D:Leigh Syndrome

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Disease Term
Synonyms DISEASE LEIGH S, Encephalomyelitides Subacute Necrotizing, Encephalomyelitis Subacute Necrotizing, ENCEPHALOMYELOPATHIES SUBACUTE NECROTIZING, Encephalomyelopathy Subacute Necrotizing, Encephalopathies Subacute Necrotizing, ENCEPHALOPATHY SUBACUTE NECROTIZING, ENCEPHALOPATHY SUBACUTE NECROTIZING INFANTILE, Encephalopathy Subacute Necrotizing Juvenile, Infantile Leigh Disease, Infantile Necrotising Encephalomyelopathy
Documents 24
Hot Single Events 8
Hot Interactions 0

Single Events

The table below shows the top 200 pain related interactions that have been reported for Leigh Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Leigh Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT290576 Positive_regulation of NPTX2 1 0.06 3.32 0.31 99.96
2 INT112728 Negative_regulation of COQ7 1 0.50 4.8 0.89 98.82
3 INT112729 Positive_regulation of Negative_regulation of COQ7 1 0.43 1.31 0.26 94.72
4 INT122767 Binding of Lrpprc 1 0.41 0.27 0.48 93.84
5 INT308323 Regulation of APOBR 1 0.01 1.91 0 90.92
6 INT308322 Regulation of ATP6 1 0.25 1.84 0 90.92
7 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 88.16
8 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 84.16
9 INT122768 Gene_expression of Lrpprc 1 0.66 0.27 0.45 77.60
10 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 74.96
11 INT7580 Positive_regulation of Mbp 54 0.70 23.37 17.14 72.40
12 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 67.92
13 INT317580 Gene_expression of Mrs2 2 0.67 10.17 3.08 52.28
14 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 36.56
15 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 26.40
16 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 26.00
17 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 25.00
18 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 25.00
19 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 21.12
20 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
21 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
22 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
23 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
24 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
25 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
26 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 5.00
27 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
28 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
29 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
30 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
31 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
32 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
33 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
34 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
35 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
36 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
37 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
38 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
39 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
40 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
41 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
42 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
43 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
44 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
45 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 5.00
46 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
47 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
48 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
49 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
50 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 5.00
51 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
52 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
53 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
54 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
55 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
56 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
57 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 5.00
58 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
59 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
60 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
61 INT12485 Binding of DNAH8 17 0.48 4.24 2.54 5.00
62 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
63 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
64 INT33053 Positive_regulation of Cox6c 9 0.69 3.74 2.23 5.00
65 INT68865 Gene_expression of ACOX1 13 0.52 5.49 2.09 5.00
66 INT117197 Gene_expression of Zmat3 19 0.05 8.3 2.05 5.00
67 INT91550 Gene_expression of PPM1D 7 0.10 0.68 1.81 5.00
68 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
69 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
70 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
71 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
72 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
73 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
74 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 5.00
75 INT91074 Negative_regulation of Mrs2 3 0.43 1.19 0.6 5.00
76 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
77 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 5.00
78 INT354345 Gene_expression of Aldh5a1 1 0.55 0.83 0.43 5.00
79 INT354335 Negative_regulation of Gene_expression of Mrs2 1 0.32 1.45 0.43 5.00
80 INT309242 Localization of Nat1 1 0.01 0.17 0.42 5.00
81 INT354338 Localization of Mrs2 1 0.64 1.19 0.38 5.00
82 INT5223 Negative_regulation of PDP1 8 0.41 1.74 0.37 5.00
83 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 5.00
84 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 5.00
85 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 5.00
86 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 5.00
87 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 5.00
88 INT354340 Binding of Aldh5a1 1 0.30 0.42 0.25 5.00
89 INT354337 Positive_regulation of Negative_regulation of Mrs2 1 0.43 0.5 0.24 5.00
90 INT354336 Binding of Mrs2 1 0.36 0.59 0.2 5.00
91 INT354343 Positive_regulation of Gene_expression of Mrs2 1 0.38 0.56 0.2 5.00
92 INT285702 Negative_regulation of Tpmt 2 0.28 1.4 0.19 5.00
93 INT204348 Gene_expression of PPARGC1A 10 0.75 2.73 0.19 5.00
94 INT354344 Regulation of Regulation of Mrs2 1 0.23 0.83 0.18 5.00
95 INT354346 Regulation of Mrs2 1 0.53 0.83 0.18 5.00
96 INT261026 Localization of Gclc 3 0.36 0.88 0.06 5.00
97 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 5.00
98 INT309245 Binding of SETX 1 0.08 1.98 0.06 5.00
99 INT309246 Localization of ATXN2 1 0.10 1.45 0.03 5.00
100 INT309254 Localization of ATXN1 1 0.09 1.45 0.03 5.00
101 INT309258 Localization of TBP 2 0.27 1.78 0.03 5.00
102 INT354342 Transcription of Mrs2 1 0.62 0.1 0.03 5.00
103 INT164193 Localization of ATN1 2 0.73 1.47 0.03 5.00
104 INT309250 Localization of ATXN3 1 0.14 1.46 0.03 5.00
105 INT309256 Localization of ATXN7 1 0.11 1.46 0.03 5.00
106 INT258134 Gene_expression of NPTX2 2 0.40 0.65 0 5.00
107 INT309255 Gene_expression of NDUFV1 1 0.01 2.33 0 5.00
108 INT354334 Transcription of Gpld1 1 0.62 0.11 0 5.00
109 INT354333 Transcription of Nrsn1 1 0.48 0.11 0 5.00
110 INT354332 Transcription of Aldh5a1 1 0.67 0.12 0 5.00
111 INT354341 Transcription of RGD1307443 1 0.09 0.12 0 5.00
112 INT354339 Transcription of Dcdc2 1 0.48 0.11 0 5.00
113 INT309248 Negative_regulation of ATXN8OS 1 0.06 1.49 0 5.00
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