D:Knee Injuries

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Disease Term
Synonyms Injuries Knee, Injury Knee, Knee Injury
Documents 324
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Knee Injuries. They are ordered first by their relevance to Knee Injuries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT353912 Binding of ACLY and LARS 1 0.25 0.28 0.06 47.36
2 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
3 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 5.00
4 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
5 INT247469 RCT Regulation of OAP 1 0.02 1.8 1.19 5.00
6 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
7 INT270762 IL1B Positive_regulation of IL1B Negative_regulation of IKBKB 1 0.02 1.13 0.66 5.00
8 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66 5.00
9 INT321842 Binding of Ros1 and SCFV 1 0.01 1.34 0.54 5.00
10 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 5.00
11 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 5.00
12 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34 5.00
13 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33 5.00
14 INT323855 IL6 Positive_regulation of Positive_regulation of TNF 1 0.04 1.03 0.31 5.00
15 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3 5.00
16 INT254643 Binding of Mapk8ip1 and Slc9a3r2 1 0.00 0.27 0.12 5.00
17 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1 5.00
18 INT277053 Protein_catabolism of TIMP1 Positive_regulation of COL5A2 1 0.01 0.14 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Knee Injuries. They are ordered first by their pain relevance and then by number of times they were reported in Knee Injuries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 99.90
2 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 95.24
3 INT69132 Negative_regulation of ACLY 5 0.42 2.95 0.92 93.32
4 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 91.48
5 INT112372 Positive_regulation of GPSM2 8 0.41 5.49 1.94 91.44
6 INT181269 Positive_regulation of Gene_expression of USE1 3 0.24 1.43 1.18 91.44
7 INT181265 Positive_regulation of Gene_expression of GPSM2 2 0.24 0.19 0.11 91.44
8 INT181272 Positive_regulation of Gene_expression of ACLY 3 0.44 1.29 0 91.44
9 INT9664 Binding of LBP 127 0.48 94.9 63.42 91.12
10 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7 90.24
11 INT181266 Gene_expression of GPSM2 18 0.32 0.54 1.64 90.08
12 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 89.80
13 INT50525 Positive_regulation of LR 5 0.07 1.5 0.73 82.36
14 INT35584 Binding of ACLY 22 0.35 31.78 7.17 77.28
15 INT100861 Binding of CRP 179 0.48 175.2 26.45 77.20
16 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 72.84
17 INT307262 Positive_regulation of PKD2L1 2 0.49 1.77 0.32 72.84
18 INT318985 Positive_regulation of Positive_regulation of ACLY 1 0.08 1.77 0.15 72.84
19 INT23420 Positive_regulation of Spn 8 0.49 4.81 0.69 72.20
20 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 68.36
21 INT77818 Positive_regulation of EMG1 24 0.54 2.73 1.59 68.24
22 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 62.88
23 INT101539 Regulation of EMG1 23 0.48 0.99 0.33 62.64
24 INT321839 Positive_regulation of SMARCAD1 1 0.45 0.47 0.18 60.48
25 INT9456 Gene_expression of Anpep 9 0.78 1.69 4.26 60.32
26 INT148050 Positive_regulation of SCFV 6 0.49 3.4 0.3 60.32
27 INT114664 Binding of BMP2 12 0.37 6.54 0.91 60.20
28 INT183714 Gene_expression of EMG1 17 0.60 1.59 0.19 58.48
29 INT321841 Negative_regulation of SMARCAD1 1 0.41 0.52 0.2 57.28
30 INT186601 Negative_regulation of SCFV 2 0.14 1.38 0.41 57.12
31 INT20712 Regulation of gp 8 0.36 1.06 1.67 55.48
32 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 53.32
33 INT203896 Binding of Impact 3 0.10 1.47 0.49 52.52
34 INT140978 Gene_expression of Impact 8 0.18 2.4 0.17 52.52
35 INT196707 Transcription of EMG1 1 0.40 0.05 0.06 51.92
36 INT259193 Positive_regulation of Fth1 2 0.14 1.75 0.09 51.28
37 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 50.00
38 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 50.00
39 INT192680 Localization of Pain1 6 0.73 5.01 4.42 50.00
40 INT198888 Gene_expression of Apoc4 12 0.27 5.44 3.09 50.00
41 INT183668 Binding of SGCA 15 0.36 9.86 2.42 50.00
42 INT192679 Positive_regulation of Localization of Pain1 3 0.49 1.94 1.41 50.00
43 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 49.84
44 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 49.84
45 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23 47.88
46 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 45.28
47 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 42.64
48 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 42.36
49 INT196713 Gene_expression of VMO1 2 0.54 1.11 0.59 42.24
50 INT196709 Transcription of VMO1 1 0.42 0 0.04 42.24
51 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 41.76
52 INT157382 Gene_expression of Csi 17 0.58 3.93 0.82 40.04
53 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 35.72
54 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 34.52
55 INT94119 Localization of Tnfrsf1b 8 0.75 5.66 2.42 33.28
56 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 32.96
57 INT165228 Binding of BMI1 13 0.47 25.36 7.97 29.00
58 INT202008 Binding of OPA6 2 0.35 1.98 1.11 28.48
59 INT156827 Localization of MRI1 25 0.65 16.06 8.33 27.44
60 INT280526 Gene_expression of MSLNL 1 0.53 0.12 0 27.12
61 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31 24.20
62 INT162064 Gene_expression of PKD2L1 12 0.63 2.71 1.1 23.96
63 INT353914 Positive_regulation of Gene_expression of LARS 1 0.44 0.22 0 21.76
64 INT217744 Positive_regulation of GNS 4 0.24 1.39 1 21.44
65 INT30238 Positive_regulation of Anpep 14 0.66 2.77 3.38 21.36
66 INT51570 Regulation of Anpep 6 0.43 1.7 2 21.36
67 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 20.96
68 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 20.96
69 INT9219 Gene_expression of LARS 3 0.59 0.87 0.12 20.48
70 INT75907 Binding of LEP 53 0.46 46.65 8.44 18.76
71 INT87192 Positive_regulation of Gene_expression of Tnfrsf1b 7 0.35 3.66 1.04 16.92
72 INT151820 Positive_regulation of Binding of Tnfrsf1b 4 0.48 2.49 1.27 15.04
73 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 12.16
74 INT196714 Binding of VMO1 4 0.30 1.51 1.46 10.88
75 INT196710 Positive_regulation of VMO1 9 0.64 3.49 3.08 8.08
76 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
77 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
78 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
79 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
80 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
81 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
82 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
83 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
84 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
85 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
