D:Insulin Resistance

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Disease Term
Synonyms Pre Diabetic, Resistance Insulin
Documents 1189
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Insulin Resistance. They are ordered first by their relevance to Insulin Resistance and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT253128 Il6 Positive_regulation of Gene_expression of Ins1 1 0.14 3.2 0.19 100.00
2 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 100.00
3 INT238826 Binding of INS and RBP4 1 0.10 2.07 0 100.00
4 INT227339 Binding of TNF and Ins1 1 0.28 4.08 0.31 100.00
5 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32 100.00
6 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22 100.00
7 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22 100.00
8 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0 100.00
9 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03 100.00
10 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 100.00
11 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 100.00
12 INT246835 Iars Positive_regulation of Ins1 1 0.06 0.86 0.03 100.00
13 INT238827 RBP4 Positive_regulation of Gene_expression of INS 1 0.14 1.15 0 100.00
14 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05 100.00
15 INT340291 Ea1 Regulation of Gene_expression of Ins1 1 0.03 0.62 0.46 100.00
16 INT240906 Ros1 Positive_regulation of Gene_expression of Ins1 1 0.03 0.51 0.04 100.00
17 INT172818 Binding of T2dm2 and Hypism 1 0.00 3.62 0.1 100.00
18 INT120974 Pomc Positive_regulation of Gene_expression of Ins1 1 0.11 0.42 0.25 100.00
19 INT240620 Binding of INS and SHBG 4 0.12 3.35 0.15 100.00
20 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12 100.00
21 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05 100.00
22 INT58648 Binding of HSD11B1 and INS 1 0.04 1.65 0.07 100.00
23 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07 100.00
24 INT258084 Binding of IL6 and Regulation of Gene_expression of INS 1 0.11 0.62 0.05 100.00
25 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32 100.00
26 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35 100.00
27 INT235313 Cyp3a23/3a1 Positive_regulation of Ins1 1 0.14 0.82 0.05 100.00
28 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 100.00
29 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 100.00
30 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 100.00
31 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 100.00
32 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 100.00
33 INT291040 Binding of CFH and INS 1 0.25 1.32 0.08 100.00
34 INT172833 Binding of FFAR1 and T2dm2 1 0.00 1.55 0 100.00
35 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09 100.00
36 INT275759 Binding of xn and Ins1 1 0.01 1.95 0 100.00
37 INT330855 Binding of Ins1 and Tgs1 1 0.02 0.86 0.09 100.00
38 INT351001 Binding of Adh7 and Ins1 1 0.00 1.62 0.05 100.00
39 INT172836 Binding of INS and T2dm2 1 0.00 1.65 0.08 100.00
40 INT335607 Binding of INS and TGS1 1 0.04 0.95 0 100.00
41 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 100.00
42 INT242960 Binding of Ins1 and Ffar1 1 0.19 1.33 0.04 100.00
43 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36 100.00
44 INT172835 Binding of AGT and T2dm2 1 0.00 1.73 0 100.00
45 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0 100.00
46 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32 100.00
47 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27 100.00
48 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27 100.00
49 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 100.00
50 INT240888 Sod1 Regulation of Gene_expression of Ins1 1 0.08 0.18 0.04 100.00
51 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04 100.00
52 INT278250 Binding of PCOS1 and Ins1 1 0.00 1.23 0.04 100.00
53 INT238315 Binding of Ins1 and Hypism 1 0.00 0.37 0.04 100.00
54 INT225774 SNRNP70 Regulation of Binding of Insr and Enpp1 1 0.03 0.77 0.04 100.00
55 INT246136 Binding of Ins1 and Capn10 1 0.14 0.86 0.03 100.00
56 INT202246 Binding of INS and Igfbp1 1 0.05 0.38 0 100.00
57 INT311229 DPP4 Positive_regulation of Gene_expression of INS 1 0.32 0.57 0 100.00
58 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0 100.00
59 INT352795 Binding of INS and FGF21 1 0.05 2.03 0 100.00
60 INT258492 Binding of Ins1 and Cdipt 1 0.00 0.92 0 100.00
61 INT246838 Iars Positive_regulation of Phosphorylation of Ins1 1 0.05 0.86 0.03 99.96
62 INT207550 GH1 Regulation of Binding of GH1 and INS 1 0.22 0.55 0.07 99.96
63 INT207552 Binding of GH1 and INS 1 0.23 0.55 0.07 99.96
64 INT140814 Adipoq Regulation of Retn 1 0.03 0.8 0 99.96
