D:Laryngeal Edema

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Disease Term
Synonyms EDEMA LARYNGEAL, EDEMAS LARYNGEAL, Laryngeal Edemas
Documents 98
Hot Single Events 22
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Laryngeal Edema. They are ordered first by their relevance to Laryngeal Edema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT232013 SERPING1 Negative_regulation of C1S 1 0.24 0.72 0.04 67.00
2 INT232012 SERPING1 Negative_regulation of C1R 1 0.18 0.72 0.04 67.00
3 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12 54.88
4 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07 52.76
5 INT332699 Binding of KNG1 and TRGC1 1 0.16 3.37 0.75 5.00
6 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
7 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39 5.00
8 INT332707 Binding of TRGC1 and Klk1 1 0.32 1.64 0.36 5.00
9 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21 5.00
10 INT326464 KNG1 Positive_regulation of SERPING1 1 0.19 1.53 0.18 5.00
11 INT232018 Binding of SERPING1 and KNG1 1 0.15 0.81 0.14 5.00
12 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11 5.00
13 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09 5.00
14 INT232010 PLG Positive_regulation of TRGC1 1 0.08 0.51 0.09 5.00
15 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05 5.00
16 INT232016 SERPING1 Regulation of C1S 1 0.15 0.57 0 5.00
17 INT327101 Binding of AREG and EGF 1 0.05 0.35 0 5.00
18 INT327100 Binding of BTC and EGF 1 0.04 0.35 0 5.00
19 INT327099 Binding of EGF and EREG 1 0.05 0.35 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Laryngeal Edema. They are ordered first by their pain relevance and then by number of times they were reported in Laryngeal Edema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT94026 Regulation of SERPING1 12 0.61 10.28 0.37 99.48
2 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14 99.44
3 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75 99.20
4 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75 98.96
5 INT151400 Binding of JAG1 14 0.37 7.96 0.39 97.60
6 INT45413 Transcription of Serping1 1 0.68 0.9 0 97.08
7 INT74260 Positive_regulation of Serping1 5 0.64 6.05 0.8 94.84
8 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 94.16
9 INT326468 Regulation of Negative_regulation of TRGC1 1 0.19 2.8 0.17 94.16
10 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 94.04
11 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72 92.92
12 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 92.28
13 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 90.72
14 INT37864 Regulation of Negative_regulation of Serping1 1 0.10 0.69 0.09 90.72
15 INT78429 Positive_regulation of TRGC1 11 0.44 4.6 2.1 88.84
16 INT46384 Binding of TRGC1 16 0.41 4.87 1.28 85.48
17 INT328954 Negative_regulation of Binding of TRGC1 2 0.38 0.57 0.13 85.48
18 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 84.48
19 INT8775 Binding of IGHE 167 0.48 102.61 23.54 83.12
20 INT62060 Positive_regulation of Gene_expression of TRGC1 3 0.61 4.7 0.88 82.68
21 INT232021 Positive_regulation of Gene_expression of SERPING1 8 0.49 4.99 0.31 82.68
22 INT10129 Gene_expression of F12 4 0.65 3.4 0.37 82.00
23 INT314336 Positive_regulation of Negative_regulation of TRGC1 2 0.41 2.23 0.21 79.92
24 INT62061 Gene_expression of TRGC1 32 0.69 17.43 3.37 79.24
25 INT314337 Negative_regulation of Gene_expression of TRGC1 3 0.52 5.24 0.8 79.24
26 INT316315 Negative_regulation of Binding of SERPING1 2 0.37 1.4 0.34 76.76
27 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 76.32
28 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 75.28
29 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37 74.84
30 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16 74.84
31 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 74.56
32 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2 72.76
33 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 71.20
34 INT228644 Positive_regulation of Negative_regulation of SERPING1 5 0.46 4.21 0.21 71.12
35 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 69.84
36 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 67.40
37 INT16385 Regulation of C3 20 0.41 9.98 1.92 63.24
38 INT23621 Regulation of C4A 10 0.44 5.07 0.84 63.24
39 INT125725 Regulation of C1QC 1 0.06 0.83 0.18 63.24
40 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 62.36
41 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 62.36
42 INT125724 Negative_regulation of C1QC 1 0.10 0.82 0.18 62.36
43 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 62.00
44 INT58589 Regulation of F12 3 0.39 1.9 0.16 57.44
45 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 56.40
46 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27 54.88
47 INT3167 Binding of KNG1 48 0.48 23.26 26.77 52.08
48 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 51.44
49 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02 51.44
50 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 51.44
51 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 49.04
52 INT316319 Negative_regulation of C1R 1 0.38 0.64 0.04 48.40
53 INT232027 Positive_regulation of Positive_regulation of SERPING1 2 0.46 1.48 0.08 45.96
54 INT3076 Regulation of KNG1 52 0.60 20.39 27.89 42.04
55 INT14205 Regulation of KLK1 10 0.60 4.38 1.28 42.04
56 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 41.08
57 INT145530 Negative_regulation of Positive_regulation of KLK1 2 0.42 1.02 0.57 39.36
58 INT11493 Positive_regulation of KLK1 21 0.67 9.22 5 38.56
59 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 35.24
60 INT184641 Regulation of TRGC1 4 0.40 2.84 0.34 32.72
61 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 31.52
62 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 30.12
63 INT11488 Negative_regulation of KLK1 15 0.57 9.92 3.06 30.00
64 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 24.80
65 INT66720 Negative_regulation of BDKRB2 5 0.57 1.92 3.11 24.36
66 INT20664 Binding of ACE 60 0.48 35.27 9.16 19.08
67 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
