D:Langerhans-cell Histiocytosis

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Disease Term
Synonyms DISEASE LETTERER SIWE, Disease Schueller Christian, GENERALIZED HISTIOCYTOSES, Generalized Histiocytosis, GRANULOMATOSIS LANGERHANS CELL, HAND SCHUELLER CHRISTIAN SYNDROME, HISTIOCYTOSES GENERALIZED, Histiocytosis Generalized, Histiocytosis Langerhans Cell, Histiocytosis X, LANGERHANS CELL GRANULOMATOSIS
Documents 111
Hot Single Events 25
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Langerhans-cell Histiocytosis. They are ordered first by their relevance to Langerhans-cell Histiocytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT204246 ETFA Regulation of CD68 1 0.37 1.05 0.04 69.00
2 INT204247 S100B Regulation of CD68 1 0.03 1.05 0.04 69.00
3 INT322206 CCL18 Positive_regulation of Gene_expression of COL7A1 1 0.05 0.28 0.05 45.60
4 INT322208 HRCT1 Positive_regulation of PDX1 1 0.01 1.31 0.34 5.00
5 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
6 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
7 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
8 INT322207 CCL18 Regulation of Gene_expression of COL7A1 1 0.07 0.88 0.09 5.00
9 INT199031 Binding of ALB and F2 1 0.05 1.78 0.08 5.00
10 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
11 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
12 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Langerhans-cell Histiocytosis. They are ordered first by their pain relevance and then by number of times they were reported in Langerhans-cell Histiocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT198709 Localization of LCH 1 0.78 3.27 0.1 100.00
2 INT198708 Gene_expression of LCH 1 0.57 2.93 0 100.00
3 INT244657 Regulation of Lch 3 0.40 6.63 0.13 100.00
4 INT198710 Phosphorylation of LCH 1 0.53 1.16 0 100.00
5 INT154828 Binding of Lch 2 0.31 3.51 0.06 100.00
6 INT244658 Localization of Lch 1 0.49 1.92 0 100.00
7 INT155152 Negative_regulation of Lch 1 0.32 1.05 0.09 100.00
8 INT198712 Negative_regulation of LCH 1 0.36 0.97 0.15 100.00
9 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79 100.00
10 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 99.36
11 INT23775 Regulation of S100B 24 0.62 16.75 2.57 99.14
12 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 99.00
13 INT58761 Regulation of CD1D 3 0.26 1.54 1.33 98.94
14 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 98.80
15 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13 98.68
16 INT143850 Gene_expression of S100a1 19 0.73 9.52 1.54 98.32
17 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 96.76
18 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 96.76
19 INT204256 Gene_expression of HCLS1 1 0.03 5.24 0.07 96.76
20 INT155154 Binding of CD1D 2 0.36 1.7 0.12 96.20
21 INT155153 Binding of S100a1 15 0.35 6.42 1.63 96.20
22 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 95.56
23 INT198711 Binding of NCK1 1 0.05 1.08 0.03 93.52
24 INT94456 Binding of CD1A 3 0.36 2.71 0.48 90.20
25 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 89.88
26 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 75.00
27 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 71.48
28 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 71.48
29 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21 71.48
30 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 67.28
31 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 67.28
32 INT149332 Gene_expression of CD163 19 0.75 13.63 3.65 67.28
33 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 64.00
34 INT221041 Binding of CCL18 3 0.47 2.08 0.59 58.72
35 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 54.40
36 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 53.60
37 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 49.20
38 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 48.48
39 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 45.60
40 INT139664 Gene_expression of CCL18 83 0.76 37.05 21.95 44.88
41 INT221045 Positive_regulation of Gene_expression of CCL18 17 0.67 5.27 3.54 44.88
42 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 24.24
43 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 22.76
44 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 22.76
45 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 22.76
46 INT27217 Negative_regulation of LYZ 6 0.42 3.1 2.26 22.76
47 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96 22.76
48 INT37253 Negative_regulation of PTPRC 12 0.37 6.13 1.26 22.76
49 INT248322 Negative_regulation of CD68 4 0.34 4.2 0.44 22.76
50 INT4047 Binding of F13A1 105 0.43 66.54 11.81 20.52
51 INT38672 Binding of KRT20 69 0.39 48.01 6.31 20.52
52 INT51066 Binding of S100B 24 0.48 13.5 0.97 20.52
53 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 19.84
54 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 19.84
55 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 19.84
56 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 19.84
57 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 17.32
58 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 16.80
59 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 16.08
60 INT68228 Positive_regulation of TNFRSF8 5 0.56 6.26 0.84 15.48
61 INT107118 Positive_regulation of ALK 4 0.49 3.64 0.52 15.48
62 INT28788 Regulation of LYZ 5 0.42 1.8 1.24 11.80
63 INT285743 Regulation of CD68 2 0.33 1.82 0.2 11.80
64 INT91209 Binding of VIM 15 0.36 12.02 0.53 10.96
65 INT204258 Binding of NSMCE1 4 0.36 6.41 0.42 9.84
66 INT20388 Binding of LYZ 8 0.39 5.65 1.93 9.44
67 INT167381 Localization of DES 4 0.73 4.15 0.77 9.12
68 INT204254 Localization of KIT 8 0.73 6.78 0.61 9.12
69 INT134223 Localization of CD99 4 0.73 4.42 0.16 9.12
70 INT204255 Localization of MYOG 1 0.18 1.82 0.03 9.12
71 INT183933 Binding of CD68 8 0.31 8.74 1.06 8.64
72 INT204259 Binding of CD163 3 0.24 3.29 0 8.16
73 INT204253 Binding of TTF1 1 0.16 1.71 0 7.68
74 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
75 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
76 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
77 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
78 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
79 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
80 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
81 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
82 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
83 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
84 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
85 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
86 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
87 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
88 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
89 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