65 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4 99.88
66 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31 99.82
67 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0 99.80
68 INT278251 Binding of PCOS1 and Hypism 1 0.00 1.22 0.04 99.76
69 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43 99.64
70 INT230460 Binding of TLR2 and TLR6 2 0.07 1.9 0.25 99.64
71 INT157080 Ghrl Positive_regulation of Localization of Gnrhr 2 0.23 0.7 0.26 99.60
72 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0 99.52
73 INT304347 INS Positive_regulation of Phosphorylation of IRS1 1 0.09 0.77 0 99.50
74 INT157265 PPARG Positive_regulation of PPARA 1 0.22 1.15 0.09 99.50
75 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09 99.50
76 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09 99.44
77 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09 99.44
78 INT253127 Il6 Regulation of Gene_expression of Ptpn1 1 0.24 1.31 0.17 99.40
79 INT255754 Negative_regulation of Ins1 Positive_regulation of Akt1 1 0.14 1.73 0.1 99.40
80 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0 99.36
81 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49 99.36
82 INT340298 Ea1 Positive_regulation of Ppargc1a 1 0.05 1.03 0.64 99.36
83 INT304350 INS Positive_regulation of Protein_catabolism of IRS1 1 0.09 0.78 0 99.36
84 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 99.36
85 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1 99.32
86 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44 99.30
87 INT221402 Binding of INS and LPA 1 0.00 0.63 0 99.28
88 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16 99.20
89 INT120976 Pomc Regulation of Ins1 1 0.10 0.47 0.23 99.20
90 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14 99.20
91 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14 99.20
92 INT253122 Ins1 Positive_regulation of Akt1 2 0.15 1.81 0.14 99.14
93 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03 99.12
94 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14 99.12
95 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12 99.12
96 INT291105 FFAR1 Negative_regulation of PDP1 1 0.05 0.29 0 99.08
97 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37 99.02
98 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09 98.98
99 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83 98.92
100 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19 98.92
101 INT253154 TNF Positive_regulation of Ptpn1 1 0.73 0.91 0.15 98.88
102 INT329219 Ins1 Positive_regulation of Gene_expression of Slc2a4 1 0.04 0.93 0.05 98.80
103 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 98.76
104 INT350015 ARID1B Regulation of Localization of INS 1 0.03 2.6 0.04 98.76
105 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 98.68
106 INT157266 PPARA Positive_regulation of ADIPOR1 1 0.00 1.19 0.09 98.66
107 INT348012 Samsn1 Positive_regulation of Vps54 1 0.00 1.93 0.15 98.60
108 INT253132 Il6 Positive_regulation of Gene_expression of Ptpn1 1 0.42 0.54 0.03 98.56
109 INT226207 Binding of Ins1 and Positive_regulation of Pik3cb 1 0.01 2.08 0 98.52
110 INT226190 Binding of Igf1 and Positive_regulation of Pik3cb 1 0.17 1.04 0 98.52
111 INT275758 Binding of xn and Igfbp3 1 0.03 5.39 0.04 98.48
112 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19 98.48
113 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63 98.44
114 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05 98.44
115 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04 98.42
116 INT281005 Hdlcl1 Regulation of OTOR 1 0.00 1.62 0.26 98.40
117 INT207846 Hypism Regulation of INS 1 0.06 1.14 0.04 98.20
118 INT350823 Binding of SAA1 and SELS 1 0.17 2.75 0.05 98.20
119 INT210897 Binding of SNRNP70 and IGHD1-14 1 0.01 1.63 0.08 98.20
120 INT301659 Gene_expression of Mapk8 Positive_regulation of Positive_regulation of Srebf1 1 0.33 0.8 0.08 98.16
121 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08 98.16
122 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07 98.16
123 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42 98.14
124 INT323493 Binding of Ins1 and Ghrl 1 0.12 1.25 0 98.12
125 INT189321 Binding of Apoa1 and Hdlcl1 1 0.00 0.68 0.2 98.12
126 INT157268 Adipor1 Positive_regulation of Adipor2 1 0.01 0.89 0.08 98.10
127 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08 98.10
128 INT157272 Adipor1 Positive_regulation of APRT 1 0.12 0.88 0.07 98.10
129 INT284311 RPS6KB1 Positive_regulation of Phosphorylation of IRS1 1 0.18 0.24 0 98.08
130 INT348786 Tlr4 Positive_regulation of Mapk8 1 0.33 1.09 0.11 98.00
