D:Isaacs Syndrome

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Disease Term
Synonyms Acquired Neuromyotonia, Continuous Muscle Activity Syndrome, Continuous Myokymia, Continuous Myokymias, Gamstorp Wohlfart Syndrome, Gamstorp Wohlfart Syndromes, ISAAC SYNDROME, Isaacs Mertens Syndrome, Isaacs Pseudomyotonia Syndrome, Myokymia Continuous, MYOKYMIAS CONTINUOUS
Documents 39
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Isaacs Syndrome. They are ordered first by their relevance to Isaacs Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329116 Binding of LGI1 and CNTNAP2 1 0.38 1.3 0.44 79.36
2 INT329119 Binding of CNTN2 and CNTNAP2 1 0.08 2.41 0.73 64.96
3 INT329120 Binding of KCNA1 and CNTNAP2 1 0.09 1.23 0.75 59.24
4 INT329122 Binding of KCNA1 and LGI1 1 0.08 0.29 0.43 5.00
5 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
6 INT329118 Binding of KCNA1 and CNTN2 1 0.02 0 0.14 5.00
7 INT329121 Binding of LGI1 and ADAM22 1 0.14 0.5 0.06 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Isaacs Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Isaacs Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36 100.00
2 INT34790 Localization of KCNA1 4 0.43 11.34 3.99 98.80
3 INT143551 Binding of KCNA1 13 0.46 8.81 2.81 98.40
4 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66 98.16
5 INT329156 Regulation of CNTNAP2 1 0.19 2.35 0.48 98.16
6 INT178590 Regulation of CNTN2 7 0.24 2.91 0.68 98.16
7 INT329143 Binding of CNTNAP2 1 0.47 5.04 1.32 95.60
8 INT329148 Gene_expression of CNTNAP2 17 0.76 6 2.95 93.04
9 INT329158 Positive_regulation of Gene_expression of CNTNAP2 1 0.49 1.3 0.26 93.04
10 INT166623 Binding of BMPR2 1 0.29 0.35 0.13 84.88
11 INT329144 Binding of LGI1 1 0.38 5.79 1.59 79.36
12 INT329151 Positive_regulation of Gene_expression of KCNA1 1 0.11 1.18 0.24 76.68
13 INT329140 Localization of CNTNAP2 1 0.73 3.56 1.31 75.92
14 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 75.36
15 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 75.12
16 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 75.00
17 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 75.00
18 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 75.00
19 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 75.00
20 INT329149 Localization of LGI1 1 0.73 4.95 1.79 74.68
21 INT132613 Gene_expression of LGI1 2 0.71 5.9 4.15 66.08
22 INT329150 Regulation of Gene_expression of LGI1 1 0.41 0.87 0.11 66.08
23 INT329160 Regulation of Gene_expression of CNTNAP2 1 0.44 0.87 0.11 66.08
24 INT132334 Negative_regulation of Gene_expression of KCNA1 4 0.43 1.52 1.14 65.96
25 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 63.40
26 INT187356 Binding of Kcnn3 1 0.25 1.17 0.19 61.44
27 INT329159 Positive_regulation of LGI1 1 0.46 1.07 0.29 61.24
28 INT329152 Positive_regulation of CNTNAP2 1 0.49 0.54 0.15 61.24
29 INT69395 Gene_expression of CNTN2 28 0.68 13.29 4.37 60.80
30 INT178591 Binding of CNTN2 4 0.23 1.56 0.44 51.16
31 INT156320 Regulation of LGI1 2 0.38 1.18 0.45 43.52
32 INT150142 Negative_regulation of Kcnn3 5 0.59 2.82 0.58 37.76
33 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 30.88
34 INT72294 Binding of CA3 3 0.32 0.54 0.55 10.16
35 INT187357 Negative_regulation of Kcns2 1 0.01 1.06 0.1 5.04
36 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
37 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
38 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
39 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
40 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
41 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
42 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
43 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
44 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
45 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
46 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
47 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
48 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
49 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
50 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
51 INT38564 Binding of AIS 36 0.38 27.77 9.31 5.00
52 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 5.00
53 INT55101 Gene_expression of Cst7 16 0.75 2.39 5.92 5.00
54 INT145532 Localization of Dlg4 25 0.79 1.97 4.36 5.00
55 INT150144 Gene_expression of Kcnn3 31 0.78 7.67 4.24 5.00
56 INT187360 Gene_expression of Kcnn2 17 0.55 2.51 3.91 5.00
57 INT25464 Binding of SAA1 11 0.42 6.89 3.72 5.00
58 INT9549 Regulation of CHKB 25 0.47 13.61 3.2 5.00
59 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
60 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 5.00
61 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89 5.00
62 INT150141 Positive_regulation of Gene_expression of Kcnn3 14 0.66 3.54 1.64 5.00
63 INT87571 Negative_regulation of KCNQ1 6 0.41 1.69 1.51 5.00
64 INT132612 Negative_regulation of LGI1 2 0.39 0.79 1.07 5.00
65 INT150137 Transcription of Kcnn3 4 0.53 0.46 0.87 5.00
66 INT187355 Gene_expression of Kcnn1 2 0.28 1.47 0.86 5.00
67 INT254930 Gene_expression of CELSR3 4 0.76 5.01 0.76 5.00
68 INT132333 Negative_regulation of KCNA1 8 0.47 0.87 0.71 5.00
69 INT187358 Localization of Kcnn3 2 0.72 1.65 0.51 5.00
70 INT329161 Negative_regulation of CNTNAP2 1 0.42 0.73 0.51 5.00
71 INT148522 Gene_expression of KCNQ2 2 0.75 0.25 0.26 5.00
72 INT148299 Negative_regulation of KCNQ4 2 0.11 0.37 0.24 5.00
73 INT239610 Localization of KCNQ1 4 0.62 1.47 0.2 5.00
74 INT272484 Negative_regulation of Myod1 8 0.39 6.77 0.2 5.00
75 INT254929 Gene_expression of KCNQ4 1 0.14 0 0.13 5.00
76 INT187359 Negative_regulation of Mvp 1 0.06 1.12 0.12 5.00
77 INT329154 Binding of ADAM22 1 0.11 0.96 0.12 5.00
78 INT254926 Gene_expression of KCNQ3 1 0.18 0.16 0.11 5.00
79 INT254931 Gene_expression of KCNQ5 1 0.12 0 0.07 5.00
80 INT254934 Negative_regulation of Gene_expression of KCNQ4 1 0.09 0 0.06 5.00
81 INT254932 Negative_regulation of Gene_expression of KCNQ5 1 0.08 0 0.03 5.00
82 INT254935 Negative_regulation of KCNQ5 1 0.08 0 0.03 5.00
83 INT254924 Negative_regulation of Gene_expression of KCNQ2 1 0.13 0.16 0.03 5.00
84 INT254933 Positive_regulation of Gene_expression of KCNQ2 1 0.15 0.16 0 5.00
85 INT254925 Regulation of Gene_expression of KCNQ3 1 0.12 0 0 5.00
86 INT254928 Regulation of Gene_expression of KCNQ2 1 0.13 0 0 5.00
87 INT329147 Positive_regulation of Gene_expression of LGI1 1 0.42 0 0 5.00
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