D:Intestinal Perforation

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Disease Term
Synonyms Intestinal Perforations, Perforation Intestinal, Perforations Intestinal
Documents 200
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Intestinal Perforation. They are ordered first by their relevance to Intestinal Perforation and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04 5.00
2 INT233771 Binding of KRT7 and KRT20 1 0.01 1.72 0 5.00
3 INT233777 Binding of KRT20 and Cea 1 0.01 3.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Intestinal Perforation. They are ordered first by their pain relevance and then by number of times they were reported in Intestinal Perforation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.08
2 INT9210 Regulation of IL6 166 0.62 125.61 49.95 97.52
3 INT102311 Regulation of IL6R 4 0.12 2.37 0.74 97.52
4 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 89.96
5 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 88.92
6 INT287307 Binding of ENO1 9 0.48 11.24 2.51 85.80
7 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 84.64
8 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 77.80
9 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 75.00
10 INT122813 Binding of Krt20 11 0.32 13.77 0.88 75.00
11 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 75.00
12 INT93166 Positive_regulation of Ttf1 4 0.41 3.62 0.08 75.00
13 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 72.20
14 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 66.68
15 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 66.04
16 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2 66.04
17 INT287308 Negative_regulation of ENO1 5 0.59 4.07 1.24 65.28
18 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 64.52
19 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 64.52
20 INT227332 Phosphorylation of Csf3 2 0.43 2.01 0.31 63.88
21 INT192851 Phosphorylation of Il6 7 0.68 3.12 0.82 62.20
22 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 61.64
23 INT77856 Binding of Cps1 6 0.30 2.32 0.95 60.64
24 INT120722 Gene_expression of TYMP 35 0.75 19.26 1.31 59.84
25 INT206798 Binding of VAMP7 1 0.30 2.23 0.26 58.60
26 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 58.40
27 INT225667 Transcription of Apc 3 0.52 3.73 0.32 56.64
28 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39 53.36
29 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 52.80
30 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 52.80
31 INT44817 Negative_regulation of Gene_expression of Shbg 9 0.34 9.84 1.11 52.80
32 INT44003 Gene_expression of F3 40 0.75 27.92 8.29 50.48
33 INT88820 Positive_regulation of Gene_expression of F3 8 0.67 5.48 1.08 50.48
34 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 50.00
35 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 50.00
36 INT55812 Positive_regulation of LOC259246 2 0.03 1.87 0.09 50.00
37 INT37390 Regulation of Crp 39 0.46 28.74 11.45 47.76
38 INT59010 Positive_regulation of Regulation of Crp 2 0.27 2.11 1.09 47.76
39 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 42.00
40 INT138555 Negative_regulation of Tymp 3 0.39 3.31 0.74 41.76
41 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 40.80
42 INT287309 Positive_regulation of ENO1 5 0.59 5.67 1.52 34.96
43 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 29.92
44 INT192428 Gene_expression of PRND 1 0.38 0.78 0.09 23.64
45 INT168373 Gene_expression of Capns1 4 0.58 4.55 1.34 23.44
46 INT211375 Regulation of Gene_expression of TYMP 2 0.43 2.44 0.22 23.44
47 INT251830 Binding of TYMP 2 0.13 4.36 0.37 21.28
48 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 16.44
49 INT182320 Binding of MTX1 14 0.18 8.5 7.65 8.28
50 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
51 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
52 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
53 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
54 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
55 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
56 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
57 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
58 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
59 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
60 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
61 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
62 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
63 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
64 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
65 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
66 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
67 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
68 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
69 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
70 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
71 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
72 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
73 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
74 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
75 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 5.00
76 INT66026 Gene_expression of Cxcl1 74 0.78 31.87 23.37 5.00
77 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
78 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 5.00
79 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
80 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 5.00
