D:Joint Instability

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Disease Term
Synonyms Hypermobilities Joint, Hypermobility Joint, Instabilities Joint, Instability Joint, JOINT HYPERMOBILITIES, Joint Hypermobility, JOINT INSTABILITIES, Joint Laxities, JOINT LAXITY, Laxities Joint, Laxity Joint
Documents 447
Hot Single Events 27
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Joint Instability. They are ordered first by their relevance to Joint Instability and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT87037 Binding of FBXO6 and Col5a3 1 0.00 0.48 0.09 91.36
2 INT87038 Binding of ADRA1D and Col5a3 1 0.03 0.48 0.09 91.36
3 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12 84.80
4 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12 84.80
5 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12 84.80
6 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06 65.20
7 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06 65.20
8 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0 64.36
9 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0 64.36
10 INT289789 Comp Positive_regulation of Gene_expression of Rer1 1 0.55 0.8 0.03 59.08
11 INT289795 Binding of COMP and Comp 1 0.02 0.99 0 26.60
12 INT313618 Binding of Acly and Pdgfb 1 0.00 0.18 0.03 26.24
13 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92 5.00
14 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
15 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99 5.00
16 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72 5.00
17 INT317586 Binding of SCLY and Ppap2b 1 0.00 0.78 0.72 5.00
18 INT203033 Cnr1 Regulation of Cnr2 1 0.15 0.29 0.56 5.00
19 INT184460 Il1 Positive_regulation of Adamts1 1 0.04 0.99 0.4 5.00
20 INT198970 GAPDH Negative_regulation of ADAMTS3 1 0.47 0 0.35 5.00
21 INT198971 GAPDH Negative_regulation of ADAMTS5 1 0.47 0 0.35 5.00
22 INT198969 GAPDH Negative_regulation of TIMP1 1 0.47 0 0.35 5.00
23 INT184459 Il1 Regulation of Gene_expression of Adamts1 1 0.03 0.73 0.34 5.00
24 INT323855 IL6 Positive_regulation of Positive_regulation of TNF 1 0.04 1.03 0.31 5.00
25 INT184466 Adamts1 Positive_regulation of Adamts4 1 0.13 1.03 0.3 5.00
26 INT184457 Adamts1 Positive_regulation of Positive_regulation of Adamts4 1 0.13 1.03 0.3 5.00
27 INT184458 Il17a Positive_regulation of Transcription of Adamts1 1 0.05 0.87 0.18 5.00
28 INT184464 Gtf3a Positive_regulation of Adamts1 1 0.01 0.87 0.17 5.00
29 INT184467 Gtf3a Positive_regulation of Transcription of Adamts1 1 0.01 0.87 0.17 5.00
30 INT275320 Binding of Adamts5 and Adamts4 1 0.02 0.6 0.17 5.00
31 INT275318 Binding of Gpr143 and Adamts4 1 0.00 0.6 0.17 5.00
32 INT275319 Tg(Ngf)47Kma Positive_regulation of Gpr143 1 0.00 0.59 0.17 5.00
33 INT275317 Binding of Gpr143 and Adamts5 1 0.01 0.61 0.17 5.00
34 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 0.00 0.52 0.14 5.00
35 INT304813 Binding of MNX1 and RT1-CE1 1 0.00 0.34 0.1 5.00
36 INT309780 Binding of PTH and PTH1R 3 0.12 0.3 0.09 5.00
37 INT353912 Binding of ACLY and LARS 1 0.25 0.28 0.06 5.00
38 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
39 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
40 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
41 INT238270 Binding of VMO1 and MSLNL 1 0.11 0.42 0 5.00
42 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
43 INT312290 Binding of Col9a1 and Matn3 1 0.02 0.65 0 5.00
44 INT289791 Comp Regulation of Gene_expression of Col7a1 1 0.20 0.21 0 5.00
45 INT184468 Negative_regulation of CRX Negative_regulation of Vwf 1 0.02 0.1 0 5.00
46 INT184461 Binding of Adamts1 and Furin 1 0.09 0 0 5.00
47 INT332159 Gh Positive_regulation of Gene_expression of Igfbp3 1 0.07 1.11 0 5.00
48 INT289788 Binding of Comp and Scn8a 1 0.16 1.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Joint Instability. They are ordered first by their pain relevance and then by number of times they were reported in Joint Instability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1 100.00
2 INT156294 Binding of Hm 2 0.07 1.7 0.86 100.00
3 INT82350 Gene_expression of Hm 5 0.15 0.64 0.92 98.80
4 INT339528 Protein_catabolism of Eaf2 1 0.01 0.84 0.08 98.04
5 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 98.04
6 INT275312 Positive_regulation of Utp14b 1 0.24 1.08 0.39 96.12
7 INT275311 Positive_regulation of Gene_expression of Utp14b 1 0.26 1.08 0.39 96.12
8 INT275313 Gene_expression of Utp14b 1 0.34 1.08 0.39 96.12
9 INT339530 Regulation of Eaf2 1 0.00 0.76 0.1 95.64
10 INT196324 Localization of Cyp2b10 5 0.73 2.81 0.13 94.92
11 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 93.92
12 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2 93.64
13 INT82829 Gene_expression of COMP 104 0.78 57 9.81 93.36
14 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 92.72
15 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 92.24
16 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 91.92
17 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18 91.92
18 INT11106 Gene_expression of Lbp 10 0.67 10.29 4.52 89.44
19 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 88.52
20 INT307262 Positive_regulation of PKD2L1 2 0.49 1.77 0.32 88.52
21 INT318985 Positive_regulation of Positive_regulation of ACLY 1 0.08 1.77 0.15 88.52
22 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15 87.44
