D:Lichen

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Disease Term
Synonyms Hypertrophic Lichen Planus, Koebner Phenomenon, Lichen Planus, Lichen Ruber Planus, LICHEN RUBRA PLANUS, Lichen Simplex, Lichen Simplex Chronicus, Lichenification, Neurodermatitis
Documents 267
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Lichen. They are ordered first by their relevance to Lichen and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 58.68
2 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 58.68
3 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91 34.60
4 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
5 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
6 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
7 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
8 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 5.00
9 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2 5.00
10 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 5.00
11 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
12 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1 5.00
13 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82 5.00
14 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
15 INT221847 Binding of Calca and Ntrk1 1 0.03 0.9 0.65 5.00
16 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6 5.00
17 INT327164 RETNLB Regulation of TNF 1 0.00 2.27 0.6 5.00
18 INT327165 RETNLB Regulation of Gene_expression of CRP 1 0.01 2.25 0.59 5.00
19 INT327166 RETNLB Regulation of IL36RN 1 0.00 2.25 0.59 5.00
20 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55 5.00
21 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 5.00
22 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41 5.00
23 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 5.00
24 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 5.00
25 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
26 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
27 INT334533 Binding of Foxq1 and Ngf 1 0.05 0.8 0.38 5.00
28 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00
29 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22 5.00
30 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22 5.00
31 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21 5.00
32 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00
33 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
34 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14 5.00
35 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14 5.00
36 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14 5.00
37 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14 5.00
38 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13 5.00
39 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13 5.00
40 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13 5.00
41 INT182607 Binding of MLH1 and MSH3 1 0.04 0.81 0.11 5.00
42 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
43 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
44 INT278264 Gene_expression of Ntf3 Positive_regulation of Smcp 1 0.02 0.32 0 5.00
45 INT334538 Il18 Positive_regulation of Localization of IFN1@ 1 0.34 0.65 0 5.00
46 INT190681 Binding of Bcl2 and Fkbp1a 1 0.01 0.46 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Lichen. They are ordered first by their pain relevance and then by number of times they were reported in Lichen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT153814 Localization of LPA 19 0.65 18.25 7.68 100.00
2 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.02
3 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.02
4 INT13354 Transcription of TNF 108 0.72 85.81 42.32 99.02
5 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58 99.02
6 INT107986 Gene_expression of PMS1 2 0.19 1.58 0.39 98.76
7 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.36
8 INT236916 Gene_expression of Ccnd2 5 0.46 2.48 0.14 97.88
9 INT9205 Binding of DSP 12 0.44 9.9 1.21 97.80
10 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 97.12
11 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42 96.44
12 INT335647 Gene_expression of OSMR 1 0.48 2.78 0.72 95.24
13 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 94.84
14 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 93.88
15 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06 93.64
16 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 93.44
17 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 92.92
18 INT93879 Positive_regulation of TRERF1 2 0.61 2.09 0.64 90.88
19 INT49487 Gene_expression of Sele 65 0.76 68.11 19.41 90.84
20 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 89.92
21 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 89.92
22 INT3167 Binding of KNG1 48 0.48 23.26 26.77 88.24
23 INT49486 Gene_expression of Cma1 6 0.52 4.17 1.13 86.56
24 INT92934 Gene_expression of GRPR 2 0.67 5.13 1.57 86.00
25 INT92935 Binding of GRPR 2 0.32 1.99 0.62 86.00
26 INT3364 Binding of SGCG 87 0.47 31.93 17.24 85.68
27 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 85.64
28 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 85.32
29 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 85.32
30 INT14497 Gene_expression of GRP 82 0.78 17.67 32.27 84.32
31 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 83.88
32 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 81.52
33 INT32130 Gene_expression of TPSG1 12 0.51 6.59 1.88 80.72
34 INT187656 Positive_regulation of RAPH1 1 0.31 1.73 0.14 76.72
35 INT147606 Positive_regulation of TLR1 5 0.67 4.35 0.47 76.52
36 INT140647 Gene_expression of DSG1 45 0.75 27.95 1.33 75.00
37 INT45725 Binding of Pdia3 8 0.47 3.61 4.42 75.00
38 INT8159 Binding of ELL 7 0.36 12.62 0.84 75.00
39 INT140645 Gene_expression of DSG3 6 0.78 4.48 0.52 75.00
40 INT140646 Gene_expression of EVPL 1 0.58 0.69 0.08 75.00
41 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14 75.00
42 INT109910 Gene_expression of CCL16 104 0.74 76.1 43.97 74.64
43 INT150540 Binding of TLR2 50 0.45 35.86 10.43 74.16
44 INT177509 Regulation of CCL21 6 0.45 5.43 1.66 72.92
45 INT177505 Regulation of CCR7 3 0.38 2.19 0.42 72.68
46 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 72.64
47 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 71.24
48 INT6481 Binding of TNF 624 0.48 510.2 214.82 70.24
49 INT6852 Localization of TNF 883 0.81 705.95 270.84 68.92
50 INT53449 Gene_expression of PPL 8 0.75 3.8 1.69 68.04
51 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 67.36
52 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 67.36
53 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 66.80
54 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 66.40
55 INT100861 Binding of CRP 179 0.48 175.2 26.45 65.92
56 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 62.64
57 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51 59.60
58 INT51014 Transcription of IL2 42 0.71 21.56 12.7 59.20
59 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 59.12
60 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 58.68
61 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 57.52
62 INT77947 Regulation of Gene_expression of IL12A 6 0.24 5.23 0.94 57.52
63 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 57.20
64 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 57.20
65 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 56.32
66 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 55.40
67 INT3970 Positive_regulation of Sord 9 0.70 4.29 3.93 53.64
68 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36 53.64
69 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47 53.64
70 INT42116 Positive_regulation of ME1 5 0.05 1.56 1.33 53.64
71 INT15752 Positive_regulation of Ema 15 0.40 14.57 2.34 50.92
72 INT109917 Positive_regulation of Gene_expression of CCL16 17 0.66 11.87 2.94 47.52
73 INT108483 Positive_regulation of Gene_expression of CCL21 7 0.69 5.76 2.45 46.96
