D:Intestinal Polyps

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Disease Term
Synonyms Intestinal Polyp, Polyp Intestinal, Polyps Intestinal
Documents 28
Hot Single Events 36
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Intestinal Polyps. They are ordered first by their relevance to Intestinal Polyps and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT322596 Myc Negative_regulation of TNFSF10 Positive_regulation of BIRC3 1 0.12 1.38 0 88.80
2 INT322597 Myc Negative_regulation of Gene_expression of CFLAR 1 0.11 1.35 0 88.80
3 INT322558 Binding of AKT1 and TNFSF10 1 0.05 1.59 0 83.52
4 INT322555 TNFSF10 Positive_regulation of MCL1 1 0.16 1.26 0 83.20
5 INT322557 TNFSF10 Positive_regulation of BIRC3 1 0.12 1.27 0 83.20
6 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18 68.48
7 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 50.64
8 INT236110 Binding of Ppara and Olfm4 1 0.00 1.22 0.4 19.24
9 INT236111 Binding of Pdpk1 and Ppara 1 0.26 1.21 0.39 18.44
10 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03 16.24
11 INT194595 Binding of TNFSF10 and TNFRSF10B 4 0.15 9.3 0.53 11.68
12 INT194596 Binding of HLA-DRB4 and TNFSF10 3 0.08 6 0.38 11.36
13 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61 5.00
14 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
15 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54 5.00
16 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54 5.00
17 INT282285 Cpox Regulation of Gene_expression of Ptger2 1 0.00 0.84 0.5 5.00
18 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46 5.00
19 INT183645 Ppp1r14b Positive_regulation of Macf1 1 0.00 1.23 0.38 5.00
20 INT183647 Dss1 Positive_regulation of Macf1 1 0.01 1.23 0.38 5.00
21 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 0.00 1.29 0.38 5.00
22 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
23 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 5.00
24 INT348364 PROC Negative_regulation of TNF 1 0.01 0.89 0.23 5.00
25 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 0.05 0.84 0.21 5.00
26 INT348363 PCTP Positive_regulation of PROC 1 0.01 0.41 0.2 5.00
27 INT348372 Binding of PROC and Stard10 1 0.01 0.41 0.2 5.00
28 INT234437 asa Negative_regulation of Ppara 1 0.13 0.4 0.09 5.00
29 INT322560 Binding of TNFSF10 and DICER1 1 0.07 1.76 0.07 5.00
30 INT348365 Binding of PROC and TNF 1 0.00 0.19 0.05 5.00
31 INT236722 Ppara Positive_regulation of Binding of Apoa1 1 0.10 0.18 0.04 5.00
32 INT236725 Binding of Ppara and KLK15 1 0.02 0.08 0.04 5.00
33 INT322554 TFAM Negative_regulation of CDH16 1 0.00 1.6 0.04 5.00
34 INT297377 Binding of PPARA and Rxra 1 0.02 0.25 0.03 5.00
35 INT297375 Binding of VDR and Rxra 1 0.02 0.2 0.03 5.00
36 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03 5.00
37 INT297374 Binding of TXNRD1 and Rxra 1 0.01 0.2 0.03 5.00
38 INT322559 TNFSF10 Positive_regulation of CASP9 1 0.03 1.79 0 5.00
39 INT322561 Negative_regulation of TNFSF10 Positive_regulation of CASP9 1 0.03 1.15 0 5.00
40 INT282288 Binding of Hmgcr and Nos2 1 0.03 1.99 0 5.00
41 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0 5.00
42 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0 5.00
43 INT183649 Binding of Ctnnd2 and Gtf3a 1 0.02 1.05 0 5.00
44 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0 5.00
45 INT236719 Binding of Dr1 and Rxra 1 0.01 0 0 5.00
46 INT236720 Binding of Ctnnd2 and Tcf4 3 0.24 2.8 0 5.00
47 INT236723 VEGFA Positive_regulation of Positive_regulation of Ppara 1 0.12 1.01 0 5.00
48 INT282287 Binding of Cpox and Hmgcr 1 0.01 0.99 0 5.00
49 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Intestinal Polyps. They are ordered first by their pain relevance and then by number of times they were reported in Intestinal Polyps. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 100.00
2 INT18853 Negative_regulation of APCS 13 0.57 4.51 2.3 100.00
3 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 99.20
4 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 98.80
5 INT61115 Localization of Ppard 2 0.66 1.99 0.28 98.68
6 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 98.64
7 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 98.64
8 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 97.60
9 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 97.60
10 INT183629 Gene_expression of Ctnnd2 14 0.75 11.78 0.48 97.32
11 INT220177 Binding of Apc 21 0.37 15.34 1.37 95.32
12 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 95.16
13 INT194462 Localization of Ppara 94 0.78 68.33 12.09 94.80
14 INT103094 Binding of PPARA 308 0.47 177.26 34.75 93.80
15 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 92.80
16 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 90.64
17 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 89.92
18 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62 89.40
19 INT171848 Positive_regulation of Ctsa 8 0.27 5.24 1.13 88.68
20 INT248151 Positive_regulation of Negative_regulation of PLA2G6 2 0.28 1.18 0.45 87.80
21 INT38807 Negative_regulation of PLA2G6 29 0.59 10.1 6.42 87.12
22 INT348369 Negative_regulation of Localization of PLA2G6 1 0.08 0.63 0.09 87.12
23 INT145650 Localization of PLA2G6 15 0.76 8.87 2.06 86.56
24 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 86.36
25 INT64863 Localization of PLA2G4A 9 0.44 3.33 1.07 85.28
26 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91 84.56
