D:Insulinoma

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Disease Term
Synonyms Adenoma Beta Cell, ADENOMAS BETA CELL, Beta Cell Adenoma, BETA CELL ADENOMAS, Beta Cell Tumor, Beta Cell Tumors, Insulinomas, Insuloma, Insulomas, Tumor Beta Cell, Tumors Beta Cell
Documents 55
Hot Single Events 49
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Insulinoma. They are ordered first by their relevance to Insulinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 98.72
2 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04 94.20
3 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96 94.20
4 INT303656 SST Negative_regulation of Localization of GAST 1 0.12 1.45 0.82 94.20
5 INT202431 Binding of IGF2 and INSRR 1 0.01 0.85 0 76.68
6 INT202430 Binding of IGF2 and INS 1 0.16 0.85 0 76.68
7 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1 36.80
8 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2 36.16
9 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2 36.16
10 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41 5.36
11 INT303652 Binding of SST and SSTR2 1 0.26 0.46 0.57 5.00
12 INT303654 Binding of SST and SSTR5 1 0.22 0.46 0.57 5.00
13 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54 5.00
14 INT303651 Binding of SSTR2 and SSTR5 1 0.24 0.23 0.45 5.00
15 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
16 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4 5.00
17 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3 5.00
18 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
19 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19 5.00
20 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18 5.00
21 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
22 INT303659 SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 5.00
23 INT303657 Gene_expression of SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 5.00
24 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
25 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
26 INT205046 MUC13 Negative_regulation of Localization of COL17A1 1 0.31 0.62 0 5.00
27 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
28 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
29 INT205048 MUC13 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 5.00
30 INT205059 MUC13 Negative_regulation of Localization of ROPN1L 1 0.34 0.62 0 5.00
31 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
32 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
33 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
34 INT205047 MUC13 Negative_regulation of SLPI 1 0.06 0.61 0 5.00
35 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
36 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
37 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
38 INT205049 LGALS4 Negative_regulation of Localization of MUC13 1 0.34 0.61 0 5.00
39 INT205050 LGALS4 Negative_regulation of Localization of ROPN1L 1 0.36 0.62 0 5.00
40 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
41 INT205058 LGALS4 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 5.00
42 INT205045 LGALS4 Negative_regulation of SLPI 1 0.06 0.61 0 5.00
43 INT205056 LGALS4 Negative_regulation of Localization of COL17A1 1 0.32 0.62 0 5.00
44 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00
45 INT205053 MUC13 Negative_regulation of Localization of LGALS4 1 0.34 0.61 0 5.00
46 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Insulinoma. They are ordered first by their pain relevance and then by number of times they were reported in Insulinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT217539 Localization of INSM1 1 0.04 7.01 0.2 100.00
2 INT136531 Binding of Men1 8 0.47 9.62 0.65 99.98
3 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71 99.80
4 INT812 Localization of INS 1026 0.81 515.6 145.31 99.72
5 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 99.60
6 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 99.20
7 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12 99.12
8 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19 99.12
9 INT303649 Gene_expression of Ptprf 1 0.58 0.96 0.11 98.98
10 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 98.96
11 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 98.72
12 INT243480 Gene_expression of SSTR5 1 0.55 4.25 0.85 98.66
13 INT310259 Localization of ST11 1 0.08 4.06 0 98.40
14 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.26
15 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 97.76
16 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42 97.68
17 INT17625 Localization of GCG 210 0.80 55.69 24.97 97.56
18 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 97.56
19 INT2243 Localization of GAST 67 0.81 34.54 16.19 97.08
20 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 96.60
21 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 96.16
22 INT303676 Regulation of Gene_expression of SSTR5 1 0.32 1.69 0.28 95.40
23 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44 95.20
24 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 95.12
25 INT303671 Negative_regulation of Regulation of GCG 1 0.13 1.44 0.22 94.66
26 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 94.66
27 INT4494 Regulation of GCG 41 0.45 18.38 9.68 94.50
28 INT397 Localization of SST 232 0.81 58.05 101.19 94.20
29 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 92.36
