D:Intervertebral Disk Displacement

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Disease Term
Synonyms Disc Displacement Intervertebral, Disc Displacements Intervertebral, Disc Herniated, Discs Herniated, Disk Displacement Intervertebral, Disk Displacements Intervertebral, DISK HERNIATED, Disk Prolapse, Disk Prolapsed, Disk Prolapses, Disk Slipped
Documents 690
Hot Single Events 84
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Intervertebral Disk Displacement. They are ordered first by their relevance to Intervertebral Disk Displacement and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259014 Tnfrsf18 Positive_regulation of TNFSF18 1 0.08 0.39 0 99.68
2 INT123221 Binding of ADRA1D and TNFAIP6 1 0.03 0.76 0.25 98.80
3 INT103156 Tnf Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.94 0.27 95.00
4 INT103152 TNF Positive_regulation of Positive_regulation of VEGFA 1 0.09 0.93 0.26 93.84
5 INT259017 Binding of TNFSF18 and Tnfrsf18 1 0.08 1.27 0.16 90.28
6 INT259016 Positive_regulation of Binding of TNFSF18 and Relt 1 0.06 0.67 0 83.68
7 INT259018 Positive_regulation of Binding of TNFSF18 and Tnfrsf18 1 0.11 0.67 0 83.68
8 INT259015 Binding of TNFSF18 and Relt 1 0.04 0.67 0 83.68
9 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48 37.28
10 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12 36.56
11 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34 5.00
12 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3 5.00
13 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26 5.00
14 INT160541 Binding of BDNF and PSIP1 4 0.49 1.94 1.02 5.00
15 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73 5.00
16 INT297972 MAPK14 Negative_regulation of ING5 1 0.21 1.67 0.33 5.00
17 INT297965 MAPK14 Negative_regulation of GADD45A 1 0.05 1 0.21 5.00
18 INT250908 Binding of Mmp2 and Tsp1 1 0.04 0.09 0.15 5.00
19 INT250906 Binding of Mmp2 and Thbs2 1 0.06 0.09 0.15 5.00
20 INT250911 Thbs2 Regulation of Mmp2 1 0.05 0.3 0.13 5.00
21 INT250910 Thbs2 Regulation of Tgm2 1 0.04 0.3 0.13 5.00
22 INT250913 Col7a1 Regulation of Thbs2 Regulation of Col7a1 1 0.00 0.35 0.13 5.00
23 INT250912 Thbs2 Regulation of Thbs2 Regulation of Col7a1 1 0.03 0.35 0.13 5.00
24 INT250907 Thbs2 Regulation of Col7a1 1 0.03 0.35 0.13 5.00
25 INT297967 MAPK14 Negative_regulation of SCUBE3 1 0.01 0.67 0.12 5.00
26 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08 5.00
27 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08 5.00
28 INT297964 Binding of CDK8 and MAP3K11 1 0.26 0.29 0.07 5.00
29 INT297969 Positive_regulation of Binding of CDK8 and MAP3K11 1 0.35 0.29 0.07 5.00
30 INT297971 Positive_regulation of Binding of CDK8 and MAPK1 1 0.22 0.3 0.07 5.00
31 INT297963 Binding of CDK8 and MAPK1 1 0.16 0.29 0.07 5.00
32 INT298000 MAP3K4 Positive_regulation of Gene_expression of Gadd45b 1 0.27 0.72 0.03 5.00
33 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03 5.00
34 INT298002 Gene_expression of Gadd45b Positive_regulation of MAPK14 1 0.29 0.67 0.03 5.00
35 INT298001 Gene_expression of Gadd45b Positive_regulation of MAP3K4 1 0.25 0.72 0.03 5.00
36 INT184209 IL1B Negative_regulation of Gene_expression of SOX6 1 0.46 0.05 0.03 5.00
37 INT297962 MAP3K4 Positive_regulation of MAPK14 1 0.21 0.66 0.03 5.00
38 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0 5.00
39 INT184210 IL1B Negative_regulation of Gene_expression of COL1A2 1 0.04 0 0 5.00
40 INT320028 Gene_expression of GDF6 Positive_regulation of Gene_expression of COL7A1 1 0.01 0 0 5.00
41 INT297966 CDKN1A Positive_regulation of TP53 1 0.08 0.49 0 5.00
42 INT184211 GOPC Negative_regulation of Gene_expression of ADAMTS5 1 0.07 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Intervertebral Disk Displacement. They are ordered first by their pain relevance and then by number of times they were reported in Intervertebral Disk Displacement. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 100.00
2 INT157400 Gene_expression of Tnfrsf18 15 0.39 7.3 2.13 99.84
3 INT259010 Gene_expression of TNFSF18 1 0.31 4.54 0.49 99.84
4 INT259004 Positive_regulation of Gene_expression of Tnfrsf18 1 0.34 2.73 0.06 99.84
5 INT259012 Positive_regulation of Gene_expression of TNFSF18 1 0.27 2.82 0.06 99.84
6 INT58076 Gene_expression of L3MBTL4 1 0.03 0.58 0.26 99.84
7 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.82
8 INT58075 Gene_expression of Epb4.1l5 2 0.02 0.58 0.26 99.66
9 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 99.50
10 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.48
11 INT259007 Positive_regulation of Tnfrsf18 10 0.34 4.94 0.36 99.48
12 INT259013 Positive_regulation of TNFSF18 1 0.24 3.64 0.16 99.48
13 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 99.48
14 INT9347 Localization of Il1b 58 0.81 26.13 31.53 99.48
15 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.48
16 INT19511 Localization of Il6 212 0.81 118.17 67.67 99.48
17 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 99.48
18 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.36
19 INT90405 Positive_regulation of Gene_expression of IL6R 3 0.03 1.85 0.31 99.36
20 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 99.28
21 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 99.02
22 INT49505 Binding of NOTCH3 6 0.47 6.4 1.03 98.96
23 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.80
24 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 98.80
25 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 98.80