86 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
87 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
88 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
89 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
90 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
91 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 5.00
92 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
93 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
94 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 5.00
95 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
96 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 5.00
97 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
98 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
99 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
100 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
101 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
102 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
103 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
104 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
105 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
106 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
107 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
108 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
109 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
110 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 5.00
111 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
112 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
113 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
114 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
115 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
116 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
117 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
118 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
119 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
120 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
121 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
122 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
123 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
124 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
125 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
126 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
127 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
128 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
129 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 5.00
130 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
131 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
132 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
133 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
134 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
135 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 5.00
136 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49 5.00
137 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 5.00
138 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 5.00
139 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
140 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
141 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
142 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
143 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
144 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 5.00
145 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
146 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 5.00
147 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
148 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
149 INT237329 Gene_expression of PARPBP 5 0.24 6.36 11.01 5.00
150 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
151 INT238920 Positive_regulation of SLC9A3R2 44 0.50 27.86 10.51 5.00
152 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 5.00
153 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
154 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 5.00
155 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 5.00
156 INT1168 Binding of PROC 62 0.38 44.15 9.04 5.00
157 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
158 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 5.00
159 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
160 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87 5.00
161 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 5.00
162 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
163 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
164 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
165 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 5.00
166 INT143357 Binding of Ros1 48 0.36 27.76 6 5.00
167 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
168 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 5.00
169 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
170 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
171 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12 5.00
172 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
173 INT173591 Gene_expression of ADAMTS4 7 0.48 3.65 4.8 5.00
174 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 5.00
175 INT92199 Negative_regulation of Gene_expression of IL1RN 14 0.58 10.11 4.71 5.00
176 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
177 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 5.00
178 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 5.00
179 INT97131 Positive_regulation of CD14 25 0.67 12.03 4.21 5.00
180 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21 5.00
181 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 5.00
182 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 5.00
183 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 5.00
184 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 5.00
185 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7 5.00
186 INT27595 Negative_regulation of EMG1 14 0.38 4.26 3.61 5.00
187 INT33739 Gene_expression of ITGA2B 25 0.75 8.19 3.6 5.00
188 INT129960 Negative_regulation of Gene_expression of MMP13 19 0.53 7.17 3.55 5.00
189 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 5.00
190 INT171254 Binding of OAP 7 0.39 8.04 3.42 5.00
191 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
192 INT155039 Gene_expression of ADAMTS5 23 0.67 7.85 3.22 5.00
193 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
194 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03 5.00
195 INT124974 Regulation of Tnfrsf1b 4 0.59 4.59 3.01 5.00
196 INT24821 Binding of VTN 14 0.47 5.83 3 5.00
197 INT133085 Gene_expression of Mapk8ip1 7 0.66 6.13 2.98 5.00
198 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 5.00
199 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78 5.00
200 INT103020 Gene_expression of SGCA 22 0.56 14.29 2.75 5.00
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