D:Lewy Body Disease

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Disease Term
Synonyms Cortical Lewy Body Disease, Dementia Lewy Body, Diffuse Lewy Body Disease, Lewy Body Dementia, Lewy Body Disease Cortical, LEWY BODY DISEASE DIFFUSE, LEWY BODY TYPE SENILE DEMENTIA
Documents 16
Hot Single Events 41
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lewy Body Disease. They are ordered first by their relevance to Lewy Body Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118786 Binding of KIAA0101 and NANS 1 0.28 4.67 0.3 95.28
2 INT296868 Binding of B4galnt2 and Map1lc3a 1 0.04 0.69 0.03 50.00
3 INT296867 Binding of B4galnt2 and Mtor 1 0.00 0.51 0 50.00
4 INT296869 Mtor Positive_regulation of Gene_expression of B4galnt2 1 0.01 1.56 0 50.00
5 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 5.00
6 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 5.00
7 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 5.00
8 INT327789 Binding of IgG and Alms1 1 0.01 1.1 0.17 5.00
9 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17 5.00
10 INT327791 Binding of AQP4 and Alms1 1 0.03 1.1 0.17 5.00
11 INT340744 CSF2 Regulation of BDNF 1 0.13 1.45 0.14 5.00
12 INT340742 Positive_regulation of CSF2 Regulation of BDNF 1 0.22 1.46 0.14 5.00
13 INT327792 Binding of IGFALS and Alms1 1 0.00 1.15 0.11 5.00
14 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03 5.00
15 INT340743 Negative_regulation of CSF2 Positive_regulation of ZNF807 1 0.00 1.77 0 5.00
16 INT340745 CSF2 Positive_regulation of ZNF807 1 0.00 1.76 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lewy Body Disease. They are ordered first by their pain relevance and then by number of times they were reported in Lewy Body Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT771 Regulation of Nts 93 0.61 13.13 53.57 100.00
2 INT797 Regulation of Penk 812 0.62 111.13 542.24 99.92
3 INT5993 Positive_regulation of Nts 122 0.70 26.82 70.45 99.92
4 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.92
5 INT250272 Positive_regulation of Gene_expression of AQP4 11 0.54 9.79 1.85 99.40
6 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47 99.40
7 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41 99.40
8 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99 99.40
9 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 99.00
10 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55 99.00
11 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 98.84
12 INT251679 Negative_regulation of Gene_expression of AQP4 2 0.38 10.37 0.77 98.56
13 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44 98.56
14 INT250282 Negative_regulation of AQP4 32 0.54 32.96 9.07 98.56
15 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 98.56
16 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3 97.76
17 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 97.72
18 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 97.44
19 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 97.28
20 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 96.32
21 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 96.16
22 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 96.12
23 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 95.80
24 INT6849 Localization of IL1B 229 0.81 112.56 69.63 94.68
25 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 92.48
26 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 91.28
27 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 91.12
28 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 88.28
29 INT119209 Positive_regulation of Sncg 3 0.08 0.54 2.39 87.68
30 INT125767 Positive_regulation of Gene_expression of S100b 6 0.49 4.08 1.52 86.84
31 INT82168 Positive_regulation of S100b 20 0.68 9.72 3.08 86.84
32 INT152791 Gene_expression of Sncg 1 0.08 0.37 0.08 86.04
33 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 86.00
34 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 82.96
35 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27 82.48
36 INT327778 Positive_regulation of Regulation of AQP4 1 0.37 2.84 0.07 81.52
37 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93 81.44
38 INT157960 Regulation of AQP4 11 0.48 21.36 3.06 81.12
39 INT36293 Gene_expression of Mtor 24 0.25 14.5 2.04 80.80
40 INT296852 Negative_regulation of Gene_expression of Atg7 1 0.47 4.67 0.19 80.32
41 INT296856 Negative_regulation of Gene_expression of Mtor 1 0.05 2.08 0.09 80.32
42 INT296844 Gene_expression of Atg7 1 0.62 10.64 0.86 79.36
43 INT296849 Positive_regulation of Positive_regulation of Mtor 1 0.05 1.24 0 77.44
44 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32 76.08
45 INT161248 Positive_regulation of Gene_expression of Mtor 2 0.06 6.47 0.51 75.64
46 INT296857 Gene_expression of B4galnt2 1 0.07 9.46 0.55 75.00
47 INT237038 Gene_expression of Becn1 18 0.36 13.68 0.31 75.00
48 INT296855 Gene_expression of Atg10 1 0.36 1.55 0 75.00
