D:Leg Ulcer

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pChart

Disease Term
Synonyms Leg Ulcers, Ulcer Leg, Ulcers Leg
Documents 449
Hot Single Events 49
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Leg Ulcer. They are ordered first by their relevance to Leg Ulcer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230455 FOXG1 Negative_regulation of HBS1L 1 0.02 1.73 0.18 97.68
2 INT107425 Binding of ST3GAL4 and IFNK 1 0.08 1.12 0.17 75.00
3 INT118300 Vwf Positive_regulation of Crp 1 0.00 0.87 0.3 73.68
4 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 10.60
5 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
6 INT298717 Fgf2 Positive_regulation of Gene_expression of PDGFA 1 0.01 0.23 0.15 5.00
7 INT298716 Ngf Positive_regulation of Gene_expression of PDGFA 1 0.01 0.22 0.15 5.00
8 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
9 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Leg Ulcer. They are ordered first by their pain relevance and then by number of times they were reported in Leg Ulcer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 99.92
2 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15 99.92
3 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 99.88
4 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01 99.48
5 INT34008 Positive_regulation of Binding of Tbxa2r 5 0.42 1.97 1.46 99.48
6 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 99.24
7 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 99.22
8 INT105466 Binding of HM13 1 0.36 1.13 0.09 99.14
9 INT28909 Binding of Acla1 1 0.08 4.52 0.26 98.60
10 INT92612 Transcription of Pepd 1 0.55 1.71 0.08 98.56
11 INT36675 Negative_regulation of Pepd 3 0.47 8.99 0.63 98.52
12 INT36676 Gene_expression of Pepd 2 0.36 1.41 0.82 98.52
13 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 98.12
14 INT99909 Regulation of Positive_regulation of CPOX 2 0.35 1.88 0.53 97.96
15 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64 97.20
16 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 97.08
17 INT14572 Binding of INS 205 0.48 175.43 13.38 97.08
18 INT230456 Negative_regulation of Binding of HBS1L 1 0.05 1.73 0.18 97.00
19 INT40084 Binding of HBS1L 8 0.36 9.15 0.69 96.68
20 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 95.60
21 INT3647 Positive_regulation of Gene_expression of F13A1 20 0.41 15.71 5.02 95.60
22 INT153313 Regulation of Localization of F13A1 2 0.36 2.34 0.48 93.64
23 INT24815 Binding of LDHA 9 0.36 6.73 0.89 90.96
24 INT17086 Binding of HSD11B1 84 0.47 122.28 6.16 90.92
25 INT695 Binding of POMC 304 0.48 56.66 126.85 90.24
26 INT16214 Localization of F13A1 36 0.74 21.8 4.87 90.12
27 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 89.64
28 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 89.20
29 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 89.20
30 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 89.20
31 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 88.64
32 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 88.40
33 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 88.20
34 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 88.04
35 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 88.04
36 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 88.04
37 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 87.28
38 INT4047 Binding of F13A1 105 0.43 66.54 11.81 86.76
39 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 86.00
40 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 86.00
41 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 85.52
42 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 85.40
43 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 84.88
44 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 84.88
45 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 84.88
46 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 83.36
47 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 82.00
48 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 81.76
49 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 81.76
50 INT3915 Gene_expression of SCD 25 0.57 13.94 6 79.28
51 INT153732 Positive_regulation of Gene_expression of SCD 9 0.47 3.28 0.29 79.28
52 INT37136 Transcription of Vwf 4 0.56 3.57 0.56 77.36
53 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 77.32
54 INT21938 Positive_regulation of Atp7b 26 0.10 11.33 7.1 77.24
55 INT49286 Binding of IFNK 2 0.25 2.48 0.34 76.16
56 INT161091 Gene_expression of PAOD1 1 0.33 0.88 0.23 75.00
57 INT107426 Gene_expression of ST3GAL4 3 0.49 1.24 0.24 75.00
58 INT48635 Negative_regulation of Pts 15 0.49 15.38 2.43 74.24
59 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 72.76
60 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 72.72
61 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 72.56
62 INT23219 Regulation of FOXG1 8 0.22 1.32 2.34 70.84
63 INT274725 Regulation of TBL1XR1 5 0.11 2.08 0.64 70.00
64 INT36767 Localization of Atp7b 11 0.20 4.13 4.5 66.80
65 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7 65.76
66 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 64.80
67 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 64.48
68 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 64.32
69 INT107294 Positive_regulation of Cdt1 3 0.24 1.52 0.43 63.04
70 INT274742 Localization of TBL1XR1 2 0.24 1.4 0.26 62.96
71 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63 60.68
72 INT334041 Gene_expression of Cdt1 5 0.29 2.69 0.32 55.40
73 INT116375 Binding of Del(7)Tyr<c-23DVT>-p 10 0.06 8.78 0.57 53.68
74 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 53.36
75 INT28910 Negative_regulation of Acla1 1 0.10 1.16 0.1 52.96
76 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 52.80
77 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 52.80
78 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 50.00
79 INT15812 Localization of CALCB 10 0.30 8.77 6.36 50.00
80 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 49.96
81 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 49.96
82 INT92493 Gene_expression of Fdps 19 0.75 11.28 10.08 49.84
83 INT37252 Binding of Fdps 4 0.20 3.57 0.63 49.68
84 INT209503 Positive_regulation of CADPS 3 0.42 7 1.11 45.84
85 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 45.68
86 INT48636 Positive_regulation of Pts 8 0.42 7.14 1.01 45.12
87 INT111820 Positive_regulation of Fdps 10 0.42 10.63 3.01 44.52
88 INT45612 Negative_regulation of pad 8 0.37 6.74 2.57 44.36
89 INT318136 Positive_regulation of Gene_expression of HBB 1 0.04 2.65 0 40.84
90 INT128794 Negative_regulation of Gene_expression of HBB 1 0.59 5.98 0.06 40.44