131 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08 97.94
132 INT157263 PPARA Positive_regulation of APRT 1 0.54 0.92 0.08 97.94
133 INT157270 PPARA Positive_regulation of Adipor2 1 0.05 0.92 0.08 97.94
134 INT213261 TNF Positive_regulation of CRP 1 0.24 1.59 0.06 97.92
135 INT329224 Prkag1 Positive_regulation of Localization of Ins1 1 0.03 1.14 0 97.88
136 INT314623 Ex Positive_regulation of INS 1 0.10 1.46 0 97.88
137 INT328142 Binding of Atp10a and Snrpn 1 0.30 0.3 0 97.84
138 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2 97.80
139 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2 97.80
140 INT352794 Binding of APOB and FGF21 1 0.01 1.98 0 97.68
141 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08 97.64
142 INT255164 Regulation of PM20D2 Regulation of FLNA 1 0.00 0.82 0 97.56
143 INT210899 Binding of SELE and IGHD1-14 1 0.39 3.31 0.11 97.44
144 INT230817 Ins1 Positive_regulation of Regulation of Agt 1 0.07 1.11 0.04 97.04
145 INT255165 PM20D2 Regulation of FLNA 1 0.00 0.76 0 97.00
146 INT226206 Gtf3a Positive_regulation of Akt1 1 0.00 1.02 0 96.84
147 INT226193 Gtf3a Positive_regulation of Pik3cb 1 0.00 1.02 0 96.84
148 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 96.52
149 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0 96.52
150 INT235623 Binding of INS and INSR 1 0.14 0.47 0 96.52
151 INT256573 Gopc Regulation of Ins1 1 0.10 0.71 0 96.30
152 INT255742 hs Positive_regulation of Phosphorylation of Akt1 1 0.10 1.11 0 96.24
153 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04 96.14
154 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0 96.12
155 INT353061 HSD11B1 Regulation of Gene_expression of LEP 1 0.20 5.03 0 96.12
156 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0 96.12
157 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03 96.04
158 INT291173 Ins1 Regulation of Baat 1 0.12 0.83 0 96.00
159 INT207259 Binding of CNBP and TXNIP 1 0.01 0.94 0 95.88
160 INT242961 Ffar1 Regulation of Localization of Ins1 1 0.23 2.08 0.08 95.84
161 INT240882 Sod1 Positive_regulation of Phosphorylation of Creb1 1 0.31 0.1 0 95.80
162 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37 95.48
163 INT255745 Gene_expression of Hspa1a Positive_regulation of Phosphorylation of Akt1 1 0.31 0.56 0 95.48
164 INT321189 SPEF1 Regulation of Gene_expression of DSE 1 0.09 0.97 0.03 95.44
165 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14 95.30
166 INT18325 Grem2 Positive_regulation of Ins1 1 0.02 0.9 0.88 95.28
167 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68 95.24
168 INT253148 Ins1 Regulation of Phosphorylation of Tbc1d4 1 0.09 0.42 0.09 95.08
169 INT255737 hs Positive_regulation of Hspa1a 1 0.09 1.1 0 95.04
170 INT240907 Mapk14 Positive_regulation of Creb1 1 0.13 0.34 0 94.92
171 INT255166 Binding of MOCS1 and MPO 1 0.00 0.7 0.05 94.92
172 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 94.88
173 INT207265 ZNF236 Positive_regulation of Gene_expression of TXNIP 1 0.04 1.6 0 94.60
174 INT305270 Lep Negative_regulation of Localization of Car2 1 0.16 1.28 0 94.56
175 INT207258 TXNIP Regulation of ZNF236 1 0.04 1.87 0 94.52
176 INT275756 xn Regulation of Ins1 1 0.01 3.25 0 94.32
177 INT291095 FFAR1 Regulation of PDHA1 1 0.03 0.27 0 94.28
178 INT240874 Sod1 Negative_regulation of Ros1 1 0.11 0.09 0 94.08
179 INT240896 Gene_expression of Sod1 Negative_regulation of Ros1 1 0.12 0.69 0 94.00
180 INT240941 Binding of Akt1 and Ins1 1 0.06 0.75 0.11 93.76
181 INT301646 Srebf1 Negative_regulation of Gene_expression of Irs2 1 0.08 0.62 0.08 93.68
182 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05 93.68
183 INT301645 Binding of Alb and Slc27a1 1 0.02 0.38 0.08 93.68
184 INT301614 Binding of Slc27a1 and Cd36 1 0.09 0.38 0.08 93.68
185 INT199212 Binding of IGFBP1 and INS 1 0.05 1.77 0.04 93.60
186 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1 93.60
187 INT240893 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Irs1 1 0.08 0.36 0.04 93.44
188 INT240892 Negative_regulation of Ros1 Negative_regulation of Phosphorylation of Irs2 1 0.11 0.17 0 93.44
189 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15 93.40
190 INT301637 Positive_regulation of Ros1 Positive_regulation of Phosphorylation of Ins1 1 0.00 0.91 0.1 93.32
191 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 93.28
192 INT230818 Ins1 Positive_regulation of Gene_expression of Agt 1 0.07 1.11 0.04 93.20
193 INT301613 Binding of Fabp4 and Cd36 1 0.05 0.38 0.08 93.20
194 INT301651 Binding of Alb and Fabp4 1 0.01 0.38 0.08 93.20
195 INT310280 Gpt Positive_regulation of SLPI 1 0.30 0.43 0 93.12
