D:Intestinal Polyposis

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pChart

Disease Term
Synonyms Cronkhite Canada Syndrome, Polyposis Intestinal
Documents 16
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Intestinal Polyposis. They are ordered first by their relevance to Intestinal Polyposis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252177 VEGFA Regulation of Gene_expression of CPOX 1 0.03 0.56 0.14 34.96
2 INT235075 Ptger2 Positive_regulation of Positive_regulation of Nos2 1 0.00 0.43 0 5.00
3 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0 5.00
4 INT268397 Binding of Kras and Regulation of ARAF 1 0.03 1.16 0 5.00
5 INT268341 SMAD2 Positive_regulation of SMAD4 1 0.31 0.56 0 5.00
6 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0 5.00
7 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.07 0.53 0 5.00
8 INT268398 Binding of LRP1 and Wnt2 1 0.01 0.36 0 5.00
9 INT268395 Binding of APC and Kras 1 0.04 1.21 0 5.00
10 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0 5.00
11 INT268396 Binding of BRAF and Ebp 1 0.01 1.72 0 5.00
12 INT268344 SMAD3 Positive_regulation of SMAD4 1 0.17 0.56 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Intestinal Polyposis. They are ordered first by their pain relevance and then by number of times they were reported in Intestinal Polyposis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT140336 Negative_regulation of Csf1 3 0.43 3.64 0.36 89.32
2 INT235060 Negative_regulation of Gene_expression of Csf1 1 0.42 2.56 0 89.32
3 INT178498 Negative_regulation of Fgf2 11 0.42 4.21 0.84 89.32
4 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 88.96
5 INT247568 Negative_regulation of Negative_regulation of VEGFA 5 0.41 5.35 0.43 88.96
6 INT187793 Gene_expression of Csf1 10 0.77 22.35 0.66 88.84
7 INT203133 Gene_expression of Cxam 3 0.07 6.17 1.22 88.72
8 INT151229 Positive_regulation of Cxam 10 0.15 6.13 1.35 86.24
9 INT116836 Binding of FAP 6 0.37 6.76 1.47 86.00
10 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 81.20
11 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 69.96
12 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 67.52
13 INT301374 Localization of Stk11 1 0.23 1.58 0 65.84
14 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 64.96
15 INT97473 Positive_regulation of FAP 4 0.34 2.72 0.18 63.56
16 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05 47.20
17 INT235072 Binding of Hfgi1 2 0.14 3.35 0.13 44.60
18 INT268383 Gene_expression of MUTYH 1 0.46 2.56 0 41.20
19 INT268374 Gene_expression of FAP 2 0.37 6.6 0 41.20
20 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 40.48
21 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 34.36
22 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 29.92
23 INT116605 Binding of Nos2 28 0.37 16.88 8.18 27.68
24 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09 27.60
25 INT268370 Phosphorylation of FAP 1 0.24 1.11 0 27.60
26 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 24.76
27 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 24.20
28 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 22.64
29 INT235070 Positive_regulation of Gene_expression of Cxam 1 0.03 1.35 0.1 17.92
30 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 10.92
31 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 10.56
32 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
33 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
34 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
35 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
36 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
37 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
38 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
39 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
40 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
41 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
42 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
43 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
44 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 5.00
45 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
46 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
47 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
48 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
49 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
50 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
51 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
52 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
53 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
54 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
55 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
56 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
57 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
58 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
59 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
60 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 5.00
61 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 5.00
62 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
63 INT35487 Localization of PTGER2 103 0.46 51.24 17.45 5.00
64 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
65 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
66 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
67 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
68 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
69 INT25396 Localization of Ptger2 83 0.78 46.81 14.81 5.00
70 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
71 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
72 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 5.00
73 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
74 INT1762 Negative_regulation of PTGER2 64 0.43 28.21 11.27 5.00
75 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 5.00
76 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
77 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 5.00
78 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
79 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 5.00
80 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 5.00
81 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
82 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
83 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
84 INT60285 Negative_regulation of Racgap1 27 0.56 21.71 8.14 5.00
85 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72 5.00
86 INT79168 Binding of TNC 39 0.47 16.51 7.55 5.00
87 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
88 INT175482 Positive_regulation of Gene_expression of CALM1 12 0.44 3.47 6.54 5.00
89 INT93007 Regulation of Gene_expression of CALM1 7 0.41 3.47 6.08 5.00
90 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
91 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
92 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4 5.00
93 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
