D:Immune Complex Diseases

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Disease Term
Synonyms DISEASE IMMUNE COMPLEX, Diseases Immune Complex, HYPERSENSITIVITIES TYPE III, Hypersensitivity Type Iii, IMMUNE COMPLEX DISEASE, Type Iii Hypersensitivities, TYPE III HYPERSENSITIVITY
Documents 24
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Immune Complex Diseases. They are ordered first by their relevance to Immune Complex Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT182043 Binding of Gpi1 and IgG 1 0.13 0.94 0.25 57.04
2 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11 48.64
3 INT203140 Binding of C5ar1 and C5 1 0.39 0.81 0.38 26.28
4 INT299745 Binding of Masp1 and IgG 1 0.03 0.69 0.26 13.84
5 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78 5.00
6 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87 5.00
7 INT182044 Binding of Proc and IgG 1 0.00 2.38 0.74 5.00
8 INT203150 Binding of Ighg2b and IgG2a 1 0.11 1.35 0.47 5.00
9 INT203151 Binding of Rnase1 and Trav6-3 1 0.03 1.51 0.36 5.00
10 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 5.00
11 INT220903 Regulation of Binding of Crp and Cd40 1 0.05 0.37 0.05 5.00
12 INT220906 Binding of Crp and Cd40 1 0.04 0.37 0.05 5.00
13 INT220901 Regulation of Binding of Saa1 and Cd40 1 0.04 0.36 0 5.00
14 INT220902 Binding of C4b and C4bp 1 0.45 1.02 0 5.00
15 INT220907 Binding of C4bp and Cfb 1 0.08 0.52 0 5.00
16 INT220900 Binding of C4bp and Cd40 1 0.21 0.72 0 5.00
17 INT220908 Binding of Saa1 and Cd40 1 0.04 0.36 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Immune Complex Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Immune Complex Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 97.88
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 95.24
3 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 92.56
4 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 91.44
5 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 91.40
6 INT299744 Gene_expression of Hbs1l 1 0.05 1.74 0.78 91.04
7 INT299743 Positive_regulation of Hbs1l 1 0.04 0.9 0.41 91.04
8 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 90.64
9 INT155160 Binding of C3 20 0.47 7.77 2.61 85.68
10 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 80.08
11 INT26428 Localization of HK1 3 0.00 1.45 0.26 78.68
12 INT63524 Localization of Gpi1 10 0.61 5.42 2.49 77.92
13 INT6852 Localization of TNF 883 0.81 705.95 270.84 77.56
14 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 75.52
15 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 75.52
16 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 75.52
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 75.52
18 INT182037 Localization of C3 10 0.68 6.69 1.54 69.76
19 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 69.44
20 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 69.44
21 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 65.64
22 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89 64.80
23 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75 64.80
24 INT203146 Protein_catabolism of C5 1 0.64 1.62 0.64 62.16
25 INT192653 Binding of Capns1 8 0.26 9.94 0.51 58.48
26 INT20207 Binding of Ighm 14 0.46 2.88 1.79 58.20
27 INT299741 Binding of Hbs1l 1 0.03 1.04 0.46 58.20
28 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 50.28
29 INT145774 Positive_regulation of C5 7 0.67 4.88 2.79 50.24
30 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 49.20
31 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 49.20
32 INT181015 Gene_expression of C3ar1 12 0.58 8.9 2.18 47.48
33 INT220894 Positive_regulation of C3ar1 4 0.09 3.75 0.41 47.48
34 INT220897 Gene_expression of Cfi 1 0.01 0.91 0.11 47.48
35 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 47.44
36 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 47.44
37 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 47.44
38 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 47.04
39 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 47.04
40 INT701 Localization of IGHE 87 0.80 40.5 10.62 46.32
41 INT20044 Negative_regulation of Gpi1 50 0.59 29.96 26 45.84
42 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 28.36
43 INT46389 Positive_regulation of Cfb 20 0.23 8.29 1.49 27.44
44 INT166437 Binding of C5 4 0.36 3.28 0.63 26.28
45 INT203145 Binding of C5ar1 1 0.35 0.81 0.38 26.12
46 INT218463 Negative_regulation of Binding of Cfb 7 0.08 2.31 0.28 23.84
47 INT220895 Negative_regulation of Binding of C3 3 0.28 0.95 0.16 23.84
48 INT220889 Negative_regulation of Binding of C4b 1 0.36 0.53 0.07 23.84
49 INT184378 Binding of Cfb 54 0.20 12.49 2.36 23.24
50 INT172104 Binding of C4b 4 0.41 3.89 0.13 21.88