26 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2 98.80
27 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.68
28 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64 98.68
29 INT123222 Binding of ITIH1 1 0.13 0.75 0.25 98.44
30 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 98.40
31 INT259011 Transcription of TNFSF18 1 0.25 0.25 0 98.16
32 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 98.12
33 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 98.12
34 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 98.12
35 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.40
36 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.40
37 INT6849 Localization of IL1B 229 0.81 112.56 69.63 96.84
38 INT102311 Regulation of IL6R 4 0.12 2.37 0.74 96.60
39 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 96.24
40 INT9210 Regulation of IL6 166 0.62 125.61 49.95 96.20
41 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 95.68
42 INT85048 Regulation of NGF 19 0.62 11.61 10.5 95.32
43 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 95.00
44 INT56808 Positive_regulation of CECR 7 0.41 2.07 1.12 93.76
45 INT6481 Binding of TNF 624 0.48 510.2 214.82 93.32
46 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 93.24
47 INT75497 Regulation of JUN 28 0.61 11.04 7.09 92.92
48 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 92.72
49 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 92.56
50 INT101441 Positive_regulation of FTH1 15 0.54 7.03 3.22 92.52
51 INT51474 Binding of Il6 55 0.48 44.99 20.52 92.28
52 INT10705 Binding of Il1b 9 0.36 2.8 5.53 91.68
53 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 91.64
54 INT259003 Regulation of Cd55 1 0.05 0.17 0 90.08
55 INT259006 Regulation of Cd19 2 0.13 1.39 0 89.28
56 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 88.80
57 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 88.40
58 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 88.24
59 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 88.24
60 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 87.76
61 INT132860 Binding of BDNF 33 0.47 14.7 6.99 87.56
62 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 87.40
63 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 87.12
64 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 87.00
65 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 87.00
66 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 86.00
67 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 85.00
68 INT9660 Regulation of TNF 363 0.62 312.94 139.99 84.32
69 INT250902 Positive_regulation of Positive_regulation of Tsp1 1 0.27 0.14 0 84.32
70 INT425 Localization of PRL 455 0.81 189.64 144.8 83.84
71 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83 83.68
72 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09 83.68
73 INT10706 Regulation of Il6 150 0.62 93.23 62.34 83.60
74 INT5948 Regulation of Il1b 44 0.60 22.8 25.4 83.12
75 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 83.04
76 INT231989 Positive_regulation of Tsp1 8 0.53 8.27 0.59 82.96
77 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 82.56
78 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 82.44
79 INT258998 Positive_regulation of Relt 1 0.18 1.33 0 81.36
80 INT9077 Regulation of Tbxa2r 13 0.45 5.49 3.75 81.32
81 INT33630 Regulation of Ltb4r 5 0.09 2.95 2.47 81.32
82 INT77286 Binding of RPLP0 2 0.21 0.58 0.1 81.24
83 INT54506 Gene_expression of KRR1 5 0.75 6.68 2.1 80.88
84 INT123224 Gene_expression of TNFAIP6 12 0.70 7.13 1.21 80.40
85 INT246299 Negative_regulation of RGS1 1 0.01 0.85 0.81 79.04
86 INT78773 Regulation of PLA2G2A 11 0.61 9.76 1.91 78.12
87 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03 78.08
88 INT134965 Negative_regulation of Ecm1 7 0.18 7.86 1.7 78.08
89 INT39819 Localization of C4A 4 0.62 3.1 0.72 78.00
90 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55 77.72
91 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89 76.40
92 INT246298 Localization of RGS1 1 0.02 1.72 1.6 76.32
93 INT57783 Negative_regulation of Ltb4r2 2 0.27 0.65 0.85 75.76
94 INT145312 Localization of CHI3L1 8 0.78 12.71 1.26 75.00
95 INT53768 Localization of HNP1 1 0.05 0.49 0.5 75.00
96 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 74.84
97 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 74.32
98 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 72.44
99 INT312566 Positive_regulation of Gene_expression of CECR 1 0.19 1.67 0.38 72.44
100 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 71.36
101 INT259005 Positive_regulation of Gene_expression of Relt 1 0.12 0.95 0.2 70.60
102 INT258999 Gene_expression of Relt 1 0.16 0.94 0.2 70.60
103 INT72565 Localization of IL1RN 45 0.80 23.59 13.17 69.52
104 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 69.28
105 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 69.12
106 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 68.60
107 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 67.88
108 INT123223 Binding of TNFAIP6 5 0.35 3.36 1.65 67.20
109 INT250898 Gene_expression of Lect1 1 0.11 0.12 0.04 66.52
110 INT250901 Localization of Thbs2 1 0.78 0.86 0.03 65.48
111 INT37245 Protein_catabolism of IL4I1 2 0.34 0.6 0.57 65.04
112 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 63.92
113 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 63.00