27 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 84.16
28 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 83.52
29 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 82.16
30 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 81.80
31 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32 81.16
32 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 80.96
33 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 80.96
34 INT91773 Positive_regulation of PLA2G4A 10 0.50 4.4 1.54 80.48
35 INT122041 Binding of Ppara 308 0.48 189.17 51.48 80.16
36 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 80.08
37 INT112243 Negative_regulation of Transcription of COX5A 1 0.57 0.89 0.11 72.72
38 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 70.72
39 INT74782 Transcription of COX5A 2 0.69 1.13 0.24 69.84
40 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96 68.92
41 INT108325 Gene_expression of Scrib 26 0.39 48.33 1.39 67.72
42 INT108326 Positive_regulation of Gene_expression of Scrib 5 0.26 9.02 0.36 67.72
43 INT122038 Transcription of Ppara 35 0.71 20.5 5.12 67.48
44 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 67.24
45 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39 66.84
46 INT194468 Positive_regulation of Phosphorylation of Ppara 4 0.46 2.11 0.38 65.00
47 INT215379 Positive_regulation of Binding of Ppara 15 0.66 8.04 2.36 64.80
48 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 63.32
49 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41 62.76
50 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 61.80
51 INT55980 Positive_regulation of Protein_catabolism of PROC 1 0.16 1.64 1.04 60.28
52 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 59.96
53 INT55979 Protein_catabolism of PROC 8 0.22 2.8 1.49 59.88
54 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 58.56
55 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1 58.32
56 INT85233 Localization of SGSM3 11 0.78 10.91 3.41 55.04
57 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 55.00
58 INT236109 Localization of Pdpk1 1 0.49 0.75 0.12 51.12
59 INT190017 Localization of Scrib 6 0.10 7 0.38 50.92
60 INT78877 Gene_expression of EWSR1 10 0.75 11.16 0.97 50.64
61 INT297366 Binding of EWSR1 1 0.36 1.8 0.33 50.64
62 INT108342 Negative_regulation of EPHB2 18 0.57 9.48 4.46 49.72
63 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15 47.84
64 INT162463 Localization of BID 6 0.73 7.47 1.5 47.84
65 INT237967 Positive_regulation of Localization of BID 2 0.21 2.83 0 47.84
66 INT76858 Binding of PLA2G4A 4 0.30 1.22 0.52 46.96
67 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5 45.48
68 INT171715 Gene_expression of Sema5b 46 0.31 6.46 7.48 45.04
69 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 43.24
70 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 43.24
71 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 41.36
72 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 40.92
73 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 40.32
74 INT215930 Positive_regulation of Mmp15 2 0.24 1.79 0.99 38.84
75 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 34.04
76 INT87644 Phosphorylation of SGSM3 12 0.80 2.08 7.04 33.60
77 INT160633 Gene_expression of Vdr 21 0.77 10.01 2.73 33.04
78 INT183242 Negative_regulation of Gene_expression of PTEN 6 0.55 3.81 0.16 32.96
79 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 32.00
80 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 31.12
81 INT112962 Regulation of Positive_regulation of Ppara 17 0.45 10.63 2.58 30.04
82 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 29.40
83 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 28.88
84 INT64815 Binding of Jun 49 0.48 21.47 8.59 26.96
85 INT3818 Regulation of Apc 13 0.39 12.52 1.68 25.16
86 INT95056 Positive_regulation of Gene_expression of Ppard 5 0.52 3.84 1.6 22.24
87 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 20.00
88 INT197171 Negative_regulation of Binding of Ppara 15 0.43 11.51 4.41 18.88
89 INT236105 Negative_regulation of Binding of Pdpk1 1 0.30 1.22 0.39 18.88
90 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39 18.44
91 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 17.32
92 INT152153 Negative_regulation of Mmp7 7 0.58 5.94 1.22 14.40
93 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 14.24
94 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44 11.68
95 INT37679 Positive_regulation of HLA-DRB4 12 0.34 11.93 1.16 11.36
96 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 11.00
97 INT183635 Negative_regulation of Positive_regulation of Ppara 11 0.42 10 1.2 10.88
98 INT235435 Negative_regulation of E2f2 1 0.01 1.44 0.03 9.80
99 INT25387 Binding of Ptger2 42 0.47 16 7.98 9.68
100 INT183637 Gene_expression of Ppp1r14b 3 0.04 1.42 0.1 9.36
101 INT6994 Binding of Ptgds 15 0.36 7.06 3.54 8.68
102 INT282276 Binding of Tfdp1 1 0.16 1.16 0.31 8.68
103 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07 8.48
104 INT102428 Binding of C2 17 0.32 5.12 1.58 7.84
105 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
106 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
107 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
108 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
109 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
110 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
111 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