23 INT39948 Binding of FLNA 45 0.42 58.05 4.27 86.56
24 INT289776 Localization of Dnajc1 1 0.11 1.86 0.08 86.40
25 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 86.32
26 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29 86.16
27 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 85.92
28 INT323052 Gene_expression of TNXB 1 0.70 1.43 0.07 79.52
29 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58 75.32
30 INT5793 Binding of CTS 110 0.48 63.91 40.62 75.00
31 INT45510 Binding of Scn8a 4 0.31 3.89 0.25 74.92
32 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 74.88
33 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42 73.44
34 INT323050 Positive_regulation of TNXB 1 0.45 1.43 0.07 73.28
35 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 72.72
36 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 71.56
37 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0 70.64
38 INT339529 Gene_expression of Eaf2 1 0.01 0.75 0 70.16
39 INT184451 Gene_expression of Adamts2 6 0.51 2.51 1.42 69.76
40 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96 69.76
41 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 69.36
42 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 68.76
43 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3 68.76
44 INT251 Regulation of INS 398 0.62 232.47 55.04 68.28
45 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9 68.28
46 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 68.08
47 INT233816 Negative_regulation of PTH1R 2 0.58 4.08 1.07 66.32
48 INT11107 Binding of Lbp 12 0.42 4.42 3.41 65.20
49 INT309781 Positive_regulation of Gene_expression of PTH1R 2 0.46 1.88 0.87 64.88
50 INT184450 Binding of Adamts2 1 0.32 0.6 0 62.48
51 INT339527 Negative_regulation of Eaf2 1 0.01 0.42 0.11 62.12
52 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 60.20
53 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 58.32
54 INT184439 Protein_catabolism of Adamts1 1 0.51 1.08 0.23 57.12
55 INT65261 Regulation of Col7a1 18 0.55 8.7 1.33 55.76
56 INT289778 Gene_expression of Rer1 1 0.65 0.67 0.03 53.88
57 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58 53.76
58 INT312286 Binding of Col9a1 1 0.10 1.37 0 53.52
59 INT312283 Binding of Matn3 1 0.06 1.31 0 53.52
60 INT312284 Binding of Comp 1 0.30 3.08 0 53.52
61 INT259244 Negative_regulation of TNXB 1 0.42 2.15 0.13 50.00
62 INT184306 Localization of Comp 2 0.69 5.1 0.12 49.56
63 INT289780 Positive_regulation of Localization of Dnajc1 1 0.08 0.84 0 48.92
64 INT211942 Transcription of Runx2 3 0.69 2.46 0.08 48.16
65 INT323049 Positive_regulation of IGKV2-30 1 0.00 3.44 0.07 47.28
66 INT2102 Gene_expression of Rhd 7 0.51 1.37 1.93 45.76
67 INT119001 Regulation of ACLY 5 0.44 4.83 0.36 44.40
68 INT309782 Regulation of PTH1R 1 0.45 0.88 0.28 44.40
69 INT14572 Binding of INS 205 0.48 175.43 13.38 43.48
70 INT2541 Binding of Calca 200 0.48 67.14 134.62 42.48
71 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 40.32
72 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23 39.84
73 INT162064 Gene_expression of PKD2L1 12 0.63 2.71 1.1 39.64
74 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 38.76
75 INT225012 Regulation of Localization of Mtpn 2 0.01 0.14 0.13 37.48
76 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 37.12
77 INT133144 Localization of Mtpn 18 0.24 7.88 2.77 37.00
78 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 36.64
79 INT164066 Negative_regulation of SIL1 3 0.21 2.75 0.96 34.44
80 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 30.32
81 INT299115 Regulation of INPP5K 6 0.39 4.11 0.59 29.32
82 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 26.48
83 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83 26.36
84 INT312282 Gene_expression of Col9a3 1 0.52 1.16 0 25.64
85 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 21.84
86 INT142340 Positive_regulation of Chkb 3 0.47 6.44 0.38 20.68
87 INT312285 Positive_regulation of Positive_regulation of Chkb 1 0.24 1.02 0 20.68
88 INT263804 Localization of MSLNL 3 0.55 2.13 0.14 20.60
89 INT335494 Binding of MSLNL 1 0.05 0.38 0.14 20.60
90 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 19.68
91 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 18.20
92 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 16.76
93 INT184440 Positive_regulation of Adamts1 18 0.68 13.28 1.87 13.52
94 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 12.12
95 INT155565 Gene_expression of Efemp2 22 0.67 7.24 0.13 10.24
96 INT128496 Regulation of CASP1 5 0.38 3.4 1.09 10.12
97 INT312287 Gene_expression of Col9a1 1 0.21 2.94 0 8.60
98 INT184436 Regulation of Gene_expression of Adamts1 6 0.60 9.53 0.62 8.12
99 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 7.88
100 INT165228 Binding of BMI1 13 0.47 25.36 7.97 5.64
101 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.36
102 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
103 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
104 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
105 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
106 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
107 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
108 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
109 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
110 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