196 INT310279 Tmprss11d Positive_regulation of SLPI 1 0.18 0.43 0 93.12
197 INT253135 Ins1 Regulation of Il6 1 0.13 0.42 0.09 92.88
198 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 92.60
199 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 92.60
200 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 92.60

Single Events

The table below shows the top 200 pain related interactions that have been reported for Insulin Resistance. They are ordered first by their pain relevance and then by number of times they were reported in Insulin Resistance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
2 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 100.00
3 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 100.00
4 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
5 INT812 Localization of INS 1026 0.81 515.6 145.31 100.00
6 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 100.00
7 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 100.00
8 INT251 Regulation of INS 398 0.62 232.47 55.04 100.00
9 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 100.00
10 INT14572 Binding of INS 205 0.48 175.43 13.38 100.00
11 INT3214 Localization of Ins1 527 0.80 196.9 79.26 100.00
12 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 100.00
13 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 100.00
14 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 100.00
15 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
16 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 100.00
17 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 100.00
18 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 100.00
19 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 100.00
20 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37 100.00
21 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 100.00
22 INT1114 Localization of Ins1 748 0.80 192.95 165.48 100.00
23 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 100.00
24 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 100.00
25 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9 100.00
26 INT237322 Gene_expression of Irs1 52 0.77 21.07 2 100.00
27 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 100.00
28 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 100.00
29 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 100.00
30 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 100.00
31 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 100.00
32 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 100.00
33 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 100.00
34 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 100.00
35 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 100.00
36 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 100.00
37 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18 100.00
38 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31 100.00
39 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 100.00
40 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18 100.00
41 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 100.00
42 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67 100.00
43 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 100.00
44 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 100.00
45 INT2578 Binding of Ins1 74 0.48 33.57 12.92 100.00
46 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 100.00
47 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83 100.00
48 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 100.00
49 INT28739 Binding of Ins1 35 0.37 22.43 2.14 100.00
50 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 100.00
51 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 100.00
52 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 100.00
53 INT67146 Positive_regulation of Gene_expression of Hypism 4 0.17 9.08 1.09 100.00
54 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 100.00
55 INT2774 Binding of Crp 241 0.48 195.89 44.39 100.00
56 INT17425 Regulation of Gene_expression of Ins1 23 0.45 18.99 5.61 100.00
57 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 100.00
58 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 100.00
59 INT86437 Binding of IL6 154 0.48 121.22 29.3 100.00
60 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 100.00
61 INT75908 Regulation of LEP 77 0.60 60.16 15.19 100.00
62 INT82079 Positive_regulation of Lep 79 0.70 40 11.07 100.00
63 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14 100.00
64 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7 100.00
