D:Kallmann Syndrome

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Disease Term
Synonyms Kallmann S Syndrome, Kallmann Syndrome 1, KALLMANN SYNDROME 2, Syndrome Kallmann, Syndrome Kallmann S
Documents 8
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Kallmann Syndrome. They are ordered first by their relevance to Kallmann Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 5.00
2 INT272439 Binding of ARAF and Prokr2 1 0.01 0.59 0.09 5.00
3 INT272417 Binding of PROK1 and Positive_regulation of MAPK1 1 0.01 0.08 0.05 5.00
4 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 5.00
5 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 5.00
6 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0 5.00
7 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0 5.00
8 INT272418 CGA Regulation of Gene_expression of PROK1 1 0.01 0.34 0 5.00
9 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 0.03 0.52 0 5.00
10 INT272416 PROK1 Positive_regulation of Gene_expression of VEGFA 1 0.26 0 0 5.00
11 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0 5.00
12 INT277803 Regulation of GNRH1 Regulation of CGA 1 0.00 0.61 0 5.00
13 INT334920 GNRH1 Positive_regulation of Gene_expression of PLOD1 1 0.16 0.52 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Kallmann Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Kallmann Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT334926 Positive_regulation of MEHMO 1 0.02 10.11 2.37 95.24
2 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 93.68
3 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 93.68
4 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 88.16
5 INT32963 Negative_regulation of Localization of GNRHR 3 0.29 2.48 0.84 87.68
6 INT272420 Positive_regulation of Prokr2 1 0.18 1.02 0.17 85.68
7 INT912 Localization of FSHR 91 0.79 23.61 15.58 84.96
8 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 84.96
9 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 72.48
10 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 72.48
11 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 71.92
12 INT7033 Binding of FSHR 19 0.37 6.66 1.52 71.36
13 INT268379 Gene_expression of ARAF 22 0.16 9.34 1.07 69.16
14 INT272438 Gene_expression of PROK1 32 0.63 15.06 1.01 65.76
15 INT7234 Binding of GNRH1 43 0.47 21.59 12.36 64.92
16 INT334927 Negative_regulation of MEHMO 1 0.01 3.46 0.1 57.52
17 INT135578 Gene_expression of Prokr1 22 0.70 11.71 8.31 56.20
18 INT199383 Gene_expression of Prokr2 8 0.59 7.37 5.21 55.84
19 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 43.68
20 INT146563 Gene_expression of PROK2 15 0.75 4.12 0.61 36.40
21 INT268386 Positive_regulation of ARAF 6 0.17 4.84 0.33 31.44
22 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
23 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
24 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
25 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
26 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
27 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
28 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
29 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
30 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
31 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
32 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
33 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
34 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
35 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
36 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
37 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
38 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
39 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
40 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
41 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
42 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
43 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
44 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92 5.00
45 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
46 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05 5.00
47 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
48 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
49 INT7035 Regulation of CGA 87 0.45 29.04 28.45 5.00
50 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 5.00
51 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
52 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
53 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
54 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 5.00
55 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
56 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 5.00
57 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 5.00
58 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
59 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 5.00
60 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
61 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
62 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
63 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 5.00
64 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
65 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
66 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
67 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
68 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
69 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 5.00
70 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
71 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
72 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
73 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
74 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
75 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
76 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87 5.00
77 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 5.00
78 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
79 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
80 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
81 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
82 INT4146 Binding of SHBG 49 0.47 31 4.71 5.00
83 INT28546 Regulation of SHBG 23 0.54 16.35 3.88 5.00
84 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 5.00
85 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 5.00
86 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
87 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 5.00
88 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
89 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99 5.00
90 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 5.00
91 INT25031 Negative_regulation of Gene_expression of PLOD1 14 0.54 3.86 2.89 5.00
92 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
93 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 5.00
94 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 5.00
95 INT5344 Negative_regulation of BRD2 12 0.56 4.71 1.89 5.00
96 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 5.00
97 INT136523 Binding of Prokr1 2 0.48 0.85 1.47 5.00
98 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 5.00
99 INT25032 Negative_regulation of Gene_expression of FSHR 11 0.39 1.99 1.2 5.00
100 INT60286 Gene_expression of PKLR 5 0.65 2.14 1.04 5.00
101 INT130194 Positive_regulation of PROK1 9 0.65 0.97 0.7 5.00
102 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
103 INT252266 Localization of GPHA2 2 0.05 0.67 0.46 5.00
104 INT253069 Binding of PROK1 4 0.36 0.89 0.34 5.00
105 INT25047 Positive_regulation of Regulation of FSHR 3 0.31 0.92 0.29 5.00
106 INT334924 Binding of MEHMO 1 0.01 9.69 0.26 5.00
107 INT272432 Regulation of PROK1 2 0.42 1.16 0.18 5.00
108 INT272436 Negative_regulation of Gene_expression of PROK1 3 0.40 2.3 0.17 5.00
109 INT272430 Localization of PROK1 4 0.66 2.01 0.14 5.00
110 INT272434 Positive_regulation of Gene_expression of PROK1 2 0.47 0.86 0.14 5.00
111 INT272427 Regulation of Gene_expression of ARAF 2 0.02 1.33 0.12 5.00
112 INT272425 Binding of ARAF 3 0.07 0.85 0.04 5.00
113 INT272429 Positive_regulation of PROK2 2 0.32 0.24 0.03 5.00
114 INT272431 Transcription of PROK1 1 0.42 0.06 0 5.00
115 INT272435 Transcription of PROK2 1 0.34 1.66 0 5.00
116 INT272419 Regulation of Prokr1 1 0.08 0.29 0 5.00
117 INT272437 Positive_regulation of Transcription of PROK2 1 0.30 1.67 0 5.00
118 INT272433 Regulation of Gene_expression of PROK1 1 0.49 0.7 0 5.00
119 INT272428 Positive_regulation of Transcription of PROK1 1 0.37 0.06 0 5.00
120 INT272426 Regulation of Regulation of PROK1 1 0.21 0.33 0 5.00
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