D:Keratoconjunctivitis

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Disease Term
Synonyms Keratoconjunctivitides
Documents 43
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Keratoconjunctivitis. They are ordered first by their relevance to Keratoconjunctivitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 78.08
2 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 33.76
3 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 33.76
4 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 33.36
5 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69 25.48
6 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 5.00
7 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9 5.00
8 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36 5.00
9 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 5.00
10 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34 5.00
11 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26 5.00
12 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26 5.00
13 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26 5.00
14 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14 5.00
15 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14 5.00
16 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 5.00
17 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 5.00
18 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05 5.00
19 INT273774 Binding of GPER and RB1 1 0.01 0.45 0 5.00
20 INT328626 Binding of TBCE and MUC16 1 0.15 0.79 0 5.00
21 INT328627 Binding of LGALS3 and MUC16 1 0.04 0.73 0 5.00
22 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Keratoconjunctivitis. They are ordered first by their pain relevance and then by number of times they were reported in Keratoconjunctivitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT265227 Binding of AD7 1 0.22 1.3 0 97.84
2 INT265229 Binding of PSEN2 2 0.16 1.37 0 97.84
3 INT265228 Binding of TBC1D8 1 0.16 1.3 0 97.84
4 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 96.64
5 INT257732 Regulation of Positive_regulation of RB1 2 0.39 2.35 0.09 96.64
6 INT347433 Gene_expression of AD8 1 0.30 1.14 0.1 96.36
7 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 95.72
8 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 95.72
9 INT63905 Regulation of RB1 13 0.62 12.67 1.28 95.20
10 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03 94.56
11 INT347434 Gene_expression of TBC1D8 1 0.25 0.61 0 94.56
12 INT46169 Transcription of IgG 14 0.67 7.71 1.01 94.44
13 INT254253 Transcription of Ighm 5 0.45 3.6 0.81 94.44
14 INT241132 Transcription of Cd79a 2 0.27 1.96 0 94.44
15 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 91.32
16 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 87.64
17 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 85.96
18 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 82.88
19 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 82.16
20 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18 82.16
21 INT194993 Binding of RB1 15 0.37 10.96 0.4 78.76
22 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 78.16
23 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 78.08
24 INT273783 Regulation of Gene_expression of RB1 1 0.29 0.67 0 73.36
25 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 69.12
26 INT33845 Binding of GPER 20 0.36 5.61 1.81 67.68
27 INT210218 Localization of Tnfsf13b 2 0.40 4.76 0.22 62.56
28 INT354864 Positive_regulation of Localization of Tnfsf13b 1 0.16 4.03 0 62.56
29 INT28680 Positive_regulation of Tnfsf13b 5 0.39 6.46 1.1 60.32
30 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 56.40
31 INT36287 Binding of CD4 96 0.47 58.93 11.88 48.64
32 INT160235 Positive_regulation of Gene_expression of FIGF 4 0.20 5.53 1 44.92
33 INT112110 Positive_regulation of FIGF 3 0.18 5.28 0.37 44.92
34 INT112109 Gene_expression of FIGF 13 0.31 8.31 1.44 44.56
35 INT28679 Gene_expression of Tnfsf13b 5 0.60 2.75 1.53 40.80
36 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 36.76
37 INT195080 Positive_regulation of Tnc 4 0.45 26.67 2.34 36.76
38 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 33.76
39 INT96338 Gene_expression of HPSE 17 0.75 18.71 2.73 30.32
40 INT45075 Gene_expression of Sugt1 24 0.27 8.5 1.33 29.28
41 INT23257 Regulation of CRP 127 0.62 100.05 21.87 20.20
42 INT257447 Binding of TBCE 4 0.08 4.68 0.66 19.12
43 INT240359 Binding of Tnc 2 0.35 11.67 1.48 18.16
44 INT354785 Regulation of Binding of Tnc 1 0.06 1.63 0.53 18.16
45 INT354787 Regulation of Binding of HSPG2 1 0.23 1.63 0.53 18.16
46 INT219108 Negative_regulation of Gene_expression of MUC5AC 11 0.31 9.74 1.08 14.32
47 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 13.44
48 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 8.48
49 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 8.36
50 INT78190 Gene_expression of Tnc 10 0.75 21.23 2.91 8.36
51 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
52 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
53 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
54 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
55 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
56 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
57 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
58 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
59 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
60 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
61 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
62 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
63 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
64 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
65 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
66 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
67 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
68 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
69 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
70 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
71 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 5.00
72 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
73 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
74 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
75 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
76 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
77 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
78 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
79 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
80 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
81 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
82 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
83 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
84 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
85 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
86 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
87 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