112 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
113 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
114 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
115 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
116 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
117 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
118 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 5.00
119 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 5.00
120 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
121 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
122 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 5.00
123 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
124 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
125 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
126 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
127 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
128 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 5.00
129 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72 5.00
130 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
131 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
132 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
133 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
134 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
135 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
136 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
137 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
138 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 5.00
139 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05 5.00
140 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05 5.00
141 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 5.00
142 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 5.00
143 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
144 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 5.00
145 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 5.00
146 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
147 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
148 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
149 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11 5.00
150 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
151 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 5.00
152 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
153 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
154 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
155 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 5.00
156 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
157 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
158 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71 5.00
159 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 5.00
160 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 5.00
161 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16 5.00
162 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
163 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 5.00
164 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48 5.00
165 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
166 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
167 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
168 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98 5.00
169 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53 5.00
170 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
171 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
172 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 5.00
173 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 5.00
174 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
175 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 5.00
176 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95 5.00
177 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
178 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
179 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
180 INT25396 Localization of Ptger2 83 0.78 46.81 14.81 5.00
181 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
182 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
183 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
184 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
185 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
186 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
187 INT114274 Gene_expression of Rxra 67 0.70 36.77 12.5 5.00
188 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
189 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
190 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 5.00
191 INT79685 Positive_regulation of Gene_expression of Pparg 17 0.70 14.63 11.03 5.00
192 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 5.00
193 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 5.00
194 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
195 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07 5.00
196 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
197 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
198 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
199 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
200 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 5.00
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