D:Immune Reconstitution Inflammatory Syndrome

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Disease Term
Synonyms Disease Immune Reconstitution, Immune Reconstitution Disease, Immune Reconstitution Syndrome, IMMUNE RECONSTITUTION SYNDROMES, Immune Restoration Syndrome, Reconstitution Disease Immune, Reconstitution Syndrome Immune, Reconstitution Syndromes Immune, Restoration Syndrome Immune, Syndrome Immune Reconstitution, Syndrome Immune Restoration
Documents 53
Hot Single Events 96
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Immune Reconstitution Inflammatory Syndrome. They are ordered first by their relevance to Immune Reconstitution Inflammatory Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34 100.00
2 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36 100.00
3 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14 100.00
4 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14 100.00
5 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26 100.00
6 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26 100.00
7 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26 100.00
8 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05 100.00
9 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03 100.00
10 INT199041 AGRP Regulation of IGHE 1 0.00 1.39 0.03 98.00
11 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75 84.08
12 INT221417 IL12A Positive_regulation of Binding of IFN1@ 1 0.14 0.98 0.33 76.80
13 INT228229 Binding of Cd4 and Ntm 1 0.02 1.03 0.03 69.12
14 INT274384 AGRP Negative_regulation of HIVEP1 1 0.00 0.77 0.03 61.44
15 INT221416 Binding of IL1B and Positive_regulation of NFKB2 1 0.02 0.88 0.23 50.00
16 INT342829 AGRP Positive_regulation of Binding of AGRP and Cd4 1 0.15 0.2 0 38.16
17 INT342830 Binding of AGRP and Cd4 1 0.13 0.2 0 36.64
18 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06 31.92
19 INT348971 Binding of MOG and CARTPT 1 0.06 0.73 0.08 18.88
20 INT258492 Binding of Ins1 and Cdipt 1 0.00 0.92 0 11.76
21 INT317427 IFN1@ Positive_regulation of ISYNA1 1 0.12 0.49 0.45 5.00
22 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21 5.00
23 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2 5.00
24 INT308533 ITIH4 Positive_regulation of Protein_catabolism of Tjp2 1 0.01 1.28 0.18 5.00
25 INT308518 HSP90B1 Positive_regulation of Positive_regulation of SOAT1 1 0.00 0.65 0.18 5.00
26 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18 5.00
27 INT308534 Binding of HIVEP1 and Alms1 1 0.00 0.96 0.13 5.00
28 INT352303 Binding of AIF1 and CD68 1 0.01 0.71 0.1 5.00
29 INT274385 Binding of ABAT and CDIPT 1 0.00 1.21 0 5.00
30 INT348972 Binding of CSF2 and MOG 1 0.21 0.41 0 5.00
31 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Immune Reconstitution Inflammatory Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Immune Reconstitution Inflammatory Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 100.00
2 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 100.00
3 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53 100.00
4 INT95131 Binding of Cd4 27 0.37 21.62 5.07 100.00
5 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 100.00
6 INT259116 Transcription of BRCA1 3 0.44 3.77 0 100.00
7 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 100.00
8 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55 100.00
9 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34 100.00
10 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31 100.00
11 INT216267 Binding of IARS 4 0.32 5.34 0.37 100.00
12 INT221271 Negative_regulation of Binding of BRCA1 1 0.28 0.93 0 100.00
13 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 100.00
14 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72 100.00
15 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 100.00
16 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 99.98
17 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 99.98
18 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 99.92
19 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.92
20 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.84
21 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 99.84
22 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 99.84
23 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 99.80
24 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 99.76
25 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 99.76
26 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 99.76
27 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 99.74
28 INT17049 Localization of CD4 57 0.75 35.33 6.89 99.72
29 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83 99.72
30 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.68
31 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 99.68
32 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 99.64
33 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.64
34 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 99.64
35 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 99.64
36 INT83328 Regulation of Gene_expression of Cd4 6 0.43 2.55 1.42 99.64
37 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 99.58
38 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.56
39 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.56
40 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 99.56
41 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 99.48
42 INT221428 Negative_regulation of Negative_regulation of FOXP3 1 0.35 1.97 0.7 99.48
43 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.48
44 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 99.48
45 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 99.40
46 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 99.40
47 INT17747 Regulation of Cd4 14 0.41 10.02 2.12 99.32
48 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 99.28
49 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 99.24
50 INT16404 Regulation of CD4 54 0.61 33.05 10.29 99.24
51 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 99.22
52 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.22
53 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 99.22
54 INT57257 Gene_expression of IL7 69 0.62 50.24 20.36 99.20
55 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 99.16
56 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 98.96
57 INT98567 Negative_regulation of Gene_expression of Cd4 8 0.40 6.1 0.75 98.92
58 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 98.88
59 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69 98.88
60 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.80
61 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 98.16
62 INT189176 Positive_regulation of Localization of TH1L 5 0.23 2.93 0.42 97.76
63 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 97.44
64 INT188754 Localization of AGRP 15 0.74 8.88 0.6 97.32
65 INT234422 Gene_expression of PML 14 0.75 15.93 1.14 97.16
66 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1 97.16
67 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.96
68 INT208149 Regulation of Positive_regulation of Cd4 1 0.06 0.93 0 96.96
69 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51 96.68
70 INT58904 Localization of TH1L 40 0.68 27.11 10.52 96.58
71 INT36287 Binding of CD4 96 0.47 58.93 11.88 96.52
72 INT97798 Localization of IRF6 86 0.73 33.27 20.94 96.48
73 INT64473 Regulation of Gene_expression of IL4 17 0.58 6.61 3.96 96.24
74 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 96.08
75 INT81796 Binding of AGRP 62 0.36 37.19 5.3 95.40
76 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 95.32
77 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 95.08
