D:Leukoplakia

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Disease Term
Synonyms Lesion Leukoplakic, LESIONS LEUKOPLAKIC, Leukokeratoses, LEUKOKERATOSIS, LEUKOPLAKIAS, Leukoplakic Lesion, LEUKOPLAKIC LESIONS
Documents 70
Hot Single Events 4
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Leukoplakia. They are ordered first by their relevance to Leukoplakia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
2 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
3 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
4 INT310727 Binding of DKC1 and TERT 1 0.23 0.91 0.05 5.00
5 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04 5.00
6 INT206705 Negative_regulation of Binding of FLT1 and VEGFA 3 0.11 1.9 0 5.00
7 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Leukoplakia. They are ordered first by their pain relevance and then by number of times they were reported in Leukoplakia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 96.36
2 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 92.40
3 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 87.84
4 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 86.68
5 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 80.00
6 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 75.00
7 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 74.84
8 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 73.64
9 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 67.04
10 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 46.64
11 INT38672 Binding of KRT20 69 0.39 48.01 6.31 38.16
12 INT310728 Binding of DKC1 1 0.25 2.36 0.38 33.92
13 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
14 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
15 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
16 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
17 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
18 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
19 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
20 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
21 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
22 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
23 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
24 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
25 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
26 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
27 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
28 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64 5.00
29 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
30 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 5.00
31 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
32 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
33 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
34 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
35 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
36 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
37 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
38 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
39 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
40 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
41 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
42 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
43 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 5.00
44 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
45 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76 5.00
46 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
47 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37 5.00
48 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
49 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
50 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38 5.00
51 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
52 INT35612 Gene_expression of REG3A 37 0.78 33.33 10.13 5.00
53 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
54 INT67612 Binding of PPARG 38 0.48 22.67 8.94 5.00
55 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
56 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
57 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
58 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
59 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 5.00
60 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11 5.00
61 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
62 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
63 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
64 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2 5.00
65 INT19916 Gene_expression of GPHA2 18 0.48 9.78 6.04 5.00
66 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 5.00
67 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 5.00
68 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 5.00
69 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
70 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
71 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88 5.00
72 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 5.00
73 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
74 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
75 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
76 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55 5.00
77 INT47674 Positive_regulation of Myoz1 21 0.54 4.37 3.57 5.00
78 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99 5.00
79 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 5.00
80 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
81 INT102233 Gene_expression of MMP7 40 0.76 15.78 2.93 5.00
82 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 5.00
83 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 5.00
84 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
85 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 5.00
86 INT222961 Negative_regulation of Binding of PPARA 22 0.41 10.76 2.72 5.00
