D:Islet Cell Adenoma

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Disease Term
Synonyms Adenomas Islet Cell, Island Cell Tumor, ISLAND CELL TUMORS, Islet Cell Adenomas, ISLET CELL TUMOR, Islet Cell Tumors, Nesidioblastoma, Tumor Island Cell, Tumor Islet Cell, Tumors Island Cell, Tumors Islet Cell
Documents 93
Hot Single Events 76
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Islet Cell Adenoma. They are ordered first by their relevance to Islet Cell Adenoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2 93.20
2 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2 93.20
3 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1 93.20
4 INT202431 Binding of IGF2 and INSRR 1 0.01 0.85 0 86.08
5 INT202430 Binding of IGF2 and INS 1 0.16 0.85 0 85.36
6 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 73.16
7 INT205049 LGALS4 Negative_regulation of Localization of MUC13 1 0.34 0.61 0 20.48
8 INT205050 LGALS4 Negative_regulation of Localization of ROPN1L 1 0.36 0.62 0 20.48
9 INT205058 LGALS4 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 20.48
10 INT205045 LGALS4 Negative_regulation of SLPI 1 0.06 0.61 0 20.48
11 INT205056 LGALS4 Negative_regulation of Localization of COL17A1 1 0.32 0.62 0 20.48
12 INT205053 MUC13 Negative_regulation of Localization of LGALS4 1 0.34 0.61 0 20.48
13 INT205046 MUC13 Negative_regulation of Localization of COL17A1 1 0.31 0.62 0 19.72
14 INT205048 MUC13 Negative_regulation of Localization of SLPI 1 0.06 0.61 0 19.72
15 INT205059 MUC13 Negative_regulation of Localization of ROPN1L 1 0.34 0.62 0 19.72
16 INT205047 MUC13 Negative_regulation of SLPI 1 0.06 0.61 0 19.72
17 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57 5.00
18 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 5.00
19 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
20 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3 5.00
21 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3 5.00
22 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24 5.00
23 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19 5.00
24 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18 5.00
25 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 5.00
26 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13 5.00
27 INT215036 Gh Positive_regulation of Gene_expression of Trh 1 0.08 1.4 0.06 5.00
28 INT263900 Binding of Col1a1 and Cea 1 0.01 0.63 0 5.00
29 INT263918 Binding of PTPRC and Cea 1 0.00 0.37 0 5.00
30 INT269140 Binding of Il6 and Rps7 1 0.02 0.85 0 5.00
31 INT215035 Trh Positive_regulation of Gh 1 0.07 0.89 0 5.00
32 INT269139 Binding of Csnk2a2 and Sub1 1 0.02 0.68 0 5.00
33 INT263899 Binding of PTPRC and TMED7-TICAM2 1 0.00 0.85 0 5.00
34 INT269138 Binding of Il6ra and Rps7 1 0.01 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Islet Cell Adenoma. They are ordered first by their pain relevance and then by number of times they were reported in Islet Cell Adenoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12 100.00
2 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19 100.00
3 INT172806 Localization of ISL1 4 0.26 2.64 0.29 100.00
4 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26 100.00
5 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.98
6 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 99.96
7 INT205105 Gene_expression of AXIN2 1 0.74 6.6 0 99.84
8 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 99.84
9 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 99.84
10 INT205099 Positive_regulation of Gene_expression of AXIN2 1 0.48 3.48 0 99.84
11 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 99.72
12 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 99.52
13 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 99.16
14 INT1893 Localization of Gh 1041 0.79 340.23 256.58 98.88
15 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 98.86
16 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 98.72
17 INT78213 Gene_expression of Cspt 3 0.40 2.41 0.29 98.56
18 INT812 Localization of INS 1026 0.81 515.6 145.31 98.44
19 INT29635 Localization of Eno2 9 0.76 6.05 1.35 98.32
20 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 98.08
21 INT21841 Positive_regulation of PPPD1 4 0.38 3.46 0.16 97.64
22 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 96.56
23 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 96.12
24 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 95.44
25 INT217539 Localization of INSM1 1 0.04 7.01 0.2 93.28
26 INT185028 Binding of IGF2 4 0.46 1.72 0.07 92.96
27 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 92.72
28 INT205095 Gene_expression of CELA3A 1 0.62 2.58 0.06 91.96
29 INT2464 Gene_expression of AMY2A 21 0.75 13.76 2.78 91.96
30 INT136720 Gene_expression of PRSS2 6 0.50 4.99 1.43 91.96
31 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33 91.96
32 INT36947 Gene_expression of PNLIP 13 0.45 11.04 1.23 91.96
33 INT205082 Gene_expression of CPA2 1 0.65 1.1 0.07 91.96
34 INT48803 Gene_expression of CELA3B 9 0.22 7.24 2.06 91.96
