D:Iridocyclitis

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Disease Term
Synonyms CYCLITIDES HETEROCHROMIC, CYCLITIS HETEROCHROMIC, Heterochromic Cyclitides, Heterochromic Cyclitis, Iridocyclitides
Documents 114
Hot Single Events 14
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Iridocyclitis. They are ordered first by their relevance to Iridocyclitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65157 Binding of MRAP and Drb1 1 0.01 0.16 0.07 86.32
2 INT65158 Binding of HLA-DPB1 and Drb1 1 0.07 0.16 0.07 84.72
3 INT65159 Binding of UTY and Drb1 1 0.00 0.18 0.1 77.12
4 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84 13.24
5 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
6 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
7 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 5.00
8 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47 5.00
9 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 5.00
10 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43 5.00
11 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
12 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
13 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 5.00
14 INT259936 CTLA4 Regulation of PTPN22 1 0.45 1.64 0.28 5.00
15 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25 5.00
16 INT259938 Binding of CTLA4 and PTPN22 1 0.36 0.85 0.08 5.00
17 INT259935 CSK Positive_regulation of Negative_regulation of LCK 1 0.09 0.57 0.03 5.00
18 INT259940 CSK Positive_regulation of Phosphorylation of LCK 1 0.09 0.51 0.03 5.00
19 INT259939 Negative_regulation of Binding of CSK and PTPN22 1 0.19 0.62 0.03 5.00
20 INT285399 Binding of DEFB1 and HLA-B 1 0.01 1.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Iridocyclitis. They are ordered first by their pain relevance and then by number of times they were reported in Iridocyclitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 98.86
2 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 98.86
3 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 98.86
4 INT79515 Binding of WDR11 1 0.33 0.96 0.43 98.86
5 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 98.80
6 INT3353 Localization of HLA-B 25 0.75 16.05 8.62 98.48
7 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.28
8 INT65154 Positive_regulation of HLA-DPB1 5 0.34 1.37 0.84 98.04
9 INT65149 Positive_regulation of Drb1 4 0.53 2.62 1.99 98.04
10 INT4697 Positive_regulation of Gene_expression of HLA-B 32 0.61 17.32 5.97 97.92
11 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 91.88
12 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 91.00
13 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 89.40
14 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 81.60
15 INT65155 Binding of UTY 1 0.00 0.18 0.1 77.12
16 INT65153 Binding of HLA-DPB1 5 0.34 3.29 1.4 74.88
17 INT81960 Gene_expression of CALU 2 0.75 2.94 0.55 74.72
18 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 74.56
19 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 74.56
20 INT58038 Binding of Drb1 5 0.22 3.42 3 74.36
21 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 73.00
22 INT231573 Binding of PTPN22 5 0.44 7.94 2.33 73.00
23 INT57337 Gene_expression of HLA-DPB1 7 0.62 2.46 0.07 69.92
24 INT65150 Gene_expression of Drb1 10 0.44 12.97 5.82 69.44
25 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 63.20
26 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 59.32
27 INT17885 Negative_regulation of YWHAZ 6 0.56 2.74 1.58 47.92
28 INT121861 Regulation of BID 4 0.31 2.73 1.15 45.36
29 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 42.40
30 INT184743 Localization of BTG3 4 0.68 3.6 0.78 36.24
31 INT308261 Positive_regulation of Localization of BTG3 1 0.39 1.61 0.32 36.24
32 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 36.00
33 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 35.80
34 INT425 Localization of PRL 455 0.81 189.64 144.8 35.20
35 INT253 Regulation of PRL 184 0.62 47.27 65.79 29.44
36 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 27.32
37 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 26.76
38 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 26.48
39 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 11.28
40 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 11.28
41 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 9.20
42 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 6.44
43 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.28
44 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
45 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
46 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
47 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
48 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
49 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
50 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
51 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
52 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
53 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
54 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
55 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
56 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
57 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
58 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
59 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
60 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
61 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
62 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
63 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
64 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
65 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
66 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
67 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
68 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
69 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
70 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
71 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
72 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 5.00
73 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
74 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
75 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
76 INT2064 Positive_regulation of BTG3 29 0.49 25.58 15.37 5.00
77 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
78 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 5.00
79 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
80 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
81 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
82 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
83 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 5.00
84 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 5.00
85 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
86 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
87 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
88 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
89 INT182320 Binding of MTX1 14 0.18 8.5 7.65 5.00
90 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
91 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
92 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
93 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
94 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73 5.00
95 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
96 INT181018 Binding of S100a8 20 0.45 22.14 3.18 5.00
97 INT15584 Binding of S100A12 14 0.48 15.14 3 5.00
98 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94 5.00
99 INT152861 Binding of S100a9 11 0.37 12.19 2.91 5.00
100 INT154334 Localization of S100A12 9 0.80 9.32 2.89 5.00
101 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74 5.00
102 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
103 INT181061 Localization of S100a9 9 0.74 4.98 2.19 5.00
104 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08 5.00
105 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 5.00
106 INT148705 Binding of TNFRSF1A 8 0.38 5.19 1.81 5.00
107 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
108 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 5.00
109 INT131488 Binding of MAS1 9 0.36 8.49 1.01 5.00
110 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 5.00
111 INT39369 Binding of NARFL 14 0.29 16.7 0.93 5.00
112 INT80024 Negative_regulation of KLRD1 3 0.04 0.91 0.88 5.00
113 INT161311 Positive_regulation of Negative_regulation of LCK 2 0.45 0.74 0.83 5.00
114 INT250281 Positive_regulation of Positive_regulation of CD40LG 3 0.23 3.19 0.73 5.00
115 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 5.00
116 INT340441 Positive_regulation of Binding of MTX1 1 0.17 1.7 0.72 5.00
117 INT148420 Binding of DEFB1 3 0.36 3.81 0.48 5.00
118 INT122156 Binding of CA1 3 0.47 1.52 0.44 5.00
119 INT352983 Protein_catabolism of IL10 1 0.13 1.04 0.41 5.00
120 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31 5.00
121 INT274273 Regulation of Gene_expression of NARFL 3 0.10 4.39 0.2 5.00
122 INT238186 Phosphorylation of CSK 4 0.33 1.44 0.07 5.00
123 INT272530 Negative_regulation of Localization of NARFL 3 0.09 2.98 0.07 5.00
124 INT259943 Phosphorylation of LCK 1 0.33 1.02 0.06 5.00
125 INT259944 Positive_regulation of Phosphorylation of LCK 1 0.18 0.56 0.03 5.00
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