68 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
69 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
70 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
71 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
72 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 5.00
73 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
74 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
75 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 5.00
76 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
77 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
78 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
79 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
80 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
81 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
82 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
83 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
84 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
85 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
86 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
87 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98 5.00
88 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
89 INT5847 Transcription of FOS 31 0.69 11.11 6.41 5.00
90 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
91 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
92 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 5.00
93 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5 5.00
94 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47 5.00
95 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
96 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 5.00
97 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
98 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 5.00
99 INT49217 Positive_regulation of Positive_regulation of KNG1 7 0.41 3.64 4.18 5.00
100 INT14778 Gene_expression of FCGR3A 25 0.75 16.25 3.86 5.00
101 INT121818 Binding of STAT3 25 0.47 11.16 3.67 5.00
102 INT76229 Binding of BDKRB1 5 0.33 1.46 3.66 5.00
103 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 5.00
104 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
105 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06 5.00
106 INT118791 Binding of AKT1 32 0.48 15.51 2.25 5.00
107 INT88375 Negative_regulation of Localization of KNG1 4 0.39 1.12 1.91 5.00
108 INT82886 Positive_regulation of Mip 7 0.49 3.61 1.89 5.00
109 INT65545 Localization of EGFR 35 0.79 20.8 1.88 5.00
110 INT135961 Positive_regulation of Hc 8 0.67 3.67 1.87 5.00
111 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8 5.00
112 INT26451 Gene_expression of KLK1 14 0.75 5.79 1.66 5.00
113 INT77164 Binding of F12 8 0.47 2.66 1.48 5.00
114 INT131457 Gene_expression of FCGR1A 11 0.75 4.88 1.45 5.00
115 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 5.00
116 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39 5.00
117 INT32101 Regulation of Mip 3 0.26 0.89 1.31 5.00
118 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28 5.00
119 INT156672 Localization of SERPING1 10 0.74 12.15 1.25 5.00
120 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21 5.00
121 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 5.00
122 INT306856 Transcription of CDC25A 2 0.28 0.85 0.92 5.00
123 INT144482 Negative_regulation of Gene_expression of SERPING1 8 0.43 6.06 0.89 5.00
124 INT35141 Regulation of PLG 6 0.44 2.64 0.85 5.00
125 INT306854 Positive_regulation of CDC25A 3 0.37 1.57 0.82 5.00
126 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7 5.00
127 INT90699 Regulation of F12 4 0.45 2.7 0.67 5.00
128 INT81371 Binding of Serping1 3 0.37 2.67 0.55 5.00
129 INT3557 Positive_regulation of C1S 10 0.67 8.73 0.54 5.00
130 INT221932 Gene_expression of F12 4 0.66 2.61 0.5 5.00
131 INT64842 Negative_regulation of Gene_expression of Serping1 2 0.35 0.56 0.36 5.00
132 INT328286 Positive_regulation of C1orf38 1 0.01 2.93 0.33 5.00
133 INT302888 Positive_regulation of HIST1H4PS1 3 0.05 1.52 0.32 5.00
134 INT174519 Gene_expression of C1R 4 0.35 0.51 0.29 5.00
135 INT26453 Binding of KLK1 2 0.47 0.84 0.28 5.00
136 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28 5.00
137 INT232024 Protein_catabolism of KLK1 2 0.64 1.21 0.28 5.00
138 INT186057 Binding of CCND1 8 0.31 5.92 0.26 5.00
139 INT311965 Positive_regulation of Gene_expression of Serping1 2 0.16 1.33 0.24 5.00
140 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21 5.00
141 INT92343 Negative_regulation of CENPJ 20 0.57 6.25 0.2 5.00
142 INT276344 Positive_regulation of PIM1 3 0.25 1.07 0.17 5.00
143 INT229968 Binding of C1S 6 0.36 5.87 0.16 5.00
144 INT122708 Localization of Mip 2 0.61 0.17 0.16 5.00
145 INT232025 Regulation of Gene_expression of SERPING1 3 0.56 1.75 0.15 5.00
146 INT332697 Negative_regulation of Klk1 1 0.42 0.88 0.13 5.00
147 INT316318 Phosphorylation of SERPING1 2 0.81 1.7 0.13 5.00
148 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12 5.00
149 INT316317 Negative_regulation of Gene_expression of KLK1 1 0.41 1.04 0.12 5.00
150 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11 5.00
151 INT82402 Negative_regulation of Negative_regulation of TRGC1 3 0.50 2.32 0.09 5.00
152 INT341046 Negative_regulation of Binding of C1S 1 0.30 1.18 0.08 5.00
153 INT341047 Negative_regulation of Negative_regulation of C1S 1 0.31 1.17 0.08 5.00
154 INT232023 Positive_regulation of Gene_expression of C1S 1 0.27 0.16 0.07 5.00
155 INT249280 Phosphorylation of PRKDC 2 0.13 0.3 0.07 5.00
156 INT232022 Positive_regulation of Gene_expression of C1R 1 0.20 0.16 0.07 5.00
157 INT293769 Positive_regulation of CCND3 3 0.06 0.23 0 5.00
158 INT327105 Transcription of CCND3 1 0.04 0.28 0 5.00
159 INT326466 Regulation of Gene_expression of F12 1 0.03 0.6 0 5.00
160 INT327104 Transcription of PIM1 1 0.13 0.29 0 5.00
161 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0 5.00
162 INT328285 Negative_regulation of Localization of SERPING1 1 0.37 0.95 0 5.00
163 INT206695 Gene_expression of GFM1 3 0.58 0.77 0 5.00
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