35 INT13897 Localization of Sst 65 0.81 14.91 32.24 91.52
36 INT9012 Localization of Vip 283 0.81 31.71 106.16 91.52
37 INT217536 Regulation of INSM1 1 0.02 1.38 0.04 91.28
38 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 91.20
39 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 91.12
40 INT57157 Gene_expression of TDGF1 5 0.75 3.97 4.02 90.52
41 INT249 Localization of GHRH 215 0.80 78.02 51.87 90.04
42 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 90.04
43 INT14572 Binding of INS 205 0.48 175.43 13.38 89.52
44 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62 88.76
45 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13 88.44
46 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 88.40
47 INT205098 Positive_regulation of Gene_expression of MAFB 1 0.33 1.13 0.03 87.88
48 INT9781 Binding of INSRR 64 0.31 19.1 25.2 87.84
49 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 87.76
50 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07 87.76
51 INT205100 Gene_expression of MAFB 1 0.37 1.13 0.03 87.48
52 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 87.36
53 INT3041 Positive_regulation of MIA3 34 0.56 21.11 6.49 87.36
54 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 87.04
55 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 86.68
56 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 86.20
57 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 85.52
58 INT20388 Binding of LYZ 8 0.39 5.65 1.93 85.44
59 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 85.04
60 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 83.84
61 INT112166 Localization of Gast 15 0.72 8.86 2.91 83.56
62 INT3214 Localization of Ins1 527 0.80 196.9 79.26 83.56
63 INT8740 Localization of Gcg 65 0.78 19 9.81 83.56
64 INT215031 Localization of Ppy 2 0.23 1.73 0.37 83.56
65 INT5008 Localization of Calca 204 0.81 80.35 125.16 83.56
66 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 83.04
67 INT30 Gene_expression of Gast 158 0.78 99 41.45 83.04
68 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 82.08
69 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 82.08
70 INT78525 Gene_expression of RAD21 1 0.03 1.49 0.28 82.08
71 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 81.76
72 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0 81.76
73 INT397 Localization of SST 232 0.81 58.05 101.19 81.68
74 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 81.68
75 INT70893 Positive_regulation of Gene_expression of IGF2 5 0.67 6.13 0.44 81.16
76 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 80.72
77 INT695 Binding of POMC 304 0.48 56.66 126.85 79.28
78 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 78.88
79 INT140637 Negative_regulation of IFI27 11 0.40 9.48 0.69 78.88
80 INT215026 Positive_regulation of Ppy 1 0.03 1.85 0.16 78.04
81 INT134973 Binding of Ts1 2 0.31 2.51 0.09 77.92
82 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 76.52
83 INT121800 Positive_regulation of Gene_expression of Arigg4 7 0.31 10.86 2.02 76.48
84 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 76.28
85 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 75.36
86 INT20981 Binding of HRAS 42 0.48 24.49 4.23 75.28
87 INT82374 Binding of SYP 13 0.36 13.69 0.85 75.20
88 INT217537 Gene_expression of INSM1 1 0.04 5.1 0.04 73.28
89 INT443 Localization of POMC 1020 0.81 284.52 443.17 72.32
90 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 71.84
91 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07 71.84
92 INT215025 Negative_regulation of Gene_expression of Ghrh 10 0.41 7.8 0.65 71.44
93 INT119818 Negative_regulation of CHGA 10 0.57 8.21 2.04 70.88
94 INT47889 Binding of MMP2 9 0.41 6.37 1.68 69.40
95 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 69.36
96 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 68.16
97 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 68.16
98 INT738 Regulation of POMC 459 0.62 111.19 243.74 66.36
99 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 66.36
100 INT159232 Negative_regulation of SYP 4 0.41 4.45 0.38 65.84
101 INT88390 Gene_expression of LGALS4 27 0.69 12.28 4.15 59.44
102 INT230979 Gene_expression of EPHA4 4 0.65 0.83 0.33 54.28
103 INT17934 Localization of MLN 16 0.80 2.83 2.24 52.24
104 INT39919 Negative_regulation of MLN 9 0.36 2.91 1.06 52.24
105 INT2132 Localization of SCT 29 0.81 8.39 5.43 51.52
106 INT4820 Negative_regulation of SCT 7 0.43 4.06 3.01 51.52
107 INT2243 Localization of GAST 67 0.81 34.54 16.19 50.72
108 INT628 Negative_regulation of GAST 10 0.58 4.44 2.08 50.72
109 INT625 Localization of PGC 35 0.80 11.33 3.05 50.00
110 INT629 Negative_regulation of Localization of PGC 8 0.45 5.79 1.33 50.00
111 INT32704 Negative_regulation of PGC 11 0.54 5.75 1.23 50.00
112 INT252 Localization of GH1 529 0.80 227.4 122.05 49.92
113 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 49.92
114 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 46.04
115 INT260162 Gene_expression of PPPD1 4 0.55 4.26 0.04 46.04
116 INT202435 Transcription of IGF2 3 0.58 2.44 0.29 44.24
