D:Lacerations

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Disease Term
Synonyms Laceration
Documents 884
Hot Single Events 28
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lacerations. They are ordered first by their relevance to Lacerations and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29 93.28
2 INT155610 FPR1 Positive_regulation of Phosphorylation of SGSM3 1 0.04 0.68 0.71 86.60
3 INT332741 BPIFA1 Negative_regulation of ENO1 1 0.32 0.99 0.17 74.00
4 INT332740 Binding of ENO1 and BPIFA1 1 0.31 0.71 0.09 44.36
5 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62 33.32
6 INT302466 Positive_regulation of F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.1 0.35 33.32
7 INT354519 Cacna1c Regulation of Mri1 1 0.00 1.15 0.21 9.92
8 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
9 INT354522 Binding of HBG2 and Wipi1 1 0.00 2.64 0.87 5.00
10 INT274785 S100B Positive_regulation of Ngf 1 0.05 0.61 0.8 5.00
11 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79 5.00
12 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77 5.00
13 INT274786 Ngf Positive_regulation of Gene_expression of S100B 1 0.05 0.63 0.71 5.00
14 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
15 INT274781 Agrn Positive_regulation of Chrna2 1 0.08 0.18 0.41 5.00
16 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37 5.00
17 INT302468 INCENP Positive_regulation of Gene_expression of MMP9 1 0.01 0.72 0.26 5.00
18 INT280008 Binding of IFNA1 and PAEP 2 0.08 1.29 0.25 5.00
19 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
20 INT181646 interleukin-17 Positive_regulation of ISYNA1 1 0.01 0.26 0.2 5.00
21 INT181617 IL17A Positive_regulation of ISYNA1 1 0.01 0.27 0.2 5.00
22 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15 5.00
23 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14 5.00
24 INT208459 Galns Negative_regulation of Negative_regulation of BCAN 1 0.01 0.44 0.13 5.00
25 INT355023 Phosphorylation of Rtn4r Negative_regulation of Binding of Mag and Rtn4r 1 0.00 0.38 0.11 5.00
26 INT355008 Binding of Mag and Rtn4r 1 0.02 0.36 0.1 5.00
27 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08 5.00
28 INT355021 Cntf Positive_regulation of SOAT1 1 0.02 0.7 0.08 5.00
29 INT280004 Binding of IFNA1 and CDIPT 1 0.01 0.74 0.08 5.00
30 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08 5.00
31 INT280007 Binding of CLTC and PAEP 1 0.06 0.8 0.08 5.00
32 INT355009 Cntf Positive_regulation of Il6st 1 0.02 0.69 0.08 5.00
33 INT355020 Lif Positive_regulation of SOAT1 1 0.02 0.7 0.08 5.00
34 INT280005 Binding of PAEP and CDIPT 1 0.01 0.74 0.08 5.00
35 INT355010 Lif Positive_regulation of Il6st 1 0.02 0.69 0.08 5.00
36 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07 5.00
37 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03 5.00
38 INT280006 Binding of CLTC and IFNA1 1 0.04 1.59 0 5.00
39 INT211067 Pth Regulation of DMD 1 0.01 0.12 0 5.00
40 INT304776 Binding of KMS and KTWS 1 0.01 2.24 0 5.00
41 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
42 INT345059 Binding of C3 and C2 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lacerations. They are ordered first by their pain relevance and then by number of times they were reported in Lacerations. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT194253 Positive_regulation of FIG4 2 0.27 1.39 0.12 99.86
2 INT151401 Localization of JAG1 4 0.65 1.88 0.58 99.68
3 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 98.76
4 INT332744 Regulation of ENO1 1 0.47 1.76 0.43 98.40
5 INT113319 Positive_regulation of QRFP 5 0.40 3.86 0.1 97.96
6 INT287307 Binding of ENO1 9 0.48 11.24 2.51 97.64
7 INT136303 Regulation of Serpina3f 1 0.44 0.85 0.52 95.36
8 INT122924 Binding of ipv 27 0.42 31.81 1.99 95.28
9 INT59175 Localization of TNMD 4 0.70 4.14 0.71 94.44
10 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 93.28
11 INT123977 Binding of Lat 2 0.32 0.56 0.39 92.36
12 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 92.24
13 INT2774 Binding of Crp 241 0.48 195.89 44.39 91.56
14 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 90.76
15 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 89.32
16 INT9664 Binding of LBP 127 0.48 94.9 63.42 88.72
17 INT160280 Positive_regulation of ipv 14 0.44 15.73 1.02 86.72
18 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 86.72
19 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 86.64
20 INT9689 Negative_regulation of Mbtps1 1 0.27 0.48 1.01 86.36
21 INT226471 Negative_regulation of ST2 3 0.11 1.88 0.28 86.24
22 INT105021 Binding of GOPC 187 0.40 60.39 20.38 85.52
23 INT100009 Phosphorylation of FPR1 3 0.38 1.02 1.9 85.36
24 INT87644 Phosphorylation of SGSM3 12 0.80 2.08 7.04 85.00
25 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 84.56
26 INT85233 Localization of SGSM3 11 0.78 10.91 3.41 84.24
27 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 83.64
28 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 80.96
29 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 78.52
30 INT332743 Binding of BPIFA1 1 0.32 3.7 0.32 78.12
31 INT346641 Protein_catabolism of TNMD 1 0.57 2.1 0 75.28
32 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 75.00
33 INT332742 Gene_expression of BPIFA1 1 0.66 1.77 0.53 74.76
34 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 74.72
35 INT143664 Gene_expression of ST2 9 0.77 5.03 1.73 74.24
36 INT143665 Positive_regulation of Gene_expression of ST2 1 0.69 0.7 0.04 74.24
37 INT297020 Positive_regulation of CLTC 5 0.36 3.38 0.41 68.04
38 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 63.76
39 INT812 Localization of INS 1026 0.81 515.6 145.31 62.28
40 INT344613 Negative_regulation of Gene_expression of CLTC 2 0.31 1.19 0.37 62.00
41 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 61.60
42 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 61.44
43 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 60.40
44 INT162803 Regulation of F5 3 0.44 3.68 0.81 58.76
45 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 56.32
46 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 56.32
47 INT61645 Negative_regulation of Gc 15 0.51 10.44 2.71 56.32
48 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 55.12
49 INT61644 Gene_expression of Gc 16 0.70 11.35 1.95 55.12
50 INT55604 Positive_regulation of BPIFA1 4 0.43 2.31 0.24 52.24
51 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 51.84
52 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 48.48
53 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 47.32
54 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 46.72
55 INT93274 Gene_expression of QRFP 12 0.58 7 1.46 45.76
56 INT192428 Gene_expression of PRND 1 0.38 0.78 0.09 41.44
57 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 41.24
58 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 40.72
59 INT175828 Regulation of FASTK 1 0.24 1.48 0.11 39.36
60 INT343017 Positive_regulation of Azi1 1 0.21 2.39 0.16 38.16
61 INT343019 Positive_regulation of Positive_regulation of Azi1 1 0.21 1.58 0.13 38.16
62 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 37.12
63 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 35.40
64 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95 34.48
65 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 33.32
66 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 30.64
67 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 30.24
68 INT287308 Negative_regulation of ENO1 5 0.59 4.07 1.24 30.08
69 INT192448 Positive_regulation of Gene_expression of CLTC 5 0.32 3.01 0.33 28.80
70 INT78329 Binding of ADC 7 0.31 7.57 0.73 28.68
71 INT355488 Positive_regulation of Binding of ADC 1 0.09 2.28 0.18 28.68
72 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 27.76
