D:Kuru

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pChart

Disease Term
Synonyms Encephalopathy Kuru, Kuru Encephalopathy
Documents 30
Hot Single Events 16
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Kuru. They are ordered first by their relevance to Kuru and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 97.68
2 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0 75.32
3 INT287035 Gopc Positive_regulation of Prtn3 1 0.02 0.48 0.12 5.00
4 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07 5.00
5 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07 5.00
6 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06 5.00
7 INT250150 Binding of IKBKG and SACM1L 1 0.00 2.78 0.06 5.00
8 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04 5.00
9 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0 5.00
10 INT287034 Pgp Regulation of Positive_regulation of Prnp 1 0.13 0.09 0 5.00
11 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Kuru. They are ordered first by their pain relevance and then by number of times they were reported in Kuru. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT167203 Binding of PRNP 25 0.48 20.09 1.84 100.00
2 INT251948 Binding of PRND 1 0.35 0.86 0 100.00
3 INT50080 Binding of APOE 38 0.45 29.61 2.67 100.00
4 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26 99.84
5 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11 99.74
6 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 99.66
7 INT85621 Regulation of PRNP 16 0.60 8.7 1.15 98.88
8 INT251490 Localization of TSE2 1 0.04 1.71 0 98.74
9 INT100601 Localization of PRNP 17 0.66 13.61 0.71 98.44
10 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 97.72
11 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3 97.36
12 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 95.68
13 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57 85.84
14 INT69572 Localization of Prnp 96 0.81 38.11 5.45 84.16
15 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 80.60
16 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71 80.08
17 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 79.04
18 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 77.52
19 INT284668 Positive_regulation of Gene_expression of LRRK2 1 0.16 0.86 0 70.08
20 INT284669 Gene_expression of LRRK2 3 0.65 4.58 1.14 69.36
21 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44 63.68
22 INT185299 Gene_expression of PNKD 5 0.22 6.35 0 60.56
23 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 50.00
24 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03 40.92
25 INT133386 Positive_regulation of PNKD 2 0.45 1.71 0.69 40.16
26 INT284670 Localization of LRRK2 3 0.78 2.22 0 37.20
27 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62 31.68
28 INT69570 Binding of Prnp 75 0.48 44.26 4.37 31.16
29 INT175417 Binding of SACM1L 8 0.29 6.06 0.22 21.76
30 INT188726 Positive_regulation of IGLV3-1 4 0.49 2.39 0.07 21.28
31 INT119348 Binding of IKBKG 7 0.15 4.03 1.14 16.24
32 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
33 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
34 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
35 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
36 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
37 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 5.00
38 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
39 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
40 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 5.00
41 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
42 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
43 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
44 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 5.00
45 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 5.00
46 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 5.00
47 INT60957 Negative_regulation of Abcb1b 18 0.57 6 4.73 5.00
48 INT108761 Localization of Alms1 24 0.70 13.92 3.74 5.00
49 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
50 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
51 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 5.00
52 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 5.00
53 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 5.00
54 INT58756 Binding of GPI 10 0.48 7.17 3 5.00
