D:Intracranial Hypertension

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Disease Term
Synonyms Csf Pressure Increased, Elevated Icp, ELEVATED ICP INTRACRANIAL PRESSURE, Elevated Intracranial Pressure, Hypertension Intracranial, Icp Elevated Intracranial Pressure, Icp Elevation, Icp Increase, Icp Intracranial Pressure Elevation, Icp Intracranial Pressure Increase, INCREASED CEREBROSPINAL FLUID PRESSURE
Documents 372
Hot Single Events 97
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Intracranial Hypertension. They are ordered first by their relevance to Intracranial Hypertension and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT254133 PLEC Regulation of MCRS1 1 0.03 0.33 0.13 100.00
2 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 90.08
3 INT170656 Ntf3 Positive_regulation of Csf2 1 0.35 1.46 0.44 84.40
4 INT170653 Ngf Regulation of Csf2 1 0.34 1.11 1.05 77.60
5 INT220288 MARS Regulation of AFM 1 0.06 1.14 0.08 30.72
6 INT170655 Binding of Csf2 and Ngf 1 0.36 1.25 1.18 22.08
7 INT170658 Binding of Ntf3 and Csf2 1 0.33 0.8 0.74 22.08
8 INT170657 Ntf3 Regulation of Csf2 1 0.31 0.46 0.43 20.88
9 INT170654 Binding of Ntf3 and Ngf 1 0.38 1.66 1.54 20.72
10 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 5.00
11 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36 5.00
12 INT344238 MCRS1 Regulation of TREX1 1 0.08 1.02 0.34 5.00
13 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34 5.00
14 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26 5.00
15 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26 5.00
16 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26 5.00
17 INT295329 ecs Positive_regulation of TF 1 0.00 1.2 0.23 5.00
18 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
19 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14 5.00
20 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14 5.00
21 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
22 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
23 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
24 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
25 INT220290 Binding of AFM and MARS 1 0.05 1.09 0.07 5.00
26 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05 5.00
27 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
28 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
29 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Intracranial Hypertension. They are ordered first by their pain relevance and then by number of times they were reported in Intracranial Hypertension. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT175554 Binding of MCRS1 21 0.23 25.2 8.59 100.00
2 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 100.00
3 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 100.00
4 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 100.00
5 INT27345 Positive_regulation of ANIB1 9 0.07 9.81 3.46 100.00
6 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 100.00
7 INT57147 Binding of ANIB1 3 0.31 1.65 0.44 100.00
8 INT68338 Gene_expression of PLEC 4 0.75 0.44 0.32 100.00
9 INT254136 Regulation of PLEC 1 0.23 0.33 0.13 99.98
10 INT21032 Gene_expression of Adh1 23 0.78 22.1 6.14 99.60
11 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 99.58
12 INT16257 Regulation of Gene_expression of Ntf3 8 0.43 4 5.63 99.58
13 INT122368 Regulation of Regulation of Ngf 1 0.27 1.37 1.27 99.58
14 INT155052 Regulation of Gene_expression of Csf2 6 0.37 7.75 0.8 99.58
15 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 99.42
16 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 99.34
17 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 99.34
18 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 99.34
19 INT16256 Regulation of Ntf3 15 0.49 9.75 13.07 99.34
20 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 99.16
21 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 99.16
22 INT225966 Regulation of Gene_expression of Aqp4 18 0.62 20.39 2.3 99.16
23 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 98.92
24 INT51083 Gene_expression of Adc 14 0.53 8.24 2.25 98.80
25 INT344122 Regulation of Gene_expression of Adc 1 0.04 1 0.3 98.80
26 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 98.72
27 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 98.04
28 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 97.92
29 INT180497 Binding of MRI1 45 0.42 28.35 14.77 97.84
30 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 97.68
31 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 97.40
32 INT75224 Positive_regulation of Gene_expression of Ntf3 23 0.69 11.79 13.08 97.40
33 INT14690 Localization of CSF2 124 0.80 85.17 27.26 97.36
34 INT88626 Positive_regulation of CCRN4L 4 0.49 4.05 2.38 97.12
35 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49 97.04
36 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 96.66
37 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 96.60
38 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 96.46
39 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 96.24
40 INT3521 Regulation of Csf2 38 0.54 11.09 12.73 96.24
41 INT24961 Positive_regulation of Defb22 8 0.03 3.56 6.04 96.04
42 INT225965 Localization of Aqp4 26 0.81 18.85 3.75 96.00