73 INT50933 Transcription of Il6 38 0.72 24.31 11.58 25.76
74 INT50196 Transcription of Il1b 25 0.69 19.08 10.43 25.76
75 INT143666 Positive_regulation of ST2 15 0.69 11.76 0.85 25.12
76 INT13397 Localization of DMD 21 0.78 7.96 1.08 25.08
77 INT192427 Localization of PRND 1 0.42 0.53 0.03 25.00
78 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 24.92
79 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 24.88
80 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59 24.68
81 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 21.52
82 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 20.16
83 INT49556 Gene_expression of NOLC1 11 0.49 29.44 1.07 14.72
84 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 14.44
85 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 13.64
86 INT25022 Binding of PAEP 66 0.42 22.83 6.59 11.16
87 INT9191 Localization of EDN1 94 0.81 57.01 14.78 9.12
88 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17 8.80
89 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 6.60
90 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 6.56
91 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.44
92 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
93 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
94 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
95 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
96 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
97 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
98 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
99 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
100 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
101 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
102 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
103 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
104 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
105 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
106 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
107 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
108 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
109 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
110 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
111 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
112 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
113 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 5.00
114 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
115 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
116 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
117 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 5.00
118 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 5.00
119 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
120 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
121 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
122 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
123 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
124 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
125 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
126 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 5.00
127 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
128 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
129 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
130 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 5.00
131 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
132 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
133 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
134 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
135 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
136 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
137 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
138 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
139 INT19078 Binding of Ngf 78 0.48 31.03 44.33 5.00
140 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 5.00
141 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
142 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
143 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
144 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
145 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
146 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
147 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
148 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
149 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
150 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
151 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
152 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
153 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
154 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
155 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
156 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 5.00
157 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
158 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 5.00
159 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
160 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
161 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
162 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
163 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
164 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
165 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 5.00
166 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
167 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
168 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
169 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
170 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 5.00
171 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
172 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
173 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
174 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
175 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
176 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
177 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 5.00
178 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
179 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 5.00
180 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
181 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
182 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 5.00
183 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
184 INT65907 Negative_regulation of Gene_expression of Ngf 36 0.59 19.5 20.03 5.00
185 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
186 INT48663 Negative_regulation of Gene_expression of Gfap 45 0.59 18.34 19.84 5.00
187 INT64261 Negative_regulation of Positive_regulation of Ngf 21 0.59 16.28 19.78 5.00
188 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
189 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 5.00
190 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
191 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
192 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
193 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
194 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
195 INT49922 Positive_regulation of Positive_regulation of Ngf 21 0.67 14.46 17.68 5.00
196 INT15358 Transcription of Ngf 29 0.72 10.43 16.94 5.00
197 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
198 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49 5.00
199 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
200 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
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