D:Leptospirosis

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Disease Term
Synonyms Canicola Fever, INFECTIOUS JAUNDICE, LEPTOSPIRA, Leptospira Infection, Leptospira Infections, Leptospiroses, WEIL DISEASE, Weil S Disease
Documents 209
Hot Single Events 75
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Leptospirosis. They are ordered first by their relevance to Leptospirosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT232714 Binding of UBE2K and MMRN1 1 0.00 0.1 0 96.80
2 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91 86.96
3 INT257826 PAFAH1B1 Positive_regulation of Paf 1 0.02 1.02 0 85.44
4 INT232715 Binding of LAMB2 and SAFB 1 0.00 0.29 0 72.84
5 INT232717 Binding of COL4A4 and SAFB 1 0.00 0.3 0 72.84
6 INT232716 Binding of FN1 and SAFB 1 0.00 0.3 0 72.84
7 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
8 INT323332 Binding of Ighm and Chd7 1 0.02 0 0 5.00
9 INT323333 Binding of Ighm and Ict1 1 0.02 0 0 5.00
10 INT208639 Binding of NCAM1 and GOPC 1 0.12 0.28 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Leptospirosis. They are ordered first by their pain relevance and then by number of times they were reported in Leptospirosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 100.00
2 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 100.00
3 INT207451 Binding of PLA2G7 3 0.48 11.12 1.32 100.00
4 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 99.92
5 INT257820 Positive_regulation of PAFAH1B1 1 0.68 11.09 1.69 99.88
6 INT206796 Positive_regulation of VAMP7 2 0.56 4.12 0.07 99.88
7 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.84
8 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 99.84
9 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 99.84
10 INT201037 Gene_expression of SUMF2 3 0.26 1.6 0 99.80
11 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 99.72
12 INT257824 Localization of PAFAH1B1 1 0.74 6.58 1 99.70
13 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 99.66
14 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 99.56
15 INT180752 Gene_expression of PAFAH1B1 3 0.66 9.89 0.75 99.48
16 INT157725 Gene_expression of ACLS 2 0.13 2.89 0.17 99.40
17 INT214736 Regulation of Gene_expression of Sult2a2 1 0.05 1.72 0 99.28
18 INT214738 Gene_expression of Sult2a2 1 0.07 2.43 0 99.28
19 INT257821 Transcription of PAFAH1B1 1 0.61 1.11 0.14 99.24
20 INT257825 Binding of PAFAH1B1 1 0.37 0.89 0.17 99.20
21 INT14867 Gene_expression of Igh-6 47 0.67 30.05 11.75 99.06
22 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 99.04
23 INT61500 Binding of FN1 39 0.48 27.33 3.13 98.96
24 INT106709 Binding of LAMB2 13 0.06 4.89 1.26 98.96
25 INT99095 Binding of COL4A4 7 0.37 3.51 0.29 98.96
26 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 98.76
27 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 98.60
28 INT257817 Regulation of PAFAH1B1 1 0.60 4.93 0.7 98.56
29 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 98.22
30 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.12
31 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 98.06
32 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.80
33 INT257818 Regulation of Gene_expression of PAFAH1B1 1 0.44 0.76 0.15 97.76
34 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 97.32
35 INT74423 Localization of IL10 91 0.80 61.6 22.95 97.28
36 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 97.04
37 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 97.04
38 INT80329 Positive_regulation of THBD 12 0.47 20.96 2.45 96.92
39 INT191586 Localization of THBD 7 0.58 9.44 1.17 96.92
40 INT73497 Regulation of IL10 33 0.45 22.6 9.19 96.88
41 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 95.60
42 INT232745 Binding of UBE2K 1 0.00 0.1 0 95.44
43 INT202743 Localization of NANS 5 0.68 3.15 0.35 95.32
44 INT257816 Negative_regulation of PAFAH1B1 1 0.58 3.66 0.49 94.96
45 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 94.28
46 INT191584 Protein_catabolism of Fdps 1 0.12 1.92 0.16 94.20
47 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 93.60
48 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 93.04
49 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 92.32
50 INT194298 Gene_expression of DHPS 1 0.62 8.84 0.37 91.44
51 INT66082 Regulation of CSAD 5 0.27 4.72 1.99 89.72
52 INT47390 Negative_regulation of Paf 18 0.58 14.81 9.66 89.00
53 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 89.00
54 INT201036 Localization of SUMF2 2 0.06 1.31 0 88.60
55 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 88.08
56 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 87.88
57 INT101895 Binding of SLC17A5 5 0.36 7.08 0.18 87.84
58 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.68
59 INT317014 Binding of SUMF2 1 0.03 0.29 0 87.56
60 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 87.56
61 INT132573 Negative_regulation of Gene_expression of TH1L 16 0.42 11.52 5.76 87.28
62 INT44540 Binding of GPT 3 0.36 6.14 0.23 86.76
63 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 86.32
64 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 86.16
65 INT318974 Gene_expression of Zc3hav1 1 0.01 3.67 0.09 85.28
66 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 85.12
67 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 84.96
68 INT242263 Regulation of ACAT1 4 0.09 0.66 0.1 84.80
69 INT79063 Regulation of Gene_expression of NOS2 6 0.43 3.68 1.7 84.48
70 INT2512 Negative_regulation of Cp 27 0.51 10.15 8.37 83.76
71 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 82.32
72 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 81.36
73 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 80.60
74 INT10870 Regulation of IgG 67 0.59 43.27 12.74 80.60
75 INT105021 Binding of GOPC 187 0.40 60.39 20.38 80.16
76 INT59167 Binding of CSRP1 7 0.35 7.33 0.55 79.68
77 INT235306 Gene_expression of IGKC 5 0.38 3.18 0.34 79.68
78 INT69421 Positive_regulation of ACAT1 5 0.23 1.56 1.08 79.36
79 INT14026 Positive_regulation of Igh-6 24 0.68 10.84 4.32 79.04
80 INT214737 Localization of Sult2a2 1 0.07 0.58 0 76.84
81 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 75.76
82 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 75.32
83 INT120453 Positive_regulation of Positive_regulation of GGTLC1 1 0.06 1.19 0.09 75.00
84 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 75.00
85 INT257812 Negative_regulation of Positive_regulation of Paf 1 0.03 2.08 0.17 74.40
86 INT30222 Negative_regulation of Sult2a2 4 0.28 1.08 1.6 74.00
87 INT47391 Positive_regulation of Paf 16 0.62 12.31 3.79 73.80
88 INT242903 Gene_expression of SPI1 5 0.13 9.68 0.63 72.40
89 INT47540 Binding of Cp 20 0.41 15.54 7.01 71.32
90 INT111820 Positive_regulation of Fdps 10 0.42 10.63 3.01 70.56
91 INT37252 Binding of Fdps 4 0.20 3.57 0.63 70.56
