D:Keratosis

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Disease Term
Synonyms Acanthotic Nevus, Actinic Keratoses, Actinic Keratosis, Blennorrhagica Keratosis, Blennorrhagicas Keratosis, Blennorrhagicum Keratoderma, Blennorrhagicums Keratoderma, Keratoderma Blennorrhagicum, KERATODERMA BLENNORRHAGICUMS, Keratoma, Keratomas
Documents 229
Hot Single Events 48
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Keratosis. They are ordered first by their relevance to Keratosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT154538 SF Regulation of Gene_expression of PPY 1 0.11 1 0.14 86.84
2 INT154539 SF Regulation of Protein_catabolism of PPY 1 0.12 0.85 0.11 70.68
3 INT154537 SF Positive_regulation of Gene_expression of PPY 1 0.15 0.81 0.11 67.12
4 INT148556 PPARG Regulation of Gene_expression of PPARA 1 0.30 1.2 0.31 27.28
5 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08 9.20
6 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04 9.20
7 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08 9.00
8 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 5.00
9 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 5.00
10 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 5.00
11 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 5.00
12 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
13 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
14 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
15 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00
16 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
17 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14 5.00
18 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 5.00
19 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 5.00
20 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
21 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07 5.00
22 INT231434 FN1 Positive_regulation of Gene_expression of PDGFA 1 0.04 0.83 0.07 5.00
23 INT231436 FN1 Positive_regulation of Gene_expression of VEGFA 1 0.06 0.83 0.07 5.00
24 INT231442 FN1 Positive_regulation of Gene_expression of HGF 1 0.05 0.83 0.07 5.00
25 INT231441 PDGFA Positive_regulation of Gene_expression of VEGFA 1 0.17 0.83 0.07 5.00
26 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03 5.00
27 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03 5.00
28 INT241588 Binding of FAS and Fas 1 0.05 2.34 0 5.00
29 INT278264 Gene_expression of Ntf3 Positive_regulation of Smcp 1 0.02 0.32 0 5.00
30 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0 5.00
31 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0 5.00
32 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0 5.00
33 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0 5.00
34 INT276759 ABCB1 Regulation of TOP2A 1 0.04 0.61 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Keratosis. They are ordered first by their pain relevance and then by number of times they were reported in Keratosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 100.00
2 INT80040 Binding of sks 1 0.31 0.92 0.08 100.00
3 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 100.00
4 INT151983 Negative_regulation of CFLAR 13 0.57 13.51 2.05 99.92
5 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 99.84
6 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81 99.84
7 INT101516 Positive_regulation of PPARD 8 0.49 4.75 2.19 99.82
8 INT84891 Gene_expression of PPARD 10 0.78 6.8 3.64 99.72
9 INT84889 Positive_regulation of Gene_expression of PPARD 4 0.70 2.94 1.49 99.72
10 INT241488 Phosphorylation of Mal 1 0.48 0.37 0 99.52
11 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 99.48
12 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 98.68
13 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 98.64
14 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 98.20
15 INT138895 Positive_regulation of Negative_regulation of Hmox2 2 0.01 1.23 1.53 98.20
16 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 97.84
17 INT69743 Gene_expression of Hmox2 36 0.78 20.77 14.26 97.64
18 INT69742 Positive_regulation of Gene_expression of Hmox2 12 0.69 8.29 8.08 97.64
19 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 97.46
20 INT294726 Positive_regulation of Lts1 5 0.49 4.06 0.87 97.40
21 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 97.40
22 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 97.40
23 INT68094 Negative_regulation of SERPINB3 12 0.43 10.55 1.49 97.28
24 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 96.84
25 INT82737 Regulation of Hmox2 7 0.14 4.6 2.44 95.32
26 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36 93.72
27 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 93.36
28 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06 92.76
29 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 92.24
30 INT126586 Binding of PARP1 15 0.43 4.96 0.53 91.52
31 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 90.36
32 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 90.00
33 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 89.12
34 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 89.12
35 INT99187 Negative_regulation of Positive_regulation of PPARG 5 0.42 5.07 2.99 86.88
36 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 86.48
37 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 85.56
38 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 85.52
39 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 85.24
40 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 83.36
41 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 82.48
42 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 82.48
43 INT154541 Positive_regulation of SF 1 0.23 0.96 0.13 81.56
44 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33 80.68
45 INT100277 Positive_regulation of Gene_expression of TBL1XR1 5 0.19 1.9 0.25 80.68
46 INT216873 Binding of TBL1XR1 3 0.36 4.44 0.4 80.24
47 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 80.08
48 INT201602 Positive_regulation of Uvbi1 2 0.04 1.17 0.04 80.08
49 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 79.52
50 INT154540 Regulation of Gene_expression of PPY 2 0.10 1.08 0.13 79.28
51 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 79.00
52 INT112991 Positive_regulation of Gene_expression of PPY 7 0.29 6.26 0.99 78.72
53 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62 78.36
54 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83 78.36
55 INT21737 Binding of MC1R 129 0.48 45.45 56.54 78.20
56 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 78.00
57 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 78.00
58 INT116540 Binding of Twist1 35 0.48 16.32 2.85 77.88
59 INT26337 Negative_regulation of Hmmr 6 0.30 1.11 4.01 77.32
60 INT27882 Gene_expression of HSP90B2P 52 0.75 36.51 9.59 76.80
61 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 75.80
62 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 75.20
63 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 73.44
64 INT143867 Positive_regulation of Mcl1 7 0.58 9.24 1.13 73.32
65 INT320315 Protein_catabolism of BAK1 3 0.76 3.13 0.13 72.80
66 INT154542 Protein_catabolism of SF 1 0.40 0.85 0.11 70.68
67 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 70.00
68 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 69.80
69 INT122553 Protein_catabolism of PPY 2 0.36 1.54 0.28 69.76
70 INT103094 Binding of PPARA 308 0.47 177.26 34.75 67.36
71 INT59600 Regulation of TNFRSF10B 4 0.39 3.63 0.98 65.40
72 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 64.88
73 INT228434 Positive_regulation of MAL 2 0.04 0.81 0.05 64.88
74 INT320314 Localization of SPDYE6 1 0.38 1.6 0 64.80