111 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
112 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
113 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
114 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
115 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 5.00
116 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
117 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
118 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
119 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
120 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
121 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
122 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
123 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
124 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 5.00
125 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
126 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
127 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
128 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
129 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
130 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 5.00
131 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
132 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
133 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
134 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
135 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 5.00
136 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
137 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
138 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
139 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
140 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
141 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
142 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
143 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
144 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
145 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
146 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
147 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
148 INT50308 Binding of Cnr1 61 0.48 14.41 33.52 5.00
149 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
150 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 5.00
151 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
152 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
153 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
154 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
155 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
156 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
157 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
158 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
159 INT1030 Localization of Lbp 52 0.74 38.92 24.91 5.00
160 INT25607 Binding of Il1 82 0.47 64.4 23.9 5.00
161 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 5.00
162 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
163 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
164 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
165 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
166 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
167 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
168 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
169 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31 5.00
170 INT95318 Binding of Pain1 17 0.22 21.26 20.14 5.00
171 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
172 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
173 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13 5.00
174 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 5.00
175 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
176 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
177 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
178 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 5.00
179 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
180 INT167521 Regulation of Pain1 11 0.27 10.88 14 5.00
181 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
182 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
183 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
184 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
185 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
186 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 5.00
187 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
188 INT156696 Positive_regulation of Pain1 10 0.23 10.92 12.42 5.00
189 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
190 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58 5.00
191 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
192 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5 5.00
193 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
194 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
195 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 5.00
196 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81 5.00
197 INT85144 Binding of Cnr2 14 0.47 6.41 9.49 5.00
198 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 5.00
199 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 5.00
200 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 5.00
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