D:Intrahepatic Cholestasis

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Disease Term
Synonyms Bile Duct Obstruction Intrahepatic, BILIARY STASES INTRAHEPATIC, Biliary Stasis Intrahepatic, Cholestases Intrahepatic, INTRAHEPATIC BILIARY STASES, Intrahepatic Biliary Stasis, Intrahepatic Cholestases
Documents 76
Hot Single Events 22
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Intrahepatic Cholestasis. They are ordered first by their relevance to Intrahepatic Cholestasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214380 Binding of IL1A and PRTN3 1 0.00 0.94 0.18 8.68
2 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
3 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
4 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
5 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
6 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25 5.00
7 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24 5.00
8 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
9 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
10 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
11 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
12 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
13 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
14 INT187897 Pgp Positive_regulation of Mod2 1 0.11 0.51 0.04 5.00
15 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
16 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
17 INT187899 Binding of Pgp and Mir486 1 0.00 0.25 0 5.00
18 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00
19 INT187898 Negative_regulation of Binding of Pgp and Mir486 1 0.01 0.25 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Intrahepatic Cholestasis. They are ordered first by their pain relevance and then by number of times they were reported in Intrahepatic Cholestasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT141380 Negative_regulation of Slc25a13 2 0.25 1.79 0.29 99.56
2 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 98.48
3 INT130582 Gene_expression of ABCB4 3 0.67 1.05 0.82 98.44
4 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 98.32
5 INT141381 Gene_expression of SLC25A13 2 0.27 1.77 0.29 97.98
6 INT78659 Gene_expression of Thim 17 0.28 14.34 4.4 97.36
7 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 95.48
8 INT4398 Regulation of LGALS1 7 0.44 2.16 2.31 91.20
9 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 91.20
10 INT4394 Positive_regulation of LGALS1 6 0.50 0.46 0.64 90.36
11 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 90.16
12 INT11824 Negative_regulation of GGT1 3 0.57 1.39 0.53 88.40
13 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 88.40
14 INT4397 Transcription of CSH1 7 0.57 0.65 0.72 87.20
15 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 86.80
16 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 86.52
17 INT147607 Binding of TERT 16 0.48 12.36 1.31 85.96
18 INT22906 Positive_regulation of Ggt1 3 0.45 5.42 0.92 85.68
19 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 84.76
20 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07 83.16
21 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29 81.76
22 INT340339 Negative_regulation of UGT1A 1 0.42 1.56 0.21 81.76
23 INT4396 Negative_regulation of LGALS1 2 0.51 6.32 0.14 76.52
24 INT51532 Negative_regulation of Sult1a1 2 0.50 1.72 0.55 75.00
25 INT115663 Regulation of Gene_expression of ABCB6 1 0.44 1.2 0.21 71.32
26 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43 70.80
27 INT187894 Positive_regulation of Gene_expression of ABCB6 5 0.19 1.97 0.03 70.80
28 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 70.48
29 INT106793 Positive_regulation of Positive_regulation of Dnahc8 3 0.50 0.58 1.8 70.48
30 INT187880 Binding of Abcg1 3 0.33 2.07 0.1 68.24
31 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 65.52
32 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 61.36
33 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 59.68
34 INT101693 Gene_expression of Ggt1 2 0.65 4.92 0.81 59.36
35 INT210022 Localization of Thim 1 0.01 1.02 0.14 57.92
36 INT176202 Gene_expression of Abcb4 6 0.68 5.25 0.52 55.60
37 INT210019 Positive_regulation of Gene_expression of Abcb4 2 0.47 1.89 0.29 55.60
38 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 53.12
39 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 52.72
40 INT41314 Gene_expression of GGTLC1 9 0.59 5.61 1.79 50.00
41 INT209083 Positive_regulation of GPBAR1 1 0.01 0.84 0.41 50.00
42 INT210020 Localization of Abcb4 3 0.71 1.65 0.34 43.88
43 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 43.76
44 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 42.56
45 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 38.24
46 INT93181 Positive_regulation of Thtpa 2 0.05 0.95 0.67 36.24
47 INT12035 Regulation of F2 21 0.45 12.66 1.47 35.80
48 INT21756 Regulation of Alb 15 0.43 8.21 1.19 35.80
49 INT141382 Negative_regulation of ASS1 2 0.57 1.07 0 33.76
50 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 33.20
51 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 33.20
52 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 33.20
53 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 33.20
54 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 31.28
55 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85 23.88
56 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 23.48
57 INT227411 Negative_regulation of Positive_regulation of HCC 1 0.02 1.35 0.11 19.32
58 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 17.44
59 INT187883 Gene_expression of Mod2 8 0.18 4.59 0.15 16.40
60 INT187884 Positive_regulation of Gene_expression of Mod2 3 0.12 1.31 0 16.40
61 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28 14.88
62 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 11.60
63 INT6484 Binding of IL1B 122 0.47 75.84 35.07 8.08
64 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
65 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
66 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
67 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
68 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
69 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
70 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
71 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
72 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
73 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
74 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
75 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
76 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
77 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
78 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
79 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
80 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
81 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
82 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
83 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
84 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