65 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 100.00
66 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86 100.00
67 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16 100.00
68 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 100.00
69 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 100.00
70 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 100.00
71 INT120895 Binding of CCL2 22 0.37 15.86 6.55 100.00
72 INT11937 Localization of Il6 228 0.81 139.83 64.39 100.00
73 INT66794 Binding of Vcam1 14 0.48 7.84 1.87 100.00
74 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
75 INT12762 Negative_regulation of Positive_regulation of Ins1 24 0.59 8.51 8.28 100.00
76 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 100.00
77 INT240614 Gene_expression of Etv3 5 0.38 6.1 0.99 100.00
78 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 100.00
79 INT31412 Negative_regulation of Positive_regulation of Ins1 10 0.40 7.14 2.82 100.00
80 INT219648 Gene_expression of Hd 16 0.27 8.78 0.68 100.00
81 INT34669 Localization of Hypism 8 0.25 10.79 1.2 100.00
82 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95 100.00
83 INT164010 Gene_expression of CNBP 7 0.53 9.13 1.71 100.00
84 INT28020 Binding of Adipoq 10 0.36 11.49 0.77 100.00
85 INT207568 Negative_regulation of VAT1 1 0.13 8.92 0.55 100.00
86 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 100.00
87 INT112026 Gene_expression of Pik3cd 6 0.72 4.89 2.34 100.00
88 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 100.00
89 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92 100.00
90 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 100.00
91 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 100.00
92 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91 100.00
93 INT238836 Positive_regulation of Gene_expression of RBP4 1 0.68 3.46 0 100.00
94 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45 100.00
95 INT280680 Gene_expression of Pdk4 1 0.68 1.53 0.4 100.00
96 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01 100.00
97 INT187713 Gene_expression of PCOS1 1 0.04 2.09 0.19 100.00
98 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 100.00
99 INT8741 Regulation of Positive_regulation of Ins1 5 0.41 1.36 1.67 100.00
100 INT207293 Negative_regulation of Negative_regulation of INS 12 0.49 6 0.26 100.00
101 INT141789 Gene_expression of Ucp3 19 0.78 4.12 0.75 100.00
102 INT182788 Gene_expression of ETV3 8 0.40 11.33 0.36 100.00
103 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 100.00
104 INT267698 Gene_expression of ARID1B 18 0.63 20.47 0.47 100.00
105 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4 100.00
106 INT51474 Binding of Il6 55 0.48 44.99 20.52 100.00
107 INT282406 Positive_regulation of Positive_regulation of Hypism 1 0.13 2.15 0.28 100.00
108 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65 100.00
109 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15 100.00
110 INT224414 Regulation of CIMT 15 0.39 11.75 1.42 100.00
111 INT144094 Negative_regulation of Localization of Ripk2 1 0.42 0.49 0.09 100.00
112 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 100.00
113 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 100.00
114 INT240826 Negative_regulation of Gene_expression of Ppargc1a 6 0.59 3.09 0.08 100.00
115 INT207569 Gene_expression of VAT1 4 0.17 9.86 0.53 100.00
116 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 100.00
117 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
118 INT329205 Negative_regulation of Positive_regulation of Prkag1 1 0.25 1.17 0 100.00
119 INT246826 Positive_regulation of Localization of Irs1 1 0.50 0.76 0 100.00
120 INT154603 Negative_regulation of Localization of Hypism 3 0.08 6.44 0.77 100.00
121 INT54851 Positive_regulation of Positive_regulation of Ins1 6 0.46 1.22 1.12 100.00
122 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24 100.00
123 INT182800 Positive_regulation of ETV3 5 0.46 10.01 0.14 100.00
124 INT182754 Positive_regulation of T2DM 1 0.67 4.5 0.03 100.00
125 INT152617 Negative_regulation of Gene_expression of Hypism 1 0.01 1.15 0.34 100.00
126 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 100.00
127 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 100.00
128 INT139435 Regulation of Pir 1 0.09 0.6 0.16 100.00
129 INT24983 Binding of MPO 18 0.42 17.56 3.29 100.00
130 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39 100.00
131 INT83190 Gene_expression of Olr1 26 0.59 12.47 2.91 100.00
132 INT19342 Regulation of Insr 12 0.24 6.11 1.54 100.00
133 INT15530 Positive_regulation of Gene_expression of FFAR1 4 0.39 1.84 0.16 100.00
