D:Inborn Error Of Metabolism

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Disease Term
Synonyms ERROR INBORN METABOLISM, ERRORS INBORN METABOLISM, Errors Metabolism Inborn, Errors Metabolisms Inborn, Inborn Errors Metabolism, INBORN ERRORS METABOLISMS, Inborn Errors Of Metabolism, Inborn Metabolism Error, Inborn Metabolism Errors, METABOLISM ERROR INBORN, Metabolism Errors Inborn
Documents 67
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Inborn Error Of Metabolism. They are ordered first by their relevance to Inborn Error Of Metabolism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT237670 SQSTM1 Regulation of PDB1 1 0.34 1.13 0.06 5.00
2 INT298733 INS Regulation of ACSBG1 1 0.00 0.97 0.05 5.00
3 INT298734 USE1 Regulation of ACSBG1 1 0.00 0.97 0.05 5.00
4 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
5 INT235693 Binding of Clcn1 and Gab2 1 0.19 2.96 0 5.00
6 INT235689 Alb Regulation of Gene_expression of Gab2 1 0.10 0 0 5.00
7 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
8 INT235697 Binding of Clcn1 and Syn1 1 0.00 0.48 0 5.00
9 INT339676 CSF2 Positive_regulation of HGF 1 0.08 0.46 0 5.00
10 INT237669 Binding of PDB1 and SQSTM1 1 0.27 2.55 0 5.00
11 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
12 INT235695 Gab2 Positive_regulation of Clcn1 1 0.20 0.52 0 5.00
13 INT235692 Clcn1 Positive_regulation of Binding of Alms1 1 0.05 0.9 0 5.00
14 INT339675 CSF2 Positive_regulation of Localization of FUT1 1 0.01 0.42 0 5.00
15 INT235696 Regulation of Binding of Clcn1 and Gab2 1 0.18 0.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Inborn Error Of Metabolism. They are ordered first by their pain relevance and then by number of times they were reported in Inborn Error Of Metabolism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT69478 Negative_regulation of GBA 16 0.55 7.9 0.59 99.84
2 INT34699 Negative_regulation of GCDH 2 0.58 0.83 0.27 99.84
3 INT157970 Negative_regulation of Ivd 1 0.23 0.19 0.18 99.84
4 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 99.70
5 INT55784 Negative_regulation of Neu1 4 0.24 1.93 0.33 99.70
6 INT111345 Negative_regulation of Cbs 2 0.30 2.82 0.36 99.64
7 INT112138 Negative_regulation of Acadm 4 0.42 0.58 0.53 99.48
8 INT157971 Positive_regulation of Positive_regulation of Mgat4a 1 0.05 0.19 0.19 98.78
9 INT157972 Positive_regulation of Mgat4a 1 0.08 0.19 0.19 98.32
10 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67 95.48
11 INT14690 Localization of CSF2 124 0.80 85.17 27.26 91.04
12 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 86.88
13 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49 86.12
14 INT101556 Regulation of Nt5e 5 0.40 2.81 5.2 85.36
15 INT119485 Regulation of Entpd1 1 0.27 1.26 0.93 85.36
16 INT38299 Negative_regulation of FCGR2C 6 0.21 3.92 0.52 84.60
17 INT40878 Localization of UTP14C 2 0.38 0.24 0.8 81.88
18 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26 81.28
19 INT39997 Negative_regulation of Gla 8 0.59 6.38 1.51 80.68
20 INT224924 Binding of TARM1 4 0.18 3.42 0.39 78.00
21 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34 75.76
22 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 75.00
23 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 75.00
24 INT16656 Negative_regulation of Gene_expression of YY1 8 0.57 2.62 2.12 75.00
25 INT52061 Negative_regulation of HSD17B6 5 0.57 1.5 1.16 75.00
26 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 75.00
27 INT97078 Positive_regulation of Entpd1 16 0.64 8.54 4.49 67.60
28 INT101555 Positive_regulation of Nt5e 5 0.45 2.91 1.4 67.00
29 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 65.44
30 INT163987 Negative_regulation of FMO3 2 0.59 1.43 0.66 60.48
31 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 53.04
32 INT118264 Binding of Hmbs 6 0.37 4.87 0.33 47.64
33 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 46.80
34 INT149951 Negative_regulation of Transcription of VDR 3 0.43 1.19 0.13 46.80
35 INT102745 Positive_regulation of Hmbs 17 0.61 12.41 0.78 45.64
36 INT194031 Regulation of SQSTM1 2 0.41 2.07 0.27 44.20
37 INT194030 Regulation of UBAP1 1 0.03 1.34 0.13 44.20
38 INT119708 Transcription of VDR 11 0.71 5.43 0.48 44.12
39 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 42.96
40 INT812 Localization of INS 1026 0.81 515.6 145.31 30.00
41 INT339688 Localization of TARM1 1 0.04 0.87 0.04 25.68
42 INT183066 Positive_regulation of Transcription of INS 8 0.49 5.31 0.34 23.88
43 INT183046 Transcription of INS 25 0.70 11.14 1.13 23.44
44 INT163990 Gene_expression of FMO3 6 0.78 1.03 0.64 21.88
45 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 21.20
46 INT14301 Binding of CSF2 82 0.48 67.95 8.98 14.72
