D:Impotence

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pChart

Disease Term
Synonyms Dysfunction Erectile, Dysfunctions Erectile, ERECTILE DYSFUNCTION, Erectile Dysfunctions, MALE ERECTILE DYSFUNCTION, Male Impotence, Penile Erections
Documents 39
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Impotence. They are ordered first by their relevance to Impotence and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT270680 Fos Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.03 0.39 1.05 74.52
2 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 49.72
3 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 49.08
4 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 49.08
5 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
6 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
7 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
8 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
9 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
10 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
11 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
12 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
13 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Impotence. They are ordered first by their pain relevance and then by number of times they were reported in Impotence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84 99.74
2 INT15553 Negative_regulation of Htr1b 13 0.41 2.61 7.16 99.74
3 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 97.76
4 INT65929 Positive_regulation of Nbl1 6 0.17 1.2 3.09 96.56
5 INT11796 Positive_regulation of Helt 52 0.31 11.7 29.22 94.96
6 INT68550 Positive_regulation of Negative_regulation of Htr1a 1 0.49 0.4 0.44 90.08
7 INT13244 Binding of Helt 30 0.31 4.56 18.01 89.12
8 INT102729 Gene_expression of APCS 20 0.65 8.86 2.52 85.28
9 INT37170 Binding of APCS 6 0.36 4.79 0.97 84.68
10 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 83.72
11 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 82.76
12 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 80.64
13 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89 80.64
14 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 80.00
15 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 79.96
16 INT213214 Positive_regulation of ASAP2 1 0.01 4.59 0.31 75.16
17 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 74.52
18 INT147263 Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 51 0.53 15.32 5.86 74.52
19 INT213218 Negative_regulation of USP33 1 0.01 0.92 0.15 74.52
20 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39 71.44
21 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16 71.44
22 INT52072 Negative_regulation of Ces1c 6 0.31 1.37 2.13 67.52
23 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 65.08
24 INT127460 Positive_regulation of Gene_expression of PAH 5 0.43 4.3 0.5 65.08
25 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 63.76
26 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 62.52
27 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27 62.52
28 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 60.08
29 INT213221 Negative_regulation of ASAP2 1 0.01 5.83 0.46 60.08
30 INT213212 Localization of ASAP2 1 0.01 0.78 0.13 60.08
31 INT211827 Localization of PVR 3 0.61 1.33 0.13 60.08
32 INT213211 Regulation of Localization of PVR 1 0.23 0.78 0.13 60.08
33 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 58.96
34 INT9110 Binding of PAH 32 0.41 42.1 3.1 58.56
35 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 57.56
36 INT8065 Binding of AGT 54 0.48 20.54 10.85 49.72
37 INT130999 Localization of PRKAB1 5 0.57 4.1 0.35 49.44
38 INT37544 Binding of ANGPT2 9 0.19 6.51 0.69 49.08
39 INT27916 Gene_expression of Mt1a 6 0.47 4.4 7.04 48.08
40 INT35780 Positive_regulation of Mt1a 9 0.55 4.9 6.08 47.68
41 INT264232 Positive_regulation of Mt2 5 0.40 1.76 0.54 47.68
42 INT74867 Gene_expression of Mt2 13 0.53 5.22 1.76 44.32
43 INT213219 Protein_catabolism of ALDH7A1 1 0.14 0.7 0.23 35.36
44 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 32.72
45 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 32.56
46 INT127462 Regulation of PAH 5 0.39 3.35 0.29 28.24
47 INT56972 Regulation of ANGPT2 6 0.44 3.48 0.86 22.80
48 INT20664 Binding of ACE 60 0.48 35.27 9.16 10.64
49 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 9.00
50 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 8.96
51 INT264233 Regulation of Mt2 2 0.29 0.21 0.46 6.72
52 INT9269 Regulation of Mt1a 3 0.36 0 1.43 6.08
53 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
54 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
55 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
56 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
57 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
58 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
59 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
60 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
61 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
62 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
63 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
64 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
65 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
66 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
67 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
68 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
69 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 5.00
70 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
71 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
72 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
73 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
74 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 5.00
75 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 5.00
76 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
77 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
78 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
79 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
80 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
81 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
82 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
83 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
84 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
85 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
86 INT62861 Regulation of Gria2 45 0.60 13.35 16.07 5.00
87 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
88 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
89 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
90 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
91 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
92 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