49 INT296860 Gene_expression of Atg12 1 0.36 1.56 0 75.00
50 INT296854 Gene_expression of Atg5 1 0.38 1.55 0 75.00
51 INT296845 Regulation of B4galnt2 1 0.05 4.76 0.08 75.00
52 INT296850 Positive_regulation of Gene_expression of Atg7 1 0.40 4.41 0.54 75.00
53 INT212458 Binding of Mtor 8 0.04 6.77 0.03 75.00
54 INT296866 Positive_regulation of Localization of B4galnt2 1 0.05 0.94 0 75.00
55 INT296847 Localization of B4galnt2 1 0.08 0.93 0 75.00
56 INT14690 Localization of CSF2 124 0.80 85.17 27.26 74.00
57 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 73.52
58 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 72.00
59 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 71.72
60 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 71.72
61 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 71.04
62 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 70.60
63 INT2570 Negative_regulation of Gene_expression of Ache 13 0.43 2.88 2.18 70.60
64 INT62564 Gene_expression of Syp 40 0.76 15.56 17 69.68
65 INT264600 Negative_regulation of Gene_expression of Syp 8 0.31 2.88 2.23 69.68
66 INT161382 Localization of KRT20 25 0.61 12.97 2.13 62.32
67 INT254878 Localization of Map1lc3a 5 0.57 3.32 0.2 50.68
68 INT65500 Gene_expression of App 605 0.78 429.94 98.31 50.00
69 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 50.00
70 INT75629 Gene_expression of Mtap2 41 0.66 8.19 4.51 50.00
71 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 50.00
72 INT215117 Gene_expression of Ctsa 14 0.33 8.66 1.18 50.00
73 INT171848 Positive_regulation of Ctsa 8 0.27 5.24 1.13 50.00
74 INT240423 Regulation of Ctsa 5 0.25 5.27 0.89 50.00
75 INT157303 Positive_regulation of Gene_expression of Map1lc3a 15 0.53 4.12 0.85 50.00
76 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 50.00
77 INT234494 Positive_regulation of Syp 12 0.65 2.47 0.69 50.00
78 INT23541 Positive_regulation of B4galnt2 3 0.26 0.92 0.62 50.00
79 INT23542 Negative_regulation of B4galnt2 3 0.22 1.67 0.6 50.00
80 INT296853 Positive_regulation of Atg7 4 0.37 1.45 0.18 50.00
81 INT165481 Negative_regulation of Gene_expression of Map1lc3a 7 0.45 2.55 0.14 50.00
82 INT296851 Localization of Atg7 1 0.60 0.82 0.14 50.00
83 INT296859 Negative_regulation of Gene_expression of B4galnt2 1 0.05 0.38 0.1 50.00
84 INT277345 Localization of Mtor 3 0.08 1.89 0.09 50.00
85 INT296848 Positive_regulation of Regulation of B4galnt2 1 0.05 0.92 0.08 50.00
86 INT296861 Regulation of Atg7 1 0.19 0.43 0.07 50.00
87 INT282985 Negative_regulation of Becn1 11 0.20 7.72 0.04 50.00
88 INT282977 Regulation of Becn1 4 0.25 2.29 0.04 50.00
89 INT296863 Regulation of Binding of Map1lc3a 1 0.35 0.71 0.03 50.00
90 INT296865 Regulation of Gene_expression of B4galnt2 1 0.05 0.77 0.03 50.00
91 INT282982 Binding of Map1lc3a 4 0.28 1.77 0.03 50.00
92 INT282729 Regulation of Binding of Mtor 2 0.05 1.48 0.03 50.00
93 INT254873 Regulation of Map1lc3a 5 0.58 1.24 0.03 50.00
94 INT296862 Positive_regulation of Gene_expression of Ctsa 1 0.20 1.35 0 50.00
95 INT296846 Regulation of Gene_expression of Ctsa 1 0.18 1.35 0 50.00
96 INT215121 Regulation of Gene_expression of Map1lc3a 2 0.35 0.77 0 50.00
97 INT296864 Negative_regulation of cma 1 0.20 1.22 0 50.00
98 INT296858 Regulation of Gene_expression of Mtor 1 0.04 0 0 50.00
99 INT334212 Negative_regulation of DLEU1 2 0.28 8.84 0.53 49.88
100 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97 48.72
101 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 48.24
102 INT232667 Binding of Pd 17 0.16 20.76 3.58 46.32
103 INT110245 Gene_expression of SNCA 11 0.77 8.29 3.36 42.80
104 INT110244 Positive_regulation of Gene_expression of SNCA 5 0.69 4.66 1.19 42.80
105 INT188755 Positive_regulation of Binding of CSF2 6 0.44 8.79 0.35 29.36
106 INT14301 Binding of CSF2 82 0.48 67.95 8.98 24.32
107 INT248772 Negative_regulation of Binding of CSF2 4 0.39 5.16 0.19 24.32
108 INT340751 Binding of DLEU1 1 0.20 12.05 0.49 22.24
109 INT258135 Gene_expression of CARTPT 3 0.40 5.25 1.88 18.96
110 INT340755 Negative_regulation of CARTPT 2 0.30 2.08 0.4 10.24
111 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 5.00
112 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
113 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
114 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
115 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
116 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
117 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
118 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
119 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
120 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55 5.00
121 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
122 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
123 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
124 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