43 INT247870 Negative_regulation of Localization of Aqp4 3 0.43 2 0.24 96.00
44 INT344125 Negative_regulation of Transcription of Adc 1 0.04 0.83 0.26 95.84
45 INT299223 Negative_regulation of Transcription of Aqp4 3 0.59 1.36 0.35 95.84
46 INT344124 Transcription of Adc 1 0.06 0.83 0.26 95.44
47 INT130836 Transcription of Aqp4 6 0.72 5.93 3.52 95.44
48 INT262272 Phosphorylation of Strs1 1 0.01 1.07 0.34 95.00
49 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21 94.48
50 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 94.24
51 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 92.40
52 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26 92.28
53 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 91.92
54 INT97624 Positive_regulation of Adc 13 0.69 5.56 4.87 91.60
55 INT59454 Regulation of Gene_expression of CSF2 22 0.52 19.67 2.69 91.36
56 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 91.08
57 INT235951 Positive_regulation of Positive_regulation of Aqp4 4 0.57 5.13 0.75 91.08
58 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 91.08
59 INT105287 Positive_regulation of Slco1c1 24 0.34 15.41 6.81 90.72
60 INT165821 Positive_regulation of Aqp4 27 0.70 24.37 3.22 90.68
61 INT88627 Regulation of CCRN4L 2 0.60 2.23 0.87 90.32
62 INT170652 Positive_regulation of Regulation of Ntf3 1 0.43 0.99 0.51 90.08
63 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 89.60
64 INT184894 Localization of MCRS1 9 0.47 10.04 3.31 88.96
65 INT103463 Localization of CPP 16 0.66 9.63 4.08 88.96
66 INT35584 Binding of ACLY 22 0.35 31.78 7.17 88.88
67 INT230779 Negative_regulation of Positive_regulation of MCRS1 2 0.04 3.78 0.92 88.76
68 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 87.92
69 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08 87.48
70 INT12066 Localization of Il2 16 0.75 3.06 5.7 87.48
71 INT230516 Negative_regulation of Localization of Il2 5 0.15 2.64 0.79 87.48
72 INT20379 Localization of Il4 85 0.73 51.22 20.55 87.08
73 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 87.08
74 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 86.64
75 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9 86.64
76 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 86.64
77 INT12948 Positive_regulation of Gene_expression of Cat 17 0.67 6.46 3.12 86.64
78 INT100462 Gene_expression of Sod2 5 0.68 3.41 1.48 86.64
79 INT100461 Positive_regulation of Gene_expression of Sod2 1 0.28 1 0.71 86.64
80 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 86.24
81 INT157209 Positive_regulation of Gene_expression of Adc 1 0.39 0.79 0.27 85.96
82 INT344121 Positive_regulation of Regulation of Adc 1 0.04 0.79 0.27 85.96
83 INT206031 Regulation of Adc 7 0.33 6.85 1.48 85.60
84 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 85.24
85 INT12344 Negative_regulation of Gene_expression of Il2 28 0.59 15.53 10.23 84.64
86 INT75908 Regulation of LEP 77 0.60 60.16 15.19 84.28
87 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 83.20
88 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 82.64
89 INT12157 Positive_regulation of SELL 16 0.67 14.54 5.74 82.60
90 INT15179 Positive_regulation of Gene_expression of SELL 18 0.61 14.35 2.84 82.60
91 INT15178 Positive_regulation of Positive_regulation of ITGAM 7 0.56 2.51 2.86 82.60
92 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 81.92
93 INT93077 Negative_regulation of Localization of S100B 3 0.57 0.58 0.2 81.64
94 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 81.48
95 INT17742 Localization of S100B 44 0.80 17.14 4.65 81.20
96 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 80.68
97 INT83627 Localization of ITGAM 7 0.78 7.26 1.83 80.12
98 INT97623 Negative_regulation of Adc 17 0.56 3.81 8.14 79.92
99 INT16404 Regulation of CD4 54 0.61 33.05 10.29 79.24
100 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 78.80
101 INT477 Localization of Avp 813 0.81 131.58 300.4 78.56
102 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 78.56
103 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 78.56
104 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96 78.56
105 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 78.20
106 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 77.68
107 INT18720 Localization of Csf2 72 0.67 13.65 13.41 77.04
108 INT61118 Gene_expression of Nefl 11 0.75 4.02 4.02 76.40
109 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 75.00
110 INT88625 Localization of CCRN4L 4 0.78 4.15 2.14 74.40
111 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 74.40
112 INT6765 Localization of Oprl1 49 0.81 5.11 28.87 74.40
113 INT97987 Positive_regulation of Localization of CCRN4L 1 0.49 1.73 0.6 74.36
114 INT64792 Positive_regulation of Gene_expression of ITGAM 39 0.69 23.21 6.71 73.56
115 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81 72.32
116 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 72.16
117 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 71.64
118 INT282214 Negative_regulation of Gene_expression of Adc 2 0.07 1.34 0.21 71.36
119 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 69.60
120 INT262275 Negative_regulation of GAPDH 1 0.01 1.54 0.28 67.84
121 INT295322 Binding of CEACAM8 1 0.16 1.06 0.11 67.52
122 INT120175 Negative_regulation of HK1 10 0.57 2.57 0.92 64.80