87 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 5.00
88 INT133194 Negative_regulation of TERT 23 0.48 4.01 2.45 5.00
89 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43 5.00
90 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24 5.00
91 INT27880 Positive_regulation of HSPD1 17 0.65 18.16 2.23 5.00
92 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
93 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
94 INT64676 Gene_expression of ANXA5 11 0.75 13.48 2.11 5.00
95 INT114953 Gene_expression of NR1H4 23 0.29 16.58 2.02 5.00
96 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89 5.00
97 INT37758 Gene_expression of GC 10 0.75 7.09 1.75 5.00
98 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 5.00
99 INT114730 Phosphorylation of Myoz1 8 0.14 1.15 1.71 5.00
100 INT97318 Gene_expression of SPARC 11 0.67 5.07 1.59 5.00
101 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53 5.00
102 INT167461 Gene_expression of AHSG 5 0.75 4.59 1.53 5.00
103 INT105535 Gene_expression of Myoz1 27 0.13 3.94 1.5 5.00
104 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 5.00
105 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44 5.00
106 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41 5.00
107 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41 5.00
108 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 5.00
109 INT171975 Negative_regulation of Gene_expression of INCENP 8 0.05 5.24 1.35 5.00
110 INT147607 Binding of TERT 16 0.48 12.36 1.31 5.00
111 INT132577 Binding of RXRB 12 0.30 6.58 1.25 5.00
112 INT114961 Positive_regulation of Gene_expression of NR1H4 6 0.16 3.55 1.23 5.00
113 INT118947 Positive_regulation of FABP4 6 0.67 3.44 1.07 5.00
114 INT55688 Gene_expression of MMP11 15 0.74 10.95 1.06 5.00
115 INT58755 Binding of PAM 6 0.34 3.09 0.97 5.00
116 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96 5.00
117 INT68186 Gene_expression of GOT2 11 0.65 6.01 0.91 5.00
118 INT45093 Binding of PMEL 10 0.37 4.77 0.89 5.00
119 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87 5.00
120 INT29636 Localization of PAM 5 0.73 2.1 0.87 5.00
121 INT190678 Binding of Nfatc1 6 0.26 1.04 0.83 5.00
122 INT125092 Negative_regulation of Binding of ESR1 8 0.42 4.15 0.82 5.00
123 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 5.00
124 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81 5.00
125 INT190675 Phosphorylation of Nfatc1 6 0.56 0.68 0.76 5.00
126 INT220433 Gene_expression of RXRB 3 0.14 1.83 0.63 5.00
127 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6 5.00
128 INT164268 Phosphorylation of IFI27 3 0.39 5.82 0.59 5.00
129 INT11387 Negative_regulation of PMEL 3 0.57 1.53 0.56 5.00
130 INT10142 Gene_expression of ANXA3 4 0.35 3.1 0.54 5.00
131 INT140620 Gene_expression of HYOU1 5 0.66 3.72 0.54 5.00
132 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51 5.00
133 INT106381 Negative_regulation of CEACAM7 8 0.38 7.45 0.5 5.00
134 INT68285 Gene_expression of SERPINB3 24 0.75 25.4 0.45 5.00
135 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 5.00
136 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 5.00
137 INT70561 Regulation of ESRRB 4 0.27 1.03 0.42 5.00
138 INT190362 Negative_regulation of Transcription of PPARA 5 0.42 3.19 0.42 5.00
139 INT206749 Gene_expression of ACPP 4 0.40 2.61 0.37 5.00
140 INT192347 Phosphorylation of TXK 12 0.22 6.71 0.36 5.00
141 INT190677 Localization of Nfatc1 4 0.57 0.67 0.35 5.00
142 INT226427 Gene_expression of FABP4 9 0.44 4.07 0.34 5.00
143 INT117321 Gene_expression of HAO1 3 0.08 1.55 0.33 5.00
144 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28 5.00
145 INT70894 Gene_expression of GAPDH 6 0.65 2.92 0.28 5.00
146 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28 5.00
147 INT256425 Negative_regulation of Negative_regulation of KRT19 1 0.06 1.59 0.26 5.00
148 INT122987 Negative_regulation of CLU 5 0.42 4.58 0.21 5.00
149 INT206746 Gene_expression of TPM1 7 0.75 2.15 0.21 5.00
150 INT206740 Gene_expression of ATP7A 1 0.43 1.39 0.19 5.00
151 INT206739 Gene_expression of UHRF1 1 0.44 1.39 0.19 5.00
152 INT228267 Positive_regulation of Gene_expression of TG 5 0.50 2.2 0.17 5.00
153 INT206747 Positive_regulation of SSX2IP 1 0.06 0.47 0.17 5.00
154 INT191155 Binding of HDAC4 5 0.08 2.79 0.17 5.00
155 INT66444 Regulation of Gene_expression of HP 4 0.45 3.48 0.15 5.00
156 INT111770 Regulation of PMEL 2 0.44 0.4 0.12 5.00
157 INT256427 Negative_regulation of TG 3 0.42 1.84 0.12 5.00
158 INT190679 Localization of Myoz1 2 0.16 0.57 0.11 5.00
159 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09 5.00
160 INT177318 Negative_regulation of Binding of NR1H4 5 0.14 3.39 0.08 5.00
161 INT234477 Localization of NR1H4 3 0.24 2.23 0.07 5.00
162 INT256428 Positive_regulation of CFD 4 0.15 3.67 0.05 5.00
163 INT206741 Negative_regulation of CBLN4 1 0.01 1.11 0.03 5.00
164 INT354597 Positive_regulation of Positive_regulation of PAM 1 0.09 1.41 0.03 5.00
165 INT206752 Phosphorylation of CCNE2 2 0.06 0.78 0 5.00
166 INT206735 Negative_regulation of GPHB5 1 0.15 1.12 0 5.00
167 INT206745 Gene_expression of SCGB1D2 1 0.09 1.93 0 5.00
168 INT183067 Gene_expression of MYL2 2 0.25 1.19 0 5.00
169 INT206744 Negative_regulation of Phosphorylation of CALCRL 1 0.01 0.78 0 5.00
170 INT206734 Gene_expression of SCGN 1 0.13 0.97 0 5.00
171 INT206738 Regulation of CLU 1 0.44 1.15 0 5.00
172 INT179369 Regulation of SIT1 5 0.38 0.56 0 5.00
173 INT206743 Phosphorylation of CALCRL 1 0.01 0.78 0 5.00
174 INT190682 Negative_regulation of CDV3 1 0.57 1.38 0 5.00
175 INT310726 Localization of Terc 1 0.24 0.27 0 5.00
176 INT206742 Negative_regulation of PRDX2 5 0.04 5.04 0 5.00
177 INT274377 Localization of TERT 3 0.70 0.78 0 5.00
178 INT256426 Positive_regulation of Gene_expression of FABP4 1 0.21 1.29 0 5.00
179 INT231978 Binding of SERPINB3 9 0.36 8.33 0 5.00
180 INT182972 Gene_expression of HIST4H4 3 0.24 2.69 0 5.00
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