D:Laron Syndrome

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pChart

Disease Term
Synonyms DWARFISM LARON, GH RESISTANCE PRIMARY, Growth Hormone Insensitivity Syndrome, Growth Hormone Receptor Defect, Laron Dwarfism, Laron Type Dwarfism I, Primary Gh Resistance, PRIMARY GROWTH HORMONE RESISTANCE, Severe Gh Insensitivity, Syndrome Laron
Documents 6
Hot Single Events 28
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Laron Syndrome. They are ordered first by their relevance to Laron Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29 75.00
2 INT51273 IGF1 Positive_regulation of IGFBP2 1 0.37 0.13 0.06 75.00
3 INT51276 IGF1 Negative_regulation of GH1 1 0.10 0.13 0.06 75.00
4 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06 75.00
5 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15 63.56
6 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11 63.56
7 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75 5.00
8 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
9 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56 5.00
10 INT268797 Ghrh Positive_regulation of Transcription of Gh 1 0.20 0.33 0.19 5.00
11 INT220149 Binding of IGF1 and IGFALS 2 0.39 0.44 0.1 5.00
12 INT239186 H2 Negative_regulation of Aco1 1 0.00 1.96 0.05 5.00
13 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04 5.00
14 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0 5.00
15 INT278495 IGFBP2 Positive_regulation of Gene_expression of IGF1 1 0.20 0 0 5.00
16 INT239188 Proc Positive_regulation of Akt1 3 0.01 1.72 0 5.00
17 INT278498 IGFBP3 Regulation of GH1 1 0.06 0 0 5.00
18 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0 5.00
19 INT239182 Gene_expression of Gh Negative_regulation of Cat 1 0.17 0.33 0 5.00
20 INT239184 Msr1 Negative_regulation of Msra 1 0.21 0.13 0 5.00
21 INT278494 IGFBP3 Positive_regulation of Binding of IGF1 and IGFBP3 1 0.17 0 0 5.00
22 INT278499 IGFALS Regulation of GH1 1 0.18 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Laron Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Laron Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 99.92
2 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 99.40
3 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 99.16
4 INT49130 Positive_regulation of IGFBP3 49 0.63 27.55 4.78 99.16
5 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 99.12
6 INT28861 Binding of Gh 61 0.46 25.61 6.38 98.92
7 INT65892 Negative_regulation of Binding of Gh 8 0.32 3.61 1.38 98.92
8 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 98.72
9 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 98.72
10 INT34777 Localization of IGF1 82 0.80 42.68 8.62 98.72
11 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 98.68
12 INT239094 Negative_regulation of Binding of GH1 2 0.34 1.61 0.06 97.14
13 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 97.00
14 INT9683 Binding of GH1 57 0.47 21.14 5.99 96.84
15 INT278502 Positive_regulation of Positive_regulation of IGFBP3 1 0.26 0.4 0.03 96.72
16 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05 96.72
17 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77 93.68
18 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 92.96
19 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97 92.44
20 INT252 Localization of GH1 529 0.80 227.4 122.05 91.48
21 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 90.96
22 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 90.40
23 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 89.76
24 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 89.76
25 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 89.24
26 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 89.04
27 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43 88.04
28 INT9895 Binding of GHR 18 0.36 4.8 5.65 86.60
29 INT268793 Protein_catabolism of Ghr 1 0.69 0.54 0.12 77.92
30 INT16130 Binding of IGF1 67 0.48 27.43 2.95 75.52
31 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 75.00
32 INT51279 Regulation of IGFBP3 17 0.49 15.89 2.45 75.00
33 INT48617 Negative_regulation of IGF2 4 0.25 0.22 0.36 75.00
34 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 75.00
35 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 75.00
36 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 75.00
37 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 75.00
38 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 75.00
39 INT4643 Negative_regulation of GHR 10 0.45 3.01 2 75.00
40 INT51278 Positive_regulation of IGFBP2 2 0.32 1.17 0.15 75.00
41 INT51277 Negative_regulation of Gene_expression of IGF2 1 0.25 0.07 0.06 75.00