51 INT182034 Binding of Gpi1 10 0.39 8.76 2.59 15.60
52 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 14.52
53 INT289396 Binding of Masp1 3 0.19 0.8 0.26 13.84
54 INT299742 Gene_expression of Masp1 1 0.12 0.68 0.26 13.84
55 INT20205 Binding of IgG 108 0.46 66.68 8.57 13.04
56 INT68702 Negative_regulation of C4bp 6 0.57 7.44 0.5 12.64
57 INT14690 Localization of CSF2 124 0.80 85.17 27.26 12.00
58 INT91667 Localization of IL12A 39 0.74 25.51 7.36 12.00
59 INT48393 Positive_regulation of Localization of CSF2 14 0.60 8.92 6.1 12.00
60 INT91663 Positive_regulation of Localization of IL12A 9 0.27 5.91 1.95 12.00
61 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 11.84
62 INT182853 Negative_regulation of Gene_expression of AAVS1 7 0.14 2.48 0.59 11.84
63 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 11.52
64 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 11.52
65 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 9.92
66 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
67 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
68 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
69 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 5.00
70 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
71 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
72 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
73 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
74 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
75 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
76 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
77 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
78 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
79 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
80 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
81 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
82 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
83 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
84 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
85 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
86 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
87 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
88 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
89 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
90 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 5.00
91 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
92 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 5.00
93 INT66026 Gene_expression of Cxcl1 74 0.78 31.87 23.37 5.00
94 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
95 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
96 INT182031 Gene_expression of Cia1 38 0.24 46.37 19.64 5.00
97 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
98 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
99 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
100 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 5.00
101 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
102 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
103 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
104 INT133156 Binding of Cd40 77 0.48 45.92 13.77 5.00
105 INT15011 Positive_regulation of Gpi1 29 0.47 12.47 13.48 5.00
106 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 5.00
107 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
108 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
109 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
110 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
111 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 5.00
112 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
113 INT90371 Localization of Hrec 28 0.05 19.11 10.12 5.00
114 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 5.00
115 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
116 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
117 INT73558 Regulation of IK 23 0.23 12.02 8.73 5.00
118 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
119 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
120 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
121 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
122 INT81777 Negative_regulation of Gene_expression of IK 22 0.08 11.55 8.09 5.00
123 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
124 INT94082 Regulation of Gene_expression of IK 19 0.23 10.03 7.93 5.00
125 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 5.00
126 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 5.00
127 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.00
128 INT79456 Gene_expression of PDE4A 35 0.77 19.42 7.42 5.00