93 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
94 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
95 INT13572 Localization of Helt 31 0.36 5.85 13.41 5.00
96 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
97 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
98 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
99 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
100 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
101 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
102 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
103 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
104 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
105 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
106 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
107 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
108 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
109 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
110 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
111 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
112 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
113 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
114 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
115 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43 5.00
116 INT52814 Negative_regulation of Nr3c1 9 0.57 5.69 5.41 5.00
117 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
118 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 5.00
119 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
120 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
121 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
122 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
123 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39 5.00
124 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39 5.00
125 INT125282 Negative_regulation of Positive_regulation of NR3C1 3 0.57 0.54 4.31 5.00
126 INT187346 Regulation of Dlat 12 0.29 1.82 4.28 5.00
127 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
128 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16 5.00
129 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96 5.00
130 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 5.00
131 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
132 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 5.00
133 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76 5.00
134 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53 5.00
135 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
136 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
137 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
138 INT41545 Negative_regulation of APRT 8 0.57 2.99 2.88 5.00
139 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 5.00
140 INT113149 Gene_expression of Tmprss11d 15 0.75 8.51 2.72 5.00
141 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71 5.00
142 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
143 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
144 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
145 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 5.00
146 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
147 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13 5.00
148 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94 5.00
149 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 5.00
150 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
151 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
152 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 5.00
153 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54 5.00
154 INT258051 Negative_regulation of Protein_catabolism of ABAT 3 0.04 1.86 1.52 5.00
155 INT108556 Negative_regulation of BCL2L10 8 0.32 7.77 1.49 5.00
156 INT258048 Regulation of TBK1 4 0.05 3.81 1.44 5.00
157 INT130998 Regulation of PRKAB1 11 0.45 5.7 1.33 5.00
158 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 5.00
159 INT128176 Regulation of RHOA 13 0.44 4.35 1.26 5.00
160 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23 5.00
161 INT45553 Negative_regulation of PCK1 3 0.43 0.73 1.17 5.00
162 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02 5.00
163 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
164 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 5.00
165 INT202683 Localization of FAS 6 0.73 5.86 0.8 5.00
166 INT130599 Negative_regulation of PAICS 4 0.30 2.33 0.7 5.00
167 INT231290 Positive_regulation of Positive_regulation of Helt 3 0.03 1.71 0.68 5.00
168 INT102174 Gene_expression of FASN 11 0.65 6.4 0.67 5.00
169 INT158829 Negative_regulation of FAS 5 0.41 4.12 0.48 5.00
170 INT212415 Positive_regulation of Positive_regulation of PRKAB1 4 0.36 2.63 0.37 5.00
171 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35 5.00
172 INT258059 Negative_regulation of Positive_regulation of GSR 3 0.41 1.79 0.33 5.00
173 INT258082 Negative_regulation of ABCC3 1 0.07 0.43 0.31 5.00
174 INT258080 Positive_regulation of Negative_regulation of ABCC3 1 0.06 0.44 0.31 5.00
175 INT213215 Gene_expression of SS18L1 2 0.58 3.71 0.29 5.00
176 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29 5.00
177 INT258074 Negative_regulation of HDLBP 2 0.06 2.76 0.28 5.00
178 INT197016 Positive_regulation of Gene_expression of LDLR 13 0.50 5.82 0.24 5.00
179 INT32334 Regulation of LILRA3 3 0.08 0 0.23 5.00
180 INT258055 Positive_regulation of ARG1 7 0.49 3.45 0.19 5.00
181 INT213217 Negative_regulation of Binding of PAH 2 0.32 2.03 0.19 5.00
182 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15 5.00
183 INT258046 Binding of DUT 1 0.01 0.63 0.15 5.00
184 INT258072 Binding of RERE 2 0.07 1.14 0.15 5.00
185 INT213220 Regulation of ASAP2 1 0.01 1.73 0.15 5.00
186 INT211384 Negative_regulation of FASN 2 0.41 1.19 0.14 5.00
187 INT189633 Regulation of STK11 3 0.41 3.57 0.14 5.00
188 INT243793 Phosphorylation of PIK3CD 5 0.42 1.74 0.13 5.00
189 INT258077 Negative_regulation of Gene_expression of DNMT1 2 0.30 1.27 0.12 5.00
190 INT258071 Positive_regulation of Negative_regulation of APRT 1 0.02 1.19 0.11 5.00
191 INT258063 Negative_regulation of DNMT1 3 0.28 1.36 0.11 5.00
192 INT258050 Regulation of Positive_regulation of PRKAB1 1 0.08 1.05 0.09 5.00
193 INT152262 Positive_regulation of FASN 3 0.32 1.22 0.09 5.00
194 INT206463 Positive_regulation of Positive_regulation of ASAP1 4 0.41 1.28 0.07 5.00
195 INT213213 Protein_catabolism of PAH 1 0.76 1.5 0.07 5.00
196 INT258011 Positive_regulation of Transcription of Rassf1 1 0.45 0.51 0.06 5.00
197 INT258010 Transcription of Rassf1 1 0.69 0.51 0.06 5.00
198 INT258065 Protein_catabolism of ANGPT1 1 0.01 0.47 0.04 5.00
199 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04 5.00
200 INT258058 Phosphorylation of TGFB2 1 0.08 0.89 0.04 5.00
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