D:Language Development Disorders

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Disease Term
Synonyms Auditory Processing Disorder Central, CENTRAL AUDITORY PROCESSING DISORDER, Delay Speech, Delays Speech, Development Disorder Language, DEVELOPMENTAL DISORDER SPEECH LANGUAGE, Developmental Language Disorder, DEVELOPMENTAL LANGUAGE DISORDERS, Language Delay, Language Delays, LANGUAGE DEVELOPMENT DISORDER
Documents 40
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Language Development Disorders. They are ordered first by their relevance to Language Development Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61 5.00
2 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
3 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51 5.00
4 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45 5.00
5 INT184868 Binding of Slc6a3 and Lmo1 1 0.02 0.72 0.19 5.00
6 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12 5.00
7 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
8 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
9 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
10 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Language Development Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Language Development Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT166325 Negative_regulation of RAI1 2 0.36 2.74 0.13 100.00
2 INT82572 Negative_regulation of Prkg2 4 0.14 0.82 3.03 98.80
3 INT259867 Binding of SCN1A 2 0.36 4.7 0.21 93.52
4 INT260048 Binding of PCDH19 1 0.37 4.77 0 93.12
5 INT1893 Localization of Gh 1041 0.79 340.23 256.58 91.96
6 INT153599 Gene_expression of SCN1A 8 0.75 7.01 1.47 91.04
7 INT27527 Negative_regulation of Hal 2 0.42 0.66 0.42 90.48
8 INT27554 Regulation of Eln 6 0.52 6.76 0.39 88.12
9 INT277257 Binding of Satb2 1 0.37 2.51 0 87.44
10 INT96762 Gene_expression of RAI1 9 0.56 5.77 2.17 86.20
11 INT260050 Gene_expression of PCDH19 1 0.77 12.52 0.09 84.48
12 INT177716 Gene_expression of GALNT3 7 0.53 6.91 0.75 84.04
13 INT277254 Negative_regulation of Satb2 1 0.43 3.26 0.04 83.88
14 INT257835 Negative_regulation of Btk 6 0.41 2.41 0.16 79.08
15 INT315844 Binding of Btk 2 0.16 0.59 0.03 79.08
16 INT277259 Regulation of Satb2 1 0.45 0.72 0.03 78.40
17 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 77.16
18 INT661 Gene_expression of REN 100 0.78 48.21 11.36 76.72
19 INT39512 Negative_regulation of TRAP 22 0.56 8.18 4.76 63.28
20 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 60.56
21 INT38366 Regulation of Cat 45 0.62 23.45 5.34 59.60
22 INT260047 Regulation of PCDH19 1 0.45 1.43 0 57.84
23 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 51.04
24 INT260051 Positive_regulation of PCDH19 1 0.69 1.69 0 49.76
25 INT277256 Negative_regulation of Localization of Satb2 1 0.43 0.59 0.04 48.64
26 INT277258 Localization of Satb2 1 0.81 3.59 0.04 48.64
27 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 41.52
28 INT260049 Negative_regulation of PCDH19 1 0.58 4.41 0.04 39.24
29 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 16.60
30 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 15.12
31 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 7.92
32 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 7.92
33 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
34 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
35 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
36 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
37 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
38 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 5.00
39 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 5.00
40 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
41 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
42 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
43 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
44 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
45 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 5.00
46 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01 5.00
47 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 5.00
48 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
49 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55 5.00
50 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
51 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
52 INT256285 Gene_expression of Efnb1 32 0.70 36.25 24.73 5.00
53 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
54 INT7715 Regulation of Drd2 35 0.62 10.79 22.3 5.00
55 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 5.00