81 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 5.00
82 INT48892 Transcription of Il10 31 0.71 27.26 16.77 5.00
83 INT51576 Positive_regulation of Cxcl1 42 0.69 20.12 16.41 5.00
84 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
85 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
86 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
87 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
88 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 5.00
89 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
90 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
91 INT141185 Regulation of Ros1 30 0.24 20.73 8.88 5.00
92 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
93 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
94 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 5.00
95 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
96 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84 5.00
97 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
98 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
99 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
100 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 5.00
101 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
102 INT70539 Negative_regulation of Cxcl1 13 0.57 7.15 4.58 5.00
103 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2 5.00
104 INT174816 Binding of IL6R 14 0.09 11.26 3.63 5.00
105 INT19211 Binding of Shbg 35 0.48 16.29 3.31 5.00
106 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
107 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 5.00
108 INT99911 Localization of MTX1 5 0.45 3.81 3.07 5.00
109 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 5.00
110 INT50272 Positive_regulation of Cotl1 24 0.40 6.57 2.77 5.00
111 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
112 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 5.00
113 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 5.00
114 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89 5.00
115 INT173939 Negative_regulation of IL6R 9 0.11 5.92 1.83 5.00
116 INT82255 Negative_regulation of Gene_expression of Cxcl1 10 0.58 3.42 1.66 5.00
117 INT51635 Negative_regulation of LRTOMT 5 0.41 1.17 1.49 5.00
118 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
119 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
120 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
121 INT124943 Regulation of NCAM1 10 0.44 5.25 1.27 5.00
122 INT50273 Negative_regulation of Cotl1 7 0.42 0.97 1.18 5.00
123 INT119196 Gene_expression of Cotl1 13 0.24 12.2 1.15 5.00
124 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 5.00
125 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03 5.00
126 INT1940 Localization of PIK3C2A 8 0.78 7.28 1.01 5.00
127 INT25071 Binding of PDSS1 5 0.32 2.42 0.97 5.00
128 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 5.00
129 INT87303 Regulation of Gene_expression of Cxcl1 7 0.54 1.32 0.93 5.00
130 INT68564 Binding of Fap 6 0.32 6.75 0.65 5.00
131 INT67346 Regulation of Gene_expression of F3 2 0.13 1.42 0.6 5.00
132 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 5.00
133 INT227331 Binding of Xdh 5 0.29 1.83 0.49 5.00
134 INT153758 Binding of Mitf 5 0.47 2.5 0.46 5.00
135 INT218598 Localization of Amigo2 2 0.15 2.15 0.35 5.00
136 INT216879 Binding of Hmox1 4 0.36 2.82 0.31 5.00
137 INT105781 Positive_regulation of Krt7 4 0.04 3.34 0.3 5.00
138 INT97179 Transcription of Pgr 17 0.67 4.54 0.3 5.00
139 INT297904 Positive_regulation of Foxo3 6 0.57 8.19 0.29 5.00
140 INT138556 Positive_regulation of TYMP 23 0.58 12.9 0.28 5.00
141 INT210686 Regulation of F3 2 0.12 0.91 0.27 5.00
142 INT153772 Negative_regulation of Localization of ESR1 7 0.54 4.42 0.27 5.00
143 INT34058 Gene_expression of FMR1 5 0.75 5.11 0.26 5.00
144 INT201453 Protein_catabolism of Hmox1 3 0.95 4.25 0.23 5.00
145 INT354726 Binding of Tymp 1 0.30 1.08 0.23 5.00
146 INT206797 Negative_regulation of VAMP7 1 0.35 1.68 0.22 5.00
147 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 5.00
148 INT326515 Negative_regulation of JAZF1 1 0.03 0 0.22 5.00
149 INT297905 Localization of Cotl1 1 0.20 1.93 0.22 5.00
150 INT170886 Gene_expression of AIRE 2 0.49 4.63 0.19 5.00
151 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17 5.00
152 INT297906 Binding of Foxo3 2 0.29 1.91 0.16 5.00
153 INT73080 Positive_regulation of TTF1 4 0.38 2.37 0.14 5.00
154 INT130431 Gene_expression of DNASE1 4 0.60 1.42 0.13 5.00
155 INT297907 Regulation of Positive_regulation of Cxcl1 1 0.16 0.66 0.11 5.00
156 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1 5.00
157 INT153771 Negative_regulation of Localization of CRP 3 0.38 0.99 0.09 5.00
158 INT140494 Negative_regulation of Fap 3 0.37 2.3 0.08 5.00
159 INT206796 Positive_regulation of VAMP7 2 0.56 4.12 0.07 5.00
160 INT71164 Gene_expression of PDSS1 7 0.59 4.78 0.04 5.00
161 INT281008 Negative_regulation of Gene_expression of Capns1 1 0.03 1.79 0.04 5.00
162 INT180359 Localization of AIRE 3 0.54 3.94 0.03 5.00
163 INT192427 Localization of PRND 1 0.42 0.53 0.03 5.00
164 INT242821 Negative_regulation of Localization of Fap 1 0.11 1.91 0 5.00
165 INT242822 Transcription of Fap 1 0.18 1.2 0 5.00
166 INT206795 Localization of VAMP7 1 0.57 1.17 0 5.00
167 INT242820 Localization of Fap 1 0.20 1.9 0 5.00
168 INT281506 Regulation of UNG 1 0.03 0 0 5.00
169 INT242823 Binding of CTNND2 1 0.36 6 0 5.00
170 INT175738 Regulation of ARNTL 4 0.28 0.29 0 5.00
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