134 INT81575 Gene_expression of SIL1 29 0.25 19.76 1.24 100.00
135 INT15527 Gene_expression of FFAR1 19 0.61 11.15 1.08 100.00
136 INT229372 Positive_regulation of Gene_expression of CNBP 1 0.24 1.51 0.09 100.00
137 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77 100.00
138 INT121608 Positive_regulation of Prkag1 23 0.15 9.35 4.64 100.00
139 INT97470 Regulation of FAT1 4 0.23 2.39 0.26 100.00
140 INT23611 Gene_expression of Mtor 23 0.66 3.57 5.02 100.00
141 INT170062 Negative_regulation of Gene_expression of HBM 3 0.16 4.82 0.25 100.00
142 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 100.00
143 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 100.00
144 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 100.00
145 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 100.00
146 INT187728 Regulation of PCOS1 1 0.02 0.84 0.13 100.00
147 INT253117 Positive_regulation of Negative_regulation of Nr1h2 1 0.19 0.41 0.19 100.00
148 INT2217 Positive_regulation of Positive_regulation of Ins1 21 0.69 7.66 6.32 100.00
149 INT2579 Protein_catabolism of Ins1 43 0.99 9.91 5.14 100.00
150 INT191978 Positive_regulation of Gene_expression of Ide 16 0.63 6.8 0.65 100.00
151 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 100.00
152 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 100.00
153 INT116619 Positive_regulation of Positive_regulation of Creb1 25 0.69 8.32 7.3 100.00
154 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76 100.00
155 INT352530 Positive_regulation of Positive_regulation of SOCS3 1 0.15 1.77 0.08 100.00
156 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63 100.00
157 INT21606 Positive_regulation of Regulation of Ins1 8 0.41 3.9 2.97 100.00
158 INT207564 Positive_regulation of Gene_expression of VAT1 1 0.13 1.38 0.05 100.00
159 INT141791 Regulation of Ucp3 3 0.53 1.27 0.28 100.00
160 INT280630 Regulation of Pdk4 1 0.54 0.35 0.25 100.00
161 INT212966 Negative_regulation of Gene_expression of Hdl1 8 0.27 10.98 0.49 100.00
162 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 100.00
163 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73 100.00
164 INT10267 Regulation of Positive_regulation of Ins1 11 0.24 2.74 2.63 100.00
165 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 100.00
166 INT162669 Regulation of Prkag1 4 0.09 3.77 2.1 100.00
167 INT25546 Gene_expression of Hapln1 8 0.14 5.58 0.99 100.00
168 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 100.00
169 INT280686 Binding of Pdk4 1 0.33 0.29 0.29 100.00
170 INT14735 Positive_regulation of COL6A2 3 0.42 3.13 0.22 100.00
171 INT280646 Binding of Ucp3 1 0.31 0.29 0.16 100.00
172 INT204171 Negative_regulation of Positive_regulation of Ide 2 0.06 1.73 0.16 100.00
173 INT136203 Binding of NAMSD 1 0.01 1.23 0.15 100.00
174 INT229749 Regulation of Gene_expression of CHDH 7 0.27 5.94 0.12 100.00
175 INT267924 Positive_regulation of Positive_regulation of asa 1 0.02 0.78 0 100.00
176 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 99.98
177 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 99.98
178 INT246829 Localization of Irs1 2 0.74 0.9 0 99.98
179 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63 99.96
180 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.96
181 INT65356 Localization of LEP 46 0.79 41.17 5.43 99.96
182 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23 99.96
183 INT238828 Regulation of RBP4 6 0.60 2.7 0.58 99.96
184 INT253118 Negative_regulation of Localization of Slc2a4 3 0.25 2.47 0.33 99.96
185 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11 99.96
186 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51 99.96
187 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 99.96
188 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73 99.96
189 INT21806 Positive_regulation of Hdlbp 7 0.49 4.16 0.58 99.96
190 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76 99.96
191 INT140811 Regulation of Retn 2 0.11 1.52 0.04 99.96
192 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 99.92
193 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42 99.92
194 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 99.92
195 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.92
196 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3 99.92
197 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 99.92
198 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53 99.92
199 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15 99.92
200 INT253106 Negative_regulation of Phosphorylation of Ins1 6 0.17 5.62 0.87 99.92
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