94 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
95 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 5.00
96 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
97 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
98 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
99 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75 5.00
100 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 5.00
101 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
102 INT134657 Localization of Akt1 37 0.68 11.58 4.62 5.00
103 INT62813 Negative_regulation of ZNF398 12 0.09 6.2 4.49 5.00
104 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
105 INT62821 Negative_regulation of Gene_expression of VCAM1 21 0.54 12.24 4.41 5.00
106 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
107 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
108 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
109 INT83887 Gene_expression of HMOX2 10 0.77 7.99 3.85 5.00
110 INT63121 Binding of APC 29 0.41 23.02 3.8 5.00
111 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
112 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 5.00
113 INT52839 Regulation of Racgap1 14 0.25 9.46 3.37 5.00
114 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27 5.00
115 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25 5.00
116 INT25393 Positive_regulation of Localization of Ptger2 19 0.32 9.69 3.23 5.00
117 INT25122 Binding of PTGER2 31 0.31 13.83 3.12 5.00
118 INT68961 Positive_regulation of Positive_regulation of Ptger2 12 0.44 6.91 3.02 5.00
119 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
120 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 5.00
121 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 5.00
122 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
123 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59 5.00
124 INT89852 Localization of Nos2 22 0.78 14.89 2.56 5.00
125 INT76341 Negative_regulation of Positive_regulation of Ptger2 12 0.25 6.63 2.42 5.00
126 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
127 INT110304 Negative_regulation of Gene_expression of NOSTRIN 6 0.55 2.22 2.27 5.00
128 INT41775 Gene_expression of NEUROG1 10 0.71 5.46 2.14 5.00
129 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06 5.00
130 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 5.00
131 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68 5.00
132 INT268361 Gene_expression of CACNA1G 2 0.46 1.05 1.61 5.00
133 INT180185 Gene_expression of MGMT 22 0.65 15.02 1.57 5.00
134 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 5.00
135 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
136 INT138699 Gene_expression of Pdgfc 5 0.30 3.32 1.46 5.00
137 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4 5.00
138 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38 5.00
139 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
140 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34 5.00
141 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32 5.00
142 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
143 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3 5.00
144 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12 5.00
145 INT24020 Positive_regulation of HPS1 6 0.44 6.14 1.08 5.00
146 INT268379 Gene_expression of ARAF 22 0.16 9.34 1.07 5.00
147 INT190031 Binding of Scrib 19 0.36 21.9 1.01 5.00
148 INT92139 Binding of MLH1 12 0.42 15.62 1 5.00
149 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 5.00
150 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94 5.00
151 INT89856 Positive_regulation of Localization of Nos2 6 0.49 1.79 0.9 5.00
152 INT242152 Transcription of Wnt2 8 0.57 5.22 0.88 5.00
153 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.00
154 INT184418 Negative_regulation of Positive_regulation of GOPC 15 0.26 5.47 0.87 5.00
155 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82 5.00
156 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76 5.00
157 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 5.00
158 INT139205 Binding of NRP1 27 0.45 4.34 0.71 5.00
159 INT235069 Localization of Cdh1 9 0.74 3.81 0.71 5.00
160 INT39999 Gene_expression of Gla 7 0.59 3.27 0.69 5.00
161 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 5.00
162 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65 5.00
163 INT235079 Negative_regulation of Phosphorylation of TNF 2 0.41 1.16 0.6 5.00
164 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59 5.00
165 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 5.00
166 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55 5.00
167 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47 5.00
168 INT35567 Negative_regulation of GGT5 4 0.09 1.77 0.47 5.00
169 INT201524 Localization of Wnt2 14 0.62 9.24 0.46 5.00
170 INT188050 Regulation of Gene_expression of Wnt2 9 0.37 3.13 0.44 5.00
171 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42 5.00
172 INT207242 Gene_expression of LOC148709 7 0.65 0.54 0.41 5.00
173 INT73627 Binding of Fap 8 0.36 11.14 0.4 5.00
174 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4 5.00
175 INT235063 Positive_regulation of Gene_expression of Gla 2 0.04 0.81 0.39 5.00
176 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39 5.00
177 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 5.00
178 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37 5.00
179 INT100043 Regulation of COX18 3 0.08 1.08 0.35 5.00
180 INT268386 Positive_regulation of ARAF 6 0.17 4.84 0.33 5.00
181 INT84946 Gene_expression of GGT5 5 0.06 2.31 0.31 5.00
182 INT268380 Positive_regulation of Positive_regulation of ARAF 3 0.12 3.49 0.25 5.00
183 INT180182 Negative_regulation of Negative_regulation of GOPC 2 0.25 1.58 0.24 5.00
184 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23 5.00
185 INT171716 Regulation of Fap 4 0.27 4.05 0.23 5.00
186 INT70913 Gene_expression of MTR 2 0.12 0.44 0.21 5.00
187 INT268392 Regulation of Positive_regulation of Wnt2 2 0.09 0.87 0.18 5.00
188 INT268365 Binding of SMAD2 2 0.47 0.56 0.17 5.00
189 INT206930 Negative_regulation of Gene_expression of MGMT 3 0.40 2.84 0.16 5.00
190 INT223333 Negative_regulation of Gene_expression of MTR 1 0.07 0.16 0.16 5.00
191 INT196603 Gene_expression of STK11 5 0.55 6.75 0.15 5.00
192 INT182621 Localization of MLH1 9 0.64 9.31 0.12 5.00
193 INT182623 Localization of MSH2 3 0.77 5.49 0.12 5.00
194 INT242157 Regulation of Localization of Wnt2 3 0.37 1.08 0.11 5.00
195 INT260148 Negative_regulation of Gene_expression of TGFBR2 3 0.38 3.71 0.1 5.00
196 INT223334 Gene_expression of SLC19A1 1 0.52 0.08 0.08 5.00
197 INT223330 Negative_regulation of Gene_expression of SLC19A1 1 0.33 0.08 0.08 5.00
198 INT223331 Negative_regulation of Gene_expression of GGT5 1 0.03 0.08 0.08 5.00
199 INT223332 Negative_regulation of SLC19A1 1 0.33 0.08 0.08 5.00
200 INT268387 Gene_expression of RUNX3 2 0.40 3.61 0.06 5.00
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