D:Iritis

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Disease Term
Synonyms Iritides
Documents 153
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Iritis. They are ordered first by their relevance to Iritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
2 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
3 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
4 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
5 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
6 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
7 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00
8 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22 5.00
9 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22 5.00
10 INT289997 CNTF Negative_regulation of Binding of CNTF and Casp3 1 0.05 0.99 0.22 5.00
11 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22 5.00
12 INT220851 Binding of Cd48 and Cd244 1 0.04 0.55 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Iritis. They are ordered first by their pain relevance and then by number of times they were reported in Iritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT220836 Transcription of Cd4 4 0.61 3.62 0.19 100.00
2 INT677 Positive_regulation of CST3 20 0.67 17.47 6 99.66
3 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.60
4 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 98.32
5 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 93.72
6 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 92.24
7 INT115802 Positive_regulation of Positive_regulation of HRASLS 2 0.12 3.06 1.03 89.48
8 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 89.04
9 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46 85.04
10 INT39369 Binding of NARFL 14 0.29 16.7 0.93 80.36
11 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 79.28
12 INT636 Binding of MRAP 54 0.48 40.36 18.77 77.20
13 INT181642 Negative_regulation of Narf 2 0.01 28.07 4.01 75.52
14 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 75.36
15 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 75.36
16 INT125254 Localization of Tas1r1 1 0.01 0.81 0.27 72.80
17 INT14301 Binding of CSF2 82 0.48 67.95 8.98 69.40
18 INT325465 Positive_regulation of CDC7 1 0.03 3.47 0.18 66.64
19 INT220838 Protein_catabolism of Cd28 1 0.60 0.46 0.16 56.80
20 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 52.60
21 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 52.60
22 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 52.28
23 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75 50.88
24 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 49.36
25 INT17885 Negative_regulation of YWHAZ 6 0.56 2.74 1.58 48.72
26 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 48.24
27 INT22159 Gene_expression of AMT 11 0.75 2.19 1.5 46.32
28 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 43.44
29 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 43.44
30 INT1938 Positive_regulation of DONSON 3 0.13 3.02 1.07 43.44
31 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 40.80
32 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 33.84
33 INT99965 Positive_regulation of Negative_regulation of NARFL 6 0.40 4.5 0.04 32.56
34 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 31.84
35 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 31.84
36 INT1026 Binding of Lbp 207 0.48 150.96 119.16 31.44
37 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 26.64
38 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 26.08
39 INT14690 Localization of CSF2 124 0.80 85.17 27.26 25.00
40 INT14689 Localization of CSF3R 5 0.56 3.85 1.02 25.00
41 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 23.20
42 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 23.20
43 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 22.88
44 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 22.68
45 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 18.40
46 INT9257 Positive_regulation of SELPLG 5 0.45 3.57 1.16 18.40
47 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 14.64
48 INT186631 Protein_catabolism of PSMA6 1 0.16 0.17 0 8.44
49 INT186644 Protein_catabolism of PSMA7 1 0.15 0.17 0 8.16
50 INT186626 Protein_catabolism of PSMB6 1 0.16 0.17 0 7.88
51 INT186627 Protein_catabolism of PSMB7 1 0.39 0.17 0 7.60
52 INT186663 Protein_catabolism of PSMB9 2 0.60 0.39 0.03 7.32
53 INT186659 Regulation of Protein_catabolism of PSMB9 1 0.15 0.17 0 7.32
54 INT186640 Protein_catabolism of PSMD13 1 0.14 0.17 0 7.04
55 INT186636 Protein_catabolism of CELA3B 1 0.01 0.16 0 6.00
56 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
57 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
58 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
59 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
60 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
61 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
62 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
63 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
64 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
65 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
66 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
67 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
68 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
69 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
70 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
71 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
72 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
73 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
74 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
75 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
76 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
77 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 5.00
78 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
79 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 5.00
80 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
81 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
82 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
83 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
84 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69 5.00
85 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
86 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
87 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
88 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
89 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
90 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 5.00
91 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