88 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
89 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
90 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
91 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
92 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
93 INT57257 Gene_expression of IL7 69 0.62 50.24 20.36 5.00
94 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
95 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
96 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
97 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
98 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
99 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
100 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
101 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
102 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
103 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
104 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
105 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 5.00
106 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
107 INT69306 Negative_regulation of TH1L 28 0.57 24.81 9.74 5.00
108 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
109 INT1129 Binding of Car2 69 0.35 14.01 9.2 5.00
110 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
111 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
112 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
113 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
114 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 5.00
115 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 5.00
116 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
117 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
118 INT91721 Binding of IL18 21 0.48 21.17 6.56 5.00
119 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
120 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36 5.00
121 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
122 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 5.00
123 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
124 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 5.00
125 INT132573 Negative_regulation of Gene_expression of TH1L 16 0.42 11.52 5.76 5.00
126 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 5.00
127 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 5.00
128 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 5.00
129 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 5.00
130 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
131 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46 5.00
132 INT107771 Localization of HSPG2 10 0.78 8.47 4.3 5.00
133 INT24278 Gene_expression of FUT4 33 0.75 26.7 4.29 5.00
134 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 5.00
135 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09 5.00
136 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 5.00
137 INT64473 Regulation of Gene_expression of IL4 17 0.58 6.61 3.96 5.00
138 INT11230 Regulation of MUC16 23 0.60 19.54 3.93 5.00
139 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88 5.00
140 INT35175 Localization of IL18 18 0.80 12.96 3.83 5.00
141 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 5.00
142 INT69155 Positive_regulation of Localization of IL4 13 0.40 10.18 3.56 5.00
143 INT47678 Positive_regulation of Positive_regulation of HSPG2 7 0.49 3.94 3.56 5.00
144 INT4907 Gene_expression of MUC7 10 0.67 1.69 3.55 5.00
145 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 5.00
146 INT133768 Regulation of Fasl 10 0.44 10.24 3.32 5.00
147 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
148 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 5.00
149 INT142908 Localization of FGFR1 18 0.38 11.46 2.57 5.00
150 INT188756 Positive_regulation of AGRP 43 0.60 23.67 2.51 5.00
151 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 5.00
152 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
153 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34 5.00
154 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
155 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 5.00
156 INT98132 Regulation of FAS 16 0.42 20.57 2.06 5.00
157 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 5.00
158 INT101432 Positive_regulation of Gene_expression of Atp9a 13 0.10 7.86 1.95 5.00
159 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 5.00
160 INT174240 Negative_regulation of TYMS 12 0.57 6.35 1.82 5.00
161 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53 5.00
162 INT71918 Gene_expression of ACTA1 16 0.75 7.73 1.45 5.00
163 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38 5.00
164 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 5.00
165 INT206696 Regulation of Gene_expression of TH1L 5 0.20 4.44 1.26 5.00
166 INT11887 Localization of MUC16 16 0.80 10.66 1.26 5.00
167 INT44558 Positive_regulation of PDXP 6 0.35 3.65 1.22 5.00
168 INT205189 Gene_expression of TBCE 12 0.25 9.67 1.19 5.00
169 INT54897 Negative_regulation of HSPA9 3 0.41 5.08 1.19 5.00
170 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 5.00
171 INT183967 Positive_regulation of Btg3 9 0.58 9.04 1.03 5.00
172 INT11506 Binding of MUC16 20 0.48 22.89 1.03 5.00
173 INT299153 Negative_regulation of Tnc 2 0.42 8.14 0.98 5.00
174 INT58755 Binding of PAM 6 0.34 3.09 0.97 5.00
175 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96 5.00
176 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 5.00
177 INT112874 Gene_expression of Plcb1 2 0.23 1.42 0.86 5.00
178 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 5.00
179 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79 5.00
180 INT205188 Positive_regulation of Gene_expression of TBCE 5 0.19 2.14 0.74 5.00
181 INT129756 Regulation of MUC5AC 7 0.34 6.45 0.7 5.00
182 INT35541 Transcription of MUC16 3 0.69 6.44 0.65 5.00
183 INT4785 Gene_expression of PAM 6 0.58 3.47 0.64 5.00
184 INT11889 Regulation of Gene_expression of MUC16 5 0.62 3.24 0.63 5.00
185 INT94881 Negative_regulation of Gene_expression of MUC16 4 0.42 2.51 0.61 5.00
186 INT20557 Localization of MUC7 6 0.42 0.43 0.59 5.00
187 INT207475 Binding of LGALS3 6 0.34 2.48 0.57 5.00
188 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55 5.00
189 INT226028 Gene_expression of Trove2 4 0.65 9.97 0.54 5.00
190 INT328633 Transcription of GPER 2 0.06 2.57 0.54 5.00
191 INT36686 Regulation of Tg 7 0.19 3.12 0.45 5.00
192 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44 5.00
193 INT172996 Gene_expression of MUC2 14 0.69 11.01 0.42 5.00
194 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41 5.00
195 INT36386 Positive_regulation of Gene_expression of FUT4 3 0.45 2.32 0.38 5.00
196 INT354868 Regulation of Cacna1s 1 0.03 2.02 0.37 5.00
197 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
198 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34 5.00
199 INT25502 Gene_expression of RERE 6 0.53 1.74 0.32 5.00
200 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31 5.00
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