47 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 14.44
48 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 14.44
49 INT108761 Localization of Alms1 24 0.70 13.92 3.74 8.08
50 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 7.00
51 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
52 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
53 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
54 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
55 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
56 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
57 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
58 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
59 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 5.00
60 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
61 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
62 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
63 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
64 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
65 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
66 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
67 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
68 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
69 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
70 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
71 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
72 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 5.00
73 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
74 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
75 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
76 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
77 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
78 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
79 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
80 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
81 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
82 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
83 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
84 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
85 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
86 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 5.00
87 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
88 INT35801 Regulation of Alms1 34 0.38 20.88 12.38 5.00
89 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
90 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
91 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
92 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
93 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 5.00
94 INT51165 Binding of Gal 10 0.48 2.56 8.41 5.00
95 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
96 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 5.00
97 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
98 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
99 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 5.00
100 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
101 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
102 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 5.00
103 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
104 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
105 INT2072 Localization of AMBP 33 0.65 37.58 4.84 5.00
106 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 5.00
107 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
108 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
109 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 5.00
110 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 5.00
111 INT4464 Localization of CEL 21 0.80 8.09 3.88 5.00
112 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
113 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 5.00
114 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 5.00
115 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 5.00
116 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
117 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7 5.00
118 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 5.00
119 INT171346 Gene_expression of TNFSF12 7 0.58 4.19 2.62 5.00
120 INT142724 Negative_regulation of A4GALT 11 0.53 8.23 2.61 5.00
121 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 5.00
122 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 5.00
123 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
124 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 5.00
125 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
126 INT9429 Positive_regulation of Clcn1 18 0.58 10.03 2.07 5.00
