D:Isochromosomes

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pChart

Disease Term
Synonyms ISOCHROMOSOME
Documents 12
Hot Single Events 2
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Isochromosomes. They are ordered first by their relevance to Isochromosomes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT320713 NRAS Positive_regulation of AKT1 1 0.37 0.84 0 45.76
2 INT320712 Binding of NRAS and PIK3CD 1 0.21 1.66 0 43.44
3 INT320715 NRAS Positive_regulation of PIK3CD 1 0.27 1.66 0 43.44
4 INT205862 CNTN2 Positive_regulation of TNF 1 0.01 0.08 0.04 5.00
5 INT205863 Binding of FDPS and HTLVR 1 0.00 0.07 0 5.00
6 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0 5.00
7 INT205875 Binding of FDPS and G4 1 0.02 0.13 0 5.00
8 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 5.00
9 INT210285 Ccrs1 Regulation of RAI1 1 0.00 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Isochromosomes. They are ordered first by their pain relevance and then by number of times they were reported in Isochromosomes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT282824 Regulation of PML 3 0.44 2.66 0.09 90.16
2 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04 90.16
3 INT166325 Negative_regulation of RAI1 2 0.36 2.74 0.13 73.76
4 INT52347 Negative_regulation of CHM 17 0.58 13.03 0.59 73.76
5 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 73.76
6 INT203636 Positive_regulation of CD2AP 4 0.13 1.27 0.28 69.76
7 INT320718 Positive_regulation of Positive_regulation of CD2AP 1 0.08 0.55 0 69.76
8 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 69.20
9 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 60.04
10 INT247431 Positive_regulation of Negative_regulation of RB1 2 0.45 2.58 0 60.04
11 INT281256 Positive_regulation of CCND2 1 0.20 1.42 0 60.04
12 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 58.52
13 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41 58.52
14 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0 58.52
15 INT281253 Negative_regulation of Negative_regulation of LAMTOR1 1 0.09 1.49 0 58.52
16 INT281250 Negative_regulation of Negative_regulation of CDKN2D 1 0.08 1.49 0 58.52
17 INT200671 Gene_expression of AKT3 4 0.69 1.88 0.13 58.24
18 INT320734 Positive_regulation of Gene_expression of AKT3 1 0.62 0.65 0 58.24
19 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 56.60
20 INT210280 Negative_regulation of Gene_expression of RAI1 1 0.35 1.01 0 56.60
21 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 56.36
22 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 56.36
23 INT281251 Negative_regulation of LAMTOR1 1 0.12 1.42 0 56.36
24 INT251628 Negative_regulation of CDKN2D 2 0.15 1.83 0 56.36
25 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 53.60
26 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 51.40
27 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 50.44
28 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 49.68
29 INT320723 Negative_regulation of Gene_expression of BRAF 2 0.38 1 0.03 49.68
30 INT320726 Negative_regulation of Gene_expression of TBX3 1 0.16 0.66 0 49.68
31 INT320720 Gene_expression of TBX3 1 0.29 3.53 0 49.68
32 INT320733 Negative_regulation of TBX3 1 0.16 0.66 0 48.28
33 INT320732 Binding of PIK3CD 3 0.20 1.66 0 43.44
34 INT178196 Gene_expression of Vegfc 7 0.27 7.47 0.64 42.16
35 INT320736 Binding of NRAS 1 0.32 0.82 0 38.72
36 INT301986 Positive_regulation of Gene_expression of Vegfc 1 0.21 1.09 0.21 37.00
37 INT320729 Positive_regulation of Negative_regulation of RPP14 1 0.32 1.04 0 32.16
38 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 31.72
39 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 31.72
40 INT320731 Positive_regulation of RPP14 1 0.34 1.04 0 31.72
41 INT320719 Negative_regulation of RPP14 1 0.30 1.04 0 31.72
42 INT206135 Positive_regulation of NRAS 2 0.62 2.23 0.03 29.84
43 INT244794 Gene_expression of Mnx1 2 0.29 0.54 0 28.92
44 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21 27.96
45 INT37525 Gene_expression of Mkl1 1 0.16 0.54 0.09 25.00
46 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 22.80
47 INT320721 Protein_catabolism of NRAS 1 0.59 0.89 0 16.40
48 INT79358 Gene_expression of ERVW-1 65 0.75 29.9 1.31 9.40
49 INT69395 Gene_expression of CNTN2 28 0.68 13.29 4.37 9.04
50 INT28363 Gene_expression of NRSN1 8 0.45 8.66 0.53 9.04
51 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 8.88
52 INT300639 Negative_regulation of KIDINS220 1 0.04 0.46 0 8.08
53 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