92 INT38828 Negative_regulation of STS 14 0.44 7.27 0.68 69.36
93 INT191583 Positive_regulation of Gene_expression of Fdps 2 0.15 1.55 0.44 68.80
94 INT92493 Gene_expression of Fdps 19 0.75 11.28 10.08 68.44
95 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 68.20
96 INT1869 Negative_regulation of SLC17A5 12 0.42 5.51 0.75 68.20
97 INT342901 Negative_regulation of Regulation of SLC17A5 1 0.03 1.15 0.04 68.20
98 INT318615 Negative_regulation of Gene_expression of Cp 2 0.03 1.08 0 65.84
99 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 65.84
100 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 65.00
101 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 64.48
102 INT170606 Regulation of Gene_expression of GOPC 31 0.37 6.08 3.31 64.48
103 INT219192 Positive_regulation of Regulation of CD40LG 2 0.43 2.9 0.17 61.48
104 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 60.68
105 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 60.68
106 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 58.88
107 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 54.52
108 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 52.64
109 INT331162 Negative_regulation of Gene_expression of AMIGO2 1 0.14 3.28 0.14 51.84
110 INT179222 Gene_expression of AMIGO2 7 0.66 7.68 1.77 51.84
111 INT6849 Localization of IL1B 229 0.81 112.56 69.63 50.96
112 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 50.40
113 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 50.32
114 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 50.00
115 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 50.00
116 INT20630 Positive_regulation of Gene_expression of CHKB 19 0.47 15.79 1.85 50.00
117 INT99289 Localization of STS 8 0.79 6.5 0.92 50.00
118 INT257813 Protein_catabolism of Paf 2 0.14 1.55 0.58 50.00
119 INT17228 Regulation of 16S 8 0.60 0.84 0.21 50.00
120 INT257823 Localization of IGKC 1 0.09 0 0 50.00
121 INT228302 Transcription of 16S 3 0.67 0.08 0 50.00
122 INT91432 Binding of MMRN1 23 0.36 9.79 2.95 48.16
123 INT47958 Gene_expression of ITS 10 0.75 3.44 2.52 47.04
124 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89 44.56
125 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 42.32
126 INT59433 Gene_expression of PASK 24 0.68 25.13 3.21 42.32
127 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 39.08
128 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 38.56
129 INT232718 Gene_expression of Abpa 1 0.10 0.22 0 35.84
130 INT149861 Gene_expression of CD52 14 0.75 9.35 0.47 32.96
131 INT182215 Regulation of CXCR5 4 0.27 4.49 2.18 25.20
132 INT35009 Binding of CSAD 12 0.41 10.74 3.21 23.28
133 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 21.60
134 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 21.04
135 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55 21.04
136 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 19.28
137 INT1939 Localization of Cys1 6 0.73 5.9 0.64 13.68
138 INT159060 Localization of PDR 8 0.65 10.45 0.96 12.08
139 INT135885 Negative_regulation of PDR 5 0.46 2.66 0.19 12.08
140 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
141 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
142 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
143 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
144 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
145 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
146 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
147 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
148 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
149 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
150 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
151 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
152 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
153 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
154 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
155 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
156 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
157 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
158 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
159 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
160 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
161 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
162 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
163 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
164 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
165 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
166 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 5.00
167 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
168 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
169 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
170 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
171 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 5.00
172 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
173 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
174 INT11788 Positive_regulation of Rrsv 36 0.46 10.08 9.68 5.00
175 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13 5.00
176 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
177 INT15999 Regulation of Rrsv 14 0.23 6.06 7.48 5.00
178 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
179 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
180 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 5.00
181 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
182 INT37912 Negative_regulation of Chd7 10 0.26 5.84 4.46 5.00
183 INT9842 Binding of F2 36 0.47 22.79 4.42 5.00
184 INT187819 Regulation of IFN1@ 25 0.60 12.89 3.55 5.00
185 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 5.00
186 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
187 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 5.00
188 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 5.00
189 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 5.00
190 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
191 INT77852 Binding of Chd7 8 0.31 4.1 2.51 5.00
192 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 5.00
193 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 5.00
194 INT3797 Positive_regulation of Gene_expression of Ighm 16 0.47 9.4 2.01 5.00
195 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95 5.00
196 INT20207 Binding of Ighm 14 0.46 2.88 1.79 5.00
197 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
198 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46 5.00
199 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
200 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 5.00
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