75 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 63.60
76 INT38834 Positive_regulation of Positive_regulation of PPY 2 0.42 4.18 0.61 63.32
77 INT84701 Binding of HSP90B2P 8 0.47 7.37 1.29 62.72
78 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 62.04
79 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 61.24
80 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 61.24
81 INT244704 Gene_expression of ARG1 65 0.75 37.74 1.9 60.08
82 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 58.24
83 INT97797 Localization of TLR4 18 0.77 13.78 6 53.76
84 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57 53.76
85 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 53.00
86 INT26282 Negative_regulation of ELN 9 0.51 6.37 3.76 52.92
87 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 52.92
88 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 51.20
89 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 51.08
90 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27 51.08
91 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 51.04
92 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 50.00
93 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 50.00
94 INT151289 Gene_expression of Mal 4 0.51 2.17 0.12 50.00
95 INT241487 Gene_expression of Tpcn1 2 0.05 0.29 0 50.00
96 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 49.80
97 INT15796 Regulation of IL2 66 0.61 25.43 20.62 48.04
98 INT79693 Regulation of Il4 30 0.51 21.96 8.6 48.04
99 INT76415 Regulation of Il5 6 0.18 3.56 1.4 48.04
100 INT60741 Regulation of Positive_regulation of IFNA1 9 0.16 6.98 1.24 48.04
101 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 45.24
102 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 45.12
103 INT190362 Negative_regulation of Transcription of PPARA 5 0.42 3.19 0.42 41.36
104 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 40.72
105 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 37.00
106 INT220293 Regulation of MARS 8 0.31 7.79 0.11 33.68
107 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 33.60
108 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 29.04
109 INT270698 Regulation of Gene_expression of MSRA 1 0.45 0.74 0 27.20
110 INT276766 Negative_regulation of ATP8A1 1 0.01 1.76 0.16 26.88
111 INT270697 Gene_expression of MSRA 3 0.58 1.78 0.14 25.68
112 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 25.00
113 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 25.00
114 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05 24.80
115 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 23.12
116 INT270696 Positive_regulation of Gene_expression of MSRA 1 0.51 0.73 0 21.44
117 INT47885 Gene_expression of Max 5 0.65 0.54 1.84 20.76
118 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 19.88
119 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 19.52
120 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0 13.12
121 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 13.04
122 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 12.88
123 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 11.20
124 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 10.08
125 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78 9.20
126 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 7.84
127 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 7.52
128 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 6.48
129 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
130 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
131 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
132 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
133 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
134 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
135 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
136 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
137 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
138 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
139 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
140 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
141 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
142 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
143 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
144 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
145 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
146 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
147 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
148 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
149 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
150 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
151 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
152 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
153 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
154 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
155 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 5.00
156 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
157 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
158 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
159 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
160 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
161 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
162 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
163 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
164 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
165 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
166 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
167 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
168 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
169 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
170 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
171 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 5.00
172 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
173 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
174 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
175 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
176 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
177 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
178 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
179 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
180 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
181 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
182 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
183 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
184 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
185 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
186 INT106554 Positive_regulation of Gene_expression of Bdnf 73 0.70 42.58 30.77 5.00
187 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
188 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
189 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
190 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
191 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
192 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
193 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
194 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
195 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
196 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77 5.00
197 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
198 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
199 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
200 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
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