 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18 5.00
185 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 5.00
186 INT130603 Binding of Timp1 9 0.35 8.52 3.04 5.00
187 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99 5.00
188 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 5.00
189 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 5.00
190 INT79722 Regulation of Cat 14 0.62 5.88 2.86 5.00
191 INT178108 Positive_regulation of MMP7 11 0.56 7.31 2.85 5.00
192 INT113892 Binding of Cat 6 0.48 3.95 2.65 5.00
193 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58 5.00
194 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
195 INT91429 Binding of CD44 34 0.41 17.67 2.51 5.00
196 INT133194 Negative_regulation of TERT 23 0.48 4.01 2.45 5.00
197 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37 5.00
198 INT183468 Localization of TBK1 6 0.32 4.35 2.36 5.00
199 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17 5.00
200 INT185829 Negative_regulation of Positive_regulation of MMP2 7 0.40 4.93 2.02 5.00
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