117 INT202433 Positive_regulation of Transcription of IGF2 1 0.42 0.55 0 44.24
118 INT17625 Localization of GCG 210 0.80 55.69 24.97 42.00
119 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 42.00
120 INT546 Binding of ALB 311 0.48 85.98 60.14 38.72
121 INT202434 Gene_expression of IGFBP6 3 0.53 1.52 0 34.00
122 INT121801 Binding of Aip 18 0.36 24.1 5.26 33.36
123 INT35328 Gene_expression of KRTAP19-9P 9 0.52 9.08 1.44 33.28
124 INT212176 Gene_expression of CEACAM5 7 0.75 6.05 0.24 33.28
125 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 32.44
126 INT78524 Positive_regulation of Neu1 6 0.67 8.9 4.4 32.00
127 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68 32.00
128 INT299486 Localization of Krt20 2 0.19 1.49 0 29.96
129 INT142060 Positive_regulation of Ghrh 15 0.66 7.21 1.83 25.76
130 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 23.24
131 INT74392 Binding of LGALS4 4 0.43 7.23 1.65 23.00
132 INT205074 Binding of MUC13 1 0.30 0.62 0 23.00
133 INT205101 Binding of ROPN1L 1 0.32 1.27 0 23.00
134 INT205097 Binding of COL17A1 1 0.28 0.63 0 23.00
135 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 22.16
136 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 21.44
137 INT216011 Regulation of TSC2 2 0.26 3.31 0 20.80
138 INT205096 Localization of LGALS4 2 0.71 6.06 2.05 20.48
139 INT205084 Localization of MUC13 1 0.61 0.61 0 19.72
140 INT164192 Localization of SLPI 4 0.73 1.51 0.32 19.40
141 INT205090 Localization of COL17A1 1 0.57 0.61 0 19.40
142 INT205093 Localization of ROPN1L 1 0.64 0.62 0 19.40
143 INT151032 Localization of Igf1 49 0.76 26.32 5.71 18.88
144 INT189390 Positive_regulation of MT1F 5 0.08 0.85 0.14 17.76
145 INT691 Binding of SST 67 0.48 24.66 32.67 11.36
146 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 9.52
147 INT263872 Localization of Adra1d 1 0.01 2.5 0.11 8.88
148 INT20006 Gene_expression of MT1F 27 0.68 19.55 3.18 7.44
149 INT177832 Positive_regulation of Gene_expression of MT1F 5 0.28 2.75 1.05 7.44
150 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
151 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
152 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
153 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
154 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
155 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
156 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
157 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
158 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
159 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
160 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
161 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
162 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
163 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
164 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
165 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
166 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
167 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
168 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
169 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
170 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
171 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49 5.00
172 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
173 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
174 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
175 INT22000 Positive_regulation of Sst 25 0.70 14.82 13.6 5.00
176 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
177 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 5.00
178 INT8963 Gene_expression of Trh 25 0.68 7.5 10.97 5.00
179 INT2491 Regulation of Cea 38 0.61 26.18 10.95 5.00
180 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
181 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
182 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
183 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
184 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
185 INT16869 Positive_regulation of Prl 24 0.70 15.7 7.63 5.00
186 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
187 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
188 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
189 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
190 INT12054 Negative_regulation of MIA3 32 0.45 23.2 6.18 5.00
191 INT24724 Positive_regulation of Gene_expression of SST 11 0.67 7.51 6.12 5.00
192 INT26459 Regulation of Prl 14 0.62 7.27 4.92 5.00
193 INT624 Positive_regulation of GAST 28 0.70 15.61 4.73 5.00
194 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 5.00
195 INT8965 Positive_regulation of Trh 11 0.57 5.28 4.46 5.00
196 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
197 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
198 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 5.00
199 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 5.00
200 INT11605 Regulation of Positive_regulation of Gh 10 0.45 2.08 3.85 5.00
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