125 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
126 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
127 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
128 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 5.00
129 INT90639 Positive_regulation of Slc6a3 25 0.61 10.95 10.41 5.00
130 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 5.00
131 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 5.00
132 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
133 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
134 INT54368 Positive_regulation of VTA1 13 0.59 3.81 8.13 5.00
135 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
136 INT157959 Binding of AQP4 32 0.48 43.44 7.44 5.00
137 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36 5.00
138 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 5.00
139 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 5.00
140 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 5.00
141 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
142 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
143 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
144 INT52512 Positive_regulation of SLC43A3 21 0.41 5.39 5.27 5.00
145 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 5.00
146 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
147 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
148 INT125836 Gene_expression of Slc18a2 8 0.72 2.65 4.03 5.00
149 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 5.00
150 INT36799 Negative_regulation of Ighm 21 0.41 17.47 3.65 5.00
151 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 5.00
152 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18 5.00
153 INT137262 Positive_regulation of Slc18a2 5 0.68 1.45 3.1 5.00
154 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9 5.00
155 INT169747 Localization of AQP4 17 0.75 16.64 2.79 5.00
156 INT11769 Regulation of Mptp1 8 0.60 6.38 2.68 5.00
157 INT206760 Localization of Nqo1 8 0.09 15.76 2.4 5.00
158 INT56084 Negative_regulation of SLC43A3 11 0.39 5.39 2.27 5.00
159 INT53998 Positive_regulation of MAOB 8 0.61 1.22 2 5.00
160 INT47714 Regulation of Nqo1 12 0.24 11.12 1.71 5.00
161 INT106709 Binding of LAMB2 13 0.06 4.89 1.26 5.00
162 INT193452 Negative_regulation of Ndufaf1 11 0.06 10.32 1.23 5.00
163 INT27536 Gene_expression of Caf 4 0.52 0.41 1.13 5.00
164 INT127714 Negative_regulation of GEM 6 0.37 2.24 1.01 5.00
165 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 5.00
166 INT24142 Regulation of DLEU1 1 0.21 1.01 0.85 5.00
167 INT271160 Negative_regulation of SYNE1 1 0.00 0.67 0.81 5.00
168 INT327776 Negative_regulation of Gene_expression of Nqo1 2 0.02 2.39 0.69 5.00
169 INT63133 Gene_expression of Pd 13 0.18 5.31 0.61 5.00
170 INT283110 Localization of Dag1 5 0.73 3.14 0.61 5.00
171 INT236837 Regulation of Negative_regulation of CSF2 2 0.32 1.83 0.61 5.00
172 INT327779 Regulation of Gene_expression of AQP4 5 0.48 4.5 0.6 5.00
173 INT14318 Negative_regulation of MAPT 3 0.57 2.05 0.59 5.00
174 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 5.00
175 INT139780 Binding of AQP1 7 0.32 4.62 0.54 5.00
176 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 5.00
177 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 5.00
178 INT230495 Regulation of Gene_expression of Alms1 4 0.04 4.53 0.53 5.00
179 INT271161 Negative_regulation of Negative_regulation of SYNE1 1 0.00 0.24 0.47 5.00
180 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 5.00
181 INT243418 Binding of Htt 14 0.30 5.94 0.44 5.00
182 INT208553 Phosphorylation of YWHAQ 4 0.80 3.42 0.36 5.00
183 INT169628 Binding of SNCA 4 0.47 3.53 0.36 5.00
184 INT271775 Positive_regulation of Gene_expression of Ache 3 0.69 5.16 0.34 5.00
185 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33 5.00
186 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
187 INT345348 Positive_regulation of Gene_expression of Slc18a2 1 0.28 0.41 0.27 5.00
188 INT264686 Positive_regulation of Gene_expression of IGFALS 2 0.28 2.21 0.27 5.00
189 INT327785 Transcription of AQP4 3 0.56 2.19 0.23 5.00
190 INT327787 Gene_expression of AQP9 4 0.28 2.5 0.23 5.00
191 INT327780 Negative_regulation of Negative_regulation of AQP4 1 0.33 1.12 0.18 5.00
192 INT327784 Regulation of Gene_expression of IGFALS 1 0.07 1.21 0.13 5.00
193 INT327781 Positive_regulation of Gene_expression of AQP9 1 0.17 0.54 0.13 5.00
194 INT345349 Protein_catabolism of Uchl1 1 0.54 0.94 0.13 5.00
195 INT101450 Positive_regulation of DLEU1 2 0.22 2.65 0.12 5.00
196 INT315626 Localization of DLEU1 2 0.35 4.17 0.07 5.00
197 INT243417 Binding of Bri3 2 0.32 0.98 0.05 5.00
198 INT340756 Positive_regulation of PRDX2 1 0.02 1.23 0.04 5.00
199 INT327783 Regulation of Transcription of AQP4 1 0.35 1.03 0 5.00
200 INT340753 Gene_expression of ZNF807 1 0.00 1.49 0 5.00
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