56 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18 5.00
57 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
58 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51 5.00
59 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 5.00
60 INT29086 Negative_regulation of Sert1 37 0.58 7.49 14.98 5.00
61 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
62 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33 5.00
63 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
64 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 5.00
65 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 5.00
66 INT47743 Negative_regulation of Slc6a4 22 0.59 6.23 12.23 5.00
67 INT184844 Gene_expression of Snap25 130 0.78 14.32 12.13 5.00
68 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
69 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
70 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
71 INT79556 Gene_expression of GRIN3B 16 0.77 7.71 10.75 5.00
72 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75 5.00
73 INT93967 Binding of Slc6a3 22 0.48 6.81 10.74 5.00
74 INT90639 Positive_regulation of Slc6a3 25 0.61 10.95 10.41 5.00
75 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 5.00
76 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47 5.00
77 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45 5.00
78 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
79 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
80 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
81 INT220 Negative_regulation of Ddc 16 0.59 2.94 8.66 5.00
82 INT184864 Gene_expression of Lmo1 16 0.26 8.09 8.48 5.00
83 INT109265 Transcription of Th 18 0.68 4.5 8.21 5.00
84 INT184845 Negative_regulation of Gene_expression of Slc6a3 13 0.59 3.25 7.79 5.00
85 INT171715 Gene_expression of Sema5b 46 0.31 6.46 7.48 5.00
86 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38 5.00
87 INT73760 Transcription of Drd2 14 0.72 2.11 7.19 5.00
88 INT184858 Positive_regulation of Gene_expression of Lmo1 12 0.23 5.46 7.04 5.00
89 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87 5.00
90 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
91 INT86772 Localization of Drd2 14 0.80 1.93 6.17 5.00
92 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
93 INT1493 Positive_regulation of Prkacb 8 0.59 2.75 5.99 5.00
94 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84 5.00
95 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
96 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
97 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 5.00
98 INT37151 Localization of Th 13 0.57 3.11 4.82 5.00
99 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78 5.00
100 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 5.00
101 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
102 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1 5.00
103 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 5.00
104 INT212563 Gene_expression of Adrm1 26 0.13 11.46 3.58 5.00
105 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 5.00
106 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22 5.00
107 INT153265 Regulation of Vta1 3 0.16 0.97 3.21 5.00
108 INT109095 Binding of Drd4 7 0.40 3.6 3.18 5.00
109 INT9055 Positive_regulation of Cog1 22 0.68 14.08 2.95 5.00
110 INT184863 Negative_regulation of Gene_expression of Lmo1 1 0.19 2.33 2.89 5.00
111 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62 5.00
112 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 5.00
113 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
114 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36 5.00
115 INT184857 Positive_regulation of Lmo1 4 0.23 4.59 2.03 5.00
116 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
117 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01 5.00
118 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
119 INT194074 Regulation of NAGLU 5 0.38 2.93 1.87 5.00
120 INT16205 Localization of ras 25 0.73 18.99 1.85 5.00
121 INT184859 Localization of Lmo1 1 0.23 0.3 1.75 5.00
122 INT184843 Regulation of Gene_expression of Snap25 4 0.62 2.15 1.74 5.00
123 INT184852 Positive_regulation of Gene_expression of ADHD1 6 0.40 5.06 1.66 5.00
124 INT184860 Negative_regulation of Net1 1 0.18 2.97 1.64 5.00
125 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
126 INT140245 Binding of Gli3 3 0.36 2.65 1.46 5.00
127 INT95338 Positive_regulation of Positive_regulation of CASP1 9 0.49 4.61 1.43 5.00
128 INT184865 Negative_regulation of Lmo1 1 0.14 2.01 1.36 5.00
129 INT4480 Positive_regulation of Ddc 3 0.39 0.53 1.3 5.00