91 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 40.12
92 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 39.04
93 INT62511 Negative_regulation of MCS 20 0.50 6.77 2.35 36.88
94 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33 36.40
95 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04 35.68
96 INT118291 Binding of TXK 19 0.10 11.77 1.94 35.08
97 INT239412 Binding of ABL1 8 0.28 5.39 0.18 35.08
98 INT259038 Negative_regulation of Positive_regulation of SH2B2 1 0.25 1.83 0.09 32.88
99 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 32.20
100 INT259039 Positive_regulation of Binding of ACLY 1 0.09 1.85 0.09 31.88
101 INT35584 Binding of ACLY 22 0.35 31.78 7.17 31.32
102 INT147793 Localization of COPD 70 0.64 89.01 7.3 29.92
103 INT28204 Positive_regulation of Localization of F13A1 5 0.45 3.12 0.57 29.52
104 INT14 Regulation of LDHA 22 0.57 15.26 2.14 28.72
105 INT274724 Positive_regulation of TBL1XR1 5 0.12 2.74 0.45 27.48
106 INT209354 Gene_expression of SLC9A6 15 0.58 37.52 0.29 27.00
107 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 25.00
108 INT39712 Binding of pad 82 0.48 110.92 10.33 25.00
109 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 25.00
110 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 14.20
111 INT209355 Binding of SLC9A6 8 0.42 14.9 0.09 13.04
112 INT207239 Binding of HBE1 2 0.20 1.53 0 10.60
113 INT226917 Negative_regulation of Gene_expression of Del(7)Tyr<c-23DVT>-p 1 0.05 1.12 0.03 9.36
114 INT178037 Gene_expression of Del(7)Tyr<c-23DVT>-p 18 0.22 23.44 4.07 7.00
115 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 6.96
116 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
117 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
118 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
119 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
120 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
121 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
122 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
123 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
124 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
125 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
126 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
127 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
128 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
129 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
130 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
131 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
132 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
133 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
134 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
135 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
136 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
137 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
138 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
139 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
140 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
141 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
142 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
143 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
144 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
145 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
146 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
147 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
148 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
149 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
150 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
151 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
152 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
153 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
154 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
155 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
156 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
157 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
158 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
159 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
160 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
161 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
162 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
163 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
164 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
165 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
166 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
167 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
168 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
169 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
170 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 5.00
171 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
172 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
173 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
174 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
175 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
176 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 5.00
177 INT72564 Localization of Il10 41 0.78 28.62 17.6 5.00
178 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
179 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
180 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
181 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
182 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 5.00
183 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
184 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
185 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 5.00
186 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
187 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
188 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
189 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 5.00
190 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
191 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
192 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
193 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
194 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 5.00
195 INT7105 Gene_expression of pad 54 0.77 63.68 8.8 5.00
196 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 5.00
197 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 5.00
198 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
199 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 5.00
200 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
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