85 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
86 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
87 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 5.00
88 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
89 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
90 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
91 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
92 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
93 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
94 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
95 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
96 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
97 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
98 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
99 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
100 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
101 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
102 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
103 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
104 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
105 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 5.00
106 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
107 INT1556 Regulation of Dnahc8 20 0.61 3.23 14.44 5.00
108 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
109 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
110 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
111 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 5.00
112 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
113 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
114 INT1827 Gene_expression of Aap 11 0.67 9.37 12.66 5.00
115 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 5.00
116 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
117 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
118 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
119 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
120 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
121 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 5.00
122 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
123 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 5.00
124 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
125 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 5.00
126 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
127 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
128 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 5.00
129 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
130 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
131 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
132 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
133 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
134 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
135 INT173974 Positive_regulation of Localization of Il10 25 0.68 16.81 5.87 5.00
136 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
137 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31 5.00
138 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 5.00
139 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
140 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 5.00
141 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27 5.00
142 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 5.00
143 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15 5.00
144 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
145 INT47391 Positive_regulation of Paf 16 0.62 12.31 3.79 5.00
146 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 5.00
147 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
148 INT137702 Binding of TTN 7 0.35 4.48 3.62 5.00
149 INT89592 Localization of Ccl5 10 0.61 7.65 3.62 5.00
150 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52 5.00
151 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
152 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 5.00
153 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
154 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24 5.00
155 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 5.00
156 INT120529 Positive_regulation of ABCC2 7 0.49 2.32 2.94 5.00
157 INT104182 Gene_expression of ABCC2 19 0.76 5.92 2.88 5.00
158 INT182667 Binding of DLAT 11 0.31 40.75 2.8 5.00
159 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 5.00
160 INT40315 Gene_expression of Abcc1 10 0.76 5.66 2.53 5.00
161 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 5.00
162 INT70242 Localization of HCC 18 0.66 23.95 2.35 5.00
163 INT204175 Localization of Mri1 12 0.60 2.73 2.35 5.00
164 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
165 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 5.00
166 INT67139 Negative_regulation of Mod2 7 0.34 3.17 1.98 5.00
167 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 5.00
168 INT12442 Localization of Vegfa 11 0.73 4.85 1.68 5.00
169 INT283506 Gene_expression of SLC4A2 7 0.47 4 1.4 5.00
170 INT187888 Binding of Pgp 5 0.32 0.4 1.35 5.00
171 INT164325 Negative_regulation of Abcg2 6 0.39 1.88 1.2 5.00
172 INT209961 Binding of GAGE4 3 0.03 1.8 1.16 5.00
173 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16 5.00
174 INT134743 Positive_regulation of TEAD1 6 0.36 5.33 1.14 5.00
175 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 5.00
176 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 5.00
177 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 5.00
178 INT34586 Positive_regulation of Negative_regulation of HSD11B1 6 0.49 4.39 1.05 5.00
179 INT93578 Localization of Hgf 6 0.77 2.97 1.03 5.00
180 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97 5.00
181 INT145760 Binding of Tlr2 5 0.46 3.59 0.89 5.00
182 INT135261 Positive_regulation of Pgp 2 0.68 0.18 0.89 5.00
183 INT283494 Positive_regulation of ABCB11 1 0.13 0.81 0.87 5.00
184 INT283514 Localization of NR1I2 2 0.74 3.15 0.87 5.00
185 INT38558 Positive_regulation of DBT 9 0.31 1.59 0.86 5.00
186 INT137082 Regulation of ABCC2 2 0.16 1.11 0.85 5.00
187 INT145986 Positive_regulation of CTLA4 8 0.56 2.66 0.82 5.00
188 INT11657 Gene_expression of ALPI 11 0.71 5.13 0.74 5.00
189 INT283501 Positive_regulation of Gene_expression of SLC4A2 1 0.19 1.66 0.73 5.00
190 INT133323 Positive_regulation of Mod2 8 0.13 5.55 0.72 5.00
191 INT283516 Localization of SLC4A2 1 0.21 0.8 0.69 5.00
192 INT283502 Positive_regulation of Gene_expression of ABCB4 1 0.40 0.76 0.62 5.00
193 INT283515 Regulation of ABCB11 2 0.09 0.9 0.58 5.00
194 INT64953 Negative_regulation of HLA-DRB1 9 0.58 5.15 0.56 5.00
195 INT260738 Gene_expression of Ugt1a2 2 0.02 2.22 0.5 5.00
196 INT283507 Negative_regulation of Gene_expression of DLAT 1 0.28 2.2 0.48 5.00
197 INT283518 Negative_regulation of Gene_expression of SLC4A2 1 0.16 0.87 0.48 5.00
198 INT283500 Positive_regulation of Gene_expression of ABCB11 1 0.08 0.41 0.48 5.00
199 INT283495 Gene_expression of ABCB11 1 0.10 0.41 0.47 5.00
200 INT139827 Negative_regulation of ABCB6 5 0.57 2.91 0.43 5.00
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