114 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 62.96
115 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 62.80
116 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 61.84
117 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99 60.28
118 INT297991 Gene_expression of GAS1 1 0.19 0.82 0.03 60.04
119 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 59.56
120 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 59.08
121 INT110075 Binding of FTH1 10 0.36 1.12 1.13 56.80
122 INT72579 Localization of BDNF 56 0.80 14.84 10.65 56.24
123 INT10835 Regulation of IL8 79 0.49 53.04 24.14 53.20
124 INT297992 Positive_regulation of LOXL2 1 0.33 0.8 0.03 52.92
125 INT73928 Regulation of Localization of COL7A1 3 0.52 0.65 0.44 52.56
126 INT269227 Gene_expression of LOXL2 2 0.42 1.86 0.03 51.20
127 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 50.00
128 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 50.00
129 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 50.00
130 INT10516 Localization of Vwf 30 0.79 7.54 2.77 50.00
131 INT145311 Gene_expression of FOXD4L5 1 0.03 0.09 0 50.00
132 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 48.88
133 INT250993 Gene_expression of FANCE 8 0.48 4.41 0.27 47.68
134 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 47.28
135 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 46.56
136 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 46.56
137 INT259002 Negative_regulation of Tnfrsf18 1 0.18 0.91 0.14 46.00
138 INT67783 Negative_regulation of LARS 3 0.37 1.23 0.5 42.96
139 INT250899 Gene_expression of Thbs2 17 0.75 4.97 0.13 42.96
140 INT259009 Gene_expression of TNFRSF18 3 0.65 2.15 0.23 42.80
141 INT259008 Positive_regulation of Gene_expression of TNFRSF18 1 0.49 0.89 0.13 42.80
142 INT246297 Positive_regulation of RGS1 1 0.01 0.78 0.78 41.00
143 INT131456 Negative_regulation of MMRN1 14 0.19 9.49 2.29 39.92
144 INT196255 Negative_regulation of Binding of MMRN1 3 0.04 1.57 0.52 39.92
145 INT91432 Binding of MMRN1 23 0.36 9.79 2.95 39.48
146 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 32.84
147 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 32.84
148 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 32.84
149 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 32.84
150 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 29.68
151 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 27.12
152 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 25.00
153 INT15803 Regulation of IFNG 21 0.44 12.57 5.98 25.00
154 INT184215 Negative_regulation of Gene_expression of ADAMTS4 2 0.27 0.23 0.12 19.68
155 INT222991 Negative_regulation of Gene_expression of MMRN1 10 0.13 4.39 1.14 19.44
156 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 18.92
157 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 18.76
158 INT184223 Positive_regulation of Gene_expression of ADAMTS4 6 0.43 1.07 0.98 18.44
159 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8 18.04
160 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 15.04
161 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 13.44
162 INT320039 Gene_expression of CHST7 1 0.05 0 0 8.20
163 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
164 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
165 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
166 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
167 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
168 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
169 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
170 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17 5.00
171 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
172 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
173 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
174 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
175 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
176 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
177 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
178 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 5.00
179 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
180 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
181 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
182 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 5.00
183 INT9781 Binding of INSRR 64 0.31 19.1 25.2 5.00
184 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 5.00
185 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
186 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
187 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
188 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
189 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
190 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
191 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
192 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 5.00
193 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
194 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
195 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
196 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 5.00
197 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
198 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
199 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
200 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
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