129 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2 5.00
130 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 5.00
131 INT73479 Positive_regulation of Hrec 21 0.04 16.16 6.87 5.00
132 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83 5.00
133 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
134 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 5.00
135 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
136 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 5.00
137 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
138 INT85417 Positive_regulation of Gene_expression of IK 17 0.09 9.38 5.73 5.00
139 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19 5.00
140 INT15797 Positive_regulation of HLA-E 36 0.67 15.17 5.07 5.00
141 INT90372 Negative_regulation of Hrec 12 0.03 11.73 4.74 5.00
142 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 5.00
143 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
144 INT37907 Positive_regulation of Capns1 9 0.41 3.55 4.1 5.00
145 INT126477 Gene_expression of Sdf2l1 43 0.66 22.02 3.97 5.00
146 INT68255 Regulation of Positive_regulation of IL8 12 0.41 5.71 3.91 5.00
147 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53 5.00
148 INT73500 Regulation of IL13 12 0.36 10.37 3.53 5.00
149 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
150 INT143998 Binding of IK 11 0.34 2.44 3.42 5.00
151 INT57767 Gene_expression of HK1 17 0.30 9.72 3.22 5.00
152 INT151441 Positive_regulation of Gene_expression of Trav6-3 22 0.65 10.21 3.05 5.00
153 INT116798 Gene_expression of Osm 8 0.77 4.74 3.01 5.00
154 INT16447 Binding of IL1A 10 0.45 4.01 2.78 5.00
155 INT203137 Binding of Mif 6 0.31 9.46 2.71 5.00
156 INT128365 Positive_regulation of Gene_expression of Ltb4r1 10 0.60 8.04 2.53 5.00
157 INT173504 Positive_regulation of Gene_expression of Ighg1 16 0.47 7.2 2.36 5.00
158 INT122206 Binding of Hrec 5 0.02 4 2.19 5.00
159 INT114898 Regulation of Transcription of TNF 4 0.35 2.69 2.18 5.00
160 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17 5.00
161 INT172559 Localization of Proc 16 0.02 21.49 2.08 5.00
162 INT138021 Positive_regulation of Gene_expression of Osm 2 0.43 3.04 2 5.00
163 INT206590 Negative_regulation of Artmd1 3 0.10 1.34 1.84 5.00
164 INT83358 Positive_regulation of Elane 8 0.21 8.14 1.83 5.00
165 INT13544 Localization of LTA 9 0.78 6.34 1.8 5.00
166 INT203135 Negative_regulation of Gene_expression of Osm 1 0.12 3.08 1.73 5.00
167 INT20347 Positive_regulation of PF4 5 0.67 2.91 1.72 5.00
168 INT203129 Binding of Osm 1 0.10 2.78 1.72 5.00
169 INT206586 Gene_expression of Artmd1 15 0.30 6.64 1.67 5.00
170 INT61913 Binding of IgG2a 10 0.47 5.04 1.64 5.00
171 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62 5.00
172 INT26426 Localization of C5 5 0.78 3.87 1.61 5.00
173 INT234761 Binding of IL13 6 0.35 4.18 1.55 5.00
174 INT28679 Gene_expression of Tnfsf13b 5 0.60 2.75 1.53 5.00
175 INT79455 Positive_regulation of Gene_expression of PDE4A 3 0.67 2.07 1.5 5.00
176 INT182035 Positive_regulation of Gene_expression of Gpi1 5 0.36 4.95 1.4 5.00
177 INT151229 Positive_regulation of Cxam 10 0.15 6.13 1.35 5.00
178 INT203133 Gene_expression of Cxam 3 0.07 6.17 1.22 5.00
179 INT164205 Binding of Proc 12 0.36 12.31 1.19 5.00
180 INT181408 Localization of Tnpo1 2 0.13 2.4 1.16 5.00
181 INT188669 Positive_regulation of Fcr 2 0.09 3.6 1.16 5.00
182 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12 5.00
183 INT168374 Negative_regulation of Capns1 2 0.50 5.09 1.1 5.00
184 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08 5.00
185 INT171113 Binding of Ighg2b 3 0.47 2.85 0.96 5.00
186 INT99555 Gene_expression of EBI3 3 0.09 2.6 0.9 5.00
187 INT203132 Negative_regulation of Gene_expression of Elane 1 0.20 1.5 0.86 5.00
188 INT13545 Negative_regulation of Gene_expression of LTA 5 0.34 3.23 0.86 5.00
189 INT57277 Localization of ANGPTL5 5 0.19 2.15 0.84 5.00
190 INT220888 Negative_regulation of Arhgap4 5 0.42 2.19 0.78 5.00
191 INT203130 Negative_regulation of Lilrb4 1 0.04 1.33 0.76 5.00
192 INT207565 Negative_regulation of LIPG 8 0.10 7.83 0.76 5.00
193 INT163201 Gene_expression of Gnpda1 2 0.65 1.07 0.75 5.00
194 INT135729 Gene_expression of Zap70 5 0.75 6.86 0.75 5.00
195 INT199430 Regulation of LTA 4 0.11 2.48 0.75 5.00
196 INT199433 Negative_regulation of LTA 5 0.17 3.84 0.74 5.00
197 INT182036 Gene_expression of Sh2b2 2 0.13 1.74 0.67 5.00
198 INT188684 Positive_regulation of Positive_regulation of Fcr 2 0.09 2.28 0.67 5.00
199 INT20213 Binding of Atp11c 6 0.08 2.11 0.66 5.00
200 INT145384 Binding of LTA 10 0.32 4.4 0.66 5.00
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