30 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16 91.28
31 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 91.12
32 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 89.96
33 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26 89.92
34 INT249 Localization of GHRH 215 0.80 78.02 51.87 89.28
35 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 89.28
36 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 87.64
37 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 87.64
38 INT205105 Gene_expression of AXIN2 1 0.74 6.6 0 87.04
39 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 86.36
40 INT70893 Positive_regulation of Gene_expression of IGF2 5 0.67 6.13 0.44 86.36
41 INT124407 Gene_expression of SSTR1 4 0.55 5.55 1.41 84.00
42 INT217536 Regulation of INSM1 1 0.02 1.38 0.04 83.24
43 INT127433 Negative_regulation of Gene_expression of Nup62 2 0.53 2.36 0.08 81.72
44 INT14572 Binding of INS 205 0.48 175.43 13.38 81.48
45 INT7031 Transcription of Pdyn 43 0.71 5.82 13.58 81.12
46 INT53671 Transcription of St6gal2 1 0.01 0.4 0.23 81.12
47 INT217537 Gene_expression of INSM1 1 0.04 5.1 0.04 81.08
48 INT263872 Localization of Adra1d 1 0.01 2.5 0.11 81.08
49 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 80.68
50 INT197839 Negative_regulation of PHPT1 1 0.04 2.88 0.06 79.28
51 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06 79.28
52 INT40189 Localization of IFNA2 6 0.74 7.7 1.04 78.44
53 INT5118 Regulation of SST 97 0.62 34.35 51.74 77.52
54 INT691 Binding of SST 67 0.48 24.66 32.67 77.12
55 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 77.00
56 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 77.00
57 INT185028 Binding of IGF2 4 0.46 1.72 0.07 76.68
58 INT197842 Gene_expression of PHPT1 1 0.06 5.89 0.16 76.68
59 INT197835 Positive_regulation of Gene_expression of PHPT1 1 0.04 3.17 0.07 76.68
60 INT205098 Positive_regulation of Gene_expression of MAFB 1 0.33 1.13 0.03 76.60
61 INT30629 Regulation of Positive_regulation of SST 2 0.37 1.35 0.59 76.48
62 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07 76.36
63 INT205100 Gene_expression of MAFB 1 0.37 1.13 0.03 76.20
64 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 75.96
65 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 75.96
66 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 75.36
67 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23 75.00
68 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23 75.00
69 INT53670 Transcription of Furin 3 0.50 0.39 0.81 75.00
70 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34 75.00
71 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07 75.00
72 INT53666 Regulation of Furin 4 0.37 0.3 1.24 75.00
73 INT53669 Regulation of Transcription of Furin 1 0.16 0.15 0.82 75.00
74 INT53673 Gene_expression of Furin 6 0.40 1.99 1.54 75.00
75 INT53660 Positive_regulation of Pcsk5 2 0.49 0.29 0.85 75.00
76 INT53675 Positive_regulation of Pcsk6 1 0.22 0.29 0.41 75.00
77 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 75.00
78 INT7389 Positive_regulation of Localization of Pdyn 15 0.48 1.68 11.88 75.00
79 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 75.00
80 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 74.36
81 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 74.36
82 INT9781 Binding of INSRR 64 0.31 19.1 25.2 74.20
83 INT202187 Regulation of GRN 3 0.09 1.47 0.53 71.32
84 INT303669 Regulation of SPINK5 1 0.24 0.65 0.53 71.32
85 INT41555 Gene_expression of GRN 8 0.52 10.94 0.69 71.04
86 INT197832 Localization of MEN1 1 0.80 11.01 0.63 69.12
87 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 67.40
88 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 65.08
89 INT303680 Negative_regulation of Positive_regulation of VIP 1 0.15 1.2 0.28 65.08
90 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 64.32
91 INT263879 Positive_regulation of Adra1d 1 0.00 0.47 0.04 63.32
92 INT73797 Negative_regulation of Gene_expression of MIA3 14 0.10 10.65 1.25 60.64
93 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 60.32
94 INT118350 Negative_regulation of Chga 2 0.42 1.64 0.71 58.88
95 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 57.28
96 INT44783 Gene_expression of Chga 3 0.75 1.72 1.45 57.28
97 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 57.28
98 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 56.48
99 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 54.92
100 INT2464 Gene_expression of AMY2A 21 0.75 13.76 2.78 54.92
101 INT48803 Gene_expression of CELA3B 9 0.22 7.24 2.06 54.92
102 INT136720 Gene_expression of PRSS2 6 0.50 4.99 1.43 54.92
103 INT36947 Gene_expression of PNLIP 13 0.45 11.04 1.23 54.92
104 INT205082 Gene_expression of CPA2 1 0.65 1.1 0.07 54.92
105 INT205095 Gene_expression of CELA3A 1 0.62 2.58 0.06 54.92
106 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07 54.04
107 INT216011 Regulation of TSC2 2 0.26 3.31 0 52.52
108 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 51.08
109 INT17934 Localization of MLN 16 0.80 2.83 2.24 50.72
110 INT39919 Negative_regulation of MLN 9 0.36 2.91 1.06 50.72
111 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 50.40
112 INT172921 Negative_regulation of Gene_expression of BOP 2 0.12 1.54 0.03 50.40
113 INT172923 Negative_regulation of BOP 1 0.03 1.17 0 50.40
114 INT2132 Localization of SCT 29 0.81 8.39 5.43 50.00
115 INT4820 Negative_regulation of SCT 7 0.43 4.06 3.01 50.00