130 INT184855 Regulation of Gene_expression of Lmo1 1 0.20 1.4 1.21 5.00
131 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2 5.00
132 INT184841 Localization of Snap25 12 0.81 1.45 1.09 5.00
133 INT184862 Positive_regulation of Localization of Lmo1 1 0.15 0.16 1.04 5.00
134 INT184839 Localization of Drd1a 4 0.73 0.84 1.03 5.00
135 INT231266 Gene_expression of Prh1 13 0.08 3.95 1.02 5.00
136 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
137 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 5.00
138 INT209387 Negative_regulation of Ugcg 9 0.25 7.61 0.9 5.00
139 INT184850 Negative_regulation of Negative_regulation of ADHD1 1 0.05 0.22 0.9 5.00
140 INT58550 Gene_expression of SON 8 0.43 0.99 0.88 5.00
141 INT79941 Negative_regulation of Npc1 9 0.59 3.97 0.82 5.00
142 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74 5.00
143 INT184846 Negative_regulation of Drd5 1 0.19 2.28 0.68 5.00
144 INT78183 Negative_regulation of Adrm1 8 0.09 3.4 0.65 5.00
145 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65 5.00
146 INT184848 Positive_regulation of Transcription of Drd1a 1 0.26 0.93 0.65 5.00
147 INT77698 Gene_expression of Prkg2 4 0.62 0.09 0.64 5.00
148 INT184861 Positive_regulation of Positive_regulation of Lmo1 1 0.17 0.15 0.61 5.00
149 INT86624 Binding of Efnb1 4 0.27 1.09 0.6 5.00
150 INT184838 Positive_regulation of Positive_regulation of Prkacb 1 0.01 0 0.59 5.00
151 INT42410 Positive_regulation of Cyb5d2 13 0.31 6.75 0.54 5.00
152 INT148236 Regulation of GNPTAB 4 0.27 0.87 0.5 5.00
153 INT170346 Gene_expression of Npc1 18 0.78 7.69 0.48 5.00
154 INT3477 Regulation of Npc1 6 0.45 1.87 0.47 5.00
155 INT250468 Positive_regulation of Gene_expression of Adrm1 2 0.04 2.26 0.44 5.00
156 INT38545 Gene_expression of IV 3 0.53 2.89 0.41 5.00
157 INT184866 Positive_regulation of Binding of Drd4 1 0.20 0.87 0.41 5.00
158 INT50848 Regulation of ZFP91 5 0.38 2.45 0.35 5.00
159 INT97859 Localization of Npc1 12 0.75 6.66 0.35 5.00
160 INT32509 Positive_regulation of Npc1 6 0.50 2.24 0.33 5.00
161 INT4133 Binding of Npc1 14 0.47 8.24 0.33 5.00
162 INT242816 Positive_regulation of GRINA 1 0.05 0.26 0.31 5.00
163 INT260038 Localization of Efnb1 3 0.57 1.14 0.3 5.00
164 INT9054 Negative_regulation of Positive_regulation of Cog1 3 0.08 1.38 0.28 5.00
165 INT184856 Regulation of Lmo1 1 0.20 0.56 0.26 5.00
166 INT184847 Negative_regulation of Cd99 1 0.04 0.85 0.23 5.00
167 INT137662 Negative_regulation of Drd4 2 0.39 0.86 0.23 5.00
168 INT84638 Regulation of Smpd1 3 0.37 2.36 0.22 5.00
169 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21 5.00
170 INT250467 Localization of Adrm1 2 0.06 0.97 0.19 5.00
171 INT184849 Protein_catabolism of ADHD1 1 0.10 0.94 0.19 5.00
172 INT250469 Positive_regulation of Localization of Adrm1 2 0.04 0.97 0.19 5.00
173 INT177717 Positive_regulation of Gene_expression of GALNT3 2 0.03 2.84 0.18 5.00
174 INT317881 Transcription of Eef1a1 2 0.03 1.38 0.18 5.00
175 INT240424 Binding of Ctsa 4 0.20 3.94 0.16 5.00
176 INT192194 Positive_regulation of FBXW11 3 0.34 0.84 0.14 5.00
177 INT288084 Gene_expression of Rab9 2 0.27 1.05 0.13 5.00
178 INT195744 Gene_expression of XIST 3 0.65 1.61 0.12 5.00
179 INT151522 Binding of NSD1 2 0.37 4.28 0.09 5.00
180 INT214056 Negative_regulation of NSD1 3 0.43 3.44 0.09 5.00
181 INT329075 Transcription of MYT1 1 0.27 0.37 0.08 5.00
182 INT329073 Regulation of Myt1 1 0.42 0.34 0.08 5.00
183 INT329074 Transcription of Pcmtd2 1 0.66 0.37 0.08 5.00
184 INT320841 Positive_regulation of Chit1 1 0.02 0.82 0.07 5.00
185 INT178548 Localization of AAAS 1 0.70 1.52 0.07 5.00
186 INT320843 Negative_regulation of Gene_expression of Npc1 2 0.59 5.82 0.07 5.00
187 INT288082 Positive_regulation of Npc2 2 0.48 0.67 0.04 5.00
188 INT355368 Regulation of Btk 1 0.01 0.39 0.04 5.00
189 INT329071 Negative_regulation of Arfgap1 1 0.41 1.14 0.03 5.00
190 INT198787 Localization of Cyb5d2 3 0.73 0.56 0.03 5.00
191 INT329072 Negative_regulation of Kcnq2 1 0.42 1.14 0.03 5.00
192 INT319022 Positive_regulation of Binding of Npc1 2 0.50 0.24 0.03 5.00
193 INT244771 Gene_expression of Satb2 4 0.68 1.27 0.03 5.00
194 INT320842 Localization of Npc2 1 0.76 1.01 0.03 5.00
195 INT192611 Negative_regulation of Gene_expression of Hba-a1 1 0.07 0.86 0 5.00
196 INT192615 Localization of Atrx 1 0.74 0.1 0 5.00
197 INT192609 Negative_regulation of Gene_expression of Atrx 1 0.37 0.28 0 5.00
198 INT260046 Gene_expression of PCDH11Y 1 0.48 0.62 0 5.00
199 INT288078 Gene_expression of Npc2 2 0.64 1.01 0 5.00
200 INT260037 Positive_regulation of Binding of Efnb1 1 0.24 1.04 0 5.00
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