78 INT348978 Positive_regulation of MOG 6 0.49 4.2 0.63 94.68
79 INT178589 Localization of IL2RA 3 0.68 1.99 0.45 94.56
80 INT74423 Localization of IL10 91 0.80 61.6 22.95 94.32
81 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 93.80
82 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 93.80
83 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 93.16
84 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 91.16
85 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 90.48
86 INT23257 Regulation of CRP 127 0.62 100.05 21.87 88.92
87 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 87.56
88 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 86.84
89 INT102843 Negative_regulation of PDC 5 0.57 4.26 1.82 86.72
90 INT6852 Localization of TNF 883 0.81 705.95 270.84 86.56
91 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 85.52
92 INT36018 Negative_regulation of Gene_expression of CD8A 12 0.42 6.66 1.85 85.48
93 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 82.60
94 INT86998 Regulation of HIVEP1 49 0.44 37.83 4 82.16
95 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 81.48
96 INT44323 Positive_regulation of F8 32 0.60 24.88 3.89 80.72
97 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 78.40
98 INT274391 Negative_regulation of Positive_regulation of HIVEP1 2 0.03 1.56 0.11 78.40
99 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 77.92
100 INT81794 Regulation of AGRP 12 0.39 4.94 0.9 77.76
101 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 77.36
102 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 76.92
103 INT31340 Positive_regulation of Gene_expression of Got1 20 0.46 10.5 3.17 76.92
104 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 76.80
105 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 76.36
106 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 71.68
107 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 70.16
108 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 70.16
109 INT176386 Positive_regulation of Gene_expression of TH1L 14 0.32 9.17 3.4 68.20
110 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 67.08
111 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 66.32
112 INT181848 Negative_regulation of CD14 16 0.43 8.14 2.95 64.40
113 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 60.72
114 INT25265 Transcription of HIVEP1 30 0.45 28.12 2.08 60.00
115 INT44632 Localization of Ntm 2 0.45 4.95 0.65 59.20
116 INT99586 Binding of IRF6 60 0.36 27.87 13.2 58.56
117 INT185397 Positive_regulation of Binding of IRF6 3 0.12 0.56 0.57 58.56
118 INT221423 Negative_regulation of Negative_regulation of CD14 3 0.31 2.09 1 58.00
119 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13 57.80
120 INT117544 Regulation of CD14 24 0.45 5.85 6.66 57.80
121 INT97799 Regulation of IRF6 23 0.26 6.54 3.75 57.80
122 INT91667 Localization of IL12A 39 0.74 25.51 7.36 55.76
123 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 52.60
124 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34 51.96
125 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 50.00
126 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 50.00
127 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 50.00
128 INT6484 Binding of IL1B 122 0.47 75.84 35.07 50.00
129 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 50.00
130 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 50.00
131 INT150417 Negative_regulation of Gene_expression of IRF6 20 0.41 11.48 6.28 50.00
132 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 50.00
133 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73 50.00
134 INT221433 Binding of NFKB2 6 0.11 4.74 1.7 50.00
135 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22 50.00
136 INT211808 Localization of NFKB2 4 0.19 4.17 0.58 50.00
137 INT221432 Positive_regulation of Binding of NFKB2 2 0.12 1.59 0.53 50.00
138 INT221435 Positive_regulation of Localization of NFKB2 1 0.16 0.6 0.29 50.00
139 INT349067 Negative_regulation of Binding of Eae1 1 0.01 0.95 0.11 48.12
140 INT109558 Binding of Eae1 9 0.25 10.36 3.16 47.56
141 INT44631 Gene_expression of Ntm 14 0.64 4.87 3.35 43.84
142 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 42.16
143 INT3841 Gene_expression of FCGR3B 117 0.75 58.99 28.87 39.76
144 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 39.76
145 INT96588 Gene_expression of MOG 18 0.75 11.41 1.89 34.52
146 INT340755 Negative_regulation of CARTPT 2 0.30 2.08 0.4 29.68
147 INT348977 Positive_regulation of Negative_regulation of CARTPT 1 0.08 0.69 0.08 29.68
148 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 27.60
149 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 26.36
150 INT348980 Positive_regulation of Gene_expression of MOG 1 0.38 0.69 0.08 26.00
151 INT97062 Binding of PML 10 0.41 11.63 1.65 21.60
152 INT196238 Binding of MOG 4 0.36 4.19 0.73 18.00
153 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
154 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
155 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
156 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
157 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
158 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
159 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
160 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
161 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
162 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
163 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
164 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
165 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
166 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
167 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
168 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
169 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
170 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
171 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
172 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
173 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
174 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
175 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
176 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
177 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
178 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
179 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
180 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
181 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
182 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05 5.00
183 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
184 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
185 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
186 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
187 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 5.00
188 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
189 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 5.00
190 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
191 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
192 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78 5.00
193 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
194 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
195 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
196 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
197 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
198 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
199 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 5.00
200 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75 5.00
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