116 INT172924 Gene_expression of BOP 8 0.47 3.15 0.14 49.52
117 INT172922 Positive_regulation of Gene_expression of BOP 1 0.04 1.13 0 49.52
118 INT628 Negative_regulation of GAST 10 0.58 4.44 2.08 49.20
119 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 48.80
120 INT625 Localization of PGC 35 0.80 11.33 3.05 48.48
121 INT629 Negative_regulation of Localization of PGC 8 0.45 5.79 1.33 48.48
122 INT32704 Negative_regulation of PGC 11 0.54 5.75 1.23 48.48
123 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 47.44
124 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 47.16
125 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 47.16
126 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 47.00
127 INT158 Localization of Prl 2431 0.81 378.96 952.2 46.72
128 INT30 Gene_expression of Gast 158 0.78 99 41.45 45.44
129 INT303677 Positive_regulation of SSTR2 1 0.42 0.56 0.16 43.40
130 INT303668 Positive_regulation of Gene_expression of SSTR2 1 0.42 0.66 0.16 43.40
131 INT443 Localization of POMC 1020 0.81 284.52 443.17 43.24
132 INT1893 Localization of Gh 1041 0.79 340.23 256.58 43.24
133 INT425 Localization of PRL 455 0.81 189.64 144.8 43.24
134 INT252 Localization of GH1 529 0.80 227.4 122.05 43.24
135 INT152437 Localization of SPINK5 4 0.54 3.97 0.69 40.88
136 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 40.44
137 INT546 Binding of ALB 311 0.48 85.98 60.14 39.24
138 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 38.24
139 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 37.56
140 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 36.16
141 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 36.16
142 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 36.16
143 INT197827 Regulation of PHPT1 1 0.03 2.54 0.08 34.04
144 INT202435 Transcription of IGF2 3 0.58 2.44 0.29 33.44
145 INT202433 Positive_regulation of Transcription of IGF2 1 0.42 0.55 0 33.44
146 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13 31.56
147 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 31.00
148 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 30.24
149 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 29.80
150 INT202434 Gene_expression of IGFBP6 3 0.53 1.52 0 23.20
151 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 22.80
152 INT205099 Positive_regulation of Gene_expression of AXIN2 1 0.48 3.48 0 22.56
153 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 19.92
154 INT303672 Negative_regulation of Gene_expression of SSTR2 1 0.49 0.95 0.21 18.60
155 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 18.40
156 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 16.04
157 INT144461 Negative_regulation of SSTR2 2 0.49 1.03 0.98 12.92
158 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
159 INT1005 Localization of Sst 385 0.81 26.31 244.56 5.00
160 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
161 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
162 INT90 Localization of Gast 400 0.81 137.67 113 5.00
163 INT4631 Positive_regulation of Sst 127 0.70 17.37 83.29 5.00
164 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
165 INT5098 Negative_regulation of Localization of Sst 70 0.58 3.56 51.17 5.00
166 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
167 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
168 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
169 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
170 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
171 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
172 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
173 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
174 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 5.00
175 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
176 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 5.00
177 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
178 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
179 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 5.00
180 INT2491 Regulation of Cea 38 0.61 26.18 10.95 5.00
181 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
182 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 5.00
183 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 5.00
184 INT12054 Negative_regulation of MIA3 32 0.45 23.2 6.18 5.00
185 INT24724 Positive_regulation of Gene_expression of SST 11 0.67 7.51 6.12 5.00
186 INT624 Positive_regulation of GAST 28 0.70 15.61 4.73 5.00
187 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 5.00
188 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
189 INT88390 Gene_expression of LGALS4 27 0.69 12.28 4.15 5.00
190 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91 5.00
191 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 5.00
192 INT13733 Localization of SSTR1 8 0.65 3.11 2.49 5.00
193 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
194 INT205096 Localization of LGALS4 2 0.71 6.06 2.05 5.00
195 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 5.00
196 INT104524 Localization of FSCN1 3 0.13 1.76 1.75 5.00
197 INT47889 Binding of MMP2 9 0.41 6.37 1.68 5.00
198 INT74392 Binding of LGALS4 4 0.43 7.23 1.65 5.00
199 INT71106 Negative_regulation of Iapp 4 0.33 2.82 1.24 5.00
200 INT303667 Regulation of BCL2L11 3 0.16 1.03 1.21 5.00
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