54 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
55 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
56 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
57 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
58 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
59 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
60 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
61 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
62 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
63 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
64 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
65 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
66 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
67 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
68 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
69 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
70 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
71 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
72 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
73 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
74 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
75 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
76 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 5.00
77 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
78 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
79 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
80 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
81 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
82 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
83 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 5.00
84 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
85 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
86 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 5.00
87 INT105960 Gene_expression of Cdh1 41 0.76 22.28 5.56 5.00
88 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
89 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
90 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29 5.00
91 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
92 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 5.00
93 INT121871 Localization of Camk4 9 0.81 4.67 3.84 5.00
94 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
95 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
96 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47 5.00
97 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
98 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
99 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
100 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 5.00
101 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
102 INT172678 Gene_expression of NUPL2 20 0.75 5.06 2.85 5.00
103 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84 5.00
104 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 5.00
105 INT57970 Positive_regulation of Rb1 17 0.67 7.03 2.36 5.00
106 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13 5.00
107 INT169705 Negative_regulation of Gene_expression of Cdh1 10 0.57 8.8 2.1 5.00
108 INT156720 Localization of CD1D 7 0.68 1.1 2.09 5.00
109 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
110 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
111 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 5.00
112 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 5.00
113 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57 5.00
114 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
115 INT102044 Regulation of ERVW-1 10 0.44 4.76 1.45 5.00
116 INT206244 Binding of CD24 7 0.48 5.71 1.43 5.00
117 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 5.00
118 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 5.00
119 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39 5.00
120 INT79357 Binding of ERVW-1 32 0.43 16.06 1.35 5.00
121 INT214073 Binding of TSC1 9 0.37 22 1.34 5.00
122 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 5.00
123 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 5.00
124 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 5.00
125 INT200107 Gene_expression of SDHA 9 0.37 5.29 1.02 5.00
126 INT232636 Positive_regulation of Binding of Kit 4 0.39 1.98 0.98 5.00
127 INT6833 Binding of Notch1 4 0.36 0.05 0.94 5.00
128 INT21660 Regulation of CHM 14 0.61 8.51 0.93 5.00
129 INT210276 Positive_regulation of Gene_expression of PMP22 3 0.46 1.58 0.88 5.00