127 INT23748 Localization of Ltf 15 0.79 5.43 2.07 5.00
128 INT35745 Negative_regulation of AGL 29 0.50 9.16 2.03 5.00
129 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 5.00
130 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
131 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98 5.00
132 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
133 INT167203 Binding of PRNP 25 0.48 20.09 1.84 5.00
134 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
135 INT167153 Gene_expression of A4GALT 10 0.49 10.45 1.71 5.00
136 INT121513 Positive_regulation of A4GALT 21 0.63 16.06 1.59 5.00
137 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
138 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46 5.00
139 INT105921 Localization of FUT1 13 0.23 3.92 1.39 5.00
140 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
141 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 5.00
142 INT33520 Negative_regulation of CYC1 11 0.57 5.36 1.26 5.00
143 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24 5.00
144 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22 5.00
145 INT21756 Regulation of Alb 15 0.43 8.21 1.19 5.00
146 INT36179 Regulation of GLA 11 0.44 6.56 1.12 5.00
147 INT112677 Localization of tf 20 0.48 9.66 1.06 5.00
148 INT352186 Negative_regulation of Gene_expression of A4GALT 1 0.20 2.56 1.06 5.00
149 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04 5.00
150 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 5.00
151 INT200793 Gene_expression of Csf3r 5 0.52 3.16 1 5.00
152 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93 5.00
153 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 5.00
154 INT170813 Gene_expression of Prdm6 11 0.65 4.35 0.88 5.00
155 INT122652 Regulation of B4GALNT1 5 0.11 1.76 0.88 5.00
156 INT173422 Gene_expression of ETFDH 11 0.45 5.78 0.78 5.00
157 INT225056 Positive_regulation of Gene_expression of AMBP 4 0.37 5.45 0.75 5.00
158 INT186523 Binding of ETFDH 10 0.25 5.63 0.72 5.00
159 INT37012 Binding of Clcn1 11 0.33 4.83 0.7 5.00
160 INT28012 Positive_regulation of GLS 6 0.48 0.42 0.7 5.00
161 INT143095 Positive_regulation of Gene_expression of Alb 8 0.40 1.53 0.66 5.00
162 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65 5.00
163 INT242371 Regulation of Gene_expression of ADHD1 3 0.37 5.2 0.65 5.00
164 INT76902 Binding of AGL 3 0.02 2.23 0.64 5.00
165 INT235687 Positive_regulation of Gab2 1 0.59 1.52 0.63 5.00
166 INT3491 Negative_regulation of CPT2 8 0.57 4.32 0.62 5.00
167 INT5261 Localization of AGL 10 0.36 3.17 0.61 5.00
168 INT164595 Binding of LCN2 8 0.37 6.03 0.6 5.00
169 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 5.00
170 INT121514 Localization of A4GALT 7 0.25 4.77 0.58 5.00
171 INT57526 Regulation of Ltf 8 0.45 2.73 0.56 5.00
172 INT188444 Binding of SQSTM1 5 0.44 4.69 0.54 5.00
173 INT74630 Negative_regulation of ACADVL 8 0.58 2.49 0.53 5.00
174 INT16671 Gene_expression of MBTPS1 7 0.30 4.8 0.52 5.00
175 INT24459 Positive_regulation of PDB1 7 0.46 7 0.5 5.00
176 INT211905 Negative_regulation of RIOK3 2 0.07 2.25 0.48 5.00
177 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48 5.00
178 INT87819 Localization of CD34 21 0.81 7.69 0.47 5.00
179 INT140436 Binding of TWIST1 5 0.39 2.34 0.47 5.00
180 INT93240 Gene_expression of Pgpep1 7 0.59 1.69 0.44 5.00
181 INT155775 Gene_expression of PDB1 12 0.65 10.18 0.41 5.00
182 INT188613 Gene_expression of CYP8B1 2 0.58 1.04 0.41 5.00
183 INT26154 Binding of Pgpep1 2 0.04 0.88 0.38 5.00
184 INT303100 Positive_regulation of Gene_expression of Csf3r 2 0.31 0.58 0.35 5.00
185 INT239566 Gene_expression of SDF2L1 2 0.25 0.47 0.33 5.00
186 INT235680 Gene_expression of Gab2 1 0.66 4.93 0.29 5.00
187 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
188 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 5.00
189 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26 5.00
190 INT225055 Negative_regulation of CAMK4 2 0.04 1.34 0.26 5.00
191 INT263255 Negative_regulation of Negative_regulation of AGTR1 2 0.30 2.88 0.25 5.00
192 INT189042 Regulation of FMO3 1 0.27 1.09 0.22 5.00
193 INT124714 Localization of PFKM 2 0.37 1.45 0.21 5.00
194 INT244330 Localization of ELF3 8 0.56 2.71 0.18 5.00
195 INT188446 Gene_expression of SQSTM1 5 0.71 5.34 0.18 5.00
196 INT339677 Positive_regulation of Csf3r 1 0.05 0.24 0.17 5.00
197 INT312973 Binding of ACADVL 1 0.23 2.35 0.17 5.00
198 INT188608 Negative_regulation of Gene_expression of NAGA 1 0.15 1.02 0.15 5.00
199 INT218167 Positive_regulation of Gene_expression of ETFDH 1 0.33 1.19 0.15 5.00
200 INT188614 Gene_expression of NAGA 1 0.23 1 0.13 5.00
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