90 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
91 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
92 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
93 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
94 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
95 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
96 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
97 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
98 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
99 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
100 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
101 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
102 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
103 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
104 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
105 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
106 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
107 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
108 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
109 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
110 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
111 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
112 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
113 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
114 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
115 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
116 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
117 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
118 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
119 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
120 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
121 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.00
122 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
123 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
124 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 5.00
125 INT54978 Binding of EDNRA 36 0.41 14.97 7.86 5.00
126 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
127 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86 5.00
128 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 5.00
129 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
130 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 5.00
131 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
132 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
133 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
134 INT236335 Gene_expression of SFTPD 26 0.75 15.92 4.59 5.00
135 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
136 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
137 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
138 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
139 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8 5.00
140 INT84891 Gene_expression of PPARD 10 0.78 6.8 3.64 5.00
141 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
142 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
143 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
144 INT9110 Binding of PAH 32 0.41 42.1 3.1 5.00
145 INT84890 Negative_regulation of PPARD 7 0.59 3.27 3.1 5.00
146 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 5.00
147 INT68846 Gene_expression of Tfrc 22 0.32 10.1 3.06 5.00
148 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
149 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
150 INT105694 Binding of SFTPD 11 0.46 8.47 2.45 5.00
151 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
152 INT14 Regulation of LDHA 22 0.57 15.26 2.14 5.00
153 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99 5.00
154 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 5.00
155 INT171059 Localization of PDX1 8 0.56 6.7 1.9 5.00
156 INT245577 Localization of SFTPD 7 0.63 10.43 1.84 5.00
157 INT178130 Binding of EDNRB 12 0.36 6.18 1.84 5.00
158 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83 5.00
159 INT139514 Localization of EDNRB 7 0.73 4.63 1.52 5.00
160 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 5.00
161 INT71161 Gene_expression of ITGB3 6 0.26 3.59 1.45 5.00
162 INT114490 Gene_expression of PDLIM7 17 0.78 11.35 1.42 5.00
163 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27 5.00
164 INT211198 Localization of SERPINH1 2 0.66 4.33 1.25 5.00
165 INT70067 Regulation of KNCN 2 0.07 1.71 1.17 5.00
166 INT90240 Gene_expression of MYOG 19 0.75 10 1.06 5.00
167 INT85831 Positive_regulation of CA9 5 0.60 8.29 1.02 5.00
168 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
169 INT161591 Positive_regulation of CD163 5 0.48 3.9 0.98 5.00
170 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 5.00
171 INT236328 Regulation of SFTPD 6 0.38 3.04 0.85 5.00
172 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85 5.00
173 INT84892 Negative_regulation of Gene_expression of PPARD 2 0.43 1.85 0.83 5.00
174 INT169706 Positive_regulation of Gene_expression of Itk 2 0.32 2.08 0.81 5.00
175 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 5.00
176 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66 5.00
177 INT296837 Negative_regulation of Gene_expression of PTGIS 2 0.17 1.11 0.52 5.00
178 INT60334 Gene_expression of ITGAV 6 0.26 3.15 0.51 5.00
179 INT127460 Positive_regulation of Gene_expression of PAH 5 0.43 4.3 0.5 5.00
180 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41 5.00
181 INT172557 Negative_regulation of Fdps 6 0.12 2.89 0.39 5.00
182 INT185840 Positive_regulation of Localization of PDX1 2 0.27 0.78 0.33 5.00
183 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 5.00
184 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 5.00
185 INT350970 Negative_regulation of Binding of EDNRA 1 0.41 0.86 0.29 5.00
186 INT125804 Localization of Pth 9 0.69 3.93 0.29 5.00
187 INT350971 Negative_regulation of Binding of EDNRB 1 0.13 0.86 0.29 5.00
188 INT44599 Gene_expression of CNOT4 4 0.40 3.09 0.25 5.00
189 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22 5.00
190 INT201570 Gene_expression of CR2 11 0.48 14.21 0.22 5.00
191 INT68056 Gene_expression of NSMCE1 2 0.14 0.49 0.2 5.00
192 INT239883 Transcription of SFTPC 3 0.69 1.11 0.18 5.00
193 INT173335 Negative_regulation of Gene_expression of EDNRA 2 0.19 0.71 0.17 5.00
194 INT192842 Binding of Hspa5 3 0.33 1.48 0.16 5.00
195 INT231230 Localization of SFTPC 2 0.68 2.06 0.16 5.00
196 INT176329 Protein_catabolism of MUC1 4 0.72 2.14 0.14 5.00
197 INT146139 Gene_expression of ETV4 11 0.12 8.43 0.11 5.00
198 INT320983 Negative_regulation of Localization of Pth 2 0.38 1.17 0.09 5.00
199 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08 5.00
200 INT331613 Regulation of Positive_regulation of Itk 1 0.02 0.87 0.06 5.00
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