130 INT287954 Gene_expression of DVL1 8 0.24 2.48 0.83 5.00
131 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81 5.00
132 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8 5.00
133 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
134 INT131286 Binding of Egfr 26 0.44 13.58 0.78 5.00
135 INT204842 Positive_regulation of Cd44 9 0.49 6.6 0.77 5.00
136 INT69744 Gene_expression of CDT1 3 0.65 1.6 0.75 5.00
137 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75 5.00
138 INT191811 Regulation of CD24 7 0.45 6 0.72 5.00
139 INT187096 Negative_regulation of Cd44 6 0.30 5.92 0.7 5.00
140 INT115784 Gene_expression of GNAQ 5 0.65 4.48 0.7 5.00
141 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68 5.00
142 INT178590 Regulation of CNTN2 7 0.24 2.91 0.68 5.00
143 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
144 INT204254 Localization of KIT 8 0.73 6.78 0.61 5.00
145 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6 5.00
146 INT288158 Negative_regulation of Gene_expression of Cd44 5 0.30 5.73 0.59 5.00
147 INT105959 Positive_regulation of Gene_expression of Cdh1 5 0.49 2.65 0.57 5.00
148 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57 5.00
149 INT25237 Binding of NRSN1 4 0.29 2.58 0.53 5.00
150 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 5.00
151 INT69393 Positive_regulation of CNTN2 4 0.45 0.8 0.5 5.00
152 INT301995 Regulation of Cdh1 5 0.44 3.8 0.48 5.00
153 INT178591 Binding of CNTN2 4 0.23 1.56 0.44 5.00
154 INT191803 Positive_regulation of CD24 6 0.70 5.49 0.43 5.00
155 INT172558 Positive_regulation of Cdh1 11 0.49 8.92 0.42 5.00
156 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 5.00
157 INT111822 Binding of Krt8 6 0.34 4.61 0.39 5.00
158 INT185350 Negative_regulation of Gene_expression of Egfr 24 0.59 13.21 0.35 5.00
159 INT196925 Positive_regulation of Gene_expression of Rb1 4 0.45 3.16 0.33 5.00
160 INT205755 Binding of su 3 0.04 0.43 0.33 5.00
161 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 5.00
162 INT205806 Positive_regulation of ERVW-1 16 0.49 6.43 0.31 5.00
163 INT90666 Gene_expression of GTF2F1 2 0.17 0.15 0.28 5.00
164 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26 5.00
165 INT181808 Gene_expression of Pax7 18 0.54 6.22 0.26 5.00
166 INT11156 Gene_expression of TGFA 4 0.61 3.03 0.26 5.00
167 INT178584 Regulation of Gene_expression of CNTN2 1 0.21 1.39 0.24 5.00
168 INT205796 Transcription of ERVW-1 5 0.52 2.16 0.24 5.00
169 INT234858 Binding of Cdh1 11 0.47 4.58 0.22 5.00
170 INT232831 Binding of Krt18 7 0.39 4.61 0.21 5.00
171 INT48656 Positive_regulation of Gene_expression of Cd44 7 0.69 5.93 0.21 5.00
172 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2 5.00
173 INT186702 Gene_expression of POLD4 3 0.65 0.29 0.17 5.00
174 INT125101 Gene_expression of CASP9 24 0.35 16.54 0.17 5.00
175 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 5.00
176 INT205803 Localization of ERVW-1 6 0.66 3.02 0.15 5.00
177 INT14870 Positive_regulation of Gene_expression of TGFA 2 0.46 2.12 0.15 5.00
178 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13 5.00
179 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13 5.00
180 INT301990 Gene_expression of Hn1 1 0.09 2.61 0.13 5.00
181 INT233562 Regulation of Fabp5 3 0.23 1.81 0.12 5.00
182 INT200109 Positive_regulation of Gene_expression of NUPL2 1 0.49 0.44 0.1 5.00
183 INT301991 Positive_regulation of Hn1 1 0.06 1.09 0.09 5.00
184 INT67347 Negative_regulation of Gene_expression of NRSN1 3 0.34 2.56 0.08 5.00
185 INT302000 Phosphorylation of Hn1 1 0.10 0.8 0.08 5.00
186 INT51444 Regulation of PMP22 2 0.44 1.39 0.07 5.00
187 INT242338 Binding of TSC2 2 0.22 1.56 0.04 5.00
188 INT236701 Negative_regulation of Gene_expression of Rb1 4 0.10 4.55 0.03 5.00
189 INT186460 Transcription of ASAP1 5 0.56 3.02 0.03 5.00
190 INT205807 Positive_regulation of Gene_expression of GTF2F1 1 0.03 0.15 0.03 5.00
191 INT205868 Gene_expression of G4 4 0.42 1.1 0.03 5.00
192 INT300640 Transcription of CASP9 1 0.23 1.11 0 5.00
193 INT205791 Transcription of CNTN2 1 0.25 0.7 0 5.00
194 INT301992 Binding of Hn1 1 0.04 0.69 0 5.00
195 INT205793 Binding of POLD4 1 0.02 0.21 0 5.00
196 INT281255 Positive_regulation of Negative_regulation of CDY1 1 0.28 1.64 0 5.00
197 INT300638 Transcription of DVL1 1 0.33 1.11 0 5.00
198 INT205805 Regulation of Gene_expression of NRSN1 1 0.03 0.64 0 5.00
199 INT210275 Positive_regulation of PMP22 1 0.55 0.52 0 5.00
200 INT216011 Regulation of TSC2 2 0.26 3.31 0 5.00
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