D:Iron-deficiency Anemia

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Disease Term
Synonyms Anemia Iron Deficiency, ANEMIAS IRON DEFICIENCY, Iron Deficiency Anemia, Iron Deficiency Anemias
Documents 176
Hot Single Events 54
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Iron-deficiency Anemia. They are ordered first by their relevance to Iron-deficiency Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23 100.00
2 INT238826 Binding of INS and RBP4 1 0.10 2.07 0 80.72
3 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0 16.60
4 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 15.04
5 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55 5.00
6 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 5.00
7 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 5.00
8 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 5.00
9 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
10 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
11 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
12 INT267812 Binding of ATF7IP and RLS 1 0.35 2.01 0.21 5.00
13 INT307765 Myoz1 Positive_regulation of Gene_expression of Il6 1 0.01 0.71 0.21 5.00
14 INT307764 Myoz1 Positive_regulation of Transcription of Il6 1 0.01 0.72 0.21 5.00
15 INT238825 LTF Regulation of Localization of RBP4 1 0.05 1.08 0.16 5.00
16 INT307755 TNF Regulation of Gene_expression of IL8 1 0.02 0.5 0.14 5.00
17 INT307769 TNF Regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 5.00
18 INT307771 TNF Negative_regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 5.00
19 INT321867 TNFRSF11B Negative_regulation of TNFSF11 1 0.00 0.85 0.08 5.00
20 INT321868 Binding of TNFRSF11B and Negative_regulation of TNFSF11 1 0.00 0.91 0.08 5.00
21 INT238819 Binding of LTF and RBP4 1 0.04 0.26 0 5.00
22 INT238823 LTF Positive_regulation of GOPC 1 0.01 0.29 0 5.00
23 INT319483 Binding of LCT and HSR 1 0.11 0.23 0 5.00
24 INT238822 TF Regulation of Localization of RBP4 1 0.14 0.28 0 5.00
25 INT238827 RBP4 Positive_regulation of Gene_expression of INS 1 0.14 1.15 0 5.00
26 INT238818 LTF Positive_regulation of RBP4 1 0.06 0.29 0 5.00
27 INT238824 LTF Positive_regulation of Localization of RBP4 1 0.08 0.29 0 5.00
28 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
29 INT238820 LTF Positive_regulation of Localization of GOPC 1 0.01 0.29 0 5.00
30 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Iron-deficiency Anemia. They are ordered first by their pain relevance and then by number of times they were reported in Iron-deficiency Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 100.00
2 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 100.00
3 INT296385 Binding of IDUA 12 0.39 20.73 0.93 100.00
4 INT84244 Positive_regulation of Gene_expression of IDUA 5 0.70 3.75 0.19 100.00
5 INT279349 Localization of IDUA 7 0.76 4.97 0.07 100.00
6 INT162956 Binding of ACD 3 0.32 3.04 0.05 100.00
7 INT279351 Regulation of IDUA 2 0.36 1.71 0 100.00
8 INT84826 Negative_regulation of ACD 6 0.50 4.02 0.55 100.00
9 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 100.00
10 INT296382 Positive_regulation of SLC11A2 3 0.31 1.49 0.08 99.96
11 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 99.28
12 INT36132 Negative_regulation of pid 12 0.43 15.15 1.73 99.28
13 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 99.24
14 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 98.98
15 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 98.88
16 INT58380 Binding of ALAD 13 0.47 9.87 2.44 98.32
17 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 98.26
18 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 97.36
19 INT64676 Gene_expression of ANXA5 11 0.75 13.48 2.11 96.32
20 INT127607 Gene_expression of EID1 4 0.63 5.57 1.6 96.32
21 INT45503 Binding of EPO 42 0.48 24.85 2.88 95.00
22 INT276086 Regulation of Positive_regulation of GBD3 1 0.09 1.3 0.04 95.00
23 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 94.98
24 INT106381 Negative_regulation of CEACAM7 8 0.38 7.45 0.5 94.90
25 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 94.78
26 INT276085 Positive_regulation of GBD3 1 0.10 1.29 0.04 94.52
27 INT46843 Binding of Trf 10 0.47 3.45 0.35 94.32
28 INT132453 Binding of TF 31 0.36 12.98 1.22 93.96
29 INT163114 Positive_regulation of Gene_expression of GOT1 7 0.24 8.93 0.5 93.84
30 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 93.76
31 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 93.48
32 INT9188 Localization of HBG1 12 0.75 8.14 2.24 93.16
33 INT113987 Localization of IK 29 0.23 16.73 8.25 92.60
34 INT296387 Localization of SLC40A1 2 0.44 0.94 0 89.28
35 INT186639 Gene_expression of SLC11A2 4 0.65 1.91 0 88.56
36 INT60942 Localization of S100A8 12 0.78 12.23 2.39 88.16
37 INT218316 Positive_regulation of RBP4 2 0.68 7.54 0.3 86.76
38 INT238830 Positive_regulation of Localization of RBP4 1 0.68 2.98 0 86.76
39 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 86.52
40 INT57526 Regulation of Ltf 8 0.45 2.73 0.56 86.24
41 INT218313 Localization of RBP4 5 0.79 15.68 1.4 86.08
42 INT310522 Regulation of Transcription of HAMP 1 0.60 1.36 0.05 85.60
43 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 85.48
44 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 85.24
45 INT297528 Transcription of HAMP 3 0.69 3.64 0.5 85.20
46 INT21726 Gene_expression of Tfrc 10 0.74 7.38 2.36 85.16
47 INT62112 Binding of S100A8 37 0.36 17.18 3.16 84.16
48 INT296383 Regulation of SLC11A2 1 0.07 0.33 0 83.60
49 INT296384 Regulation of SLC40A1 2 0.01 0.83 0.03 83.20
50 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 81.88
51 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 81.48
52 INT296386 Localization of DEFA6 3 0.05 0.88 0 81.40
53 INT276426 Transcription of Trf 2 0.07 0.48 0.04 81.20
54 INT2774 Binding of Crp 241 0.48 195.89 44.39 80.48
55 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 79.92
56 INT238836 Positive_regulation of Gene_expression of RBP4 1 0.68 3.46 0 79.92
57 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 79.84
58 INT96092 Binding of ANXA5 24 0.36 14.51 2.6 79.80
59 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 79.28
60 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 78.36
61 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 75.12
62 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 74.36
63 INT53065 Negative_regulation of Gene_expression of EPO 15 0.49 16.39 3.12 73.96
64 INT192918 Negative_regulation of HAMP 3 0.57 2.29 0.09 73.40
65 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 72.96
66 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 72.96
67 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 71.76
68 INT287118 Negative_regulation of Gene_expression of VDR 3 0.36 3.53 0.66 71.28
69 INT156850 Binding of VDR 40 0.47 24.86 4.87 70.72
70 INT34669 Localization of Hypism 8 0.25 10.79 1.2 63.80
71 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 62.44
72 INT77852 Binding of Chd7 8 0.31 4.1 2.51 58.44
73 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13 55.04
74 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 55.00
75 INT152796 Protein_catabolism of RLS 4 0.59 3.64 0.33 54.96
76 INT337566 Negative_regulation of MMS 1 0.02 0.61 0 53.16
77 INT307766 Negative_regulation of CADM1 1 0.02 2.13 0.44 52.60
78 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 52.00