92 INT132178 Binding of CD80 41 0.47 15.55 12.98 5.00
93 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 5.00
94 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
95 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
96 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
97 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
98 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
99 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
100 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
101 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
102 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
103 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 5.00
104 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
105 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
106 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 5.00
107 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
108 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
109 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 5.00
110 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
111 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
112 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
113 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
114 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
115 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
116 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
117 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 5.00
118 INT186623 Negative_regulation of Mag 13 0.42 12.22 6.48 5.00
119 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 5.00
120 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
121 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 5.00
122 INT115947 Regulation of Il17a 17 0.37 14.26 5.97 5.00
123 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
124 INT118124 Binding of USE1 24 0.16 16.64 5.44 5.00
125 INT44608 Gene_expression of C2 45 0.75 15.84 5.05 5.00
126 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 5.00
127 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
128 INT64653 Binding of CD2 17 0.44 6.74 4.45 5.00
129 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06 5.00
130 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 5.00
131 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
132 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
133 INT64310 Negative_regulation of GRIN2A 7 0.42 2.16 3.49 5.00
134 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48 5.00
135 INT37110 Positive_regulation of Ptgfr 10 0.69 2.38 3.44 5.00
136 INT188355 Binding of Cd28 25 0.34 8.29 3.38 5.00
137 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
138 INT151441 Positive_regulation of Gene_expression of Trav6-3 22 0.65 10.21 3.05 5.00
139 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 5.00
140 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95 5.00
141 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
142 INT185898 Gene_expression of MMP10 8 0.49 5.36 2.68 5.00
143 INT83642 Gene_expression of CD63 22 0.77 10.06 2.63 5.00
144 INT44150 Regulation of TBXA2R 10 0.19 3.94 2.62 5.00
145 INT172078 Localization of Cd3e 22 0.37 9.88 2.27 5.00
146 INT57501 Binding of CREM 11 0.27 3.67 2.15 5.00
147 INT112267 Positive_regulation of Rgc32 10 0.39 8.1 2.09 5.00
148 INT140991 Negative_regulation of Stat3 15 0.53 7.55 2.04 5.00
149 INT186134 Binding of IGHA1 5 0.01 4.71 1.99 5.00
150 INT104564 Gene_expression of Aqp3 8 0.65 4.92 1.99 5.00
151 INT173576 Negative_regulation of FDPS 25 0.57 8.42 1.91 5.00
152 INT115303 Localization of SNAP25 8 0.73 1.43 1.82 5.00
153 INT53532 Gene_expression of Lcp1 10 0.70 11.57 1.69 5.00
154 INT5319 Positive_regulation of PTGFR 9 0.32 4.96 1.44 5.00
155 INT32300 Binding of Ptgfr 3 0.36 1.51 1.36 5.00
156 INT247904 Localization of ICAM2 1 0.07 5.72 1.32 5.00
157 INT247903 Localization of ITGA1 1 0.06 5.69 1.32 5.00
158 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
159 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13 5.00
160 INT147336 Gene_expression of HLA-G 12 0.75 7.27 1.08 5.00
161 INT22830 Negative_regulation of Binding of IL2 4 0.55 4.8 1.06 5.00
162 INT99767 Regulation of THBS1 18 0.42 11.51 1.03 5.00
163 INT131161 Binding of CD58 5 0.17 3.54 1.03 5.00
164 INT15186 Negative_regulation of HRH2 8 0.51 2.26 0.99 5.00
165 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 5.00
166 INT288676 Negative_regulation of CREM 3 0.18 1.34 0.96 5.00
167 INT155867 Transcription of COL1A2 8 0.69 2.9 0.94 5.00
168 INT3776 Positive_regulation of Regulation of NARFL 2 0.37 2.44 0.93 5.00
169 INT186135 Negative_regulation of Binding of ITGAL 5 0.34 3.27 0.74 5.00
170 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 5.00
171 INT289989 Positive_regulation of Narf 1 0.02 3.85 0.73 5.00
172 INT186136 Negative_regulation of Binding of CD2 2 0.29 2.06 0.68 5.00
173 INT289988 Gene_expression of Narf 1 0.02 3.35 0.67 5.00
174 INT131160 Negative_regulation of Binding of CD58 2 0.15 1.83 0.53 5.00
175 INT141706 Localization of HLA-DRB1 9 0.75 4.87 0.48 5.00
176 INT200435 Binding of polymerase 6 0.16 5.56 0.47 5.00
177 INT289983 Regulation of Positive_regulation of Narf 1 0.01 1.12 0.46 5.00
178 INT218919 Negative_regulation of Xiap 4 0.32 4.61 0.46 5.00
179 INT186650 Localization of VAMP2 1 0.40 0.39 0.38 5.00
180 INT330977 Transcription of Aes 1 0.38 0.53 0.38 5.00
181 INT114313 Binding of RHO 7 0.36 1.45 0.36 5.00
182 INT186647 Localization of SYN2 1 0.34 0.28 0.32 5.00
183 INT186622 Negative_regulation of Chol1 9 0.42 3.86 0.32 5.00
184 INT186641 Localization of SYT4 1 0.33 0.28 0.32 5.00
185 INT92249 Gene_expression of FDPS 7 0.46 4.97 0.31 5.00
186 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31 5.00
187 INT174519 Gene_expression of C1R 4 0.35 0.51 0.29 5.00
188 INT111676 Phosphorylation of MYH14 5 0.48 2.14 0.28 5.00
189 INT289986 Positive_regulation of Transcription of Rbp3 1 0.04 1 0.27 5.00
190 INT289994 Transcription of Rbp3 1 0.06 0.99 0.27 5.00
191 INT289985 Positive_regulation of Positive_regulation of Rgc32 1 0.01 0.93 0.24 5.00
192 INT186629 Gene_expression of HLA-F 2 0.22 0.9 0.24 5.00
193 INT220840 Phosphorylation of Il17a 2 0.75 1.24 0.23 5.00
194 INT186656 Gene_expression of C1QA 1 0.48 0.35 0.23 5.00
195 INT112838 Gene_expression of PRDX6 2 0.19 0.54 0.23 5.00
196 INT186662 Gene_expression of C1QC 3 0.46 10.44 0.23 5.00
197 INT289992 Phosphorylation of Cntf 1 0.30 1 0.22 5.00
198 INT186624 Localization of Atp8a1 5 0.73 1.06 0.22 5.00
199 INT186628 Gene_expression of DCT 5 0.46 3.79 0.21 5.00
200 INT166268 Positive_regulation of Lcp1 2 0.49 2.79 0.21 5.00
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