123 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 64.52
124 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 64.52
125 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 63.64
126 INT293031 Binding of Gluco3 1 0.08 0.86 0.32 62.28
127 INT75997 Positive_regulation of Localization of Ngf 14 0.69 7.78 9.41 59.24
128 INT68279 Positive_regulation of Gene_expression of Csf2 30 0.67 16.31 6.88 59.24
129 INT98652 Positive_regulation of Localization of Ntf3 2 0.40 1.42 2.15 59.24
130 INT3034 Localization of Ngf 126 0.81 50.81 72.84 58.80
131 INT71689 Localization of Ntf3 23 0.73 11.1 7.91 58.80
132 INT151742 Positive_regulation of PLEC 3 0.41 0.89 0.17 56.40
133 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 56.16
134 INT344123 Regulation of Regulation of Adc 1 0.02 0.91 0.14 55.84
135 INT138889 Positive_regulation of Slc12a2 23 0.65 18.53 8.85 55.28
136 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 54.44
137 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 54.04
138 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 53.60
139 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27 53.60
140 INT65907 Negative_regulation of Gene_expression of Ngf 36 0.59 19.5 20.03 53.20
141 INT92662 Negative_regulation of Gene_expression of Ntf3 9 0.57 7.44 6.22 53.20
142 INT151123 Negative_regulation of Gene_expression of Csf2 21 0.53 21.76 3.22 53.20
143 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 52.64
144 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 50.40
145 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 50.00
146 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 50.00
147 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 50.00
148 INT12082 Localization of IL6 365 0.81 241.78 105.78 50.00
149 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 50.00
150 INT86437 Binding of IL6 154 0.48 121.22 29.3 50.00
151 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 50.00
152 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 50.00
153 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 50.00
154 INT305617 Positive_regulation of Gene_expression of MCRS1 1 0.05 7.16 2.91 50.00
155 INT305616 Negative_regulation of Gene_expression of MCRS1 1 0.04 3.56 1.23 50.00
156 INT74625 Gene_expression of IL36B 4 0.37 2.04 1.19 50.00
157 INT305620 Regulation of Positive_regulation of MCRS1 1 0.17 2.48 0.99 50.00
158 INT278300 Regulation of KIN 2 0.44 2.42 0.56 50.00
159 INT305618 Regulation of Gene_expression of MCRS1 1 0.04 1.24 0.43 50.00
160 INT305619 Negative_regulation of Regulation of MCRS1 1 0.04 1.35 0.35 50.00
161 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 49.72
162 INT122500 Protein_catabolism of Slco1c1 17 0.52 16.7 1.7 49.60
163 INT165379 Gene_expression of CEACAM8 8 0.75 4.21 1.64 46.00
164 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 42.56
165 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 42.08
166 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 36.56
167 INT45272 Regulation of Nps 15 0.39 8.08 2.69 35.28
168 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 34.84
169 INT49197 Binding of SELE 7 0.41 7.95 0.74 32.96
170 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 31.24
171 INT259037 Negative_regulation of Binding of ACLY 1 0.07 1.54 0.13 28.88
172 INT11787 Positive_regulation of Positive_regulation of NA 14 0.21 2.97 2.46 28.24
173 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 27.28
174 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 26.44
175 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 26.44
176 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 26.32
177 INT252 Localization of GH1 529 0.80 227.4 122.05 25.00
178 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 25.00
179 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 25.00
180 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 25.00
181 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 25.00
182 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 25.00
183 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 25.00
184 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 25.00
185 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 25.00
186 INT42132 Negative_regulation of TCEA1 13 0.51 4.12 6.28 25.00
187 INT117551 Regulation of Gene_expression of Selp 15 0.44 7.32 4.2 25.00
188 INT69944 Positive_regulation of Ndp 7 0.38 4.81 5.6 22.00
189 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 21.84
190 INT293030 Negative_regulation of Binding of Gluco3 1 0.09 0.48 0.17 21.84
191 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 21.36
192 INT180035 Positive_regulation of Gene_expression of Chdh 2 0.22 8.21 5.78 21.36
193 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 20.80
194 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 20.64
195 INT3275 Negative_regulation of Slco1c1 28 0.37 10.93 5.15 19.44
196 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 18.16
197 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 18.16
198 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 18.16
199 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 18.16
200 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 16.96
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