79 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 51.32
80 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 51.32
81 INT107401 Regulation of Das 9 0.18 3.02 1.31 51.08
82 INT142735 Regulation of RLS 33 0.53 45.83 11.35 50.72
83 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 47.84
84 INT102353 Positive_regulation of HLA-DQA2 6 0.06 4.07 0.82 46.68
85 INT306940 Positive_regulation of HAMP 3 0.49 5.06 0.36 46.64
86 INT310530 Positive_regulation of Gene_expression of HAMP 3 0.49 4.16 0.28 46.64
87 INT204156 Gene_expression of HAMP 7 0.75 8.1 0.94 45.20
88 INT285398 Positive_regulation of HLA-DRB8 1 0.01 1.11 0 43.88
89 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 43.84
90 INT102582 Positive_regulation of Gene_expression of Gdf15 11 0.69 7.66 1.68 43.84
91 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 37.32
92 INT307759 Negative_regulation of D7Cwr3P 1 0.00 1.39 0.3 36.60
93 INT86437 Binding of IL6 154 0.48 121.22 29.3 34.60
94 INT100861 Binding of CRP 179 0.48 175.2 26.45 34.60
95 INT159446 Negative_regulation of Gdf15 5 0.58 3.36 1 32.44
96 INT2910 Regulation of Abat 169 0.62 36.95 153.53 31.92
97 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 31.48
98 INT43907 Binding of CD79A 28 0.48 28.11 3.04 30.96
99 INT310513 Gene_expression of Twsg1 1 0.17 3.97 0.28 30.60
100 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 30.16
101 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 29.96
102 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 29.92
103 INT22213 Localization of Gpt 52 0.78 34.05 12.94 29.20
104 INT74879 Regulation of MPG 6 0.44 0.8 1.08 29.20
105 INT100360 Negative_regulation of TF 19 0.42 10.43 2.68 28.32
106 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 27.84
107 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8 26.84
108 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 23.64
109 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 21.52
110 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 21.52
111 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 21.52
112 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 21.52
113 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 21.52
114 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 21.52
115 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 20.92
116 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 19.76
117 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 13.76
118 INT120466 Gene_expression of LCT 21 0.78 6 1.75 12.16
119 INT319485 Regulation of Gene_expression of LCT 1 0.32 0 0 12.16
120 INT185181 Phosphorylation of Pth 2 0.64 1.51 0.3 11.68
121 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 10.80
122 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 10.80
123 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 9.96
124 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 8.16
125 INT67156 Binding of ITGA4 6 0.14 2.63 1.03 8.16
126 INT310527 Gene_expression of MDFIC 1 0.05 1.87 0.29 6.80
127 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
128 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
129 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
130 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
131 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
132 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
133 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
134 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
135 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
136 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
137 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
138 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
139 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
140 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
141 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
142 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
143 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
144 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
145 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
146 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
147 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
148 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
149 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
150 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
151 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
152 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
153 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
154 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
155 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
156 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
157 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
158 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
159 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
160 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
161 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
162 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
163 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
164 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 5.00
165 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
166 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
167 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
168 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
169 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
170 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
171 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
172 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
173 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
174 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
175 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
176 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
177 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
178 INT75742 Binding of RLS 86 0.42 95.27 19.04 5.00
179 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
180 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
181 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
182 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
183 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
184 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
185 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
186 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
187 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
188 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
189 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 5.00
190 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
191 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
192 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
193 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
194 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 5.00
195 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
196 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
197 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
198 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
199 INT9385 Localization of LDHA 74 0.81 31.67 10.5 5.00
200 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
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