55 INT58527 Gene_expression of Prtn3 20 0.71 15.99 2.9 5.00
56 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45 5.00
57 INT50057 Regulation of Notch1 3 0.39 0.87 2.14 5.00
58 INT169874 Positive_regulation of Gene_expression of Prkaca 11 0.38 1.64 2.01 5.00
59 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84 5.00
60 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57 5.00
61 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
62 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 5.00
63 INT147162 Positive_regulation of Abcb1b 13 0.57 7.29 1.15 5.00
64 INT135042 Gene_expression of Tg(MMTV-Notch4)3Rnc 9 0.15 5.17 1.13 5.00
65 INT4578 Positive_regulation of Babr 6 0.01 0.25 1.05 5.00
66 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98 5.00
67 INT185973 Negative_regulation of Syp 16 0.54 2.83 0.87 5.00
68 INT261203 Binding of HTs 5 0.32 3.01 0.71 5.00
69 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67 5.00
70 INT193863 Gene_expression of Ncstn 7 0.29 3.88 0.66 5.00
71 INT164595 Binding of LCN2 8 0.37 6.03 0.6 5.00
72 INT69478 Negative_regulation of GBA 16 0.55 7.9 0.59 5.00
73 INT237402 Positive_regulation of Gene_expression of Ncstn 3 0.26 2.78 0.48 5.00
74 INT96816 Regulation of APOE 8 0.45 6.62 0.44 5.00
75 INT287027 Gene_expression of Dtna 2 0.20 0.87 0.31 5.00
76 INT123622 Negative_regulation of Vcp 5 0.42 2.51 0.3 5.00
77 INT287028 Positive_regulation of Dtna 3 0.11 1.16 0.29 5.00
78 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
79 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27 5.00
80 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26 5.00
81 INT185926 Regulation of Positive_regulation of Prkaca 5 0.26 0.27 0.25 5.00
82 INT297236 Negative_regulation of Gsi1 1 0.06 0.92 0.22 5.00
83 INT246641 Gene_expression of YWHAQ 5 0.58 3 0.22 5.00
84 INT287030 Positive_regulation of Tg(MMTV-Notch4)3Rnc 2 0.05 0.71 0.21 5.00
85 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2 5.00
86 INT34862 Gene_expression of UBE4B 7 0.50 4.65 0.18 5.00
87 INT287026 Localization of Dtna 2 0.20 0.49 0.17 5.00
88 INT265959 Gene_expression of Prnd 2 0.54 2.33 0.15 5.00
89 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13 5.00
90 INT237045 Positive_regulation of Vcp 7 0.62 6.96 0.12 5.00
91 INT297240 Gene_expression of Gsi1 1 0.09 2.38 0.11 5.00
92 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1 5.00
93 INT250157 Gene_expression of GSS 2 0.22 1.54 0.1 5.00
94 INT354478 Protein_catabolism of GPI 1 0.07 0.48 0.1 5.00
95 INT354481 Protein_catabolism of SPRN 1 0.07 0.47 0.1 5.00
96 INT265961 Binding of Prnd 3 0.30 2.58 0.1 5.00
97 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09 5.00
98 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09 5.00
99 INT303459 Transcription of PRNP 4 0.69 1.44 0.08 5.00
100 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08 5.00
101 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08 5.00
102 INT354476 Negative_regulation of Gene_expression of Prnd 1 0.18 0.43 0.06 5.00
103 INT101612 Protein_catabolism of HTT 3 0.86 1.44 0.05 5.00
104 INT287029 Positive_regulation of Localization of Tg(MMTV-Notch4)3Rnc 1 0.05 0.44 0.05 5.00
105 INT287033 Localization of Tg(MMTV-Notch4)3Rnc 1 0.07 0.44 0.05 5.00
106 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04 5.00
107 INT275621 Positive_regulation of Atcay 3 0.06 2.15 0.04 5.00
108 INT284672 Gene_expression of ZFAND2B 1 0.11 1.03 0.04 5.00
109 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03 5.00
110 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03 5.00
111 INT297242 Transcription of Notch1 1 0.19 0.25 0 5.00
112 INT284671 Binding of HOOK2 1 0.06 0.16 0 5.00
113 INT250154 Binding of MCM3 1 0.01 0.57 0 5.00
114 INT297243 Transcription of Ncstn 1 0.22 0.12 0 5.00
115 INT297237 Positive_regulation of Transcription of Ncstn 1 0.16 0.13 0 5.00
116 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0 5.00
117 INT297238 Binding of Gsi1 1 0.05 0.5 0 5.00
118 INT250158 Binding of GSS 1 0.14 0.57 0 5.00
119 INT284603 Localization of Vcp 1 0.73 0.82 0 5.00
120 INT250156 Negative_regulation of Gene_expression of UBE4B 1 0.29 0.43 0 5.00
121 INT287032 Regulation of Dtna 1 0.08 0.24 0 5.00
122 INT287025 Negative_regulation of Gene_expression of Pgp 1 0.30 0.1 0 5.00
123 INT186224 Binding of UBE4B 3 0.22 0.32 0 5.00
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