42 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01 69.76
43 INT268791 Positive_regulation of Protein_catabolism of Ghr 1 0.39 0.29 0.09 63.24
44 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 60.72
45 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 51.28
46 INT48728 Negative_regulation of IGFBP3 28 0.59 14.84 1.21 50.00
47 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85 47.92
48 INT239155 Positive_regulation of Transcription of Sod2 1 0.62 1.75 0.03 47.92
49 INT134061 Transcription of Sod2 5 0.68 3.46 1.19 46.36
50 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 44.56
51 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 42.96
52 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 42.56
53 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72 32.48
54 INT73979 Gene_expression of Hsp90ab1 6 0.61 3.68 0.43 31.60
55 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 12.92
56 INT67350 Binding of Ghr 9 0.43 1.83 0.28 5.92
57 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
58 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
59 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
60 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
61 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
62 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 5.00
63 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
64 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
65 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
66 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
67 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
68 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
69 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
70 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
71 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
72 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
73 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
74 INT14506 Regulation of Sst 46 0.62 15.02 22.66 5.00
75 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
76 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49 5.00
77 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 5.00
78 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
79 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
80 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
81 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18 5.00
82 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
83 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
84 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
85 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83 5.00
86 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
87 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
88 INT141185 Regulation of Ros1 30 0.24 20.73 8.88 5.00
89 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
90 INT101189 Transcription of Gtf3a 49 0.17 24.39 7.93 5.00
91 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
92 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 5.00
93 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
94 INT55091 Positive_regulation of Mgst1 35 0.69 10.77 6.88 5.00
95 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
96 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
97 INT31598 Gene_expression of Mgst1 41 0.78 6.44 6.3 5.00
98 INT13857 Binding of Sst 11 0.24 2.48 5.76 5.00
99 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
100 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 5.00
101 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
102 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 5.00
103 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78 5.00
104 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6 5.00
105 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 5.00
106 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
107 INT138698 Gene_expression of Txn1 15 0.77 11.71 4.24 5.00
108 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21 5.00
109 INT119544 Gene_expression of Nfe2l2 50 0.77 19.32 4.19 5.00
110 INT10842 Transcription of Gh 18 0.64 2.94 4.13 5.00
111 INT138701 Positive_regulation of Gene_expression of Txn1 10 0.50 9.16 4.03 5.00
112 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92 5.00
113 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77 5.00
114 INT35683 Gene_expression of Gsr 24 0.46 16.94 3.6 5.00
115 INT136681 Gene_expression of Shc1 13 0.77 9.67 2.52 5.00
116 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32 5.00
117 INT67352 Transcription of Ghr 8 0.61 1.55 2.3 5.00