74 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 44.12
75 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 44.12
76 INT105021 Binding of GOPC 187 0.40 60.39 20.38 43.68
77 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 43.60
78 INT146914 Negative_regulation of TLR2 12 0.53 7.41 1.23 41.92
79 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 38.44
80 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49 38.44
81 INT171021 Negative_regulation of IL5 18 0.41 14.74 3.39 38.44
82 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04 38.16
83 INT118291 Binding of TXK 19 0.10 11.77 1.94 37.56
84 INT239412 Binding of ABL1 8 0.28 5.39 0.18 37.56
85 INT40102 Positive_regulation of Phosphorylation of POMC 3 0.44 0.57 1.3 36.84
86 INT281025 Positive_regulation of Phosphorylation of Pomc 1 0.10 0.14 0.3 36.84
87 INT126514 Positive_regulation of CCR7 16 0.43 16.21 2.79 34.60
88 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88 32.88
89 INT30280 Phosphorylation of Pomc 2 0.16 0.13 0.73 32.88
90 INT14572 Binding of INS 205 0.48 175.43 13.38 32.56
91 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 31.20
92 INT341719 Transcription of FAM49B 1 0.04 1.1 0 30.64
93 INT341718 Positive_regulation of Transcription of FAM49B 1 0.03 1.1 0 30.64
94 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 29.76
95 INT145921 Localization of CCL21 4 0.73 2.41 1.58 27.68
96 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 27.64
97 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 27.64
98 INT97638 Localization of CCL16 11 0.66 4.89 3.74 27.20
99 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 26.92
100 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 26.92
101 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 25.08
102 INT74423 Localization of IL10 91 0.80 61.6 22.95 23.60
103 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42 23.24
104 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 23.24
105 INT69158 Localization of IL4 48 0.71 31.3 11.98 22.80
106 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 22.64
107 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 21.96
108 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 21.48
109 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 21.48
110 INT190678 Binding of Nfatc1 6 0.26 1.04 0.83 20.16
111 INT190677 Localization of Nfatc1 4 0.57 0.67 0.35 17.68
112 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95 16.04
113 INT177508 Regulation of Gene_expression of CCL21 1 0.27 1.23 0.3 12.64
114 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 12.04
115 INT182627 Regulation of MSH2 1 0.26 2.27 0.18 12.04
116 INT182623 Localization of MSH2 3 0.77 5.49 0.12 12.04
117 INT170438 Negative_regulation of Gene_expression of Pax3 4 0.04 1.03 3.42 11.92
118 INT147244 Regulation of MLH1 3 0.08 2.64 0.12 11.76
119 INT182621 Localization of MLH1 9 0.64 9.31 0.12 11.76
120 INT182626 Localization of MSH3 1 0.22 0.77 0.12 11.48
121 INT182622 Regulation of MSH3 1 0.08 0.77 0.12 11.48
122 INT626 Localization of CALCA 289 0.81 125.39 221.15 11.28
123 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 11.28
124 INT190675 Phosphorylation of Nfatc1 6 0.56 0.68 0.76 11.20
125 INT163839 Regulation of CRAC1 2 0.45 1.42 0.54 11.20
126 INT182628 Localization of CRAC1 1 0.01 0.77 0.12 11.20
127 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 10.44
128 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 10.44
129 INT61628 Negative_regulation of Gene_expression of IL4 31 0.55 20.96 8.18 10.44
130 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 10.44
131 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 10.44
132 INT194380 Negative_regulation of Gene_expression of IL5 22 0.42 15.78 4.1 10.44
133 INT178572 Negative_regulation of Gene_expression of IL13 9 0.14 4.51 1.94 10.44
134 INT100694 Negative_regulation of Positive_regulation of IL4 5 0.34 3.27 1.58 10.44
135 INT226492 Negative_regulation of IL13 11 0.28 7.17 2.04 9.44
136 INT79140 Binding of HCC 36 0.31 46.96 1.87 8.72
137 INT18990 Positive_regulation of GRP 32 0.70 5.22 11.23 8.56
138 INT182182 Positive_regulation of Positive_regulation of DCPS 4 0.08 3.32 0.7 6.64
139 INT114730 Phosphorylation of Myoz1 8 0.14 1.15 1.71 6.40
140 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 6.28
141 INT47674 Positive_regulation of Myoz1 21 0.54 4.37 3.57 5.80
142 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
143 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
144 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
145 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
146 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
147 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
148 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
149 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
150 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
151 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
152 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
153 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
154 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
155 INT2541 Binding of Calca 200 0.48 67.14 134.62 5.00
156 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
157 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
158 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
159 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
160 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
161 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
162 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
163 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
164 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
165 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
166 INT6437 Binding of YY1 154 0.47 26.3 90.46 5.00
167 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
168 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
169 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
170 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 5.00
171 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
172 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
173 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 5.00
174 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
175 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 5.00
176 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
177 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
178 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
179 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
180 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
181 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
182 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
183 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
184 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
185 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
186 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
187 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
188 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
189 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
190 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17 5.00
191 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
192 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
193 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 5.00
194 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
195 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
196 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
197 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
198 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
199 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
200 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 5.00
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