118 INT89166 Transcription of Mgst1 6 0.72 2 2.27 5.00
119 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2 5.00
120 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 5.00
121 INT28739 Binding of Ins1 35 0.37 22.43 2.14 5.00
122 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
123 INT67139 Negative_regulation of Mod2 7 0.34 3.17 1.98 5.00
124 INT49371 Positive_regulation of Gene_expression of IGFBP3 27 0.70 23.13 1.9 5.00
125 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87 5.00
126 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83 5.00
127 INT31599 Negative_regulation of Mgst1 14 0.59 5.35 1.72 5.00
128 INT10786 Negative_regulation of Prl 14 0.59 6.43 1.66 5.00
129 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6 5.00
130 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48 5.00
131 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
132 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
133 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
134 INT89164 Positive_regulation of Transcription of Mgst1 4 0.60 1.53 1.13 5.00
135 INT202218 Positive_regulation of Aco1 4 0.27 12.31 1.06 5.00
136 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96 5.00
137 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 5.00
138 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91 5.00
139 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9 5.00
140 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 5.00
141 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82 5.00
142 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81 5.00
143 INT49370 Localization of IGFBP3 21 0.81 9.85 0.71 5.00
144 INT226179 Phosphorylation of Foxo1 15 0.68 3.14 0.7 5.00
145 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63 5.00
146 INT201640 Phosphorylation of Foxo4 4 0.80 3.55 0.61 5.00
147 INT239019 Negative_regulation of Phosphorylation of Foxo4 2 0.42 2.38 0.61 5.00
148 INT224959 Positive_regulation of Gene_expression of Ghsr 5 0.45 1.09 0.5 5.00
149 INT268796 Localization of Lar 1 0.07 0.73 0.48 5.00
150 INT228548 Gene_expression of Coq9 12 0.55 4.93 0.4 5.00
151 INT239149 Positive_regulation of Coq9 4 0.33 2.96 0.37 5.00
152 INT239159 Transcription of Nfe2l2 9 0.58 3.59 0.37 5.00
153 INT206142 Localization of STAT1 7 0.78 3.09 0.31 5.00
154 INT137586 Binding of Gpx1 8 0.23 2.76 0.29 5.00
155 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
156 INT99443 Regulation of Proc 6 0.23 5.28 0.24 5.00
157 INT67351 Positive_regulation of Localization of Ghr 2 0.44 0.78 0.23 5.00
158 INT67349 Localization of Ghr 6 0.66 2.53 0.23 5.00
159 INT115003 Binding of Msra 2 0.28 0.47 0.19 5.00
160 INT239162 Positive_regulation of H2-Q10 5 0.49 1.25 0.15 5.00
161 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 5.00
162 INT200512 Gene_expression of Lar 2 0.07 0.33 0.15 5.00
163 INT239167 Positive_regulation of Gene_expression of Coq9 1 0.12 0.72 0.15 5.00
164 INT268794 Binding of Prlr 1 0.02 0.16 0.11 5.00
165 INT239153 Regulation of Phosphorylation of Jun 2 0.27 1.46 0.07 5.00
166 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07 5.00
167 INT168028 Gene_expression of Mcat 6 0.57 3.51 0.06 5.00
168 INT239166 Negative_regulation of Clk1 1 0.06 0.74 0.06 5.00
169 INT239170 Phosphorylation of H2-Q10 1 0.44 0.27 0.05 5.00
170 INT239158 Negative_regulation of Positive_regulation of Aco1 2 0.17 1.26 0.05 5.00
171 INT239154 Gene_expression of Kl 1 0.57 2.79 0.04 5.00
172 INT239148 Transcription of Kl 1 0.51 1.05 0.04 5.00
173 INT196396 Positive_regulation of Msra 2 0.36 1.09 0.04 5.00
174 INT239171 Positive_regulation of Transcription of Kl 1 0.37 1.06 0.04 5.00
175 INT239165 Positive_regulation of Kl 1 0.51 1.03 0.03 5.00
176 INT239172 Negative_regulation of Positive_regulation of Kl 1 0.31 1.1 0.03 5.00
177 INT239152 Phosphorylation of Foxo3 1 0.43 1.04 0.03 5.00
178 INT239168 Transcription of Prop1 1 0.63 2.21 0 5.00
179 INT239174 Protein_catabolism of GGT1 1 0.86 0.47 0 5.00
180 INT239161 Positive_regulation of Negative_regulation of Pik3r1 1 0.30 0.77 0 5.00
181 INT239147 Regulation of Binding of Gpx1 1 0.28 0.53 0 5.00
182 INT239151 Transcription of Pou1f1 4 0.70 2.96 0 5.00
183 INT239150 Positive_regulation of Gene_expression of Kl 1 0.42 1.82 0 5.00
184 INT239157 Positive_regulation of Negative_regulation of Mtor 2 0.11 0.89 0 5.00
185 INT239173 Regulation of Protein_catabolism of GGT1 1 0.44 0.47 0 5.00
186 INT239164 Binding of Kl 1 0.35 0.95 0 5.00
187 INT239160 Positive_regulation of Gene_expression of Mcat 1 0.37 0.77 0 5.00
188 INT239156 Gene_expression of Msra 1 0.47 0 0 5.00
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